Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Mutation Pattern & Susceptibility

261 patterns of major drug resistance mutations (defined here) from 67322 clinical isolates obtained from 62008 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2013-1-18). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsNumber of
Sequences
NVP
foldn
EFV
foldn
ETR
foldn
None514900.77690.67550.8162
103N527051194211930.848
181C1478200691.6715.520
103N,181C12532004832506.810
100I,103N8167152200496.316
188L7162003578371.710
181C,190A6282002083214710
190A589120337.1341.18
103N,181C,190A40420052005 
101E,181C,190A3702001610117151
103N,190A36820022002 
101E,190A31520061206 
101E1888.643.241.81
190S16220014133140.57
106A156200118.0110.82
103N,230L144200920098.73
103S,190A14020064760.22
106M1363359550.94
101P,103N1342001020010387
103N,188L117200720074.34
101E,190S112200720063.62
181I9920061.46 
101E,181C96200410.041052
103N,106M9320012001 
181C,190S83200520056.51
101E,181C,190S77   
103N,106A71200620060.42
190E6920052005 
181V6720041.64531
106A,190A582001131 
101P5617155055.26
101E,103N54   
101E,103N,190A53   
106M,190A48   
190Q4720052005 
103N,188C46   
188C40200320031.31
103S392224.82 
103N,188H38200320030.21
230L372549.84211
101P,190A3620012001 
101P,103S3420042004 
181C,188L3420011621 
103N,190S33   
188H313.617.31 
103N,181I30   
236L292.011.01 
188L,190A28   
101E,188L27200220021.11
100I,188L2520012001341
106A,181C24   
101E,103N,181C,190A22   
106M,188C21   
103N,106A,181C21   
103T21   
181C,230L2020038.938.71
100I183.1110.012.44
101E,106M,190A18   
101E,106M18   
100I,103N,181C1720012001 
190A,230L17   
103N,181C,188C16   
103H,181C,190A15   
106M,188L15   
103S,181C,190A14   
106A,181C,190A14   
190C1318521852 
101P,188L12   
103S,106M12   
103N,181C,230L12200220021502
101E,181I12   
100I,103N,190A11   
103N,106A,190A11   
106M,181C11   
106M,181C,190A10   
100I,103N,181C,190A10   
101E,103N,181C10   
103N,181V9   
101E,190C9   
106M,230L9   
103N,181C,190S9   
103S,181C9   
103N,106M,181C9   
100I,103N,181I9   
101E,190V9   
103N,106A,181C,190A8   
103N,236L716515.01 
101E,188L,190A7   
106M,188H7   
181C,188C7   
181C,188L,190A720022002 
101E,181V7 2.21 
100I,103S6   
101E,181I,190A6   
101P,181C6   
101E,181V,190A620012001 
100I,103N,188H5   
103N,188C,190A5   
103N,181C,188L5   
101E,188C5   
103N,106M,188C5   
101E,181C,230L52001111111
100I,230L5200120015.81
100I,103N,230L4   
101E,106A,190A4   
103N,106M,190A4   
103N,106M,181C,190A4   
101P,190S4   
100I,181C42002252282
101E,181I,190S4   
181I,190A4   
103N,106M,230L4   
101P,103N,190A4   
188C,190A3   
181C,236L3   
188C,230L3   
190V320022002 
103N,181V,190A3   
101E,106M,181C,190A3   
101E,103N,188L3   
103N,190E3   
103S,106A320015.810.71
103T,181C3   
103N,181I,190A3   
100I,103N,106M3   
101E,190E3   
101E,106A,181C,190A3   
100I,101E,103N3   
101E,188H,190A3   
103N,188L,230L3   
100I,103N,106A3   
101E,181I,188L,190A3   
181C,188H2   
106A,181C,188C2   
100I,181I2   
101E,106M,181V,190A2   
103N,181C,188H2   
101E,181V,190S2   
103T,230L2   
181C,190C2   
100I,181I,190A2   
101P,230L2   
188L,230L2   
100I,103S,190A2   
100I,103N,188C2   
106M,188C,190A2   
101E,190A,230L2   
100I,101E,181I,190A2   
103S,190S2   
103S,188H,190A220012001 
101E,103H,190A2   
103N,106M,188L2   
103T,106A2   
100I,101E,190A2   
106A,188C2   
190T220011501 
100I,101E2   
106A,190S2   
101E,103N,106A2   
181V,190A2   
181C,188C,190A2   
103N,188H,190A2   
101E,103N,106A,181C,190A2   
101P,188C2   
100I,103N,188L2   
101E,103N,106M2   
101E,181C,188L2   
106A,230L2