IsolateID Category Mutations APV IDV LPV NFV RTV SQV ATV 10082 Mut G48V,L90M 3.0 4.0 15.0 10083 Mut V32I,M46I,V82A 7.0 23.0 1.0 10084 Mut I54V,V82A,L90M 21.0 120.0 8.0 10085 Mut G48V,I54V,V82A 8.0 20.0 37.0 10086 Mut G48V,I54V,V82A,L90M 100.0 175.0 580.0 10087 Mut V32I,M46I,V82A 18.0 8.0 1.0 10088 Mut I54V,V82A,L90M 15.0 8.0 1.0 10090 Mut I84V 45.0 23.0 121.0 1194 Mut D30N 1.0 24.0 1.0 0.4 1196 Mut M46L,V82A,L90M 14.0 19.0 115.0 4.0 1442 Mut I54V,V82A,L90M 24.0 33.0 119.0 9.0 16751 Mut I50V 12.0 1.0 1.0 8.0 2.0 0.5 16754 Mut I54V,V82A,L90M 0.4 3.0 4.0 16.0 1.0 0.6 16759 Mut D30N,N88D 0.3 0.5 32.0 0.7 1.0 1.0 16760 Mut G48V,L90M 1.0 1.0 1.0 2.0 17.0 1.0 16761 Mut D30N,N88D 0.3 0.3 27.0 0.4 1.0 1.0 16766 Mut M46I,I84V 6.0 3.0 8.0 15.0 6.0 2.0 16774 Mut M46I,I84V 11.0 2.0 4.0 22.0 6.0 3.0 16778 Mut M46L,I54V,V82A,L90M 3.0 14.0 23.0 47.0 3.0 4.0 16782 Mut L24I,M46I,I54V,V82A 8.0 9.0 134.0 1.0 5.0 17246 Mut G73S,L90M 6.1 12.0 6.5 6.5 20909 Mut I50V 5.9 1.0 2.9 3.3 3.8 1.0 20914 Mut I84V 10.3 1.1 3.2 1.3 4.6 0.6 20922 Mut I50V 5.3 1.3 4.0 1.0 2.5 1.3 22664 Mut D30N 0.3 0.7 10.7 0.1 0.1 22672 Mut M46I,N88S 9.7 1.6 17.3 0.3 1.4 22680 Mut I54V,V82A,L90M 11.8 15.3 25.3 41.4 2.9 22682 Mut V32I,M46I,V82A 5.8 4.6 4.2 17.3 0.4 22686 Mut D30N 0.8 0.7 14.8 0.3 0.3 22688 Mut M46I 18.6 14.0 6.9 3.1 0.7 22698 Mut L90M 1.1 0.7 3.6 2.3 0.7 22734 Mut D30N,N88D,L90M 1.7 0.7 54.2 0.5 1.9 22764 Mut I54V,V82A 4.6 8.4 7.7 20.3 1.2 22774 Mut I84V,L90M 3.3 12.6 2.5 33.5 22.6 32.4 22778 Mut D30N,N88D 1.9 1.2 36.4 1.1 1.6 22788 Mut G73S,I84V,L90M 10.9 2.7 42.9 17.7 38.5 22792 Mut I54V,V82A 26.0 26.0 49.7 47.0 4.6 22794 Mut G73S,L90M 1.7 1.2 3.6 2.7 1.8 22802 Mut N88S 4.1 0.7 11.6 1.2 1.7 22804 Mut V32I,M46L,V82A 1.0 10.2 5.2 7.4 12.1 1.5 22812 Mut L90M 4.0 2.7 9.9 8.9 3.1 22824 Mut D30N 0.5 0.7 20.4 0.1 0.2 22830 Mut I54V,V82A 7.1 2.3 7.2 21.6 0.9 22844 Mut I84V,L90M 7.6 2.5 8.9 10.2 13.8 22850 Mut D30N,N88D 2.5 0.8 54.2 0.9 2.1 22856 Mut D30N,N88D 0.8 0.7 20.9 0.5 0.5 22858 Mut I54V,V82A,L90M 4.6 2.4 7.7 26.8 0.9 22866 Mut M46I,N88S 8.2 1.1 42.8 1.8 1.5 2499 Mut D30N 1.0 50.0 2.0 0.3 2659 Mut D30N 