Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NRTI Mutation Pattern & Susceptibility

937 patterns of major drug resistance mutations (defined here) from 93413 clinical isolates obtained from 86898 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2014-5-10). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004. The data was described in Melikian et al. 2012.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsNumber of
Sequences
AZT
foldn
TDF
foldn
ABC
foldn
3TC
foldn
None651440.84200.93470.94141.0421
184V65880.51240.5633.1125200124
67N,70R,184V10653.7321.2264.53120032
41L,184V,210W,215Y75518511.6386.54820049
41L,184V,215Y7526.0411.1245.14120040
41L,67N,184V,210W,215Y73130531.6416.54620052
70R,184V6640.8140.773.41520014
41L,67N,210W,215Y606401354.7255.3295.835
41L6040.991.071.081.59
41L,210W,215Y583164213.1183.1192.822
67N,70R53828231.9191.6211.823
41L,215Y45112121.372.092.012
70R4505.3151.3131.1161.215
67N,70R,184V,215F3627.771.045.572007
65R3530.5201.8172.5209.320
74V,184V3340.390.475.292009
184V,215Y3261.3160.494.91620015
41L,67N,69D,184V,210W,215Y31943281.8197.82620025
41L,184V3120.570.542.672007
65R,184V2950.4161.2168.41620016
67N,70R,215F281102152.6142.5143.415
215Y2697.4151.4141.6122.015
41L,67N,74V,184V,210W,215Y25511151.1149.31320014
41L,74V,184V,210W,215Y2455.0190.9178.11720019
67N,184V2350.840.642.642004
67N2341.270.950.962.27
41L,67N,70R,184V,215F20959192.3136.11920018
41L,210W1980.520.721.121.12
74V1930.480.672.172.18
184V,215F1862.330.834.532003
41L,184V,215F1843.570.515.472006
184I1760.3170.5161.91710417
41L,67N,69D,210W,215Y171672153.9156.4126.816
41L,67N,74V,210W,215Y1612592.083.357.99
41L,67N,74I,184V,210W,215Y15124171.6159.61620015
41L,184V,210W148    
41L,67N,184V,215Y1461131.425.132003
41L,67N,70R,184V,215Y1447.861.545.462005
41L,67N,184V,210W141    
41L,74V,210W,215Y1353241.843.843.34
41L,67N,70R,215F13538785.553.694.19
41L,74V,184V,215Y1281.1100.686.3920011
41L,74I,184V,210W,215Y1241681.477.582008
41L,67N,70R,184V,210W,215Y1177682.566.972008
41L,67N,215Y1174482.822.483.58
74V,115F,184V1140.440.641732004
41L,67N,210W11425013.216.116.81
67N,70R,215Y1138923.712.423.22
151M,184V11112640.822132004
210W1101.130.810.831.43
151M1077.0101.095.5103.010
41L,67N,70R,215Y10715644.712.543.84
41L,67N,70R,74I,184V,215F1048.01 1412001
67N,69D,70R,184V,215F971171.055.172006
41L,67N,70R,210W,215Y9590954.756.155.16
67N,69D,70R,215F91104122.662.2123.212
41L,67N,69D,70R,184V,215F873561.356.562006
41L,215F86501 3.212.61
41L,67N,69D,74V,184V,210W,215Y852.710.617.912001
67N,70R,184V,215Y844.041.045.742004
41L,74V,184V,210W83    
215F815.021.321.822.72
41L,74V,215Y773.540.842.542.54
115F,151M,184V7378621.922022002
67N,69D,70R,184V722.831.223.722003
