IsolateID Category Mutations APV IDV LPV NFV RTV SQV ATV 10671 Mut V32I,M46L,V82A 1.6 3.3 3.1 7.4 0.5 10774 Mut G48V,I54V,V82A 4.7 25.0 34.0 28.0 45.0 147.0 29.0 11081 Mut N88S 0.1 1.0 0.5 2.9 0.6 0.6 11094 Mut G73S,I84V,L90M 5.4 19.0 7.2 34.0 44.0 70.0 15.0 11246 Mut L24I,M46I,I54V,V82A 7.0 1.0 11262 Mut M46I,L90M 4.0 2.0 11748 Mut M46I,N88S 2.8 0.8 12.0 1.3 0.9 11807 Mut D30N,N88D 1.8 0.9 73.0 1.8 2.7 11836 Mut L90M 0.9 0.3 2.0 1.3 0.8 12062 Mut M46L,I54V,V82A,L90M 5.1 22.8 33.5 34.7 77.0 8.9 12071 Mut D30N 0.4 0.4 14.0 0.3 0.3 12534 Mut V32I,M46I,V82A 6.8 10.0 8.7 11.0 16.0 0.8 4.5 12609 Mut D30N,N88D 1.4 1.4 59.0 2.3 2.5 12632 Mut I54V,V82A,L90M 2.0 24.0 20.0 72.0 73.0 27.0 12735 Mut V32I,M46I,V82A,L90M 12.0 21.0 11.0 21.0 32.0 4.6 12.0 12913 Mut L90M 1.3 0.3 5.4 2.1 1.2 13194 Mut M46I,L90M 3.5 0.9 8.0 4.4 1.7 13222 Mut M46I,L90M 4.4 5.2 8.6 8.5 3.4 14601 Mut V82I 1.1 0.6 1.2 1.3 0.7 14880 Mut M46I,L90M 5.3 12.0 3.5 3.3 1.3 14934 Mut D30N,N88D 1.5 0.9 47.0 1.3 2.3 15074 Mut D30N,N88D 0.4 0.5 7.1 0.4 0.5 15078 Mut I84V,L90M 3.6 3.6 6.2 12.0 9.0 15080 Mut G48V,L90M 2.3 3.7 3.0 4.4 12.9 15451 Mut N88S 0.0 1.5 2.3 0.3 0.4 15452 Mut N88S 0.1 2.5 5.1 0.7 1.4 15454 Mut N88S 0.0 3.0 12.8 1.3 1.2 15468 Mut M46I 2.2 4.4 3.4 5.9 0.8 15472 Mut D30N 0.4 0.9 11.1 0.9 0.4 15476 Mut L90M 0.4 0.9 2.3 1.8 0.9 15478 Mut M46L,I54V,V82A,L90M 10.8 32.2 121.7 203.2 29.1 15481 Mut N88S 0.0 2.1 8.9 1.7 0.7 15483 Mut N88S 0.1 3.1 11.0 1.2 1.5 15484 Mut N88S 0.1 1.4 15.8 3.3 1.2 15485 Mut M46I,N88S 0.1 6.3 29.9 1.4 1.8 15486 Mut M46I,N88S 0.1 5.4 16.7 1.8 1.4 15487 Mut M46I,N88S 0.1 7.6 24.6 3.3 1.2 15488 Mut M46I,N88S 0.2 7.5 18.6 1.9 1.8 15490 Mut M46I,N88S 0.2 5.5 15.1 1.5 2.0 15493 Mut I54V,V82A 0.3 1.0 1.6 8.1 0.3 15498 Mut D30N 0.3 1.2 27.6 0.6 0.4 15500 Mut D30N,N88D 0.3 1.3 29.1 1.1 1.1 16201 Mut M46I,G73S,I84V,L90M 5.2 53.0 21.0 62.0 20.0 88.0 30.0 16755 Mut M46L,V82A,L90M 0.6 