Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Monno (2003)
Title Mutational patterns of paired blood and rectal biopsies in HIV-infected patients on HAART.
Citation J Med Virol
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 17
NumPts 10
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
ML_pt10 ML131 AZT, 3TC, D4T, DDI None M41L, L74V, M184V, T215Y  K20KR, K32R, S162C, D177E, R211K  
  ML131A AZT, 3TC, D4T, DDI None   K122E, K166KR, K173KQ, R211RK, F214FL, M230R A129T 
ML_pt11 ML125_1 AZT, D4T, 3TC, DDI NVP   I135T  
  ML132LASO AZT, D4T, 3TC, DDI NVP   V35X, K49KR, V60VI, R83RK, K122KE, D123E, S163SR, D177DEG, V179VI, R211X, T215X K73KR 
ML_pt12 ML125_2 AZT, DDI, 3TC, D4T, ABC NVP   V35T, T39A, V60I, R83K, D123E, E138S, I142T, S162T, K166R, R211K  
  ML134 AZT, DDI, 3TC, D4T, ABC NVP M184MIV, L210W, T215Y Y181C K102Q, V118I, D123E, S134GR, I142F, R143RK, S162C, G196E, R211K K126KE 
ML_pt13 ML135 AZT, DDI, 3TC, D4T, ABC NVP D67N, K70R, M184V, T215F, K219E Y181C, G190A K20KR, T39TP, V118I, I135T, D177E, F214L A33AP 
ML_pt14 ML136_1 AZT, DDI, 3TC, D4T NVP D67N, T69D, K70R, M184I, T215Y, K219Q K101KE, K103KN, Y181C, G190GA V118I, K122E, I135T, I142V, T165I, F214L, D218DE, S251Q, V292I, I293V, E297Q  
  ML136_2 AZT, DDI, 3TC, D4T NVP M41ML, D67DN K103KN K20KR, T39TP, K43KE, E44ED, K49KR, V60VI, T69X, A98AS, K101KQ, V118VI, K122E, D123DE, D177DG, V179VIM, E194EG, R211K F87FS, I94IV 
ML_pt2 ML126_2 AZT, DDI, 3TC, D4T EFV M41ML, D67N, K70R, M184MV, L210LW, T215SY A98G, K101KE R83RK, K103KR, D123E, D177DG, T200TI, R211K, V245T D185DE 
  ML126_1 AZT, DDI, 3TC, D4T EFV L74LV, L210W, T215Y  K20KR, K32R, V60I, R83K, F87FL, D123E, I135V, G155R, I159L, S162H, G196E, I202V, Q207E, R211K  
ML_pt6 ML127_1 AZT, DDC, DDI, 3TC, D4T NVP M41L, D67N, L74I, M184V, L210W, T215Y K103N, Y181C K20R, V35M, T39A, E44D, K102Q, V118I, K122E, D123E, S162A, E203K, Q207QE, H208HY, R211KN, K219X, K223KE  
ML_pt7 ML128_2 D4T, DDI None M41L, L210W, T215SY  D123E, I178L, R211RK, V245E K82T 
  ML128_1 D4T, DDI None M41ML  R83RK, D123EG, I178L, R211RK, V245E  
ML_pt8 ML1229 AZT, 3TC, D4T None M41ML, D67N, K70R, M184MV, T215F, K219Q A98G, K101KE, G190GV K103KR, S117SP, D123E, S162SG, E169EG, V179VI, G196GE, Q197QR, I202V, E203EK, R206RK, Q207QH, D218DE, E224EK, V245E R83EK, Q182QR 
ML_pt9 ML1030_1 AZT, DDI, 3TC, D4T, ABC None M41L, D67N, M184MV, L210W, T215Y  E40X, R83K, K101Q, K104R, V118I, D123E, E203K, Q207E, H208HY, R211K, A272P, T286P, E297R, E312Q  
  ML1030_2 AZT, DDI, 3TC, D4T, ABC None M41L, D67N, M184V, L210W, T215Y A98AG T27TP, E40X, T69TP, R83K, K101Q, K104R, V118VI, D123E, E203K, Q207E, R211K, H221HL T84TP