Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Mutation Pattern & Susceptibility

334 patterns of major drug resistance mutations (defined here) from 131926 clinical isolates obtained from 125189 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2017-4-17). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug.The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. The Q1 and Q3 indicate the first and third quartile.

Mutation PatternsNumber of
Sequences
NVPEFVETR
foldnQ1Q3foldnQ1Q3foldnQ1Q3
None655350.79130.41.10.68990.41.00.92300.61.3
103N107965122226128212219.8430.9570.51.3
181C293720079852001.6810.93.65.5272.810.0
103N,181C194020057200200295911586.8111.911
100I,103N1670716238129200592002006.8253.610
188L1318200432002007645442001.7151.22.2
190A125112936602007.6373.7201.0100.61.6
181C,190A10532002420020080251320040114.775
101E,190A7542009191200839591623.432.34.5
103N,190A6982002  2002     
101E,181C,190A671200192002009920482001346.915
103N,181C,190A600200820020020081362005.52  
106M455656261141486842001.050.83.2
103N,230L43720011200200200112002003.852.49.8
103N,106M3752001  2001     
101E3645.2122.6102.1121.42.71.871.33.2
190S3372001513420012815502000.570.40.9
103S,190A31620071712008575.21480.22  
106A311200142002007.5144.1670.82  
103N,188L308200920020020092002002.661.75.8
101P,103N30820015200200200152002003892482
101E,190S292200820020020072002001.230.56.1
101E,181C20220052002004.053.010810.033.2200
106M,190A190         
190E18820082002002008200200110394200
181I182200131882001.1130.62.21871457
101E,181C,190S1722002  2002  9.12  
181C,190S145200720020020072002006.51  
181V13820052002002.150.83.1531  
190Q12420062002002006200200   
101E,106M,190A1232001  2001  1.01  
101E,103N,190A121         
103N,106A11120062002002006682000.42  
101E,103N1092001  2001  1.41  
106A,190A1032001  131     
101P,103S99200520020020052002001571  
106M,188C95         
103S893535.0386.832.47.11.11  
230L852548.51209.844.019211  
106M,181C84         
103N,188H8420032002002003592000.21  
101P,190A682002  2002  3.01  
101E,106M67         
188C651995312004453.42000.92  
101P65171590189505201305.264.46.6
106M,188L65         
188L,190A62         
103N,188C60         
106M,181C,190A56         
103N,190S55         
106M,230L52         
101E,188L512002  2002  1.11  
181C,188L472002  962  221  
103S,106M47         
188H453.61  7.31     
236L442.01  1.01     
106A,181C44         
181C,230L4120032002008.935.3258.71  
100I402.641.7159.748.17551.971.310
101E,103N,181C,190A39         
100I,188L392002  2002  1172  
103N,181I38         
100I,103N,181C312001  2001     
103T31         
101E,106M,181C,190A31         
101E,190C27         
190A,230L26         
103N,106A,181C25         
103N,106M,181C25         
190C241852  1852     
103S,181C,190A22         
101E,181I22         
103N,181C,230L212002  2002  1502  
103N,181V20         
100I,103N,190A20         
103H,181C,190A20         
106A,181C,190A20         
101E,103N,181C20         
103N,181C,188C18         
101P,188L18         
103N,106A,190A17         
100I,103N,181I17         
103N,106M,190A16         
103N,106M,230L16         
106M,188H16         
101E,106M,181C16         
103S,181C15         
100I,103N,230L14         
103N,236L131651  5.01     
101E,188L,190A13         
100I,103N,181C,190A13         
101E,181I,190A13         
103N,181C,188L122001  2001  1541  
103N,181C,190S12         
101E,181V122001  2.02  301  
101E,190V12         
101E,190E11         
101E,181V,190A112001  2001     
106M,188C,190A10         
100I,103S10211  15001  6.51  
103N,106A,181C,190A10         
101E,106A,190A9         
103N,106M,181C,190A9         
103N,106M,188C9         
100I,103N,106M9         
181C,188C9         
100I,230L92001  2001  5.81  
103S,106A82001  5.81  0.71  
106M,190A,230L8         
103S,106M,190A8         
101E,103N,106M8         
101E,188H,190A8         
181C,188L,190A82002  2002     
181C,236L7         
101E,103N,188L7         
100I,101E,190A7         
100I,101E,103N7         
101E,181C,230L71732  232  722  
100I,181I6         
101E,103S,190A62001  2001  1.51  
190V62002  2002     
101E,188C6         
101P,103S,190A6         
101E,106A6         
181I,190A6         
101P,181C6         
181C,188H51441  121  441  
100I,103N,188H5         
188H,190S5         
188C,230L5         
188L,230L5         
103N,188C,190A5         
103N,190E5         
100I,181C52002  252  282  
181C,190T5         
101E,103N,190S5         
101E,181I,190S5         
103T,106A5         
103T,181C5         
103N,188L,230L5         
101P,103N,190A5         
190S,230L4         
101E,106M,181V,190A4         
103N,181C,188H4         
103T,230L4         
101E,230L4         
101E,106M,190A,230L4         
188C,190A4         
103N,181V,190A4         
101E,190Q4         
100I,103N,188C4         
101E,190A,230L4         
101E,181C,188L,190A4         
103S,190S4         
101P,190S4         
188H,190A4         
188L,236L4         
103N,181I,190A4         
101E,106A,181C,190A4         
103N,188H,190A4         
101E,181C,190A,230L4         
103N,190A,230L4         
106A,230L4         
101E,181V,190S3         
181C,190C3         
190A,236L3         
101P,230L32001  2001     
100I,190A3         
100I,181C,190A3         
100I,101E,181I,190A3         
106M,181C,230L3         
103T,190A3         
101P,106M3         
106M,181C,190S3         
103N,106M,188H3         
101E,106M,188C3         
100I,101E,103N,190A3         
101E,103N,106M,190A3         
100I,101E3         
181V,190A3         
181I,188L3         
103S,181V32001  4.21  2001  
101E,190A,236L3         
181C,190V3         
100I,190S3         
100I,103N,188L3         
101E,181C,188L3         
181I,190E3         
100I,103N,106A3         
101E,181I,188L,190A3         
101E,190S,230L22001  2001     
106A,181C,188C2         
101E,103N,181I2         
103S,190A,236L2         
103N,188C,230L2         
181V,188L2         
101E,188H2         
100I,181I,190A2         
181C,190A,230L22001  471  431  
100I,103S,190A2         
101P,103S,106M2         
100I,101E,106M2         
101E,190T2         
103S,188H,190A22001  2001     
101E,106A,190V2         
101E,103H,190A2         
101E,188C,190A2         
103S,106M,230L2         
103N,106M,188L2         
106A,188C2         
101E,103T2         
190T22001  1501     
106A,190S2         
106M,181C,188C2         
101E,103N,106A2         
181C,188C,190A2         
101E,103N,106A,181C,190A2         
101P,188C2         
181C,190E2         
101E,103N,106A,190A2         
103N,188L,190A2         
181V,190S2         
100I,188H2         
101E,103N,236L2         
101E,106M,190A,236L2