1.0 2.0 5.3 0.6 0.6 16756 Mut I50V 8.0 1.0 2.0 7.0 1.0 0.6 16764 Mut M46I,L90M 20.0 27.0 8.0 7.0 4.0 16765 Mut L90M 2.0 3.0 7.0 5.0 3.0 2.0 16770 Mut D30N,N88D 1.0 2.0 50.0 2.0 2.0 3.0 16771 Mut I54V,V82A 4.0 7.0 8.0 40.0 2.0 3.0 16775 Mut I54V,V82A,L90M 1.0 6.0 11.0 58.0 3.0 4.0 16776 Mut L90M 2.0 2.0 13.0 15.0 4.0 4.0 16783 Mut D30N,N88D 1.0 2.0 65.0 3.0 3.0 5.0 16784 Mut I54V,V82A,L90M 3.0 8.0 18.0 93.0 4.0 5.0 16785 Mut D30N,N88D 3.0 4.0 77.0 2.0 3.0 5.0 16786 Mut V32I,M46I,V82A 4.0 17.0 7.0 12.0 1.0 5.0 16788 Mut I54V,V82A 3.0 13.0 15.0 33.0 4.0 6.0 16789 Mut I54V,V82A 4.0 16.0 19.0 40.0 4.0 6.0 16790 Mut I54V,V82A 4.0 15.0 17.0 33.0 3.0 6.0 16793 Mut I84V,L90M 4.0 13.0 21.0 17.0 23.0 10.0 16795 Mut N88S 0.1 2.0 13.0 2.0 1.0 14.0 16796 Mut I54V,V82A,L90M 7.0 28.0 35.0 85.0 9.0 14.0 16813 Mut M46I,I54V,V82A 1.0 4.0 5.0 14.0 1.0 2.0 19735 Mut L24I,M46I,I54V,V82A 7.6 35.9 34.3 127.0 3.6 19751 Mut M46I 4.4 12.5 3.0 1.9 0.6 19761 Mut I54V,V82A 2.3 8.3 11.5 22.1 0.9 19765 Mut L24I,M46I,I54V,V82A 2.1 6.5 8.9 49.8 1.0 19815 Mut M46I,L90M 9.1 17.2 7.2 9.2 2.9 20319 Mut V82I 0.8 0.5 0.6 0.7 0.8 0.9 0.6 20800 Mut M46I,L90M 9.6 3.9 1.5 20802 Mut I54V,V82A 20.0 16.8 1.4 20803 Mut L24I,M46I,I54V,V82A 4.5 6.4 0.7 20804 Mut M46I,I54V,V82A 2.5 3.7 0.7 20805 Mut L90M 0.5 1.4 1.5 20808 Mut L24I,M46I,I54V,V82A 25.8 33.3 3.8 20931 Mut V32I,M46L,V82A 1.4 10.2 5.2 7.4 12.1 1.5 20932 Mut I84V,L90M 3.4 12.6 2.5 33.5 22.6 32.4 20934 Mut I54V,V82A 7.1 2.3 7.2 21.6 0.9 20938 Mut I84V,L90M 5.5 8.2 3.7 20.5 15.4 16.3 20942 Mut M46I,I54V,V82A 1.0 6.8 24.6 17.2 33.7 0.8 20943 Mut I54V,V82A,L90M 8.5 156.0 99.0 205.0 260.9 52.0 21359 Mut I84V 3.9 2.3 2.6 2.5 6.4 1.9 1.8 21669 Mut M46L,I54V,V82A,L90M 21672 Mut M46I,L90M 3.6 15.0 4.3 45.0 5.9 2.6 21686 Mut D30N,N88D 0.8 1.3 1.0 54.0 2.1 1.6 22371 Mut D30N,N88D,L90M 1.9 2.8 160.4 8.2 9.6 22372 Mut D30N,N88D,L90M 1.3 3.2 74.0 4.0 7.1 22373 Mut