184V,210W,215Y661.860.864.762006
41L,67N,69D,184V,210W64    
65R,151M6410134.93182363
70R,184V,215F632331.235.232003
41L,67N,69D,74V,210W,215Y634721.826.918.92
67N,69D,70R63    
65R,115F,184V59    
41L,70R,184V597.821.123.022002
210W,215Y583121.311.821.82
41L,69D,184V,210W,215Y582161.947.452006
41L,67N,74I,210W,215Y5720035.439.038.13
41L,69D,210W,215Y5698264.764.658.06
67N,69D540.610.610.912.11
41L,67N,74V,184V,210W52    
70R,215F513132.311.832.13
41L,67N,70R,184V482722.023.521292
74I,184V480.210.413.012001
41L,74V,184V470.310.417.512001
41L,67N,184I,210W,215Y4666814.511312001
67N,184V,215Y45    
41L,184V,210W,215F456912.81 1481
115F,184V440.730.931132003
65R,184I430.331.133.132003
67N,70R,74I,184V,215F429.630.936.532001
67N,70R,74V,184V421.230.627.032003
67N,215Y411611.512.314.21
65R,151M,184V40    
67N,184V,215F40    
41L,67N,69D,70R,215F40111545.744.125.64
69D390.420.621.122.32
70E,184V390.250.653.352005
41L,67N,74V,210W38    
41L,74I,184V,215Y383012.012.011.21
41L,67N,69D,184V,215Y38135 6.351455
41L,67N,74V,184V,215Y375.810.617.412001
41L,67N,184V,215F362921.526.022002
41L,67N,184V360.410.512.11 
41L,74V,210W36    
67N,210W,215Y341011 5.114.71
41L,67N,69D,70R,74I,184V,215F33240024.022222002
184V,210W32    
41L,74V31    
65R,74V31    
41L,67N,70R,74V,215F30861 4.714.11
70E300.220.931.434.93
67N,70R,74I,184V303112.417.612001
67N,184V,210W,215Y297.231.237.532003
41L,67N295.021.021.121.72
41L,74I,184V,210W29    
65R,69~29    
41L,67N,70R,74I,215F296332.034.033.63
41L,70R29    
41L,69#,210W,215Y28    
65R,115F280.321.825.821112
67N,70R,74I,215F28    
65R,70R,151M28    
41L,67N,69D,210W27    
41L,67N,70R,184V,210W27    
41L,67N,215F27    
41L,67N,70R,184V,210W,215F279.911.315.71381
41L,67N,184V,210W,215F26    
41L,67N,74I,184V,210W26    
70R,215Y26    
41L,67N,69D,74I,184V,210W,215Y26    
41L,67N,70R,210W,215F2574025.223.016.42
41L,70R,74I,184V,215F253.330.934.632003
74I24    
67N,215F245022.011.714.02
41L,67N,69D,184I,210W,215Y24    
65R,115F,151M,184V2498517.51 1001
41L,70R,184V,215F2427212.011312001
69D,70R,184V243.320.924.022002
74V,184V,215Y23    
41L,74V,184V,215F22    
65N21 1.712.117.31
41L,210W,215F2121734.123.212.73
41L,67N,70R,74I,184V,210W,215Y2140032.431232003
41L,67N,70R,74V,184V,210W,215Y201121.011122002
41L,67N,70R,74I,184V,215Y20    
67N,70R,74V191121.624.424.22
41L,67N,70R,74V,184V,215Y19    
41L,67N,210W,215F19    
69D,70R19    
41L,67N,69D,70R,74V,184V,215F191521.127.122001
41L,67N,70R,74V,184V,215F18    
69#,215Y18    
41L,67N,69D,184V,210W,215F1828642.749.242004
41L,67N,70R,210W17    
70R,74V,184V17    
70R,74I,184V,215F17    
41L,69#,215Y17    
67N,70R,210W,215Y17    
67N,151M,184V174.620.318.522002
41L,70R,215F17    
151M,184I16    
115F,151M16    