0.5 18.0 0.2 0.2 26656 Mut L90M 1.8 1.4 4.6 2.3 3.6 26682 Mut L90M 1.2 8.0 3.7 4.0 26702 Mut L90M 1.5 1.7 5.3 5.1 2.4 26710 Mut I84V 0.8 1.3 1.0 0.5 27739 Mut V32I,M46I,V82A 2.2 1.7 4.1 2.8 5.8 1.0 27757 Mut D30N,N88D 1.3 3.1 1.3 95.7 2.6 1.8 27769 Mut N88S 0.2 5.6 29.2 1.7 1.0 27771 Mut D30N 0.5 2.6 0.6 34.3 2.7 1.1 27775 Mut D30N,N88D 0.2 0.7 0.4 5.1 0.2 0.2 27793 Mut V32I,M46L,V82A 9.2 40.4 22.7 91.0 1.6 27799 Mut G48V,I54V,V82A 0.5 15.2 7.7 9.2 15.2 22.2 27803 Mut I54V,V82A,L90M 0.8 6.8 16.9 144.0 3.9 27805 Mut D30N,N88D 0.7 1.0 1.0 67.7 0.4 0.9 27815 Mut I54V,V82A 1.8 6.3 4.9 37.7 1.0 27821 Mut G48V,I54V,V82A 0.4 9.0 13.5 6.5 7.8 20.2 27829 Mut M46I,I84V 1.5 4.8 1.4 3.5 8.3 0.7 27839 Mut M46I,I54V,V82A 0.7 2.6 10.8 3.8 6.2 0.4 27843 Mut M46I,G73S,I84V,L90M 3.2 48.4 12.6 53.4 149.4 38.4 27847 Mut D30N,N88D 0.8 1.3 35.1 2.4 2.4 27851 Mut V32I,M46I,V82A 5.3 56.3 3.8 30.4 91.7 0.7 27867 Mut M46L,I54V,V82A,L90M 3.7 5.3 25.3 19.6 15.8 3.4 27869 Mut L90M 1.0 1.3 1.1 3.4 1.0 27873 Mut M46I 3.6 3.1 7.6 5.7 1.6 27879 Mut D30N,N88D 0.9 2.9 1.3 95.7 0.7 1.3 27885 Mut G48V,L90M 1.9 2.9 0.7 1.3 9.7 21.9 27893 Mut D30N,N88D 2.7 0.7 2.2 72.8 0.4 2.2 27895 Mut G73S,I84V,L90M 2.9 37.6 7.3 45.2 66.4 41.1 27899 Mut D30N,N88D 56.2 0.6 27909 Mut G48V,I54V,V82A 0.7 3.9 9.6 9.0 5.7 31.9 27911 Mut M46I,N88S 0.9 8.4 36.0 5.6 1.5 27921 Mut D30N,N88D 0.5 0.5 0.9 22.1 0.9 1.1 27927 Mut M46L,I54V,V82A,L90M 7.3 9.9 11.4 220.3 1.8 27931 Mut G73S,I84V,L90M 1.8 9.6 5.4 16.0 31.7 8.8 27933 Mut D30N,N88D 0.2 0.3 0.3 4.3 0.3 0.1 27939 Mut D30N,N88D,L90M 1.7 2.9 41.9 6.6 8.1 27963 Mut M46L,I54V,V82A,L90M 5.3 21.6 45.8 53.2 150.4 15.2 27969 Mut D30N,N88D 0.9 1.7 21.4 0.7 0.6 27971 Mut L90M 2.0 7.6 3.0 20.2 2.5 2.8 27973 Mut V82I 0.2 0.3 0.3 0.3 0.2 0.2 27985 Mut D30N,N88D 1.1 2.1 1.9 49.6 2.9 2.2 27987 Mut G73S,L90M 0.4 4.0 0.8 10.5 4.9 4.0 27993 Mut D30N,N88D 0.3 0.6 14.2 0.6 0.7 27995 Mut D30N,N88D 0.4 3.3 26.9 1.1 1.1 28001 Mut D30N 0.3 0.3 0.3 4.0 0.2 0.1 28007 Mut M46I,N88S 0.3 12.7 48.6 1.4 1.9 28021 Mut L24I,M46I,I54V,V82A 2.6 6.2 21.2 7.9 31.3 1.2 28027 Mut M46I,L90M 0.5 0.4 0.8 3.6 1.9 0.4 28039 