Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Masquelier (2002)
Title Mechanisms of early virologic failure in antiretroviral-naive patients starting protease inhibitor-containing regimens: The APROVIR study.
Citation J Infect Dis
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 23
NumPts 13
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
apv1 apv1M10 3TC, D4T None M184V  A98S, D123E, S162A, D177E, T200P, Q207G T128TA 
  apv1M12 3TC, D4T None T215Y  A98S, V118VA, D123E, I135V, S162A, D177E, I178V, E203D, R211K  
apv10 apv10M6 D4T, DDI None   Q207E  
  apv10M8 D4T, DDI None   Q207E  
apv11 apv11M4 3TC, D4T None M184V  D123E, I135T, D177E, T200A, I202V, Q207K, R211K  
  apv11M6 3TC, D4T None M184V  D123E, I135T, D177E, T200A, I202V, Q207K, R211K  
apv12 apv12M8 AZT, 3TC None   T27X, E42D, K49R, R83K, F130L, S134X, I135R, N137X, S162G, Q197L, K201X, E204ED, Q207R, R211K, T215X F160L, V189L, R199RS, Y232C 
apv13 apv13M4 AZT, 3TC None A62V, D67G, M184V  R83K, I135T, S162C, Q174H, D177E, G196E, Q197K  
apv2 apv2M4 D4T, DDI None   T7S, K64R, T69A, A98S, D123E, I135T, S162A, D177E, Q207E, L210S  
  apv2M6 D4T, DDI None   V35VI, K64KR, A98S, D123E, I135T, S162A, D177E, Q207E L120LV 
apv3 apv3M8 AZT, 3TC None   V35I, T39A, R83K, A98S, K122E, D123E, I135IV, Q174N, I178L, Q207D, R211K  
  apv3M10 AZT, 3TC None   V35I, T39A, R83K, A98S, D123E, Q174N, I178IL, Q207D, R211K  
apv4 apv4M6 D4T, DDI None   K122KE, I135V, R211K  
  apv4M8 D4T, DDI None   K122KE, I135V, R211K, T253A  
apv5 apv5M8 D4T, DDI None   T39TI, D123E, D177E, T200AE, R211RK, F214L, V245M E248EG 
  apv5M10 D4T, DDI None   T7P, D123E, D177E, T200E, F214L, V245M, P247A  
apv6 apv6M12 3TC, D4T None A62AV, M184V  K122E, S134C W239W* 
apv7 apv7M10 3TC, D4T None  H221Y E6D, I135V, S162C, D177E, Q207K, R211G, V245E  
  apv7M12 3TC, D4T None M184V  P9S, A98S, D123E, S162A, D177E, Q207G  
apv8 apv8M6 AZT, 3TC None M184V  K49R, R83K, D123E, I135T, T200I, V245E  
  apv8M8 AZT, 3TC None M184V  V35VI, K49R, R83K, D123E, I135T, T200TI, I202IV, V245E  
apv9 apv9M8 AZT, 3TC None M184V, K219Q  V60I, R83K, V90I, K122E, I135T, S162Y, T200A  
  apv9M10 AZT, 3TC None M184V, K219Q  V60I, R83K, V90I, K122E, I135T, S162Y, T200A