65R,74V,184V160.421.121122002
41L,69D,74V,184V,210W,215Y161110.811112001
41L,67N,74V,215Y16    
41L,67N,70R,74I,210W,215Y16    
41L,67N,69D,74I,210W,215Y16240026.927.02112
41L,67N,74I,184V,215Y154.310.91 961
41L,74V,215F15    
67N,70E,184V15    
41L,67N,70R15    
41L,67N,69D,74V,184V,210W15    
41L,69D,210W15    
67N,70R,151M151811.613.113.51
41L,67N,69D,70R,184V,215Y15    
69#,210W,215Y14    
67N,69D,70R,74I,184V,215F14    
65R,67N14    
67N,184I14    
41L,67N,69D,70R,210W,215Y14    
41L,67N,69D,70R,184V,210W,215F14    
65R,70R,115F,151M1424001111201891
67N,70R,74V,215F13    
41L,74I,184V13    
65R,115F,151M13    
41L,67N,70R,74V,210W,215Y131211.41 4.61
74V,215Y13    
67N,74V,184V13    
67N,70R,184V,210W,215Y13    
41L,67N,74I,184V,215F132012.011212001
41L,67N,69D,70R,184V,210W,215Y131411.319.412001
41L,67N,184I,210W13    
41L,67N,69D,70R,74V,215F131211.51 181
41L,67N,74I,210W12    
41L,65R,184V12    
41L,69D,184V,210W120.510.612.812001
67N,69D,70R,74V,184V123621.421411492
70G,184V120.240.645.842004
41L,69#,184I,210W,215Y12    
65N,184V12    
41L,69D,184V,215Y12    
41L,74I,210W,215Y11    
41L,69#,184V,215Y11    
65R,74V,115F11    
41L,70R,215Y11    
67N,70R,74V,184V,215F114.720.617.32941
41L,74I,184V,210W,215F1168513.411912001
67N,70R,151M,184V11    
65R,70E,184V11    
65R,70R,151M,184V11    
41L,67N,70R,184I,210W,215Y11    
41L,69D,70R,184V,215Y11    
41L,74I,215Y10    
67N,69D,70R,74I,215F10    
41L,67N,70R,74I,215Y10    
67N,69D,210W,215Y10    
41L,184I10    
41L,70R,184V,215Y104.210.917.312001
67N,70R,74I10    
41L,69#,74V,210W,215Y10    
67N,69D,70R,151M10    
67N,70R,151M,215F9    
41L,67N,69D,70R,74I,184V,210W,215F9    
74V,115F9    
74I,184V,215Y90.610.314.512001
74V,115F,151M,184V96.020.82601582
41L,74V,115F,184V,210W,215Y9    
41L,67N,69D,215Y9    
41L,67N,74V,184V9    
184V,210W,215F9    
69D,184V90.420.424.021012
115F90.911.312.811.61
67N,69D,184V90.210.312.212001
41L,67N,69D,70R,74I,215F9    
74V,210W9    
41L,65R9    
69D,70R,184V,215F9    
41L,70R,210W,215Y9    
65R,70R,115F,151M,184V9240017.5117012001
70G,115F,151M,184V924522.412022002
65R,74V,115F,184V8    
69#,184V8    
74V,115F,184V,215Y8    
67N,69D,215F8    
70R,184V,215Y8    
74V,184V,215F8    
70R,151M,184V8    
41L,67N,69D81.110.810.711.31
41L,67N,70R,74V,215Y8    
41L,69#,74V,184V,210W,215Y8    
70R,74V8    
67N,70R,210W8    
41L,67N,70R,74V,184V8    
41L,70R,184V,210W,215Y814913.319.912001
41L,74I,210W8    
41L,74V,115F,184V8    
41L,67N,69D,70R,210W,215F820122.523.424.02
41L,67N,70R,74I,184V,210W,215F8    
41L,74V,115F,184V,210W8    
41L,74V,184V,210W,215F88.010.819.712001
41L,67N,70R,74V,184V,210W8    
41L,67N,69D,74V,184V,215Y71.310.615.512001
41L,67N,70R,184I,215F7    
41L,67N,70R,74I,210W,215F7    