Mut M46L,I54V,V82A,L90M 0.8 10.0 11.7 9.5 0.6 28041 Mut G48V,I54V,V82A,L90M 2.0 20.0 28.6 14.4 44.1 29.0 3049 Mut G73S,I84V,L90M 100.0 73.0 147.0 71.0 3095 Mut M46L,I54V,V82A,L90M 21.0 24.0 87.0 5.0 3096 Mut D30N,N88D 1.5 23.0 1.8 0.4 3100 Mut G48V,I54V,V82A 6.0 25.0 21.0 40.0 3105 Mut G48V,I54V,V82A 8.0 10.0 20.0 13.0 3154 Mut L90M 5.0 4.0 7.0 2.0 3171 Mut L90M 1.0 7.0 3.0 2.0 3181 Mut M46L,I54V,V82A,L90M 18.0 48.0 85.0 6.0 3187 Mut G73S,L90M 5.0 13.0 11.0 7.0 37055 Mut I54V,V82A 0.5 37061 Mut L90M 1.1 37065 Mut I84V 1.7 37067 Mut V82I 1.9 37070 Mut I84V 2.4 37075 Mut I50V 3.5 37077 Mut I50V 4.4 3897 Mut D30N 2.0 46.0 1.0 0.4 40841 Mut L90M 0.4 1.9 0.4 0.9 3.0 1.4 40845 Mut L90M 0.4 1.1 1.0 6.7 5.0 1.0 40851 Mut D30N,N88D 0.9 1.1 5.7 56.6 3.9 3.5 40852 Mut D30N,N88D 2.3 2.5 3.0 40.5 0.8 1.1 40858 Mut L90M 0.2 1.3 1.3 1.1 1.1 1.2 40864 Mut D30N,N88D 0.1 0.8 0.4 62.4 0.8 0.9 40866 Mut D30N,N88D 0.7 1.7 0.7 31.8 0.6 1.4 40867 Mut D30N,N88D 0.2 1.3 0.8 26.0 2.1 1.2 40868 Mut M46I 6.0 7.5 2.0 9.8 21.8 1.4 40869 Mut D30N,N88D 0.8 1.6 1.0 46.5 4.1 3.3 40870 Mut V82I 1.3 0.4 0.8 0.9 0.5 0.8 40872 Mut L90M 1.0 2.1 0.6 4.2 1.5 40875 Mut L90M 1.3 1.7 1.1 2.2 3.7 1.6 40880 Mut D30N,N88D 1.9 1.3 2.5 44.0 1.7 2.8 40882 Mut M46L,V82A,L90M 3.0 1.3 1.6 4.0 5.1 1.2 40883 Mut L90M 1.9 1.8 1.4 4.2 6.3 1.8 40886 Mut M46I,L90M 10.3 42.5 6.3 52.1 37.9 7.3 40887 Mut D30N,N88D 0.4 1.2 1.0 64.3 0.9 1.4 40893 Mut I84V,L90M 2.4 3.0 2.6 10.2 22.8 14.7 40894 Mut G73S,I84V,L90M 2.2 5.7 3.0 13.7 8.8 46.0 40896 Mut G73S,L90M 1.0 5.8 4.3 15.0 5.1 6.2 40900 Mut M46I,I54V,V82A 1.7 7.8 7.9 10.0 31.3 1.2 40911 Mut M46L,I54V,V82A,L90M 5.5 55.2 23.2 47.2 208.0 38.7 40913 Mut L24I,M46I,I54V,V82A 2.8 50.1 6.4 11.3 147.0 24.8 40918 Mut M46I,G73S,I84V,L90M 0.8 3.2 26.3 33.7 57.2 3.3 40920 Mut V32I,M46I,V82A,L90M 4.1 43.3 46.1 48.5 168.0 42.3 40921 Mut V32I,M46I,V82A,L90M 1.7 19.4 11.4 31.8 54.6 1.3 22670 WT 0.6 0.7 1.2 0.5 0.8 22694 WT 1.5 0.8 1.2 1.3 1.4 22724 WT 1.5 1.0 1.1 1.3 0.7 22730 WT 2.0 0.7 2.0 0.8 0.8 22752 WT 0.8 0.7 2.3 0.8 1.2 22770 WT 0.4 0.9 2.2 1.0 0.9 22796 WT 1.2 0.7 0.8 0.7 0.1 22848 WT 0.8 