HIV Drug Resistance Database

NNRTI Mutation Pattern & Susceptibility

Common patterns of antiretroviral drug resistance mutations from 4,183 persons-originally published in Antimicrobial Agents and Chemotherapy (Rhee et al. 2004 ) are arranged in decreasing prevalence in the table below.(The table was updated on 2008-7-15)

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug.

Interquartile ranges are available by clicking here.
Data on the 30 most common mutation patterns is also available in a PDF format.

Color Legends

Mutation Patterns	Number of Sequences	NVP fold_n	DLV fold_n	EFV fold_n
None	15616	0.6₄₅₄	0.6₄₄₅	0.5₄₄₁
103N	1544	41₈₄	30₈₄	17₈₃
238R	628	0.5₁	0.2₁	0.2₁
103N,181C	439	400₂₀	250₂₀	32₂₂
100I,103N	395	58₂₉	180₂₂	314₂₆
181C	379	107₁₈	35₁₈	1.1₁₈
103R	260	0.6₆	0.9₆	0.6₆
106I	247	0.3₃	0.1₃	0.2₃
98G	210	2.4₁₁	0.4₁₁	0.7₁₀
188L	192	400₁₆	5.4₁₇	61₁₇
103N,108I	176	119₄	65₂	43₄
101Q	153	1.7₂	0.8₂	1.4₂
103N,225H	147	141₁₀	20₁₀	122₁₀
179D	140	2.6₄	5.2₄	4.0₄
190A	128	71₈	0.3₈	5.2₈
101R	124	0.5₅	0.4₅	0.6₅
181C,190A	112	585₄	7.5₄	9.0₄
103N,190A	107	500₁	37₁	213₁
108I	107	2.2₄	1.3₃	1.4₄
103N,181C,190A	102	218₂	163₂	245₂
103N,238T	89	136₃	38₃	44₃
101E,190A	81	339₂	1.2₂	120₂
101E,181C,190A	80	400₆	20₇	101₇
98G,103N	80	128₉	26₉	32₉
101E	71	6.2₃	3.2₃	3.6₃
108I,181C	68	400₃	56₃	2.8₃
101P,103N	67	400₃	250₃	700₃
179E	55	2.7₃	3.1₃	1.8₃
103N,108I,181C	50	400₁	250₁	700₁
103N,188L	50	680₁	190₁	270₁
98G,181C	48	350₄	41₄	7.2₄
101Q,103N	48	94₁	91₁	68₁
106I,188L	48	291₂	2.6₂	235₂
101E,108I,181C,190A	41
103S,190A	41	400₁	2.2₁	95₁
101Q,181C,190A	39
190S	37	206₇	0.4₇	47₇
101E,190S	37	506₄	1.4₄	302₃
106I,238R	36
106A,227L	36	400₉	1.9₉	8.0₉
101E,181C,190S	31
181I	31	460₂	37₂	2.0₂
101H,190A	31	162₃	5.6₃	9.4₃
190E	30	500₄	5.5₄	500₄
103N,106M	29
103N,230L	29	780₃	250₃	450₃
106A	29	64₂	5.0₂	1.8₂
103N,188C	28
179A	28
98G,103N,108I	26
98G,100I,103N	26	188₂	225₂	550₂
103N,106A	24
98G,103N,181C	24	250₂	200₂	36₂
230V	23
101E,181C	23	400₁	250₁	4.0₁
103N,108I,238T	22
101Q,181C,190S	22	893₃	8.8₂	1500₃
98G,179E,181C	21
101Q,181C	21
101R,103N	21	51₁	27₁	21₁
101P,190A	21
98G,101E,181C,190A	21	400₃	31₃	400₃
103N,108I,181C,190A	21	400₁	250₁	700₁
103R,179D	21	10.0₅	20₅	11₅
101A,106I,181I,188L,190A,227Y	21
179T	20
179G	19
227L	19	3.0₁	0.0₁	0.5₁
181V	18	400₁	53₁	2.4₁
98G,103N,181C,190A	18	893₂	417₂	1500₂
103N,106I	18
106A,190A,227L	17
101Q,108I,181C,190A	17
101H,181C,190A	16	300₃	43₄	292₄
