Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Holguin (2004)
Title Impact of frequent natural polymorphisms at the protease gene on the in vitro susceptibility to protease inhibitors in HIV-1 non-B subtypes.
Citation J Clin Virol
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 55
NumPts 55
Subtype C, CRF02_AG, G, J, CRF13_cpx, D, B

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
AH-2388 AH-2388 None    L10S, I13V, K14R, K20I, A22T, E35D, M36I, R41K, L63P, H69K, V82I, L89M  
AH-HC11 HolgHC11 None    I13V, K14R, G16E, K20I, M36I, R41K, H69K, L89M  
AH-HC12 HolgHC12 None    I13A, K14R, K20I, E35A, M36I, R41K, L63P, H69K, L89M, N98I  
AH-HC8 HolgHC8 None    I13V, L19P, K20I, M36I, N37S, R41K, H69K, L89M, N98I  
AHHC17 HolgHC17 None    L10I, E35D, M36I, R41K, L63A, C67D, H69K, L89M  
AHHC19 HolgHC19 None    I13V, K14R, I15V, K20I, E35Q, M36I, R41K, R57K, I64M, C67E, H69K, V82I, L89M I85M 
AHHC9 HolgHC9 None    I13V, G17E, L19I, K20I, E35Q, M36I, R41K, R57K, C67E, H69K, V82I, L89M, N98I  
AH_10670 AH_10670 None    I13V, K14R, K20I, E21K, M36I, R41K, H69K, L89M  
AH_11269 AH_11269 None    I13V, K14R, K20I, M36I, R41K, I64L, H69K, L89M, I93M, N98I  
AH_13374 AH_13374 None    I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89M  
AH_14460 AH_14460 None    I13V, I15V, K20I, M36I, N37S, R41K, R57K, C67S, H69K, V82I, L89M  
AH_18006 AH_18006 None    L10V, I15V, K20R, E21K, M36I, N37D, R41K, D60N, Q61E, I62V, C67E, H69K, I72V, L89M, I93L  
AH_19156 AH_19156 None    L10V, I13V, K14R, L19P, K20I, E35D, M36I, R41K, H69K, K70R, L89M  
AH_19770 AH_19770 None    I13V, K14R, I15V, K20I, E35D, M36I, R41K, L63P, H69K, I72M, L89M  
AH_19804 AH_19804 None    I13V, K14R, K20I, E35D, M36I, R41K, K43R, I64M, H69K, L89M  
AH_19808 AH_19808 None    M36I, R41K, R57K, Q61H, L63T, H69K, L89M, I93L  
AH_20263 AH_20263 None    T12S, I13V, K14R, I15V, G16E, K20I, E21K, M36I, P39L, R41K, H69K, L89M  
AH_G2721 AH_G2721 None    L10I, I13V, K20I, E35D, M36I, R41K, H69K, V82I, L89M  
AH_G4351 AH_G4351 None    I13V, I15V, K20I, M36I, R41K, L63S, H69K, L89M  
AH_G4383 AH_G4383 None    I13V, K20I, E35D, M36I, R41K, H69K, T74S, L89M  
AH_G5905 AH_G5905 None    I13V, K20I, M36I, R41K, H69K, L89M I15N 
AH_G6301 AH_G6301 None    I13V, K14R, K20I, M36I, R41K, L63F, H69K, L89M  
AH_G7110 AH_G7110 None    L10I, I13V, K20I, M36I, R41K, C67G, H69K, I72M, L89M  
AH_G8740 AH_G8740 None    I13V, K20I, M36I, N37S, R41K, H69K, L89M  
AH_M1296 AH_M1296 None    L19I, M36I, R41K, R57K, L63S  
AH_M1911 AH_M1911 None    L10I, I13A, K14R, K20I, A22T, E35G, M36I, R41K, C67H, H69K, V77I, L89M, I93L  