0.7 0.8 1.0 0.7 22870 WT 1.0 1.0 1.2 0.8 0.8 22876 WT 2.1 0.8 2.4 1.3 0.5 2616 WT 1.0 2.0 1.0 1.0 26640 WT 0.7 4.5 1.5 2.9 26642 WT 1.2 0.8 1.0 0.2 26644 WT 1.1 0.8 1.5 0.4 2.0 26646 WT 1.6 1.5 0.6 0.7 1.2 26648 WT 1.1 0.8 0.7 0.9 26650 WT 0.9 1.1 1.8 0.7 1.6 26652 WT 1.0 1.1 0.2 0.7 26654 WT 1.2 1.3 0.4 0.4 0.6 26658 WT 1.7 2.9 1.8 1.3 26660 WT 0.2 0.6 0.2 0.2 0.4 26662 WT 0.7 3.5 1.6 2.2 26664 WT 0.6 1.4 1.0 0.2 0.6 26666 WT 1.0 1.0 0.8 1.1 26668 WT 1.6 1.6 1.1 0.7 26670 WT 4.0 2.8 0.9 1.2 26672 WT 2.1 2.0 4.3 1.6 26674 WT 1.4 2.6 1.4 2.6 26676 WT 0.9 1.1 1.0 2.9 26680 WT 1.8 1.4 1.1 0.8 26684 WT 0.9 1.7 1.3 1.2 1.5 26686 WT 0.9 0.9 0.5 0.2 0.4 26688 WT 1.3 1.3 0.2 0.4 0.9 26690 WT 1.0 1.0 0.7 0.3 0.3 26692 WT 0.6 0.8 0.7 0.3 1.3 26694 WT 0.7 0.4 0.7 0.3 0.4 26696 WT 0.9 0.7 0.8 0.5 1.0 26698 WT 1.3 2.3 1.0 0.9 0.9 26700 WT 1.9 2.5 3.2 2.2 1.5 26704 WT 3.3 6.2 1.3 1.4 26706 WT 0.9 2.8 2.6 1.4 1.3 26708 WT 1.7 1.4 1.0 1.0 26712 WT 0.6 1.0 0.4 0.5 26714 WT 0.2 0.3 0.4 0.2 27731 WT 0.5 1.3 0.4 1.5 0.8 27733 WT 0.7 1.2 1.0 1.7 1.8 0.4 27735 WT 0.8 1.6 0.5 2.1 0.3 27741 WT 0.5 0.5 1.0 1.0 0.2 0.4 27743 WT 0.2 0.3 0.4 0.3 0.2 0.2 27745 WT 0.5 0.4 0.5 1.3 0.7 0.9 27747 WT 0.5 0.6 0.2 0.5 0.2 27749 WT 0.4 0.7 0.3 1.8 1.2 27751 WT 0.2 0.7 0.5 0.3 0.3 0.2 27755 WT 0.4 0.2 0.6 0.9 0.7 0.4 27763 WT 0.4 0.4 0.3 0.2 1.4 0.2 27767 WT 0.4 0.7 0.6 0.6 0.4 0.4 27781 WT 0.7 0.7 1.3 0.9 0.9 0.6 27789 WT 1.6 1.0 1.4 1.4 0.4 1.7 27795 WT 0.6 0.6 0.7 0.5 1.1 0.4 27801 WT 0.2 0.3 0.4 0.3 0.2 0.1 27809 WT 0.6 0.9 0.4 1.3 0.6 27811 WT 0.7 0.8 0.5 0.4 0.5 27813 WT 0.3 0.6 0.8 0.4 0.4 0.5 27817 WT 0.2 0.2 0.4 0.6 0.8 0.2 27833 WT 1.0 0.6 0.9 0.2 0.2 27835 WT 0.2 0.4 0.5 0.6 0.5 27837 WT 0.9 0.6 0.3 0.8 0.7 27845 WT 0.5 0.7 0.7 0.5 2.4 0.9 27853 WT 1.7 0.8 1.2 1.1 0.6 27863 WT 1.1 1.6 1.0 0.6 1.1 27871 WT 1.1 1.4 1.0 1.7 0.5 27875 WT 0.4 0.7 0.8 0.3 0.6 0.8 27883 WT 0.4 0.2 0.5 0.9 0.4 0.5 27891 WT 0.2 0.2 0.4 0.3 0.2 0.1 27901 WT 0.3 0.8 0.5 0.6 0.5 0.3 27915 WT 0.4 0.5 0.6 0.7 0.3 0.2 27919 WT 0.8 1.2 0.8 0.6 0.6 27923 WT 0.3 0.5 0.3 0.3 0.2 0.3 27925 WT 0.6 0.9 0.5 0.8 0.5 27929 WT 0.5 0.5 0.3 