Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Grossman (2004)
Title Mutation D30N is not preferentially selected by human immunodeficiency virus type 1 subtype C in the development of resistance to nelfinavir.
Citation AAC
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 99
NumPts 70
Subtype C, B, A, CRF02_AG, D, Unknown

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
16790Pr66 16790Pr66 None    I15V, G16E, K20R, E21ED, M36I, R41K, H69K, L89M, I93L  
17745Pr115 17745Pr115 None    G16E, K20R, M36I, P39S, R41K, D60E, I62V, L63P  
17747Pr116 17747Pr116 None    L19I, M36I, R41K, L63V, H69K, L89M, I93L  
21689Pr316 21689Pr316 Unknown    I13V, I15V, K20R, M36I, R41K, Q61E, L63AT, H69K, L89LM, I93L  
21694Pr248 21694Pr248 Unknown  M46MI, V82VA, I84IV, L90LM Q58QE L10LI, I15V, K20KR, M36I, N37X, R41RK, L63LP, H69X, L89LM, I93IL L33L* 
21709Pr294 21709Pr294 Unknown    T12S, I15V, M36I, R41K, H69K, L89M, I93L  
IL102 IL102a NFV 14   I13X, I15V, M36I, L38LF, R41K, H69K, L89M, I93L  
  IL102b NFV 123   I15V, M36I, R41K, H69K, L89M, I93L  
IL105 IL105a IDV 52   L19V, M36I, P39S, R41K, I64V, I93IL Q18T, T26TI 
IL114 IL114 IDV 34 M46I, L90M  Q7X, L10I, T12S, I15V, L19E, M36I, P39X, R41K, L63T, H69K, V82VI, L89M, I93L G17A, K20N, E21R, A22R, L23S, D25R, T26Q, A28R 
IL128 IL128a NFV 30  L23LI I13IK, M36I, G40GE, R41K, H69K, L89M, I93L  
  IL128b NFV 41 D30N  K14N, M36I, R41K, H69K, L89M, I93L A22G 
  IL128c NFV 52   I15IV, D29DV, E35D, M36I, R41K, L63LP, H69K, L89M, I93L  
  IL128d NFV 65 D30DN  I15IK, E35D, M36I, R41K, L63P, I64IL, E65ED, H69K, L89M, I93L  
  IL128e NFV 74 D30N  K14N, E35D, M36I, R41K, L63LP, H69K, L89M, I93L  
IL139 IL139 NFV 16   M36T, N37P, P39PT, R41K, I62V, L63P, K70KR, A71AT, V77VI L97L* 
IL160 IL160 SQV, NFV 128 D30N N88D T12S, I15V, L19I, K20I, M36I, P39PS, R41K, K45R, L63T, H69K, A71IV, I93L  
IL178 IL178 NFV 65 N88S K20T L19KT, E35D, M36I, R41K, K45KR, L63P, H69K, L89M, I93L T31TK 
IL183 IL183a NFV 25   T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93L  
  IL183b NFV 30   T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93L  
  IL183c NFV 42   T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93L  
  IL183d NFV 48   T12S, I15V, L19T, M36I, R41K, Q61QH, H69K, T74A, L89M, I93L  
  IL183e NFV 66   W6WR, T12S, I13IK, I15V, L19T, K20KR, M36I, R41K, H69K, T74A, L89M I93LP 
  IL183f NFV 78   Q7R, V11I, T12S, I15V, L19T, M36I, R41K, L63LP, H69K, T74A, L89M, I93L  
IL184 IL184a NFV 39   T12S, I15V, L19T, M36I, L38LM, R41K, H69K, T74A, L89M, I93L  
  IL184b NFV 56   T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93L  
IL185 IL185a NFV 21   T12S, L19I, M36I, R41K, H69K, L89M, I93L  
  IL185b NFV 42   T12S, I15V, L19I, M36I, R41K, H69K, L89M, I93L  
  IL185c NFV 132 D30N  T12S, I15V, L19I, E35D, M36I, R41K, K45R, H69K, I85V, L89I, I93L, N98NI  
IL197 IL197a NFV 34   T12S, I15V, L19I, K20R, E35D, M36I, R41K, H69K, L89M, I93L  