D30N,N88D,L90M 1.1 2.6 124.0 3.6 4.4 22374 Mut D30N,N88D,L90M 2.0 5.3 57.0 3.4 9.3 22377 Mut D30N,N88D,L90M 0.4 1.3 32.8 2.1 3.7 22378 Mut D30N,N88D,L90M 2.7 5.2 140.1 10.2 21.0 22381 Mut D30N,N88D,L90M 1.2 1.7 47.0 2.5 5.0 22382 Mut D30N,N88D,L90M 1.0 2.3 67.0 3.1 3.9 22384 Mut D30N,N88D,L90M 1.3 3.5 74.0 3.3 5.2 22720 Mut M46I,I54V,V82A 0.7 3.4 4.2 6.7 30.0 0.4 22726 Mut I54V,V82A,L90M 2.8 11.0 16.0 23.0 48.0 4.7 22728 Mut I54V,V82A,L90M 3.1 14.0 18.0 39.0 77.0 5.9 22742 Mut G48V,I54V,V82A,L90M 1.3 26.0 20.0 34.0 74.0 181.0 22760 Mut L24I,M46I,I54V,V82A 1.6 19.0 17.0 19.0 45.0 1.8 22762 Mut G73S,L90M 1.6 11.0 1.9 45.0 5.4 10.0 22810 Mut G73S,I84V,L90M 3.6 8.1 6.1 27.0 28.0 23.0 22826 Mut M46L,I54V,V82A,L90M 6.0 22.0 33.0 43.0 79.0 7.1 22882 Mut I84V,L90M 9.8 11.0 4.3 18.0 17.0 20.0 23198 Mut N88S 0.1 2.5 14.6 0.6 2.4 24346 Mut V32I,M46I,V82A,L90M 15.0 32.0 13.0 29.0 58.0 4.5 27.0 26656 Mut L90M 0.8 1.2 2.5 3.0 1.3 26682 Mut L90M 0.9 2.6 2.3 1.1 26702 Mut L90M 1.3 1.9 3.2 3.0 2.6 26710 Mut I84V 1.4 1.3 3.6 1.2 27642 Mut D30N,N88D 1.0 1.9 60.0 1.5 2.0 27659 Mut D30N,N88D 0.9 2.4 83.0 1.3 2.4 4.1 27664 Mut D30N 0.5 1.1 25.0 0.6 0.5 1.9 27667 Mut N88S 0.2 4.2 7.7 0.8 1.3 6.0 27690 Mut D30N,N88D 1.4 2.3 142.0 0.8 7.6 27692 Mut D30N,N88D 0.5 0.4 12.0 0.7 0.6 0.7 27698 Mut D30N,N88D 1.0 1.9 46.0 1.1 2.0 2.3 27701 Mut D30N,N88D,L90M 1.3 3.4 91.0 4.3 5.6 4.0 27703 Mut M46I,L90M 3.2 4.6 23.0 8.2 2.1 2.1 27704 Mut M46I 2.1 7.8 35.0 7.6 5.8 6.9 27706 Mut D30N 0.3 0.4 13.0 0.3 0.3 0.8 27707 Mut D30N,N88D 0.8 1.4 45.0 1.1 1.1 1.5 27708 Mut D30N,N88D 1.2 2.6 82.0 1.8 2.7 7.4 27709 Mut D30N 0.5 0.9 14.0 0.6 0.5 1.8 27711 Mut D30N 0.9 0.9 4.6 1.0 0.8 1.4 27712 Mut D30N 0.6 1.0 34.0 0.8 1.0 2.4 29289 Mut D30N,N88D 0.7 1.0 47.0 1.4 1.5 29297 Mut D30N 0.6 1.6 38.9 1.0 0.9 29301 Mut V32I,M46L,V82A 3.0 4.3 4.5 16.5 0.7 33304 Mut G73S,L90M 1.0 7.2 1.3 21.0 5.1 8.4 34189 Mut M46I,I54V,V82A 