Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Barditch-Crovo (2001)
Title Phase I/II trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in human immunodeficiency virus-infected adults.
Citation AAC
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 14
NumPts 7
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
APre AZT, 3TC, D4T, DDI None M41L, T215Y  V60I, I135T, V245VM, I293V  
  A35 AZT, 3TC, D4T, DDI, TDF None M41L, T215Y  W24WC, V60I, S68SG, I135T, K223KR, V245VM, I293V L12L* 
BPre AZT, 3TC None M184V  E6D, K13KN, L26LF, K32N, R83K, D123E, I135T, K154KE, I202V, R211K I2M 
  B35 AZT, 3TC, TDF None M184V  R83K, D123E, I135T, I202V, R211K, V245E, A272P, I293V, E297A  
CPre AZT, 3TC None M184V  P4S, E6ED, K20R, V35I, R83X, G196E, F214FV, D218DE D76DE, I270INT 
  C35 AZT, 3TC, TDF None   P4ST, V35I, G196E, Q207QEK, D218DE, D250E K20KRT 
DPre AZT, 3TC, D4T None M184MV  K20R, V35I, D121H, K122E, Q174H, V179I, D218DE, Q269X, A272P, K277R, Q278QE Q258K, V276G 
  D35 AZT, 3TC, D4T, TDF None   K20R, V35I, D121H, K122E, K166T, Q174H, V179I, D218DE, Q269X, A272P, K277R  
EPre AZT, 3TC, D4T None M184V  R83K, T165L, R211K, D218DE, D250DE, A272P A33T 
  E35 AZT, 3TC, D4T, TDF None M184V  K43KRT, R83K, T165IL, V245VE  
FPre AZT, 3TC None M184MV  S3X, E6D, L26LF, G196E, Q207E, R211K, F214LV, D250E, A272P, I293V, P294T, A304E, N306NT, K311R, D320E, D324DE, L325LF, E328D I2Y, L210L*, I270IN, K281K*, E305HLQ, R307F, E308*L, Q330Q* 
  F35 AZT, 3TC, TDF None M184V  G196E, Q197P, Q207E, R211K, F214L, D218DE, D250E  
GPre AZT, 3TC, D4T None M184V L100LIM V75VL, F87X, D113N, D123E, K166R, Q207E, D218DE, Q258X  
  G35 AZT, 3TC, D4T, TDF None M184V  K20R, D123E, I142IT, D186DE, Q207E, D218DE, E248ED K223KI