  IL197b NFV 66   W6WR, T12S, I15V, G16R, Q18P, E35D, M36I, R41K, H69K, L89M, I93L L19D 
IL198 IL198a IDV   T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93L  
  IL198b IDV 51   T12S, I15V, L19T, M36I, R41K, H69K, T74A, L89M, I93L  
  IL198c IDV 69   W6L, T12S, I15V, G16R, L19T, M36I, R41K, H69K, T74A, L89M, I93L  
IL201 IL201a IDV 16   L10I, T12S, I15V, L19T, M36I, R41K, L63P, I64L, H69K, K70KE, L89M, I93L  
  IL201b IDV 55   W6S, L10I, T12S, I15V, L19T, M36I, R41K, L63X, I64IL, H69K  
  IL201c IDV 83  L89T L10I, T12S, I15V, L19T, M36I, L63P, I64L, H69K, I93L  
IL203 IL203a NFV   T12S, I15V, L19T, M36I, R41K, H69K, L89M, I93L  
  IL203b NFV 42   T12S, I15V, L19T, M36I, R41K, H69K, L89M, I93L  
  IL203c NFV 54   W6WL, T12S, I15V, L19T, M36I, R41K, H69K, L89M I93P 
IL210 IL210a NFV   T12S, K14KE, I15V, L19LI, M36I, R41K, L63P, H69K, I93L  
  IL210b NFV 55   T12S, I15V, G17X, L19LI, M36I, R41K, L63P, H69K, I93L  
  IL210c NFV 109   L10H, I15V, L19I, E35ED, M36I, R41K, K45KT, L63LP, H69K, L89LM I93LP 
IL211 IL211 IDV   K14R, E35ED, M36I, R41K, H69K, L89M, I93L E34E* 
IL215 IL215b IDV 106   T12S, L19T, M36I, R41K, H69K, L89M, I93L  
IL217 IL217 NFV 104 D30N N88D L10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, I64IV, H69Q, L89IM, I93L  
IL244 IL244 NFV 41   M36I, R41K, H69K, L89M, I93L  
IL248 IL248 NFV 85   I15V, L19I, M36I, R41K, H69K, L89M, I93L  
IL255 IL255 SQV, NFV 125 D30DN N88ND T12S, I15V, L19IT, E35ED, M36I, R41RK, R57RK, L63P, H69K, T74TS, L89M, I93L P44PL, F99FI 
IL262 IL262 IDV 55   W6WR, R8Q, I15V, L19T, M36I, R41K, Q61QH, H69K, L89M, I93L  
IL265 IL265 IDV 173 M46I, L76V K20T, L89LV I13V, I15V, R41K, K55R, I62V, L63P, I64IV, I93L  
IL266 IL266 SQV, RTV, IDV, NFV 180 I54IL, I84V, L90M T74TP R8RG, L10I, I15V, K20KI, E35EG, M36I, R41RK, L63P, H69K, A71V, L89M, Q92QR, I93L  
IL267 IL267 IDV, RTV, SQV, NFV 229 L90M K20T I13IV, K14R, I15V, G16GE, E35D, M36I, R41K, H69K, A71AV, T74S, L89I, I93L  
IL280 IL280a SQV, IDV 180 I84V, L90M  T12S, I15V, K20KR, M36I, R41RK, L63P, H69K, A71V, T74S, L89M, I93L  
  IL280b SQV, IDV 201 M46MI, I84V, L90M  T12S, I15V, Q18L, M36I, R41RK, L63P, H69KR, A71V, T74S, L89M, I93L D29DG, R87RT 
IL282 IL282 NFV 18   T12S, I13IM, I15V, L19T, E35ED, M36I, L38LM, R41K, L63P, H69K, L89M, I93L  
IL287 IL287 SQV, RTV, IDV, NFV 184 I84V, L90M  L5LI, L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, A71V, T74S, I93L  
IL293 IL293 NFV   L10P, K14R, I15V, M36I, N37D, R41RK, H69K, L89M, I93L  
IL297 IL297 NFV 58  N88ND T12S, I15V, L19I, M36I, R41K, H69K, T74A, L89M, I93L  
IL309 IL309c NFV 64 D30N, M46MIL  W6WR, L38LM, A71AV, V77I  
  IL309b NFV 99 D30N, M46I K20KT, N88D I13S, D25DN, L63LP, I66IF, A71AV, V77I  
IL310 IL310a NFV 89   N37S, I64IL, L89LM  
  IL310b NFV 136   L19I, M36I, R41K, H69K, L89M, I93L Q7P 
IL316 IL316 NFV 68 V82VA, I84IV, L90LM Q58QE I13IV, I15IV, G17GD, Q18KR, K20KR, E35ED, M36I, N37ND, R41RK, L63PR, H69HQ, L89LM, I93L  
