Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Fitzgibbon (1992)
Title Human immunodeficiency virus type 1 pol gene mutations which cause decreased susceptibility to 2',3'-dideoxycytidine.
Citation AAC
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 2
NumPts 1
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
AAC-DDC AACPR
Consensus 
None None   K66KR, T69TN, R83K, V90VI, K122KI, D123DE, I135V, T165TI, P243PH, A272X W88W*, E233EV, N265NY 
  clone: 19 None None   R83K, I135V, P243H, A272P N265Y 
  clone: 28 None None   R83K, I135V, T165I, A272P  
  clone: 36 None None   K66R, R83K, I135V, A272P  
  clone: 40 None None   T69N, R83K, V90I, I135V, A272P  
  clone: 8 None None   R83K, D123E, I135V, A272P E233V 
  clone: A-37 None None   R83K, W88*, K122I, I135V, A272X  
  AACPO
Consensus 
DDC None T69TD, M184MV  R83K, K122KE, I135IV, T139TI, S163ST, T165TI, R211RK, K220KE, V245VA, E248EK, A272P, K277KR Q258Q* 
  clone: 12 DDC None T69D  R83K, I135V, T165I, A272P  
  clone: 16 DDC None   R83K, I135V, A272P  
  clone: 18 DDC None T69D  R83K, K122E, I135V, S163T, Q258*, A272P  
  clone: 21 DDC None T69D  R83K, I135V, T139I, T165I, K220E, A272P  
  clone: 25 DDC None T69D  R83K, I135V, T165I, V245A, E248K, A272P  
  clone: 28 DDC None T69D  R83K, I135V, T139I, T165I, K220E, A272P  
  clone: 30 DDC None T69D, M184V  R83K, K122E, A272P  
  clone: 32 DDC None T69D  R83K, R211K, A272P  
  clone: 41 DDC None T69D  R83K, I135V, T165I, A272P  
  clone: 47 DDC None T69D  R83K, T165I, A272P  
  clone: 5 DDC None T69D  R83K, I135V, A272P, K277R