Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Mutation Pattern & Susceptibility

279 patterns of major drug resistance mutations (defined here) from 89306 clinical isolates obtained from 83566 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2014-5-10). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug.The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. The Q1 and Q3 indicate the first and third quartile.

Mutation PatternsNumber of
Sequences
NVPEFVETR
foldnQ1Q3foldnQ1Q3foldnQ1Q3
None655350.79130.41.10.68990.41.00.92300.61.3
103N68075122226128212219.8430.9570.51.3
181C202320079852001.6810.93.65.5272.810.0
103N,181C148520057200200295911586.8111.911
100I,103N997716238129200592002006.8253.610
188L875200432002007645442001.7151.22.2
190A80112936602007.6373.7201.0100.61.6
181C,190A7732002420020080251320040114.775
101E,190A4802009191200839591623.432.34.5
103N,190A4742002  2002     
101E,181C,190A470200192002009920482001346.915
103N,181C,190A464200820020020081362005.52  
106M252656261141486842001.050.83.2
101E2385.2122.6102.1121.42.71.871.33.2
103N,230L22820011200200200112002003.852.49.8
190S2162001513420012815502000.570.40.9
106A209200142002007.5144.1670.82  
103N,106M1862001  2001     
101P,103N18220015200200200152002003892482
103S,190A17820071712008575.21480.22  
101E,190S154200820020020072002001.230.56.1
103N,188L154200920020020092002002.661.75.8
101E,181C13420052002004.053.010810.033.2200
181I133200131882001.1130.62.21871457
101E,181C,190S1082002  2002  9.12  
106M,190A101         
181V10020052002002.150.83.1531  
190E9920082002002008200200110394200
181C,190S99200720020020072002006.51  
103N,106A8420062002002006682000.42  
101E,103N,190A70         
106A,190A662001  131     
101E,103N652001  2001  1.41  
190Q6520062002002006200200   
101P57171590189505201305.264.46.6
101E,106M,190A562001  2001  1.01  
103N,188H5120032002002003592000.21  
103N,188C50         
188C501995312004453.42000.92  
106M,188C49         
230L492548.51209.844.019211  
103S473535.0386.832.47.11.11  
103N,190S45         
101P,190A452002  2002  3.01  
101E,106M44         
101P,103S41200520020020052002001571  
181C,188L372002  962  221  
188L,190A37         
236L362.01  1.01     
188H363.61  7.31     
101E,188L342002  2002  1.11  
100I,188L322002  2002  1172  
103N,181I31         
106M,188L31         
106M,181C27         
106A,181C27         
181C,230L2720032002008.935.3258.71  
103T25         
106M,230L24         
101E,103N,181C,190A24         
103S,106M23         
100I222.641.7159.748.17551.971.310
190A,230L22         
100I,103N,181C212001  2001     
103N,106A,181C21         
101E,181I18         
103S,181C,190A17         
190C171852  1852     
103N,181C,188C16         
100I,103N,190A15         
103N,106A,190A15         
103H,181C,190A15         
106A,181C,190A15         
101E,190C15         
103N,181V14         
106M,181C,190A13         
101P,188L13         
103N,181C,230L132002  2002  1502  
100I,103N,181I13         
101E,103N,181C13         
106M,188H12         
100I,103N,181C,190A11         
101E,190V11         
103N,181C,190S10         
103S,181C10         
103N,106M,181C10         
101E,106M,181C,190A10         
103N,106M,190A9         
103N,106A,181C,190A9         
101E,188L,190A8         
181C,188C8         
181C,188L,190A82002  2002     
101E,181V82001  2.02  301  
103N,236L71651  5.01     
100I,103S7211  15001  6.51  
103S,106A72001  5.81  0.71  
101E,181I,190A7         
100I,103N,106M7         
101E,181C,230L71732  232  722  
101E,181V,190A72001  2001     
100I,103N,230L6         
103N,181C,188L62001  2001  1541  
101E,188C6         
101E,106M,181C6         
101P,181C6         
100I,103N,188H5         
101E,106A,190A5         
103N,188C,190A5         
103N,106M,181C,190A5         
103N,106M,188C5         
100I,101E,190A5         
103N,106M,230L5         
101P,103N,190A5         
100I,230L52001  2001  5.81  
181C,188H41441  121  441  
100I,181I4         
101E,103S,190A42001  2001  1.51  
190V42002  2002     
101E,103N,188L4         
101P,190S4         
100I,181C42002  252  282  
101E,103N,190S4         
101E,181I,190S4         
103N,181I,190A4         
181I,190A4         
101E,190E4         
101E,103N,106M4         
103N,188L,230L4         
101E,106M,181V,190A3         
103N,181C,188H3         
101E,181V,190S3         
103T,230L3         
101E,230L3         
188C,190A3         
101P,230L32001  2001     
181C,236L3         
188C,230L3         
103N,181V,190A3         
106M,188C,190A3         
100I,190A3         
103S,190S3         
103N,190E3         
103N,106M,188H3         
101E,106M,188C3         
103T,106A3         
103T,181C3         
101E,106A3         
106M,190A,230L3         
100I,101E3         
181V,190A3         
101E,106A,181C,190A3         
103S,181V32001  4.21  2001  
100I,101E,103N3         
101E,188H,190A3         
100I,103N,106A3         
101E,181I,188L,190A3         
101E,190S,230L22001  2001     
190S,230L2         
106A,181C,188C2         
181C,190C2         
100I,181I,190A2         
188L,230L2         
100I,103S,190A2         
100I,103N,188C2         
101E,190A,230L2         
100I,101E,181I,190A2         
101E,181C,188L,190A2         
103S,188H,190A22001  2001     
181C,190T2         
188H,190A2         
101E,103H,190A2         
103N,106M,188L2         
106A,188C2         
190T22001  1501     
106A,190S2         
101E,103N,106A2         
181C,188C,190A2         
101E,181C,190A,230L2         
103N,188H,190A2         
101E,190A,236L2         
101E,103N,106A,181C,190A2         
101P,188C2         
181C,190E2         
100I,103N,188L2         
101E,103N,106A,190A2         
103N,188L,190A2         
181V,190S2         
101E,181C,188L2         
106A,230L2