Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Mutation Pattern & Susceptibility

261 patterns of major drug resistance mutations (defined here) from 67322 clinical isolates obtained from 62008 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2013-1-18). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug.The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. The Q1 and Q3 indicate the first and third quartile.

Mutation PatternsNumber of
Sequences
NVPEFVETR
foldnQ1Q3foldnQ1Q3foldnQ1Q3
None514900.77690.41.10.67550.40.90.81620.51.1
103N52705119426122211939.7430.8480.51.3
181C147820069812001.6710.83.75.5203.510
103N,181C125320048200200325012586.8101.910.0
100I,103N816715236134200492002006.3163.99.3
188L716200352002007837412001.7101.22.2
181C,190A6282002020020083211420047105.475
190A58912033532007.1343.5151.180.61.6
103N,181C,190A40420051982002005200200   
101E,181C,190A370200162002001011748200151  
103N,190A3682002  2002     
101E,190A3152006181200120676200   
101E1888.645.2113.242.14.31.81  
190S1622001413420013314502000.570.40.9
106A156200112002008.0114.1760.82  
103N,230L144200920020020092002008.731.611
103S,190A14020061712004765.2950.22  
106M13633526157955842000.940.81.6
101P,103N13420010200200200102002003872695
103N,188L117200720020020072002004.342.09.4
101E,190S112200720020020062002003.62  
181I9920062002001.460.62.9   
101E,181C96200420020010.043.81081052  
103N,106M932001  2001     
181C,190S83200518920020052002006.51  
101E,181C,190S77         
103N,106A7120062002002006682000.42  
190E6920052002002005200200   
181V6720042002001.640.83.0531  
106A,190A582001  131     
101P56171590189505201305.264.46.6
101E,103N54         
101E,103N,190A53         
106M,190A48         
190Q4720052002002005200200   
103N,188C46         
188C4020033220020033.02001.31  
103S39222  4.82     
103N,188H3820032002002003592000.21  
230L372548.51209.844.019211  
101P,190A362001  2001     
101P,103S3420042002002004200200   
181C,188L342001  1621     
103N,190S33         
188H313.61  7.31     
103N,181I30         
236L292.01  1.01     
188L,190A28         
101E,188L272002  2002  1.11  
100I,188L252001  2001  341  
106A,181C24         
101E,103N,181C,190A22         
106M,188C21         
103N,106A,181C21         
103T21         
181C,230L2020032002008.935.3258.71  
100I183.11  10.01  2.441.66.5
101E,106M,190A18         
101E,106M18         
100I,103N,181C172001  2001     
190A,230L17         
103N,181C,188C16         
103H,181C,190A15         
106M,188L15         
103S,181C,190A14         
106A,181C,190A14         
190C131852  1852     
101P,188L12         
103S,106M12         
103N,181C,230L122002  2002  1502  
101E,181I12         
100I,103N,190A11         
103N,106A,190A11         
106M,181C11         
106M,181C,190A10         
100I,103N,181C,190A10         
101E,103N,181C10         
103N,181V9         
101E,190C9         
106M,230L9         
103N,181C,190S9         
103S,181C9         
103N,106M,181C9         
100I,103N,181I9         
101E,190V9         
103N,106A,181C,190A8         
103N,236L71651  5.01     
101E,188L,190A7         
106M,188H7         
181C,188C7         
181C,188L,190A72002  2002     
101E,181V7   2.21     
100I,103S6         
101E,181I,190A6         
101P,181C6         
101E,181V,190A62001  2001     
100I,103N,188H5         
103N,188C,190A5         
103N,181C,188L5         
101E,188C5         
103N,106M,188C5         
101E,181C,230L52001  111  111  
100I,230L52001  2001  5.81  
100I,103N,230L4         
101E,106A,190A4         
103N,106M,190A4         
103N,106M,181C,190A4         
101P,190S4         
100I,181C42002  252  282  
101E,181I,190S4         
181I,190A4         
103N,106M,230L4         
101P,103N,190A4         
188C,190A3         
181C,236L3         
188C,230L3         
190V32002  2002     
103N,181V,190A3         
101E,106M,181C,190A3         
101E,103N,188L3         
103N,190E3         
103S,106A32001  5.81  0.71  
103T,181C3         
103N,181I,190A3         
100I,103N,106M3         
101E,190E3         
101E,106A,181C,190A3         
100I,101E,103N3         
101E,188H,190A3         
103N,188L,230L3         
100I,103N,106A3         
101E,181I,188L,190A3         
181C,188H2         
106A,181C,188C2         
100I,181I2         
101E,106M,181V,190A2         
103N,181C,188H2         
101E,181V,190S2         
103T,230L2         
181C,190C2         
100I,181I,190A2         
101P,230L2         
188L,230L2         
100I,103S,190A2         
100I,103N,188C2         
106M,188C,190A2         
101E,190A,230L2         
100I,101E,181I,190A2         
103S,190S2         
103S,188H,190A22001  2001     
101E,103H,190A2         
103N,106M,188L2         
103T,106A2         
100I,101E,190A2         
106A,188C2         
190T22001  1501     
100I,101E2         
106A,190S2         
101E,103N,106A2         
181V,190A2         
181C,188C,190A2         
103N,188H,190A2         
101E,103N,106A,181C,190A2         
101P,188C2         
100I,103N,188L2         
101E,103N,106M2         
101E,181C,188L2         
106A,230L2