NNRTI Mutation Pattern & Susceptibility334 patterns of major drug resistance mutations (defined here) from 131926 clinical isolates obtained from 125189 persons infected with HIV1 Group M virus are arranged in decreasing prevalence in the table (updated on 2017417). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004. The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class.
Subscripts indicate the number of sequences assayed for resistance to the designated drug.The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. The Q1 and Q3 indicate the first and third quartile.

Mutation Patterns  Number of Sequences  NVP  EFV  ETR 

fold_{n}  Q1  Q3  fold_{n}  Q1  Q3  fold_{n}  Q1  Q3 

None  65535  0.7_{913}  0.4  1.1  0.6_{899}  0.4  1.0  0.9_{230}  0.6  1.3  103N  10796  51_{222}  26  128  21_{221}  9.8  43  0.9_{57}  0.5  1.3  181C  2937  200_{79}  85  200  1.6_{81}  0.9  3.6  5.5_{27}  2.8  10.0  103N,181C  1940  200_{57}  200  200  29_{59}  11  58  6.8_{11}  1.9  11  100I,103N  1670  71_{62}  38  129  200_{59}  200  200  6.8_{25}  3.6  10  188L  1318  200_{43}  200  200  76_{45}  44  200  1.7_{15}  1.2  2.2  190A  1251  129_{36}  60  200  7.6_{37}  3.7  20  1.0_{10}  0.6  1.6  181C,190A  1053  200_{24}  200  200  80_{25}  13  200  40_{11}  4.7  75  101E,190A  754  200_{9}  191  200  83_{9}  59  162  3.4_{3}  2.3  4.5  103N,190A  698  200_{2}    200_{2}       101E,181C,190A  671  200_{19}  200  200  99_{20}  48  200  13_{4}  6.9  15  103N,181C,190A  600  200_{8}  200  200  200_{8}  136  200  5.5_{2}    106M  455  65_{6}  26  114  148_{6}  84  200  1.0_{5}  0.8  3.2  103N,230L  437  200_{11}  200  200  200_{11}  200  200  3.8_{5}  2.4  9.8  103N,106M  375  200_{1}    200_{1}       101E  364  5.2_{12}  2.6  10  2.1_{12}  1.4  2.7  1.8_{7}  1.3  3.2  190S  337  200_{15}  134  200  128_{15}  50  200  0.5_{7}  0.4  0.9  103S,190A  316  200_{7}  171  200  85_{7}  5.2  148  0.2_{2}    106A  311  200_{14}  200  200  7.5_{14}  4.1  67  0.8_{2}    103N,188L  308  200_{9}  200  200  200_{9}  200  200  2.6_{6}  1.7  5.8  101P,103N  308  200_{15}  200  200  200_{15}  200  200  38_{9}  24  82  101E,190S  292  200_{8}  200  200  200_{7}  200  200  1.2_{3}  0.5  6.1  101E,181C  202  200_{5}  200  200  4.0_{5}  3.0  108  10.0_{3}  3.2  200  106M,190A  190           190E  188  200_{8}  200  200  200_{8}  200  200  110_{3}  94  200  181I  182  200_{13}  188  200  1.1_{13}  0.6  2.2  18_{7}  14  57  101E,181C,190S  172  200_{2}    200_{2}    9.1_{2}    181C,190S  145  200_{7}  200  200  200_{7}  200  200  6.5_{1}    181V  138  200_{5}  200  200  2.1_{5}  0.8  3.1  53_{1}    190Q  124  200_{6}  200  200  200_{6}  200  200     101E,106M,190A  123  200_{1}    200_{1}    1.0_{1}    101E,103N,190A  121           103N,106A  111  200_{6}  200  200  200_{6}  68  200  0.4_{2}    101E,103N  109  200_{1}    200_{1}    1.4_{1}    106A,190A  103  200_{1}    13_{1}       101P,103S  99  200_{5}  200  200  200_{5}  200  200  157_{1}    106M,188C  95           103S  89  35_{3}  5.0  38  6.8_{3}  2.4  7.1  1.1_{1}    230L  85  25_{4}  8.5  120  9.8_{4}  4.0  19  21_{1}    106M,181C  84           103N,188H  84  200_{3}  200  200  200_{3}  59  200  0.2_{1}    101P,190A  68  200_{2}    200_{2}    3.0_{1}    101E,106M  67           188C  65  199_{5}  31  200  44_{5}  3.4  200  0.9_{2}    101P  65  171_{5}  90  189  50_{5}  20  130  5.2_{6}  4.4  6.6  106M,188L  65           188L,190A  62           103N,188C  60           106M,181C,190A  56           103N,190S  55           106M,230L  52           101E,188L  51  200_{2}    200_{2}    1.1_{1}    181C,188L  47  200_{2}    96_{2}    22_{1}    103S,106M  47           188H  45  3.6_{1}    7.3_{1}       236L  44  2.0_{1}    1.0_{1}       106A,181C  44           181C,230L  41  200_{3}  200  200  8.9_{3}  5.3  25  8.7_{1}    100I  40  2.6_{4}  1.7  15  9.7_{4}  8.1  755  1.9_{7}  1.3  10  101E,103N,181C,190A  39           100I,188L  39  200_{2}    200_{2}    117_{2}    103N,181I  38           100I,103N,181C  31  200_{1}    200_{1}       103T  31           101E,106M,181C,190A  31           101E,190C  27           190A,230L  26           103N,106A,181C  25           103N,106M,181C  25           190C  24  185_{2}    185_{2}       103S,181C,190A  22           101E,181I  22           103N,181C,230L  21  200_{2}    200_{2}    150_{2}    103N,181V  20           100I,103N,190A  20           