Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Mutation Pattern & Susceptibility

354 patterns of major drug resistance mutations (defined here) from 138560 clinical isolates obtained from 131653 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2017-12-7). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsNumber of
Sequences
NVP
foldn
EFV
foldn
ETR
foldn
None1036670.79130.68990.9230
103N1158051222212210.957
181C3124200791.6815.527
103N,181C20682005729596.811
100I,103N18107162200596.825
188L14282004376451.715
190A1322129367.637110
181C,190A11312002480254011
101E,190A81320098393.43
103N,190A73720022002 
101E,181C,190A731200199920134
103N,181C,190A633200820085.52
106M581656148615
103N,106M50320012001 
103N,230L47520011200113.85
101E3825.2122.1121.87
190S35920015128150.57
103N,188L348200920092.66
103S,190A34020078570.22
101P,103N3352001520015389
106A330200147.5140.82
101E,190S319200820071.23
106M,190A256   
190E222200820081103
101E,181C216200545103
101E,181C,190S194200220029.12
181I192200131.113187
181C,190S165200720076.51
101E,106M,190A1602001200111
181V15620052.15531
190Q14520062006 
101E,103N,190A136   
106M,188C133   
101E,103N123200120011.41
103N,106A116200620060.42
106M,181C113   
106A,190A1042001131 
101P,103S102200520051571
103N,188H96200320030.21
103S923536.831.11
230L892549.84211
106M,188L87   
101E,106M79   
101P,190A742002200231
106M,181C,190A71   
188L,190A71   
188C7019954450.92
106M,230L68   
101P6817155055.26
103S,106M68   
103N,188C67   
101E,188L60200220021.11
103N,190S60   
181C,188L562002962221
181C,230L5120038.938.71
106A,181C49   
236L472111 
101E,106M,181C,190A47   
100I452.649.741.97
188H453.617.31 
100I,188L41200220021172
101E,103N,181C,190A40   
100I,103N,181C3820012001 
103N,181I38   
103T32   
103N,106M,181C32   
101E,190C29   
190A,230L28   
103N,181C,230L26200220021502
103N,106A,181C25   
100I,103N,230L25   
190C2518521852 
103S,181C,190A24   
101E,181I24   
103N,181V23   
106A,181C,190A22   
103N,106M,230L22   
100I,103N,190A21   
103H,181C,190A20   
101E,106M,181C20   
101E,103N,181C20   
101P,188L19   
103N,181C,188C18   
103N,106A,190A18   
103N,106M,190A18   
103S,181C18   
106M,188H17   
100I,103N,181I17   
106M,188C,190A16   
101E,188L,190A15   
100I,103N,181C,190A15   
103S,106M,190A15   
103N,181C,188L14200120011541
103N,236L13165151 
101E,181I,190A13   
101E,190E13   
103N,181C,190S12   
101E,181V12200122301
106M,190A,230L12   
101E,190V12   
100I,103S11211150016.51
103N,106M,188C11   
100I,101E,190A11   
181C,188C11   
101E,181V,190A1120012001 
103N,106A,181C,190A10   
100I,230L10200120015.81
101E,106A,190A9   
103N,106M,181C,190A9   
100I,103N,106M9   
103S,106A820015.810.71
100I,101E,103N8   
101E,103N,106M8   
101E,188H,190A8   
181C,188L,190A820022002 
181C,236L7   
101E,103N,188L7   
101P,103S,190A7   
101E,181C,230L71732232722
100I,181I6   
101E,103S,190A6200120011.51
190V620022002 
101E,188C6   
100I,181C62002252282
101E,106A6   
181I,190A6   
101E,181C,190A,230L6   
103N,188L,230L6   
106A,230L6   
101P,181C6   
181C,188H51441121441
100I,103N,188H5   
101E,106M,190A,230L5   
190A,236L5   
188H,190S5   
188C,230L5   
188L,230L5   
103N,188C,190A5   
101E,181C,188L,190A5   
103N,190E5   
181C,190T5   
101E,103N,190S5   
101E,181I,190S5   
103T,106A5   
103T,181C5   
101E,106A,181C,190A5   
101P,103N,190A5   
190S,230L4   
101E,106M,181V,190A4   
103N,181C,188H4   
103T,230L4   
101E,230L4   
188C,190A4   
103N,181V,190A4   
101E,190Q4   
100I,103N,188C4   
101E,190A,230L4   
100I,190A4   
100I,181C,190A4   
103S,190S4   
101P,190S4   
188H,190A4   
188L,236L4   
103S,106M,230L4   
101E,106M,188C4   
103N,181I,190A4   
103N,188H,190A4   
103N,190A,230L4   
101E,181V,190S3   
101E,188H3   
181C,190C3   
101P,230L320012001 
100I,101E,181I,190A3   
106M,181C,230L3   
103T,190A3   
101P,106M3   
106M,181C,190S3   
103N,106M,188H3   
103N,106M,188L3   
100I,101E,103N,190A3   
101E,103N,106M,190A3   
100I,101E3   
106M,181C,188C3   
181V,190A3   
181I,188L3   
103S,181V320014.212001
101E,190A,236L3   
181C,190V3   
100I,190S3   
100I,103N,188L3   
101E,103N,106A,190A3   
103S,106M,181C3   
101E,181C,188L3   
181I,190E3   
100I,103N,106A3   
101E,181I,188L,190A3   
101E,190S,230L220012001 
106A,181C,188C2   
101E,103N,181I2   
100I,188L,190A2   
103S,190A,236L2   
103N,188C,230L2   
181V,188L2   
106M,181V2   
100I,181I,190A2   
100I,101E,190S2   
181C,190A,230L22001471431
100I,103S,190A2   
101P,103S,106M2   
100I,101E,106M2   
101E,190T2   
103S,188H,190A220012001 
101E,106A,190V2   
100I,106M,181C2   
103N,106A,230L2   
181I,230L2   
101E,103H,190A2   
101E,188C,190A2   
101E,106M,230L2   
106A,188C2   
190T220011501 
101E,103T2   
106A,190S2   
181V,230L2   
101E,103N,106A2   
103S,106A,190A2   
181C,188C,190A2   
101E,103N,106A,181C,190A2   
101P,188C2   
181C,190E2   
103N,188L,190A2   
181V,190S2   
100I,188H2   
101E,103N,236L2   
101E,106M,181C,190S2   
106M,181C,188L2   
101E,106M,190A,236L2   
101E,106M,181V2