Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Johnston (2003)
Title High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment.
Citation J Virol
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 49
NumPts 40
Subtype C

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
TC-100 TC-100 D4T, DDI, 3TC NVP M184V K101KE, K103KN, G190A V35T, T39E, S48T, K122E, D123S, K173T, Q174K, D177E, Q197P, T200A, Q207E, K220KE, V245T, D250E, A272P, K277R K20KN, K30KN, N255IM 
TC-111 TC-111 Unknown Unknown   K22N, V35T, E36A, T39E, S48T, K122E, D123S, K173A, D177G, T200A, Q207E, T215TP, P236PL, V245Q, D250E K223KN 
TC-113 TC113_2003 Unknown Unknown   V35T, T39E, S48T, K122E, D123G, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, P243T, V245Q  
TC-114 TC114_2003 Unknown Unknown   Q23QH, V35T, T39E, E40ED, S48T, K122E, D123G, I135T, S162A, K173A, D177E, T200A, Q207E, V245Q K238K*R 
TC-117 TC117_2003 Unknown Unknown   V35T, E36A, T39E, E40D, S48T, V60I, K122E, D123N, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248N  
TC-41 TC41_2003 DDI, AZT, 3TC NVP A62AV, K65R, K219KQ Y181YC V35T, T39E, K103R, K122E, D123S, I142T, K173T, Q174K, T200A, Q207E, R211K, F214L  
TC-47 TC47_2003 D4T, DDI NVP  K103KN, V106VM, Y181YC K20R, V35T, E36A, T39E, E40D, S48T, S68SG, K122E, D123X, Q151X, S162A, K173A, Q174K, D177E, T200A, E203EK, Q207E, R211RK, F214FL, V245Q, E248D  
TC-51 TC-51 DDI None K65KR, L74LV E138A V35T, E36EA, T39E, S48T, V60I, K122EV, D123S, K173A, D177E, I178L, T200AE, E204K, Q207D, R211K, P243T, V245Q, A272P, K277KR, T286TA, E291D, I293V, A299X  
TC-52 TC52_2003 AZT, 3TC, D4T NVP M184V G190A V35M, T39E, S48T, K122E, D123N, I135M, K173T, Q174K, T200A, E203V, Q207E, V245Q  
TC-54 TC54_2003 AZT, 3TC, D4T NVP  E138A V35T, E36A, T39E, E40D, S48T, K49KQ, E53D, K102R, V118I, K122E, D123NS, T139A, E169EQ, K173T, Q174K, G196E, T200A, Q207E, F214L, V245Q, E248D  
TC-55 TC-55 DDI None   V8I, K20R, V35T, E36A, T39E, S48T, K122E, A158S, K173A, Q174K, D177E, T200A, Q207E, V245E, T253TA Q85QP 
TC-57 TC-57 3TC, D4T NVP   V35T, E36A, T39E, S48T, K122E, S163T, T165I, K173T, Q174QK, D177E, T200A, I202V, Q207E, R211K, K238R, V245Q  
TC-59 TC-59 DDI, AZT, 3TC EFV  K103N P14Q, K20R, V35T, E36A, T39E, K122E, D123S, I135M, S162C, K173V, Q174KR, D177E, Y188X, T200A, Q207K, R211K, V241I, V245Q, A272S  
TC-60 TC-60 DDI, ABC EFV K65R K101E, V106M, V108VI V35T, T39A, S48T, K122P, D123S, K166R, K173T, Q174K, D177E, I178L, Q207E, F214L, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V  
TC-62 TC-62 D4T, DDI, AZT, 3TC NVP, EFV M184V E138A, G190A P4S, V21I, V35T, E36A, T39E, S48T, W88C, K101R, K122E, K173I, Q174K, D177G, T200A, Q207E, R211K, V245Q, E248D F214P 
TC-63 TC63_2003 D4T, DDI, AZT, 3TC NVP, EFV  K103N V35T, T39E, S48T, K122E, D123E, K173AT, Q174QKR, D177E, I178IM, T200A, Q207E, R211K, P243Q, V245Q, A272P, K277R, E291D, V292I, I293V, A299X  
