2009-10-15: Added Protease Resistance Combination Scores
For more details follow this link
2009-09-01: Added integrase Resistance Scores
For more details follow this link
2008-11-19: Most PI and NNRTI Resistance Scores and Comments updated; integrase added; PI drugs renamed
As mentioned a week ago, we have released a new version of Sierra which handles sequences with integrase and provides a partial report for it - alignment, mutation lists, and comments but no drug interpretation.
We also changed the abbreviation for most PI drugs: by adding "/r" to explicitly indicate ritonavir boosting; for example "SQV" is now "SQV/r".
Lastly, we have made extensive score and comment updates to PI and NNRTI drugs.
For a more detailed list of changes to the algorithm please follow this link http://hivdb.stanford.edu/pages/asi/releaseNotes/updates.html#Ver5.0.0_20081104
2008-11-12: On Nov 19 2008: Most PI and NNRTI Resistance Scores and Comments will be updated; integrase added; PI drugs renamed
A week from today, November 19th 2008, we plan to release a new version of Sierra which will handle sequences with integrase and provide a partial report for it - alignment, mutation lists, and comments but no drug interpretation.
At that time we will also be changing the abbreviation for most PI drugs: by adding "/r" to explicitly indicate ritonavir boosting; for example "SQV" will be "SQV/r".
Lastly, we will make extensive score and comment updates to PI and NNRTI drugs.
for a more detailed list of changes to the algorithm please follow this link http://hivdb.stanford.edu/pages/asi/releaseNotes/updates.html#Ver5.0.0_20081104
We realize that you may need to test your systems so we have made these changes available temporarily at a different port: 5441; http://db-webservices.stanford.edu:5441/axis/services/StanfordAlgorithm?wsdl
2006-10-11: PI Resistance Scores Updated
A few scores for PI drugs were updated, especially TMC 114. For more details follow this link
2006-09-18: PI Resistance Scores Updated
Scores and comments for PI drugs were updated, especially TMC 114. For more details follow this link
2006-07-31: Score update: TMC114 added and RTV removed
Algorithm scores were added for a new PI drug TMC114, scores for RTV removed, and the algorithm version was consequently updated to 4.2.1.
2006-05-24: Score update-65N
Algorithm scores were added for the mutation 65N and the algorithm version was updated to 4.2.0.
2006-02-18: RSS Feed
An RSS feed has been created to make is easier for users to track Sierra news.
You can find it here for insertion into your favorite
RSS aggregator.
2006-02-02: Score update, drug renamed, bug fix
Algorithm scores were updated and the algorithm version was increased to
java-beta-0.9.3. One drug was renamed (FPV to fAPV). Thanks to reports
from two users (D. and E.) a bug was found and fixed. Recent updates had
caused problems with mutations at position 208, but this has been corrected
(and safeguards installed to prevent further problems of that type from
occuring during upgrades). In light of this bug fix, the Sierra version
was increased to beta-0.9.3.
2006-01-24: Score update, drug renamed
Algorithm scores were updated and the algorithm version was increased to
java-beta-0.9.2. One drug was renamed (APV to FPV).
2005-11-27: Java client released
First public release of the Java client for Sierra. It can be found on the main
Sierra page in the usage section.
