Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Mo (2006)
Title Identification and structural characterization of I84C and I84A mutations that are associated with high-level resistance to HIV protease inhibitors and impair viral replication.
Citation AAC
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 38
NumPts 38
Subtype B

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
HM_A1 HM_A1 SQV, RTV  M46I, I84A  L10I, L63H, A71V, V77I  
HM_A10 HM_A10 SQV, RTV  M46I, I54M, I84A L10F, G73T K20I, L63P, A71V, V77I  
HM_A11 HM_A11 SQV, RTV  M46I, I84A L10F L63P, A71AV, V77VI  
HM_A12 HM_A12 SQV, RTV  M46I, I54V, L76V, I84A L33F L10I, L63P, A71V  
HM_A13 HM_A13 SQV, RTV  M46I, I54V, I84A L10F, G73S K20I, M36MI, L63P, A71V  
HM_A14 HM_A14 SQV, RTV  M46I, I47V, L76V, I84A  L10I, L63P, A71V  
HM_A15 HM_A15 SQV, RTV  M46I, I54V, I84A Q58E L10I, K20R, M36I, L63AT, A71V, V82VI  
HM_A2 HM_A2 SQV, RTV  M46I, I84A L33F L63P  
HM_A3 HM_A3 SQV, RTV  M46L, I84A  L10I, L63T, A71V  
HM_A4 HM_A4 SQV, RTV  M46I, I84A L10F L63P, A71V  
HM_A5 HM_A5 SQV, RTV  M46I, I84A  L10V, L63AP, A71V  
HM_A6 HM_A6 SQV, RTV  M46I, L76V, I84A  L10I, L63P, A71V  
HM_A7 HM_A7 SQV, RTV  M46I, I47V, I54V, I84A L10F L19I, L63P, A71V  
HM_A8 HM_A8 SQV, RTV  M46I, L76V, I84A G73S L10V, K20I, M36I, A71V  
HM_A9 HM_A9 SQV, RTV  M46I, I84A  L10I, L63P, A71V, V77I  
HM_C1 HM_C1 SQV, RTV  I84C    
HM_C10 HM_C10 SQV, RTV  I84C K20T, Q58E L10I, V82I  
HM_C11 HM_C11 SQV, RTV  I84C L24I L10I, L63H  
HM_C2 HM_C2 SQV, RTV  I84C  K20I, M36I, V82I  
HM_C3 HM_C3 SQV, RTV  I84C L24I L10I, L19LI, L63H  
HM_C4 HM_C4 SQV, RTV  M46L, I84C L10F, L24I L19LV, L63P  
HM_C5 HM_C5 SQV, RTV  M46L, I84C  L10LI, K20R, M36I, L63P, V82VI  
HM_C6 HM_C6 SQV, RTV  M46I, L76V, I84C  L10I, G16A, L63P  
HM_C7 HM_C7 SQV, RTV  M46L, I84C L24I, G73S L10I, L63P, A71T, V77I  
HM_C8 HM_C8 SQV, RTV  M46I, I84C L24LI L10I, L19I, K20KR, K55KR, L63P  
HM_C9 HM_C9 SQV, RTV  M46L, I54L, I84C L24LI L10V, L63P  
HM_V1 HM_V1 SQV, RTV  I84V G73S L63P  
HM_V10 HM_V10 SQV, RTV  M46I, I54V, I84V  L10LI, K20I, L63P, A71AT, V77I, I85V  
HM_V11 HM_V11 SQV, RTV  M46I, I54V, I84V K20T L10I, L63A, A71T, V77I  
HM_V12 HM_V12 SQV, RTV  M46I, I54V, I84V L24I, L33F, G73S L10I, K20R, M36I, L63P, A71T, V82I  
HM_V2 HM_V2 SQV, RTV  M46I, L76V, I84V  L10I  
HM_V3 HM_V3 SQV, RTV  I84V  L10I, L63P, A71T, I85V  
HM_V4 HM_V4 SQV, RTV  M46L, I84V  L10I, L63C, V77I, P79AS  
HM_V5 HM_V5 SQV, RTV  I84V K20KT L10I, G16GE, M36MI, L63LH  
HM_V6 HM_V6 SQV, RTV  M46I, L76V, I84V  L10V, K20I, M36I, L63P, A71V  
HM_V7 HM_V7 SQV, RTV  M46I, I47V, I54V, I84V  L10I, L63P, A71T  
HM_V8 HM_V8 SQV, RTV  M46I, I47V, I54V, I84V L10F L63P, A71T, P79N  
HM_V9 HM_V9 SQV, RTV  M46MI, I54V, L76V, I84V L33F L10I, L63P, A71T