41L,67N,69D,74V,210W7    
67N,70R,184I,215F75.210.912.312001
41L,74V,115F,184V,215Y70.810.71 981
41L,70R,74V,215F71111.113.212.81
67N,69D,184V,210W,215Y7    
41L,184I,210W,215Y7    
67N,69#,70R7    
67N,69D,184V,215F70.910.513.012001
67N,210W7    
69D,70R,215F7    
41L,67N,69D,74I,184V,210W7    
41L,69D,74V,210W,215Y7161 3.615.91
70E,115F,184V70.210.9110.012001
151M,215Y7    
67N,70G,184V,215F70.82 7.422002
65R,67N,70R,184V7    
67N,69D,215Y77.31 1.914.71
41L,69D,74V,184V,210W7    
69#,184V,215Y7    
67N,70R,184I7    
67N,70G,184V70.220.624.022002
41L,69D,184I,210W,215Y7    
69#7    
74V,115F,184V,215F72.320.621922002
41L,67N,151M,184V,210W,215Y7    
41L,74V,210W,215F6    
74V,184I6    
41L,67N,69D,70R,184V6    
41L,67N,69D,70R,74V,184V,210W,215F6    
67N,70R,151M,184V,215F6    
65R,74I,115F,184V6    
41L,69D,74I,210W,215Y641813.518.119.91
41L,67N,69D,70R,74V,184V,210W,215Y6    
41L,69#,184V,210W,215Y6    
41L,67N,74V,184V,210W,215F61.011411112001
67N,74V,215F61.110.412.115.01
115F,184V,215Y6    
41L,67N,74V,184V,215F6    
67N,70R,184V,210W6    
41L,70R,210W6    
41L,70R,74I,215F6    
65R,70R,184V6    
41L,67N,70R,74I,210W6221 3.514.11
41L,67N,70R,74I,184I,210W,215Y6    
69#,70R,184V6    
67N,69D,70R,151M,184V69.110.811212001
70G,151M,184V6    
69#,70R,215Y6    
41L,69D,70R,184V,215F61811.315.112001
67N,70G,184V,215Y6    
67N,69D,70R,74V,215F53.311.012.313.11
74V,215F5    
74V,184V,210W5    
41L,69D,74I,184V,210W,215Y5    
65R,67N,70R5    
41L,67N,151M,184V,215Y5    
41L,67N,74I,215Y5    
41L,151M,184V5    
65R,67N,184V5    
67N,69D,70R,215Y5    
70R,74I,184V5    
70R,115F,184V5    
41L,67N,69D,74I,184V,215F5    
70R,74V,215F5    
41L,67N,74V5    
41L,69D,215Y5    
41L,74V,115F,210W,215Y5    
70R,184V,210W5    
67N,74V,184V,210W,215Y5    
41L,67N,74V,184I,210W,215Y5    
67N,69D,70R,151M,184V,215F5    
67N,69D,210W50.410.510.913.11
70R,151M5    
74I,115F,184V5    
41L,70E,210W,215Y5    
69D,151M5    
67N,70R,184V,210W,215F4    
41L,67N,70R,184I,215Y4    
67N,69D,184V,215Y4    
67N,70E,151M4    
41L,67N,70R,74I,184V4    
41L,69D4    
41L,65R,184V,210W4    
41L,67N,70R,74V,184V,210W,215F4    
41L,67N,74I,184V4    
65R,67N,151M4    
70R,74I,215F4    
65R,151M,184I4    
70E,184I4    
67N,184V,210W,215F4    
41L,70R,74V,184V4    
69#,184I,210W,215Y4    
41L,70R,74V,184V,215F4    
41L,74I,184V,215F4    
65R,67N,115F,151M,184V4    
67N,70R,74I,184V,215Y4    
69#,70R4    
67N,151M4    
65R,67N,115F,151M4110917.81 1171
41L,67N,69D,210W,215F4    
41L,67N,151M,210W,215Y4    
41L,67N,69D,74V,215Y4    
41L,74I4    
41L,67N,70R,74I,184I,215F4    
67N,70G,215F40.810.91 6.11
41L,67N,70R,74I,115F,184V,215F4    
41L,70R,74V4    
41L,67N,69D,184V,215F4    
41L,69D,74V,210W4    
41L,65R,151M4    
