Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Mutation Pattern & Susceptibility

279 patterns of major drug resistance mutations (defined here) from 89306 clinical isolates obtained from 83566 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2014-5-10). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsNumber of
Sequences
NVP
foldn
EFV
foldn
ETR
foldn
None655350.79130.68990.9230
103N680751222212210.957
181C2023200791.6815.527
103N,181C14852005729596.811
100I,103N9977162200596.825
188L8752004376451.715
190A801129367.6371.010
181C,190A7732002480254011
101E,190A48020098393.43
103N,190A47420022002 
101E,181C,190A470200199920134
103N,181C,190A464200820085.52
106M25265614861.05
101E2385.2122.1121.87
103N,230L22820011200113.85
190S21620015128150.57
106A209200147.5140.82
103N,106M18620012001 
101P,103N1822001520015389
103S,190A17820078570.22
101E,190S154200820071.23
103N,188L154200920092.66
101E,181C13420054.0510.03
181I133200131.113187
101E,181C,190S108200220029.12
106M,190A101   
181V10020052.15531
190E99200820081103
181C,190S99200720076.51
103N,106A84200620060.42
101E,103N,190A70   
106A,190A662001131 
101E,103N65200120011.41
190Q6520062006 
101P5717155055.26
101E,106M,190A56200120011.01
103N,188H51200320030.21
103N,188C50   
188C5019954450.92
106M,188C49   
230L492549.84211
103S473536.831.11
103N,190S45   
101P,190A45200220023.01
101E,106M44   
101P,103S41200520051571
181C,188L372002962221
188L,190A37   
236L362.011.01 
188H363.617.31 
101E,188L34200220021.11
100I,188L32200220021172
103N,181I31   
106M,188L31   
106M,181C27   
106A,181C27   
181C,230L2720038.938.71
103T25   
106M,230L24   
101E,103N,181C,190A24   
103S,106M23   
100I222.649.741.97
190A,230L22   
100I,103N,181C2120012001 
103N,106A,181C21   
101E,181I18   
103S,181C,190A17   
190C1718521852 
103N,181C,188C16   
100I,103N,190A15   
103N,106A,190A15   
103H,181C,190A15   
106A,181C,190A15   
101E,190C15   
103N,181V14   
106M,181C,190A13   
101P,188L13   
103N,181C,230L13200220021502
100I,103N,181I13   
101E,103N,181C13   
106M,188H12   
100I,103N,181C,190A11   
101E,190V11   
103N,181C,190S10   
103S,181C10   
103N,106M,181C10   
101E,106M,181C,190A10   
103N,106M,190A9   
103N,106A,181C,190A9   
101E,188L,190A8   
181C,188C8   
181C,188L,190A820022002 
101E,181V820012.02301
103N,236L716515.01 
100I,103S7211150016.51
103S,106A720015.810.71
101E,181I,190A7   
100I,103N,106M7   
101E,181C,230L71732232722
101E,181V,190A720012001 
100I,103N,230L6   
103N,181C,188L6200120011541
101E,188C6   
101E,106M,181C6   
101P,181C6   
100I,103N,188H5   
101E,106A,190A5   
103N,188C,190A5   
103N,106M,181C,190A5   
103N,106M,188C5   
100I,101E,190A5   
103N,106M,230L5   
101P,103N,190A5   
100I,230L5200120015.81
181C,188H41441121441
100I,181I4   
101E,103S,190A4200120011.51
190V420022002 
101E,103N,188L4   
101P,190S4   
100I,181C42002252282
101E,103N,190S4   
101E,181I,190S4   
103N,181I,190A4   
181I,190A4   
101E,190E4   
101E,103N,106M4   
103N,188L,230L4   
101E,106M,181V,190A3   
103N,181C,188H3   
101E,181V,190S3   
103T,230L3   
101E,230L3   
188C,190A3   
101P,230L320012001 
181C,236L3   
188C,230L3   
103N,181V,190A3   
106M,188C,190A3   
100I,190A3   
103S,190S3   
103N,190E3   
103N,106M,188H3   
101E,106M,188C3   
103T,106A3   
103T,181C3   
101E,106A3   
106M,190A,230L3   
100I,101E3   
181V,190A3   
101E,106A,181C,190A3   
103S,181V320014.212001
100I,101E,103N3   
101E,188H,190A3   
100I,103N,106A3   
101E,181I,188L,190A3   
101E,190S,230L220012001 
190S,230L2   
106A,181C,188C2   
181C,190C2   
100I,181I,190A2   
188L,230L2   
100I,103S,190A2   
100I,103N,188C2   
101E,190A,230L2   
100I,101E,181I,190A2   
101E,181C,188L,190A2   
103S,188H,190A220012001 
181C,190T2   
188H,190A2   
101E,103H,190A2   
103N,106M,188L2   
106A,188C2   
190T220011501 
106A,190S2   
101E,103N,106A2   
181C,188C,190A2   
101E,181C,190A,230L2   
103N,188H,190A2   
101E,190A,236L2   
101E,103N,106A,181C,190A2   
101P,188C2   
181C,190E2   
100I,103N,188L2   
101E,103N,106A,190A2   
103N,188L,190A2   
181V,190S2   
101E,181C,188L2   
106A,230L2