Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

INI Mutation Pattern & Susceptibility

41 patterns of major drug resistance mutations (defined here) from 5016 clinical isolates obtained from 4740 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2013-1-18). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsNumber of
Sequences
RAL
foldn
EVG
foldn
DTG
foldn
None48261.2641.7641.03
155H3519124581.62
140S,148H351619100054.11
143R194363.931.31
143C93241.110.81
143H72.111.210.91
92Q76.094071.62
121Y77.02112 
148R632910951.02
138A,140S,148H6   
66A51.033330.31
92Q,140S,148K,155H5   
138K40.930.63 
140A,148R412531002 
138K,147G,148R43421652 
140S,148R31194 4.01
140S,148H,155H2   
138K,140C,148R2   
138A2   
138K,140S,148H2   
140S22.034.03 
92Q,155H2105712532.12
147G21.158.761.01
92Q,140S,148R,155H2   
143H,155H2