IL32 IL32a NFV 11 M46I, N88S  K20KIM, E21K, M36I, P39LS, R41K, I62V, L63P, H69KQ, L89M L19AT, A22L 
IL351 IL351 NFV 226 M46I Q58QE I13V, K14KR, K20KR, E35ED, M36I, N37ND, R41K, H69K, L89I, I93L  
IL352 IL352 NFV 33   T12S, I15V, L19I, M36I, R41K, H69K, L89M, I93L  
IL369 IL369 NFV 111 M46I, L90M  T12S, I13V, L19I, R41K, K45Q, L63A, H69K, T74K, V77I, I85IV, L89M, I93L  
IL370 IL370 NFV 55 D30DN L10F T12S, L19V, K20KM, M36I, R41K, L63LP, H69K, T74S, N88X, L89IM, I93L  
IL384 IL384a IDV, SQV, RTV, NFV 154 M46I, I54V, V82A, L90M T74P W6WL, L10V, I15V, K20KI, M36I, N37D, R41K, L63P, H69K, A71V, L89M, I93L  
  IL384b IDV, SQV, RTV, NFV 239 M46I, I54V, V82A, L90M T74P L10V, I15V, M36I, N37D, R41K, K55R, I62V, L63P, H69K, A71V, L89M, I93L  
IL390 IL390 NFV 34   I15V, L19I, M36I, R41K, L63PS, H69K, L89M, I93L  
IL398 IL398 IDV 93   I15V, M36I, R41K, H69K, L89M, I93L  
IL400 IL400 NFV   T12S, K14R, I15V, M36I, R41K, D60E, L63P, H69K, L89M, I93L  
IL401 IL401 NFV 209 L90LM  L10R, V11F, K14R, D29DV, E35D, M36V, N37ND, R41K, L63P, I64IV, H69K, I72IV, L89LM, I93L  
IL414 IL414 NFV 27   I15V, N37D, L63LV, T74TA, V77VI  
IL428 IL428a NFV 50   T12S, I15V, L19V, M36I, R41K, H69K, T74S, L89M, I93L  
  IL428b NFV, LPV 61   T12S, I15V, L19V, M36I, R41RK, H69K, T74S, L89M, I93L  
IL433 IL433a IDV 117 M46ML, V82A, L90LM Q58E I15V, K20R, M36I, K45KR, L63T, H69K, L89M, I93L L10C 
  IL433b IDV 174 M46L, V82A, L90LM L10F, Q58QE I15V, K20R, M36I, L63PT, H69K, L89M, I93L  
IL477 IL477 NFV 208 D30N L10F, K20T, N88D T12S, I15V, L19V, E35D, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93L  
IL48 IL48 IDV 136   I15V, E35D, M36I, R41K, K45R, H69K, L89M, I93L  
IL49 IL49 NFV 64 N88NS, L90LM K20RT Q7QK, L10LI, I15V, G16E, E35D, M36I, L38LM, R41RK, R57K, L63T, H69K, T74TS, L89M, I93L  
IL503 IL503 NFV 77   N37S, L63P  
IL542 IL542 NFV 76 L90M  L10I, L19I, E35D, M36I, I62V, L63H, I64V, H69X, I93L  
IL574 IL574 NFV 56 D30N K20T Q7H, I15V, L19I, M36I, N37S, R41K, L63S, H69K, I93L R8A 
IL642 IL642 NFV 229   I15V, M36I, R41K, I47IM, H69K, L89M, I93L  
IL665 IL665 NFV 70   L10LP, I15V, M36I, R41K, K45R, L63P, H69K, I72IL, L89M, I93L V11C 
IL708 IL708 NFV 44 I84C  I15V, K20R, M36I, R41K, L63T, H69K, I72T, I93L  
IL719 IL719 NFV 149   T12S, I15V, L19I, M36I, L38LM, R41K, L63P, H69K, I93L  
IL720 IL720 IDV 341   Q7R, I15V, L19I, M36I, R41K, H69K, L89M, I93L  
IL756 IL756 IDV 50 G48V, I54T, V82A  L10I, K20R, E35D, M36I, N37D, R57K, L63P, H69R, A71V, V77VI  
IL77 IL77b NFV M46MI  G16X, K20R, M36I, N37D, R41K, H69K, L89M, I93L  
  IL77a NFV 48   K20R, M36I, N37D, R41K, H69K, L89M, I93L L24L* 
IL81 IL81 NFV 13   I15V, M36I, R41K, L63P, H69K, L89M, I93L  
IL86 IL86 IDV 58   K14R, I15V, M36I, R41K, H69K, L89M, I93L R87RI 
IL88 IL88 NFV 65   E35D, M36I, R41K, H69K, L89M, I93L A22R 
IL92 IL92 NFV 98   L10V, I15S, G16R, L19I, M36I, R41K, H69K, T74TS, L89M, I93L Q18Q* 
IL99 IL99 NFV, RTV, IDV 48 L90M K20T I15V, G16X, M36I, R41K, I64IV, H69X, L89M, I93L