TC-68 TC68_2003 3TC, D4T NVP  V106VM, K238KN K22R, V35T, E36A, T39E, E40D, S48ST, T69A, W88C, K122E, D123NS, S162H, K173A, D177E, E203Q, Q207E, R211K, V245Q H198HL 
TC-71 TC-71 DDI, AZT, 3TC None A62V, K65R, F116Y, Q151M, M184V E138A V8I, V35T, T39E, V60I, S68R, W88S, K101Q, K122E, D123S, I135T, K173T, Q174K, V179I, T200A, Q207E, R211K, F214L, V245Q, E248D  
TCDD-01 TCDD-01 AZT, 3TC, D4T NVP M184V  V35T, T39E, S48T, V60I, K122E, D123S, I135V, G141X, I142X, K173A, Q174K, D177E, I178L, T200A, Q207D, R211K R143R*G 
TCDD-02 TCDD-02_1 AZT, 3TC, D4T None   V35T, E36EA, T39E, K122E, D123G, I142X, R143X, K173A, Q174R, D177E, I178IM, T200A, Q207D, R211K  
  TC02_2003 AZT, 3TC, D4T None M184V  K11Q, V35T, E36EA, T39E, S48ST, K122E, D123G, K173A, Q174R, T200A, Q207DE, R211K, F214FL, V245Q  
TCDD-03 TCDD-03 DDI, AZT None D67N, K70R, F77FL, Q151M, T215TI, K219EQ  V35T, E36A, T39D, S48T, T69N, K122E, D123N, I142X, R143X, Y144X, S162A, K173T, Q174QK, D177E, T200A, Q207E, R211K, L228HR P140Q 
TCDD-04 TCDD-04 D4T, ABC NVP, EFV   V35T, E36A, T39D, S48T, K122E, G141X, I142X, R143X, Y144X, Q145X, D177E, T200A, Q207E, R211RK V60VIM, P170G, F171I, K173Y 
TCDD-05 TCDD-05_1 D4T, 3TC None M41L, M184V  V35T, T39E, S48T, E53D, K122E, D123S, A129X, F130X, T131X, I132X, P133X, S134X, I135X, N136X, N137X, E138X, T139X, P140X, G141X, I142X, R143X, T165I, K166N, E169T, K173R, Q174K, T200A, Q207D, R211K I159A, Q161T, S162I, S163P, M164S, I167N, L168E, F171G, R172I 
  TC05_2003 D4T, 3TC None M184V  V35T, T39E, S48T, E53ED, K122E, D123S, I135L, S162A, K173T, Q174R, T200A, Q207D, R211K, V245Q  
TCDD-08 TCDD-08_1 3TC, D4T None M184V  V35K, E36A, T39E, S48T, V60I, K173T, D177E, V179VI, T200A, Q207E, F214FL  
  TC08_2003 3TC, D4T None L74LV, M184V M230ML V8I, K20R, V35K, E36A, T39E, S48T, V60I, K103KR, K173T, D177E, T200A, Q207E, K238X P97PA, T240TR 
TCDD-12 TCDD-12 DDI, 3TC None   V35T, E36A, T39D, E40ED, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, Q197P, T200X, Q207E, R211K  
TCDD-13 TCDD-13_1 DDI, AZT, 3TC None   V35T, T39E, S48T, K122E, D123NS, S162SN, K173V, Q174K, D177E, T200A, Q207A  
  TC13_2003 DDI, AZT, 3TC None M184V E138A V35T, T39E, S48T, K49KE, K122E, D123S, K173V, Q174K, D177E, T200A, Q207A, P243T, V245Q Y144YC 
TCDD-19 TCDD-19_1 AZT, 3TC None M41ML, D67DN, K70KR, M184V  V35T, T39A, K46Q, S48T, V60I, R83RK, V90VI, K122E, D123S, I135T, E138X, T139X, P140X, G141X, I142X, S163T, K166I, K173A, D177E, T200A, Q207E, T215X N137NK, Q161N, S162E, M164P, T165G 
  TC19_2003 AZT, 3TC, DDI, D4T NVP, EFV M41L, L74V K103N, V106M V35T, T39AE, V60I, K122E, D123S, I135T, S162A, K173A, D177E, T200A, Q207E, V245Q, D250E  
TCDD-22 TCDD-22 AZT, 3TC, DDI NVP M41L, M184V, T215Y K103N K32E, V35T, E36A, T39K, K43E, S48T, K122E, D123S, K173A, T200A, Q207E  
