Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Winters (2000)
Title Genotypic, phenotypic, and modeling studies of a deletion in the beta3-beta4 region of the human immunodeficiency virus type 1 reverse transcriptase gene that is associated with resistance to nucleoside reverse transcriptase inhibitors.
Citation J Virol
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Lab
NumIsolates 7
Lab Parent Strain NL43

 

Lab RT Isolates : Susceptibility Data


IsolateNRTIDRMsNNRTIDRMsMethodDrugFold Res.
MW-consA D67S, T69~  PBMC 3TC 17 
     PBMC ABC 3.4 
     PBMC ADV 2.9 
     PBMC AZT 2.5 
     PBMC D4T 2.4 
     PBMC DDI 2.7 
     PBMC EFV <2.0 
     PBMC NVP <2.0 
MW-consB D67S, T69~, T215Y  PBMC 3TC 16 
     PBMC ABC 8.8 
     PBMC ADV <2.0 
     PBMC AZT 16 
     PBMC D4T 10 
     PBMC DDI 5.2 
     PBMC EFV <2.0 
     PBMC NVP <2.0 
MW-consC T215Y  PBMC 3TC 3.7 
     PBMC ADV 2.0 
     PBMC AZT 15 
     PBMC D4T 2.9 
     PBMC DDI 2.9 
     PBMC NVP <2.0 
MW-consD D67S, T69~  PBMC 3TC 9.3 
     PBMC ABC 3.7 
     PBMC ADV 2.8 
     PBMC AZT <2.0 
     PBMC D4T 3.0 
     PBMC DDI 6.4 
MW-consE D67S, T69~, Q151M  PBMC 3TC 5.7 
     PBMC ABC 4.6 
     PBMC ADV <2.0 
     PBMC AZT 4.2 
     PBMC D4T 12 
     PBMC DDI 4.0 
MW-consF Q151M  PBMC 3TC 3.7 
     PBMC ABC 3.5 
     PBMC ADV <2.0 
     PBMC AZT 4.7 
     PBMC D4T 9.2 
     PBMC DDI 5.1 
MW-consK V75I, F77L, Q151M  PBMC 3TC >100 
     PBMC ABC >50 
     PBMC ADV 2.5 
     PBMC AZT >100 
     PBMC D4T >100 
     PBMC DDI >100 
     PBMC EFV <2.0 
     PBMC NVP <2.0