Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Vidal (2002)
Title Genotypic and phenotypic resistance patterns in early-stage HIV-1-infected patients failing initial therapy with stavudine, didanosine and nevirapine.
Citation Antivir Ther
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 26
NumPts 13
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
VC_pat103 VC103-1 None None   R83K, I135T, D177E, R211K  
  VC103-16 D4T, DDI NVP   K49R, V90I, I135T, D177E, R211K  
VC_pat20 VC20-9 None None   K64KR, K122KE, S162SC, I202V  
  VC20-21 D4T, DDI NVP   K64R, K122E, I202IV  
VC_pat207 VC207-1 None None   I135T, I142T, Q174QR, I178M, G196E, R211K  
  VC207-23 D4T, DDI NVP  K103N K122KQ, I142T, I178IM, T200I K104Y, P157S 
VC_pat252 VC252-3 None None L74I  K103Q, E169D, Q174K, I178M, R211K T69H, R72E, E79G, Q85R, V111E 
  VC252-10 D4T, DDI NVP M41L, L74I, T215D  K103Q, E169D, Q174K, I178M, R211K T69H, R72E, E79G, Q85R, V111E 
VC_pat256 VC256-2 None None   R83K, K122P, T165I, D177E, G196E S48F, R78S, N81Y, W88WG 
  VC256-11 D4T, DDI NVP  K103N P52A, K102KN, K122P, T165IM, D177E, G196E P59R, E79G, N81Y, S134ST 
VC_pat257 VC257-1 None None   R83K, R211K  
  VC257-8 D4T, DDI NVP T215N K103N, Y181C I47N, R83K, T139TR, R211K, V245VM D237H 
VC_pat271 VC271-1 None None   K49R, R83K, K173R, G196E, Q207H, R211K  
  VC271-4 D4T, DDI NVP   K49R, R83K, G196E, Q207QH, R211K Q91K, P150PLQ 
VC_pat272 VC272-1 None None   K49R, R83K, K173KR, G196E, Q207H, R211K  
  VC272-8 D4T, DDI NVP T215FY G190A K49R, R83K, S162ST, R211NS, V245M  
VC_pat273 VC273-1 None None   I135T, I142T, V245E  
  VC273-8 D4T, DDI NVP   I135T, I142T, V245E  
VC_pat287 VC287-1 None None   I135T, E169D, F214L, V245I  
  VC287-8 D4T, DDI, AZT NVP   K46X, T69TS, K70X, G99R, S134SC, I135T, E169D, F214L, V245I G51GV, E53*K, R72R*, A98V, L100S, P119T, K122K* 
VC_pat296 VC296-1 None None   E40D, R83K, E89K, G196E, I202IV  
  VC296-6 D4T, DDI NVP   E40D, R83K, F130FL, G196E, I202IV  
VC_pat49 VC49-7 None None   R83K, D123E, I135T, I142IT, Q174QR, I178L  
  VC49-19 D4T, DDI NVP M41L, D67N, T69D, M184MV Y181YC, H221HY E44D, S48E, V118VI, K166R, I178L, Q207K  
VC_pat53 VC53-3 None None   S162C, G196E, T200TI, K201KT, R211K  
  VC53-11 D4T, DDI, AZT NVP D67HN, K70R V108VI, G190S S162C, I167F, Q197E, E203EA, R211K, L228LR G99W, Q145K, H198HY