TCDD-23 TCDD-23_1 DDC, AZT None D67G, K70R, K219Q E138A V35T, T39E, S48T, K64N, V90I, K122E, D123S, K173T, Q174K, T200A, E203K, Q207E, R211K, F214L, L228R, V245E, E248D  
  TC23_2003 DDC, AZT None D67G, T69T_T, K70R, K219Q E138A V35T, T39E, S48T, V60I, K64N, K103KR, V118I, K122E, D123S, T139A, K173T, Q174K, T200A, I202V, E203K, Q207E, R211K, F214L, D218E, L228HR, V245E, E248D  
TCDD-25 TCDD-25 D4T NVP, EFV   V35T, E36A, T39E, S48T, K64KR, K122E, K173A, Q174K, D177E, T200TA, Q207A, R211RK  
TCDD-26 TCDD-26 3TC, AZT None   V35T, E36A, T39E, K43R, S48ST, E53ED, K122E, D123NS, K173E, D177E, I178IM, T200A, E204EK, Q207EK  
TCDD-27 TCDD-27 AZT, 3TC None M41L, D67DN, K70KR, M184V, T215Y A98AG V35T, E36A, T39D, S48ST, V60I, K122E, D123N, I135T, K173A, Q174K, D177E, T200A, L205LF, Q207E, R211K  
TCDD-28 TCDD-28_1 AZT, 3TC None D67N, K70R, M184V, T215TI, K219Q  V35T, T39E, S48T, V60I, K122E, D123G, I135X, N136X, N137X, E138X, T139X, P140X, G141X, I142X, S162N, S163N, K173A, Q174K, T200A, I202IV, Q207AT Q161I, M164E, K166P, I167G, L168I 
  TC28_2003 AZT, 3TC, D4T NVP D67N, K70R, M184V, T215V, K219Q E138A, Y181C V35T, T39E, S48T, V60I, T69N, K122E, D123G, I135T, I142V, I167IV, K173A, N175Y, G190X, T200A, I202V, Q207A, V245Q, D250E  
TCDD-29 TCDD-29 AZT, 3TC None D67N, K70R, M184V, K219Q  V35T, E36A, T39E, E42G, S48T, V118I, K122E, D123N, I135T, E138X, T139X, P140X, G141X, I142X, R143X, Y144X, P170T, R172G, K173I, Q174R, N175Y, V179VI, T200A, Q207E, R211K, F214L F171P 
TCDD-30 TCDD-30_1 AZT, 3TC None M184V  V35T, T39E, S48T, E53D, K122E, D123GS, K173T, D177DE, I178IL, I195K, T200A, Q207A, R211K  
  TC30_2003 AZT, 3TC, D4T NVP M41L, D67N, K70R, T215F, K219Q Y181C V35T, T39E, S48T, E53D, V60I, K122E, D123S, K173T, D177E, I178L, T200A, Q207A, R211K, L228R, V245Q  
TCDD-31 TCDD-31_1 3TC, D4T, DDI NVP M41L, D67N, L74V, T215Y Y181I S3C, E6D, V35T, T39E, K122E, D123S, I142V, T165L, K173T, Q174K, D177E, T200A, E203D, Q207E, H208Y, R211K, V245Q, E248D, A272P, K275R, Q278H, K281R, T286A, V292I, I293V, R307K  
  TC31_2003 3TC, D4T, DDI NVP, EFV M41L, D67N, L74V, T215Y K103N, Y181C, G190A S3C, E6D, V35T, T39E, K122E, D123S, I142V, S163I, T165L, K173T, Q174K, D177E, T200A, E203D, Q207E, H208Y, R211K, V245Q, E248D  
TCDD-32 TCDD-32 AZT, 3TC EFV M184V  V35T, T39E, S48T, K122E, D123S, E138ED, T139X, P140X, G141X, T165K, P170T, R172G, K173A, D177E, T200A, Q207N, R211K F171P, Q174P, I178R 
TCDD-33 TCDD-33 DDI, D4T, AZT, 3TC None   V35T, T39E, S48ST, V60I, K122E, D123GS, G141X, I142X, R143X, K166R, K173A, Q174R, D177E, I178IM, T200A, Q207E, R211K  
TCDD-35 TC35_2003 DDC, AZT, 3TC, D4T, DDI NVP M41L, D67N, K70R, Q151M, M184V, T215FY, K219E Y181C, G190A T27S, V35T, E36A, T39E, E53D, V60I, K122E, D123S, S162Y, K166R, K173A, Q174K, D177E, I178L, T200A, E203EK, Q207E, R211K, K223KE, L228H, V245Q R172I 
TCDD-6 TC06_2003 DDI None   V21I, V35M, E36A, T39E, S48T, K122E, D123S, I135R, K173A, D177E, T200A, Q207E, V245Q