4.8 53.0 56.0 59.0 82.0 6.2 35473 Mut V32I,M46I,V82A 1.3 3.5 1.4 4.1 7.6 0.4 2.6 36155 Mut V82I 0.9 0.9 0.8 6.7 1.7 1.3 36811 Mut M46I,I84V 20.9 38.0 13.9 63.9 33.7 24.0 36815 Mut M46I,I84V 24.8 8.6 37.5 3.0 7.2 2.0 36816 Mut I84V 2.3 1.9 1.4 1.8 4.7 2.8 36818 Mut I84V 2.2 1.4 2.0 2.3 4.6 1.9 36819 Mut M46I,I84V 12.5 33.9 28.9 8.5 5.0 3.5 36938 Mut M46I,N88S 0.2 6.1 31.4 1.7 1.2 36942 Mut I54V,V82A 1.0 4.8 3.5 5.8 0.9 37028 Mut G48V,L90M 1.8 6.2 1.2 7.6 24.7 37032 Mut I50V 7.8 0.6 3.6 1.4 1.1 37033 Mut M46L,V82A,L90M 0.6 1.3 0.8 1.1 0.6 37034 Mut I84V,L90M 2.9 2.6 2.4 4.8 8.0 37044 Mut I84V 8.4 3.2 7.7 3.4 4.0 3.7 37047 Mut I84V 4.6 2.1 6.2 2.6 3.6 2.7 37083 Mut N88S 0.1 1.6 2.4 0.4 0.5 37084 Mut N88S 0.1 2.6 5.1 0.8 1.4 37086 Mut N88S 0.1 3.1 12.9 1.4 1.2 3788 Mut G48V,I54V,V82A 3.0 35.0 32.0 29.0 41.0 164.0 32.0 38070 Mut G48V,I54V,V82A,L90M 2.6 46.0 30.0 59.0 59.0 322.0 3833 Mut M46L,I54V,V82A,L90M 3.9 20.2 21.6 74.1 9.2 38622 Mut L90M 1.0 3.6 1.3 5.7 3.0 2.4 39159 Mut D30N,N88D 0.5 1.1 0.7 38.0 1.2 15.0 2.5 40960 Mut M46I,G73S,I84V,L90M 13.0 77.0 34.0 116.0 87.0 278.0 41282 Mut V82I 1.8 0.9 1.0 7.0 2.9 1.4 1.9 4257 Mut G73S,I84V,L90M 21.0 7.5 55.0 54.0 85.0 4371 Mut G73S,L90M 3.1 8.7 32.0 14.7 16.9 4390 Mut V82I 1.2 0.7 3.6 1.7 1.3 7757 Mut G48V,I54V,V82A 2.1 12.0 22.0 15.0 20.0 82.0 16.0 8418 Mut I54V,V82A,L90M 16.0 20.0 37.0 102.0 7.9 9601 Mut M46I,G73S,I84V,L90M 11.0 28.0 17.0 53.0 43.0 62.0 18.0 9644 Mut G73S,L90M 0.4 1.9 0.9 3.7 3.1 2.5 2.0 9662 Mut D30N 0.7 0.7 11.0 0.6 0.4 9961 Mut I54V,V82A,L90M 19.0 37.0 41.0 83.0 10.0 10823 WT 0.9 0.7 1.3 0.8 0.7 11258 WT 2.0 1.0 11264 WT 1.0 1.0 11266 WT 1.0 1.0 11873 WT 1.2 1.2 3.0 1.6 1.0 12035 WT 0.3 0.3 0.4 0.3 0.4 12529 WT 1.0 0.7 1.6 1.3 0.9 12624 WT 1.2 1.4 1.8 1.6 0.9 12878 WT 0.4 0.6 0.6 0.7 0.8 0.8 14578 WT 1.6 0.8 2.2 1.0 1.1 14851 WT 0.5 0.6 0.8 0.5 0.6 15456 WT 0.3 0.4 0.4 0.4 0.3 15457 WT 1.0 1.1 1.4 1.2 