AH_M2444 AH_M2444 None    L10S, T12M, I13V, K14R, G17E, K20I, E34K, M36I, Q61N, I62M, L63S, C67E, H69K, V77I, L89M  
AH_R3620 AH_R3620 None    I13V, K14R, K20I, M36I, R41K, L63S, H69K, P79S, L89M T80P 
IN0010 IN0010 None    T12S, K14KR, I15V, L19I, M36I, R41K, L63A, H69K, I93L  
IN0012 IN0012 None    T12S, K14R, I15V, L19I, M36I, R41K, D60E, L63PT, H69K, V82VI, L89M, I93L  
IN0014 IN0014 None    T12S, K14R, L19I, M36V, R41K, L63P, H69K, K70R, L89M, I93L R87RG 
IN0015 IN0015 None    T12S, K14R, I15V, L19I, M36V, R41K, L63P, H69K, K70R, L89M, I93L  
IN0075 IN0075 None    T12S, K14R, I15V, L19T, M36V, R41K, L63P, H69K, K70KR, L89M, I93L  
IN0076 IN0076 None    T12PS, K14KR, I15IV, L19I, M36IV, R41K, D60DE, L63P, H69K, K70KQ, I72IV, L89M, I93L Q58QP 
IN0077 IN0077 None    T12S, K14R, I15V, L19I, E35ED, N37NS, R41RK, L63P, I64IM, H69K, K70Q, I72V, L89LM, I93L  
IN0081 IN0081 None    T12S, K14KR, I15V, L19I, M36I, R41K, L63P, H69K, K70KR, I93L L90V 
IN0086 IN0086 None    T12S, I15V, L19I, M36I, R41K, H69K, L89M, I93L  
IN0090 IN0090 None    T12S, K14R, I15V, L19I, M36I, R41K, L63S, H69K, T74S, L89M, I93L  
IN0098 IN0098 None    T12S, L19V, K20KR, M36I, N37D, R41K, D60E, Q61EG, H69K, L89M, I93L  
IN0106 IN0106 None    T12S, I15V, L19I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, V82VI, L89M, I93L  
IN0125 IN0125 None    T12S, K14R, I15V, L19I, M36I, R41K, Q61QE, L63P, I64IM, H69K, K70Q, L89LM, I93L Q58QP 
IN0132 IN0132 None    T12S, K14R, I15V, L19I, M36I, R41K, L63S, H69K, V82I, L89M, I93L  
IN81071261 IN81071261 None    T12S, I15V, G16E, L19I, M36L, L63T, H69K, L89M, I93L  
IN81071311 IN81071311 None    T12S, I15V, L19I, M36I, R41K, L63P, H69K, L89M, I93L  
IN81071334 IN81071334 None    T12S, K14R, I15V, L19T, M36V, R41K, L63P, H69K, L89M, I93L  
IN81071353 IN81071353 None    T12S, I15V, L19I, M36V, R41K, L63P, H69K, L89M, I93L  
IN81071400 IN81071400 None    T12S, I15V, L19I, M36I, P39L, R41K, L63P, H69K, L89M, I93L T26TI 
IN81071407 IN81071407 None    T12PS, K14R, I15V, L19I, M36I, R41K, L63P, H69K, L89M, I93L  
IN81071458 IN81071458 None    T12S, K14KR, I15V, G16GE, L19I, M36V, R41K, L63T, H69K, L89M, I93L  
SP_12182 SP_12182 Unknown    I13V, G17E, K20I, E35D, M36I, R41K, H69K, L89M C67M, G68W 
SP_LP16 SP_LP16 None    T12P, I13V, K14G, K20I, M36I, R41K, K43R, H69K, K70R, L89M  
SP_LP18 SP_LP18 None    I13V, K14R, I15V, K20I, M36I, R41K, I64M, H69K, L89M  
SP_LP22 SP_LP22 None    I3V, L10I, T12P, I13V, I15V, K20I, E35N, M36I, R41K, I64M, H69K, L89M  
SP_LP24 SP_LP24 None    L10V, I13V, L19P, K20I, E35D, M36I, R41K, H69K, L89M  
SP_LP9 SP_LP9 None    I13A, K14R, K20I, M36I, R41K, L63P, H69K, L89M