101E,103N,190A	16
188C	16	32₁	4.8₁	3.0₁
101P,103S	16	647₄	525₄	1100₄
101Q,190S	16	121₁	0.1₁	50₁
238T	16	1.0₁	0.2₁	0.5₁
103R,179D,188L	16
103N,238N	15
98G,101E,108I,181C,190A	15	893₁	139₁	1500₁
101Q,103N,108I	15	175₁	72₁	86₁
98G,108I,181C	15
98G,188L	15	893₁	41₁	1500₁
100I,103N,108I	14
103N,225H,238T	14
98G,190A	14
101Q,103R	14
103Q	14
101E,103N	13
108I,181C,190A	13
103N,181C,188C	13
103N,108I,225H	13	81₁	10.0₁	42₁
103N,238R	13
227S	13
179D,181C	13
101H	13	2.4₄	2.0₄	0.8₄
103N,179E	12
230L	12	23₂	43₂	13₂
103N,108I,190A	12
101H,108I,181C,190A	12
101Q,103N,181C,190A	12
98G,181C,190A	11
230I	11
100I,103N,225H	11
179D,188L	11
103N,188H	11
106A,190A	11
103N,106A,227L	11	349₄	87₄	278₄
98G,101E,181C	11
103N,190S	10
106I,179D	10
188H	10	3.6₁	12₁	7.3₁
106A,181C	10
98G,103N,108I,181C	10
101Q,108I,181C	10
179E,188L	10
100I,188L	10
101H,181C,190S	10
236L	9	2.0₁	53₁	1.0₁
190Q	9	500₄	9.8₄	533₄
106I,181C	9
101Q,103N,225H	9
106M	9	19₁	2.0₁	11₁
101Q,190A	9
103S	9	22₂	6.2₂	4.8₂
103N,181C,238T	9
101E,103N,181C,190A	9
103N,108I,181C,238T	9
98G,106I,188L	9
106M,179D	9
106I,179E,188L	9	222₂	87₂	280₂
103N,227Y	9	17₂	500₂	83₂
101E,188L	8	263₁	56₁	238₁
101P,188L	8
225H	8	1.2₄	0.2₄	0.8₄
103T	8
101R,181C	8
238N	8	34₁	19₁	4.0₁
181C,188L	8
106I,181C,190A	8
101E,103N,181C	8
188L,190A	8
101I	8
98G,106I	7
101R,103N,181C	7
101R,103N,181C,190A	7
181C,238R	7
103N,181I	7
103E	7
106L,188L	7
236S	7
98G,108I	7
101P	7	303₂	36₂	34₂
98G,108I,179E	7	9.8₃	2.6₃	8.3₃
103N,108I,230L	6
98G,103N,238T	6
103N,227L	6
106I,181C,188L	6
103S,190A,238T	6	218₁		85₁
98G,238R	6
190R	6
98G,101E,190A	6
98G,179E	6
101Q,106I,188L	6
181C,230L	6	690₂	206₂	15₂
100I,103N,238R	6
179D,190Q	6
98G,103S,190A	6	400₁	5.6₁	148₁
101Q,181I	6
103R,179D,190A	6
190A,238R	5
103N,106I,190A	5
98G,101E,181C,190S	5
101R,238R	5
101E,108I,181C	5
103N,106M,181C	5
100F	5
101E,103R,190A	5
101E,108I,190A	5	680₁	200₁	270₁
103N,108I,238N	5
101N,103N	5
103N,190A,225H	5
101Q,106A	5
103N,106A,181C	5
101Q,103N,181C	5
108I,227L	5
106L	5
179E,181C	5	893₁	800₁	7.8₁
101E,106I,190A	5
101R,181C,190A	5
101N	5
103N,108I,227L	5
103R,181C	5
98G,103R	5	1.2₁	0.1₁	0.5₁
103N,179F,181C	5
101Q,103R,181C	5	120₁	19₁	3.6₁
101Q,190C	5
101A,106I,181V,188L,190A	5
103R,179D,181C	4
101N,103H,181C,190A	4
181C,190S	4
103N,188C,190A	4
106I,190A	4
190A,227L	4
106M,190A	4
98G,103N,108I,227L	4
103N,108I,179E	4
108I,190A	4	196₁	0.2₁	15₁
101E,103R,108I,181C,190A	4