1.0 15458 WT 0.9 1.7 2.4 1.7 1.2 15474 WT 2.3 1.2 2.0 2.1 1.2 17551 WT 0.9 0.8 1.8 0.9 0.8 17593 WT 0.5 0.3 0.6 0.3 0.2 19811 WT 0.3 0.9 1.0 0.6 0.9 19813 WT 1.5 1.1 1.6 1.3 1.1 20610 WT 0.5 0.5 0.5 0.6 0.5 0.7 20614 WT 0.8 1.0 1.4 0.8 0.7 21690 WT 1.1 1.0 1.1 0.9 1.0 21692 WT 0.6 1.0 1.1 0.8 0.9 21696 WT 0.5 0.7 0.7 0.6 0.7 21698 WT 0.7 0.9 0.9 1.2 0.9 0.8 21704 WT 0.6 0.7 0.8 0.5 0.6 22666 WT 0.6 0.8 0.6 1.2 0.8 0.5 22668 WT 0.8 1.1 1.1 1.1 1.4 1.1 22706 WT 0.8 0.9 0.8 1.3 1.2 1.5 22710 WT 0.7 1.2 0.9 1.5 1.1 1.0 22712 WT 0.9 1.1 1.1 1.4 1.3 0.8 22740 WT 0.6 0.9 0.5 1.5 0.9 0.5 22816 WT 0.8 1.1 0.8 1.9 1.5 1.1 22820 WT 0.7 1.0 0.8 1.5 1.1 0.9 22828 WT 1.2 1.5 1.3 3.1 3.5 1.2 22862 WT 0.7 1.0 0.7 1.7 1.1 0.7 23546 WT 0.6 0.7 0.6 1.1 0.9 0.6 26640 WT 1.1 2.3 1.4 0.6 26642 WT 0.4 0.5 0.6 0.5 26644 WT 0.4 0.5 0.8 0.8 0.7 26646 WT 2.0 1.4 1.5 2.2 1.7 26648 WT 0.8 0.7 1.1 0.7 26650 WT 1.5 1.4 1.4 1.5 1.1 26652 WT 0.9 0.9 1.1 0.5 26654 WT 1.0 0.8 1.2 1.1 0.8 26658 WT 0.8 1.5 1.3 0.6 26660 WT 0.3 0.4 0.2 0.3 0.5 26662 WT 0.9 1.8 0.9 0.6 26664 WT 0.6 0.5 0.9 0.5 0.7 26666 WT 0.8 0.9 0.8 0.5 26668 WT 0.6 0.6 0.8 0.5 26670 WT 0.8 1.1 0.5 0.3 26672 WT 0.5 0.5 0.6 0.4 26674 WT 0.8 1.2 0.9 0.8 26676 WT 0.3 0.4 0.5 0.1 26680 WT 0.8 1.3 1.3 0.7 26684 WT 0.3 0.5 1.4 0.5 0.3 26686 WT 0.8 0.8 0.8 1.0 1.2 26688 WT 0.6 0.7 0.6 0.8 0.9 26690 WT 0.5 0.7 1.0 0.9 0.7 26692 WT 0.6 0.8 0.9 1.0 0.9 26694 WT 1.3 0.8 0.8 1.4 0.9 26696 WT 2.1 1.3 2.5 2.8 1.3 26698 WT 2.0 1.4 2.7 2.3 1.2 26700 WT 1.3 1.1 2.0 1.8 1.2 26704 WT 0.9 1.4 0.9 0.5 26706 WT 0.7 1.0 1.4 1.1 0.8 26708 WT 0.9 1.0 0.8 0.6 26712 WT 1.0 2.7 2.8 1.0 26714 WT 1.1 1.1 1.9 1.9 1.1 27640 WT 0.4 0.4 0.7 0.3 0.4 27644 WT 0.9 1.7 2.7 1.5 1.1 27646 WT 1.1 0.7 1.7 0.9 0.8 27648 WT 0.4 0.3 0.5 0.4 0.5 27661 WT 0.7 1.0 1.2 1.2 0.7 1.1 27663 WT 0.8 0.9 1.1 1.1 0.9 0.9 27665 WT 0.5 0.4 0.5 0.6 0.3 0.5 27666 WT 0.8 1.3 5.8 2.4 0.8 2.9 27669 