0.4 0.3 27937 WT 1.0 0.5 0.6 0.5 0.3 27945 WT 1.1 1.1 1.5 1.0 0.4 1.1 27949 WT 1.7 1.8 0.5 2.9 0.8 27965 WT 0.7 0.6 0.9 0.9 0.3 0.7 27967 WT 0.3 0.3 0.4 0.5 0.4 0.4 27975 WT 0.4 0.2 0.8 0.5 0.6 0.3 27979 WT 1.0 0.8 1.2 1.7 1.0 0.4 27983 WT 0.5 0.6 0.3 0.5 0.4 27989 WT 0.3 0.3 0.5 0.3 0.4 0.3 27991 WT 0.5 0.7 1.0 0.8 0.9 28009 WT 0.3 0.5 1.6 0.5 0.6 28011 WT 0.8 0.8 0.7 1.0 0.9 0.8 28013 WT 0.8 1.8 0.8 0.6 0.7 0.8 28019 WT 0.6 1.0 1.1 0.3 0.8 3014 WT 0.4 1.0 0.4 0.3 3035 WT 0.3 1.0 0.3 0.3 3047 WT 0.3 1.0 0.3 1.0 3117 WT 1.0 1.0 1.0 1.6 3150 WT 1.0 1.0 1.0 0.3 36508 WT 0.7 1.0 2.2 0.6 0.7 36512 WT 0.6 0.7 0.5 0.3 0.4 36517 WT 1.4 0.5 2.9 0.7 0.7 36521 WT 1.1 2.9 7.3 2.4 1.9 36523 WT 2.4 0.5 3.2 2.0 0.9 36536 WT 0.6 0.7 1.1 0.8 0.9 36540 WT 0.6 0.6 1.2 0.7 0.7 36544 WT 0.6 0.7 0.9 2.2 0.9 36546 WT 0.6 0.7 0.6 1.2 0.4 36564 WT 1.5 1.2 2.6 3.3 1.2 36570 WT 0.5 1.7 1.0 1.1 1.1 36577 WT 1.2 1.2 2.8 2.8 0.4 36579 WT 0.9 1.2 2.6 3.5 0.7 36587 WT 0.6 0.9 3.9 1.4 0.9 36589 WT 0.7 0.8 0.7 0.9 0.5 36606 WT 0.6 0.6 0.9 1.5 0.5 37057 WT 0.8 37059 WT 0.9 37063 WT 1.4 37064 WT 1.4 40822 WT 0.6 0.7 0.9 0.4 0.9 0.6 40823 WT 1.2 0.5 0.9 0.5 0.7 0.6 40824 WT 0.9 0.6 1.1 1.8 0.8 0.8 40825 WT 0.8 0.4 1.2 1.6 1.2 0.2 40826 WT 0.4 0.2 0.9 0.5 0.2 0.3 40827 WT 0.4 0.9 0.5 0.6 0.5 0.6 40828 WT 0.4 0.5 0.8 0.8 1.3 1.6 40829 WT 1.8 1.8 1.2 1.1 1.5 1.1 40831 WT 0.6 0.7 1.1 0.7 0.7 1.4 40832 WT 0.1 0.3 0.4 0.5 0.5 0.3 40833 WT 0.2 0.6 0.5 0.2 0.9 0.2 40834 WT 0.4 0.3 0.5 0.3 1.0 0.5 40835 WT 0.5 0.5 0.8 0.7 0.4 0.8 40836 WT 0.5 0.5 0.5 0.5 0.4 0.6 40837 WT 0.5 0.6 0.7 0.8 0.1 0.5 40839 WT 0.4 0.4 0.9 0.5 0.4 0.2 40840 WT 0.4 0.4 0.6 1.0 0.3 0.7 40842 WT 0.6 0.3 0.7 0.4 0.5 0.4 40843 WT 0.9 0.9 0.8 0.9 0.6 1.1 40844 WT 0.3 0.4 0.6 0.4 0.8 0.3 40846 WT 0.4 0.8 1.1 1.5 0.7 0.6 40848 WT 0.3 0.3 0.3 0.5 0.1 0.3 40849 WT 0.6 1.3 0.6 1.3 1.3 1.4 40850 WT 1.4 3.1 1.2 2.0 2.9 0.4 40855 WT 0.3 0.4 0.3 0.4 0.5 0.2 40856 WT 0.7 1.1 0.7 0.4 1.2 0.9 40857 WT 0.9 0.5 0.9 0.6 1.7 0.9 40859 WT 0.6 1.4 1.3 1.7 1.1 1.0 40861 WT 1.5 1.2 0.8 0.4 0.5 1.0 40862 WT 1.0 1.5 2.0 0.4 0.5 0.2 40863 WT 0.5 0.2 1.0 0.8 0.7 0.5