Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Mutation Pattern & Susceptibility

334 patterns of major drug resistance mutations (defined here) from 131926 clinical isolates obtained from 125189 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2017-4-17). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsNumber of
Sequences
NVP
foldn
EFV
foldn
ETR
foldn
None655350.79130.68990.9230
103N1079651222212210.957
181C2937200791.6815.527
103N,181C19402005729596.811
100I,103N16707162200596.825
188L13182004376451.715
190A1251129367.6371.010
181C,190A10532002480254011
101E,190A75420098393.43
103N,190A69820022002 
101E,181C,190A671200199920134
103N,181C,190A600200820085.52
106M45565614861.05
103N,230L43720011200113.85
103N,106M37520012001 
101E3645.2122.1121.87
190S33720015128150.57
103S,190A31620078570.22
106A311200147.5140.82
103N,188L308200920092.66
101P,103N3082001520015389
101E,190S292200820071.23
101E,181C20220054.0510.03
106M,190A190   
190E188200820081103
181I182200131.113187
101E,181C,190S172200220029.12
181C,190S145200720076.51
181V13820052.15531
190Q12420062006 
101E,106M,190A123200120011.01
101E,103N,190A121   
103N,106A111200620060.42
101E,103N109200120011.41
106A,190A1032001131 
101P,103S99200520051571
106M,188C95   
103S893536.831.11
230L852549.84211
106M,181C84   
103N,188H84200320030.21
101P,190A68200220023.01
101E,106M67   
188C6519954450.92
101P6517155055.26
106M,188L65   
188L,190A62   
103N,188C60   
106M,181C,190A56   
103N,190S55   
106M,230L52   
101E,188L51200220021.11
181C,188L472002962221
103S,106M47   
188H453.617.31 
236L442.011.01 
106A,181C44   
181C,230L4120038.938.71
100I402.649.741.97
101E,103N,181C,190A39   
100I,188L39200220021172
103N,181I38   
100I,103N,181C3120012001 
103T31   
101E,106M,181C,190A31   
101E,190C27   
190A,230L26   
103N,106A,181C25   
103N,106M,181C25   
190C2418521852 
103S,181C,190A22   
101E,181I22   
103N,181C,230L21200220021502
103N,181V20   
100I,103N,190A20   
103H,181C,190A20   
106A,181C,190A20   
101E,103N,181C20   
103N,181C,188C18   
101P,188L18   
103N,106A,190A17   
100I,103N,181I17   
103N,106M,190A16   
103N,106M,230L16   
106M,188H16   
101E,106M,181C16   
103S,181C15   
100I,103N,230L14   
103N,236L1316515.01 
101E,188L,190A13   
100I,103N,181C,190A13   
101E,181I,190A13   
103N,181C,188L12200120011541
103N,181C,190S12   
101E,181V1220012.02301
101E,190V12   
101E,190E11   
101E,181V,190A1120012001 
106M,188C,190A10   
100I,103S10211150016.51
103N,106A,181C,190A10   
101E,106A,190A9   
103N,106M,181C,190A9   
103N,106M,188C9   
100I,103N,106M9   
181C,188C9   
100I,230L9200120015.81
103S,106A820015.810.71
106M,190A,230L8   
103S,106M,190A8   
101E,103N,106M8   
101E,188H,190A8   
181C,188L,190A820022002 
181C,236L7   
101E,103N,188L7   
100I,101E,190A7   
100I,101E,103N7   
101E,181C,230L71732232722
100I,181I6   
101E,103S,190A6200120011.51
190V620022002 
101E,188C6   
101P,103S,190A6   
101E,106A6   
181I,190A6   
101P,181C6   
181C,188H51441121441
100I,103N,188H5   
188H,190S5   
188C,230L5   
188L,230L5   
103N,188C,190A5   
103N,190E5   
100I,181C52002252282
181C,190T5   
101E,103N,190S5   
101E,181I,190S5   
103T,106A5   
103T,181C5   
103N,188L,230L5   
101P,103N,190A5   
190S,230L4   
101E,106M,181V,190A4   
103N,181C,188H4   
103T,230L4   
101E,230L4   
101E,106M,190A,230L4   
188C,190A4   
103N,181V,190A4   
101E,190Q4   
100I,103N,188C4   
101E,190A,230L4   
101E,181C,188L,190A4   
103S,190S4   
101P,190S4   
188H,190A4   
188L,236L4   
103N,181I,190A4   
101E,106A,181C,190A4   
103N,188H,190A4   
101E,181C,190A,230L4   
103N,190A,230L4   
106A,230L4   
101E,181V,190S3   
181C,190C3   
190A,236L3   
101P,230L320012001 
100I,190A3   
100I,181C,190A3   
100I,101E,181I,190A3   
106M,181C,230L3   
103T,190A3   
101P,106M3   
106M,181C,190S3   
103N,106M,188H3   
101E,106M,188C3   
100I,101E,103N,190A3   
101E,103N,106M,190A3   
100I,101E3   
181V,190A3   
181I,188L3   
103S,181V320014.212001
101E,190A,236L3   
181C,190V3   
100I,190S3   
100I,103N,188L3   
101E,181C,188L3   
181I,190E3   
100I,103N,106A3   
101E,181I,188L,190A3   
101E,190S,230L220012001 
106A,181C,188C2   
101E,103N,181I2   
103S,190A,236L2   
103N,188C,230L2   
181V,188L2   
101E,188H2   
100I,181I,190A2   
181C,190A,230L22001471431
100I,103S,190A2   
101P,103S,106M2   
100I,101E,106M2   
101E,190T2   
103S,188H,190A220012001 
101E,106A,190V2   
101E,103H,190A2   
101E,188C,190A2   
103S,106M,230L2   
103N,106M,188L2   
106A,188C2   
101E,103T2   
190T220011501 
106A,190S2   
106M,181C,188C2   
101E,103N,106A2   
181C,188C,190A2   
101E,103N,106A,181C,190A2   
101P,188C2   
181C,190E2   
101E,103N,106A,190A2   
103N,188L,190A2   
181V,190S2   
100I,188H2   
101E,103N,236L2   
101E,106M,190A,236L2