67N,151M,184V,215Y4    
74V,210W,215Y4    
65R,74I,184V4    
70R,210W4    
74V,184V,210W,215Y4    
41L,69#,184V,210W4    
67N,69D,115F,151M,184V4    
67N,69D,70R,74V4    
41L,67N,69D,70R,74V,210W,215F4    
67N,69D,70R,151M,215F4    
41L,67N,74I,184V,210W,215F4771 7.012001
41L,67N,69#,210W,215Y4    
70E,151M4    
69#,70R,184I,210W,215Y4    
67N,151M,184I3    
67N,74I,184V,215F3    
67N,70R,115F,151M,184V,215F3    
70E,151M,184V3    
41L,67N,74I,210W,215F3    
41L,184I,215Y3    
65R,70R3    
41L,74V,115F,184V,215F3    
67N,70E,151M,184V3    
184I,210W3    
41L,67N,69D,70R,215Y34812.31 5.21
41L,67~,70R,74I,215F3    
41L,67N,74I,215F3    
184I,215F3    
41L,67N,70R,74V,210W3    
41L,67N,69D,184V30.610.413.012001
67N,70G,74V,184V3    
67N,69D,70R,184V,215Y39.111.217.812001
41L,67N,184I,210W,215F3    
41L,69D,74I,184V,210W3    
41L,65R,70R,151M,184I3    
67N,69D,70R,74I,184V3    
41L,69D,70R,215F3    
70R,184I3    
41L,67N,69D,70R,74I,184V,215Y3    
74I,215F3    
115F,184V,215F30.510.911112001
41L,74V,184I,215Y3    
41L,70R,74I,184V,210W,215F3    
41L,67N,74V,215F3    
69#,70R,74V3    
41L,74I,115F,184V,210W,215Y3    
69#,70R,184V,215F3    
67N,74V,184V,215F3    
67N,69D,151M3    
67~,70R,215F3    
67N,210W,215F3    
41L,67N,69D,74I,184V,210W,215F3    
69~,151M,184V3    
41L,67N,70R,184I,210W3    
41L,67N,70E,184V,210W,215Y3    
67N,70E3    
41L,67N,70R,74V3    
41L,67N,70R,151M,184V,215F3    
67N,115F,151M,184V,215F3    
65R,70R,151M,184I3    
184I,215Y3    
67N,70R,74I,115F,184V31.821.021422001
41L,115F,184V,210W,215Y3    
41L,65R,67N3    
41L,67N,69D,70R,74V,210W,215Y3    
67N,74I,184V3    
74I,115F,184V,215F3    
67N,70R,74I,215Y3    
67N,115F,151M3    
70R,74V,115F,184V3    
41L,115F,184V,215Y3    
69#,74V,210W,215Y3    
41L,67N,69D,70R,74V,184V,215Y3    
67N,70R,210W,215F3    
41L,70R,184I,210W,215Y3    
67N,70R,74V,215Y3    
69D,151M,184V3    
41L,67N,69D,74I,184I,210W3    
41L,67N,70G,74V,215F3    
41L,74V,115F,215Y3    
67N,69D,151M,184V3    
65R,67N,70G30.512.813.71131
41L,65R,67N,151M,210W,215Y3    
67N,69D,70R,115F,151M,184V,215F2    
41L,70R,74V,184V,210W,215F2    
41L,67N,151M,215F2391 8.016.61
69~,115F,151M,184V2    
41L,69#,74I,215Y2    
67N,69D,74V,115F,184V2    
41L,65R,151M,184V2    
41L,65R,74V,184V2    
151M,184V,215F2    
65R,184V,215F2    
65R,115F,151M,184I2    
67N,115F,184V2    
41L,69#,215F2    
41L,69D,184V2    
69#,210W,215F2    
41L,67N,70R,151M,215F2    
41L,65R,70R,151M2    
67N,74I,215Y2    
41L,67N,70R,74V,210W,215F2    
74I,184V,215F2    
65R,115F,184I2    
41L,67N,69D,151M,184V,210W,215Y2    
41L,70R,74I,210W,215Y2    
41L,69D,184V,215F2    
41L,69#,210W2    
70G2    
65N,115F,184V2    
41L,67~,70R,74V,215F2    
41L,67N,74I,115F,184V,215Y2    