101Q,103N,190A	4
101A,106I,181I,188L,190A	4
181C,190A,238R	4
225L	4
101Q,103H,108I,181C,190A	4
100I,103S	4
100I	4	3.1₁	30₁	10.0₁
103N,179E,225H	4
101H,190S	4
101R,190E	4
98G,103N,108I,181C,190A	4
98G,106I,181C,190A	4
230R	4
103N,108I,238R	4
103N,106I,181C	4
98G,101E,108I,181C	4
106A,108I,227L	4
101E,103N,108I	4
101E,181V	4		15₁	2.2₁
101E,190A,238T	4
100I,103N,181I	4
101Q,103N,108I,181C	4
103R,179D,230L	4
179D,190A	4
190A,238T	4
101E,190V	4
101E,181C,230L	4
101R,108I,181C	4
101Q,108I,181C,227L	4
179E,190S	4	149₃	0.4₁	128₃
101Q,179D,181C,190A	4
106A,179D,190A,227L	4
101Q,179F,181C,190A	3
101E,106I,181C,190S	3
103N,179E,238T	3
101E,190A,238R	3
101E,188C	3
103N,190A,238R	3
106I,179D,188L	3
188L,238T	3
101E,106I,188L,190A	3
181C,188C	3
101Q,103R,108I,181C,190A	3
98G,101H,181C,190A	3
98G,101Q,103N,181C,190A	3
98G,101Q	3
98P	3
98G,103N,225H	3
103R,179D,181C,190A	3
101Q,188L	3
100I,103N,181C	3
100I,103N,179T	3
103N,181C,238N	3	300₁	200₁	58₁
101E,181I	3
100I,103N,238T	3
103S,108I,190A	3
103N,179F,181C,190A	3
108I,181I	3
106I,188C	3	30₁	0.9₁	3.7₁
103R,106M,179D	3
181C,190A,238T	3
101Q,106A,227L	3
100I,103N,238N	3
106M,188C	3
101P,103N,106I	3
101E,108I,181C,190A,227L	3
98G,101H,108I,181C,190A	3
181N	3
103S,181C	3
98G,103R,179E	3
101E,106A,190A	3
103N,106I,230L	3
98G,101Q,181C,190A	3
181C,188L,190A	3
98G,101E,108I,181C,190A,227L	3
98G,103R,179E,181C,190A	3
103N,225H,238R	3
103R,188L	3
106M,179D,190A	3
106I,108I	3
179T,238R	3
108I,179Q,181C	3
101S,190A	3
98G,190S	3	680₁	1.0₁	270₁
101P,103N,190A	3
103N,181C,190A,238T	3
98G,108I,190A,227L	3
98G,190Q	3	400₁	2.0₁	700₁
101Q,103N,188H	3
101H,108I,181C	3	893₁	800₁	10.0₁
103R,106A,179D	3
101R,108I	3	2.0₁	0.8₁	1.0₁
98G,101R,181C	3
101P,181C	3
101P,103S,108I	3
103N,106A,181C,227L	3
179A,190E	3
101H,188L	3
101E,106I,190S	3
108I,181C,227L	3
101H,181C,190A,227Y	3
101H,106I,108I,181C,190A	3
101E,181I,188L,190A	3
108I,190A,227L,230L	3
106M,179E	3	114₁	20₁	700₁
108I,179E,181C	3
101R,190A	2
100I,103N,190A	2
98G,179E,181C,190A	2
98G,101E	2
181S	2
106M,179D,227L	2
101H,188L,190A	2
106M,190A,227L	2
101Q,106A,190A	2
101H,181C	2	300₁	200₁	13₁
101E,103R	2
103N,106I,181C,190A	2
101E,106M	2
101V,106I,181C,190A	2
101E,103N,108I,181C,190A	2
101Q,103N,108I,181C,190A	2
108I,238R	2
101E,108I,181C,190S	2
98G,181C,190S	2
227Y	2
101E,108I,181I,188L,225Y,227V,230L,238G	2
179D,181I	2
98G,101E,106I,108I,181C,190A	2	178₁	38₁	253₁