WT 0.8 1.0 1.2 1.1 0.7 0.8 27676 WT 0.5 0.8 1.1 0.7 0.5 0.6 27682 WT 0.9 0.8 1.3 0.8 0.8 0.8 27686 WT 0.4 0.8 1.5 1.0 0.7 0.7 27694 WT 0.6 0.7 0.8 0.6 0.7 0.7 27697 WT 0.6 0.7 0.8 0.9 0.6 0.7 27699 WT 0.5 0.6 1.0 0.5 0.4 0.6 27705 WT 0.4 0.5 0.6 0.6 0.5 0.7 27714 WT 1.5 1.6 2.1 2.2 1.3 1.5 27715 WT 1.0 1.0 1.0 1.0 1.0 27717 WT 0.7 0.6 1.1 0.5 2.4 27719 WT 1.0 1.0 1.0 1.0 1.0 27721 WT 0.3 1.0 1.3 0.7 2.0 27723 WT 1.0 1.0 1.0 1.0 1.0 27725 WT 0.6 1.2 1.4 2.0 0.9 29283 WT 0.9 1.3 2.5 1.4 1.0 29287 WT 0.6 0.7 1.1 0.9 0.6 29293 WT 1.1 1.1 1.5 1.7 0.9 29295 WT 0.8 1.0 1.4 1.3 1.1 29305 WT 0.8 1.3 1.8 1.4 1.2 29307 WT 0.5 0.7 1.3 0.9 1.0 33148 WT 1.3 1.3 1.1 2.6 1.6 1.5 33152 WT 0.8 0.6 0.7 0.9 0.8 0.7 33252 WT 0.6 1.0 0.7 0.8 0.7 0.6 0.8 33444 WT 1.4 1.3 1.3 2.3 1.6 1.2 33643 WT 0.9 1.0 1.0 1.4 0.9 0.9 33737 WT 0.3 0.4 0.4 1.0 0.5 0.4 34086 WT 1.5 1.5 1.4 1.8 1.7 1.1 1.4 34208 WT 0.5 0.6 0.6 0.6 0.6 0.5 35461 WT 0.6 0.8 0.6 1.0 0.7 0.8 0.7 35526 WT 0.4 0.5 0.4 0.9 0.5 0.7 37043 WT 1.8 1.5 1.6 1.3 1.1 1.3 37088 WT 0.4 0.5 0.4 0.5 0.4 37089 WT 1.1 1.1 1.4 1.3 1.0 37090 WT 0.9 1.7 2.5 1.7 1.2 37948 WT 0.8 0.8 0.9 0.8 0.8 0.8 0.9 37952 WT 0.5 0.9 0.7 1.7 0.7 0.8 0.7 38068 WT 1.1 1.0 1.0 1.3 1.1 1.2 1.1 3809 WT 1.5 1.0 2.2 1.8 1.1 38146 WT 0.9 1.2 0.8 2.3 1.0 1.0 1.0 38174 WT 0.4 0.9 0.8 0.7 0.6 1.0 0.9 38270 WT 0.4 0.4 0.4 0.5 0.4 0.6 38354 WT 0.9 1.0 0.7 1.3 1.0 0.8 0.9 38404 WT 0.8 0.7 0.7 1.0 1.0 0.7 38424 WT 1.2 2.0 1.1 3.7 1.6 1.2 3872 WT 0.7 0.8 0.8 0.9 1.1 38890 WT 1.4 1.4 1.2 1.5 1.3 1.2 1.3 38900 WT 1.0 1.6 1.1 2.3 1.2 1.0 1.2 40735 WT 0.7 1.0 1.1 1.6 1.5 1.3 1.0 41184 WT 0.6 0.8 0.5 1.3 0.6 0.5 42010 WT 1.0 0.6 0.8 1.3 0.8 0.6 0.7 42032 WT 0.9 0.8 1.3 0.8 0.5 42034 WT 1.8 1.1 3.3 1.5 1.0 42036 WT 1.8 1.2 2.4 1.5 1.1 42040 WT 0.7 0.6 0.7 0.5 0.5 42042 WT 1.1 0.9 2.2 1.1 1.1 4583 WT 0.8 0.8 1.2 1.2 0.7 9517 WT 0.8 1.0 0.9 1.1 0.8 9678 WT 1.4 1.0 0.8 1.6 1.2 0.8 0.9