103H,181C,190A  20           106A,181C,190A  20           101E,103N,181C  20           103N,181C,188C  18           101P,188L  18           103N,106A,190A  17           100I,103N,181I  17           103N,106M,190A  16           103N,106M,230L  16           106M,188H  16           101E,106M,181C  16           103S,181C  15           100I,103N,230L  14           103N,236L  13  165_{1}    5.0_{1}       101E,188L,190A  13           100I,103N,181C,190A  13           101E,181I,190A  13           103N,181C,188L  12  200_{1}    200_{1}    154_{1}    103N,181C,190S  12           101E,181V  12  200_{1}    2.0_{2}    30_{1}    101E,190V  12           101E,190E  11           101E,181V,190A  11  200_{1}    200_{1}       106M,188C,190A  10           100I,103S  10  21_{1}    1500_{1}    6.5_{1}    103N,106A,181C,190A  10           101E,106A,190A  9           103N,106M,181C,190A  9           103N,106M,188C  9           100I,103N,106M  9           181C,188C  9           100I,230L  9  200_{1}    200_{1}    5.8_{1}    103S,106A  8  200_{1}    5.8_{1}    0.7_{1}    106M,190A,230L  8           103S,106M,190A  8           101E,103N,106M  8           101E,188H,190A  8           181C,188L,190A  8  200_{2}    200_{2}       181C,236L  7           101E,103N,188L  7           100I,101E,190A  7           100I,101E,103N  7           101E,181C,230L  7  173_{2}    23_{2}    72_{2}    100I,181I  6           101E,103S,190A  6  200_{1}    200_{1}    1.5_{1}    190V  6  200_{2}    200_{2}       101E,188C  6           101P,103S,190A  6           101E,106A  6           181I,190A  6           101P,181C  6           181C,188H  5  144_{1}    12_{1}    44_{1}    100I,103N,188H  5           188H,190S  5           188C,230L  5           188L,230L  5           103N,188C,190A  5           103N,190E  5           100I,181C  5  200_{2}    25_{2}    28_{2}    181C,190T  5           101E,103N,190S  5           101E,181I,190S  5           103T,106A  5           103T,181C  5           103N,188L,230L  5           101P,103N,190A  5           190S,230L  4           101E,106M,181V,190A  4           103N,181C,188H  4           103T,230L  4           101E,230L  4           101E,106M,190A,230L  4           188C,190A  4           103N,181V,190A  4           101E,190Q  4           100I,103N,188C  4           101E,190A,230L  4           101E,181C,188L,190A  4           103S,190S  4           101P,190S  4           188H,190A  4           188L,236L  4           103N,181I,190A  4           101E,106A,181C,190A  4           103N,188H,190A  4           101E,181C,190A,230L  4           103N,190A,230L  4           106A,230L  4           101E,181V,190S  3           181C,190C  3           190A,236L  3           101P,230L  3  200_{1}    200_{1}       100I,190A  3           100I,181C,190A  3           100I,101E,181I,190A  3           106M,181C,230L  3           103T,190A  3           101P,106M  3           106M,181C,190S  3           103N,106M,188H  3           101E,106M,188C  3           100I,101E,103N,190A  3           101E,103N,106M,190A  3           100I,101E  3           181V,190A  3           181I,188L  3           103S,181V  3  200_{1}    4.2_{1}    200_{1}    101E,190A,236L  3           181C,190V  3           100I,190S  3           100I,103N,188L  3           101E,181C,188L  3           181I,190E  3           100I,103N,106A  3           101E,181I,188L,190A  3           101E,190S,230L  2  200_{1}    200_{1}       106A,181C,188C  2           101E,103N,181I  2           103S,190A,236L  2           103N,188C,230L  2           181V,188L  2           101E,188H  2           100I,181I,190A  2           181C,190A,230L  2  200_{1}    47_{1}    43_{1}    100I,103S,190A  2           101P,103S,106M  2           100I,101E,106M  2           101E,190T  2           103S,188H,190A  2  200_{1}    200_{1}       101E,106A,190V  2           101E,103H,190A  2           101E,188C,190A  2           103S,106M,230L  2           103N,106M,188L  2           106A,188C  2           101E,103T  2           190T  2  200_{1}    150_{1}       106A,190S  2           106M,181C,188C  2           101E,103N,106A  2           181C,188C,190A  2           101E,103N,106A,181C,190A  2           101P,188C  2           181C,190E  2           101E,103N,106A,190A  2           103N,188L,190A  2           181V,190S  2           100I,188H  2           101E,103N,236L  2           101E,106M,190A,236L  2          