101Q,106I	2
101Q,103S,190A	2
106A,181C,190A,227L	2
101E,106I,181C,190A	2
100I,103N,230L	2
101Q,103N,238T	2
98G,100V	2
106I,179D,181C	2
98G,108I,181C,190A	2
188F	2
101E,181C,190A,227L	2
103N,181D	2
108I,181V	2
98G,103C,106I,188F	2
101Q,108I,181C,238N	2
103H,181C,190A	2
103N,179A	2
98G,108I,227L	2
98G,181C,227L	2
98G,181I	2
101Q,188L,190A	2
101R,188L	2
98G,100I,103N,181C	2
101R,103N,108I,181C	2
103N,108I,225H,238T	2
190S,238T	2
101E,108I,181C,190A,225H	2
101H,103N	2
101Q,103N,106A	2
188D	2
108A	2
101Q,103S,181C,190A	2
101E,103N,238T	2
103N,230V	2
179C	2
101T	2
188L,227L	2
238I	2
100I,101R,103N	2
101Q,106A,190A,227L	2
98G,101E,190S	2
101E,106M,190A,227L	2
101E,108I	2
100I,103N,227Y	2
179S	2
101Q,108I,181C,190A,227L	2
181C,227L	2	400₁	1.0₁	10.0₁
101P,106A,190A	2
101E,106I,181C	2
98G,101E,181C,190A,227L	2
103N,236S	2
101Q,238R	2
100P	2
106A,181C,227L	2
103N,181C,225H	2
238Q	2
106L,188L,238R	2
101Q,181C,188L	2
101N,103N,190A	2
101P,103N,238R	2
101H,106I,181C,190A,227L	2
108I,181C,238R	2
98G,103N,108I,190A	2
103N,238Q	2
103N,179D	2
188L,238R	2
98G,188L,190A	2
103N,181C,190S	2
181H	2
230V,238R	2
98G,103N,179E,181C	2
103R,190A	2
103N,181C,190A,227L	2
103N,236L	2	165₁	190₁	5.0₁
101E,106I,108I,181C,190A	2
101Q,106I,190S	2
103N,108I,181C,190A,238T	2
98G,103N,106I,181C,190A	2
103N,238S	2
101Q,103R,190A	2
98G,101Q,190S	2
103N,225H,230L	2
103N,179E,181C	2
103N,188F	2
181F	2
100I,103N,108I,238T	2
103N,106A,225H,227L	2
106G	2
100I,181C	2
108I,190S	2
101H,103N,181C	2
101E,181C,190A,238R	2
98G,101R,190A	2
181C,225H	2
103N,106A,181C,190A	2
179D,238R	2
101Q,103N,108I,225H	2
98L	2
98V	2
101R,103N,238T	2
190A,238E	2
103R,179E,181C	2
101A,106I,181V,188L,190A,227Y	2
108I,238T	2	1.9₁	2.8₁	1.0₁
103S,190S	2
103N,188L,238R	2
103R,179D,181I	2
103R,108I,179T,181C	2
98G,103N,108I,181C,227L	2
227L,230L	2
101Q,103R,108I,179F,181C,190A	2	300₁	35₁	400₁
106I,181C,190S	2
101R,106M,188C	2
101R,103R,190E	2
98G,103N,181I	2
101R,103N,108I,181C,227L	2
101Q,190Q	2
103R,106I,179D,188L	2
103R,181C,188L	2
101R,103N,225H	2
106I,188L,190A,238R	2
181H,188L	2
100I,101E,190S	2
101N,179L,181C	2
101S,103N,108I	2
98G,101R,103R,190E	2
101E,103R,108I	2
100I,103R,179D,230L	2
98G,101A,181C,190A	2
98G,106I,188L,238R	2

Color Legends

NVP	DLV	EFV
~ 4	~ 4	~ 4
4 ~ 20	4 ~ 20	4 ~ 20
20 ~	20 ~	20 ~

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Mutation Pattern & Susceptibility

The Team

The Data