69D,70R,74I,184I,210W,215F2    
41L,67N,69D,74I,184V,215Y2    
41L,151M2    
41L,65R,67N,151M2    
41L,70R,74I,184V,215Y2    
41L,67N,74I,184I,210W2    
67N,69D,70R,184I25.211.013.412001
210W,215F2    
67~,70R,74I,184V,215F2    
41L,67N,70R,74V,115F,184V,215Y2    
41L,67N,74V,115F,184V,215F2    
41L,67N,74V,210W,215F2    
41L,69D,184V,210W,215F2    
67N,74V,115F,184V,215F2    
41L,67N,70G,184V,215Y2    
41L,70G,210W,215Y2    
41L,67N,69D,74V,184V,210W,215F2    
41L,67N,70R,74I,184V,210W2    
41L,74V,115F2    
41L,67N,70R,115F,184V2    
67N,184I,215F2    
41L,65R,69~2    
67N,70E,184I2    
69D,115F,151M,184V2    
115F,151M,184V,215Y2240013.2120012001
70R,74V,210W,215Y2    
41L,67N,69D,74V,184V2    
41L,184I,210W2    
41L,74I,210W,215F2    
74V,115F,151M25.21 201151
41L,74I,215F2    
67N,70R,74V,210W,215Y2    
65R,69~,70R,151M2    
67N,70R,74V,184V,215Y2    
69~2    
67N,69D,184V,210W,215F2    
41L,65R,115F,151M2    
69#,184V,210W,215Y2    
69#,184V,210W,215F2    
70R,74I,115F,184V2    
41L,69D,215F2    
67N,70G,151M,184V2    
41L,67N,69D,74I,210W,215F2    
67N,70E,115F,151M2    
67N,115F,151M,184V2    
65R,67N,69D20.411.313.01161
67N,69D,74I,184V,215Y2    
70G,74V,184V,215Y2    
67N,69D,70R,184V,210W,215F2    
67N,70R,74V,115F,184V20.510.51 1001
69D,210W,215Y2    
65N,115F2 2.617.41231
41L,67~,70R,184V,215Y2    
41L,67~,70R,74V,184V,215F2    
65R,67N,69~,151M2    
67N,69D,70R,184I,215F2    
69~,151M2    
65R,69D2    
67N,74V,184V,215Y2    
65R,69~,151M2    
41L,67N,69D,70R,74V,184V,210W2    
67N,70R,184I,215Y2    
70G,74V2    
65R,70R,74V2    
69#,74V,184V,215Y2    
69D,184V,210W,215Y2    
67N,70G2    
41L,67N,69D,215F2    
41L,70R,74I,184V,210W,215Y2    
41L,65N,210W,215Y2    
41L,67N,69D,74V,184V,215F2    
41L,74V,115F,210W2    
41L,70R,74I,215Y2    
41L,74V,184I,210W,215Y2    
70R,210W,215Y2    
41L,67N,69D,70R2    
65R,69~,74V2    
41L,67N,70G,215Y2    
65R,69D,70R20.211.213.618.21
41L,69#,70R,215Y2    
67N,70R,115F,151M,184V2    
41L,69#,184V,210W,215F2    
67N,70R,74V,115F,151M,184V2    
67N,69D,70R,210W,215F2    
41L,67N,69D,70R,74V,215Y2    
67N,69D,74V2    
41L,69#,184I,215Y2    
115F,184V,210W,215Y2    
69#,184V,215F2    
67N,70E,115F,184V2    
69D,70R,151M,184I2    
41L,67~,70R,184V,215F2    
41L,70R,74V,184V,210W,215Y2    
41L,67N,184I,215Y2    
41L,69D,70R,184V,210W,215F2    
65R,70R,115F2    
69D,70R,215Y2    
41L,69D,70R,210W,215Y2    
74V,115F,215Y2    
65R,70E,115F,184V2    
41L,69#,184V,215F2    
41L,67N,69D,151M,210W,215Y215412.614.014.81
41L,67N,70R,151M2    
41L,65R,67N,184V,210W,215Y2    
74V,115F,151M,184V,215Y2    
41L,67N,69D,115F,151M,184V,215F2    
41L,67N,70R,151M,184V2    
67N,70G,115F,151M,184I,215Y23722 2421332
41L,69D,70R,74I,215F2