Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

ETV (TMC125) Genotype-Phenotype

Select reference and gene to see isolate summary
Author (yr)TitleCitationIsolate
Vingerhoets (2003) Antiviral Activity of TMC125, a Potent Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI), against >5000 Recombinant Clinical Isolates Exhibiting a Wide Range of NNRTI Resistance unpublishedRT Lab : 35
Andries (2004) TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1 AACRT Lab : 6
Das (2004) Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 varian J Med ChemRT Lab : 15
Brillant (2004) In vitro Resistance Development for a second generation NNRTI: TMC125 unpublishedRT Lab : 7
Vingerhoets (2004) Antiviral Activity of TMC125 against a Panel of Site-directed Mutants Encompassing Mutations Observed in vitro and in vivo unpublishedRT Lab : 4
Vingerhoets (2005) TMC125 displays a high genetic barrier to the development of resistance: evidence from in vitro selection experiments J VirolRT Lab : 1