Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Roge (2003)
Title K65R with and without S68: A new resistance profile in vivo detected in most patients failing abacavir, didanosine and stavudine.
Citation Antivir Ther
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 20
NumPts 8
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
bc3 bc3-B None None   D123E, I135T, R211K  
  bc3-F2 ABC, D4T, DDI None K65R  S68G, D123E, I135T, I178IM, R211K  
cw8 cw8-B None None K70T H221HY S162C, Q197H, R211K  
  cw8-F1 ABC, D4T, DDI None K70E, Q151M H221Y D113E, E138D, S162C, Q197H, R211K Q91QP 
  cw8-F2 ABC, D4T, DDI None K70E, Q151M H221Y N57Y, S68SG, S162C, Q197H, R211K, I244K N54NK, D113K 
ea1 ea1-B None None   D123E, I135T, R211K  
  ea1-F ABC, D4T, DDI None K65R, K219R V179D S68SG, T107TA, D123E, I135T, A158S, E169D, T200A, R211RK, F214L  
ehh6 ehh6-B None None D67N, K219Q  D123E, D177E, G196E, T200I, H208HY, R211K  
  ehh6-F1 ABC, D4T, DDI None D67N, K70R, V75T, T215AV, K219Q  K64Y, D123E, D177E, G196E, T200I, H208Y, R211K  
  ehh6-F2 ABC, D4T, DDI None D67N, K70R, V75T, T215V, K219Q  K64Y, D123E, D177E, G196E, T200I, H208HY, R211K, D218E  
hj2 hj2-B None None   K122E, S162A, T200A, Q207E, R211K  
  hj2-F1 ABC, D4T, DDI None K65R  S68G, D113X, K122E, S162A, T200A, Q207E, R211K  
  hj2-F2 ABC, D4T, DDI None   K122E, S162A, T200A, Q207E, R211K  
md4 md4-B None None   R83K, S162C, D177E, I178L, Q207E, R211KQ  
  md4-F1 ABC, D4T, DDI None K65R  R83K, S162C, D177E, I178L, I195L, Q207E, R211K R143RI 
sm5 sm5-B None None   T200X  
  sm5-F ABC, D4T, DDI None K65R  I178M, T200A  
so7 so7-B None None M41ML, L210W, T215N V106VI S68SG, K122KE, E204EQ, R211K  
  so7-F1 ABC, D4T, DDI None M41L, D67N, L74V, L210W, T215Y, K219R  V60I, E204Q, R211K, D218E L120I 
  so7-F2 ABC, D4T, DDI None M41L, D67N, L74V, L210W, T215Y, K219R  V60I, K64N, R72RK, E204Q, R211K, D218E