INI Mutation Pattern & Susceptibility
|47 patterns of major drug resistance mutations (defined here) from 8345 clinical isolates obtained from 7995 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2014-5-10). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.|
The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class.
Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here.
Data on the 30 most common mutation patterns is also available in a PDF format.
|Mutation Patterns||Number of|
|138A,140S,148H||6|| || || |
|138A||5|| || || |
|140A,148R||5||1501|| || |
|92Q,140S,148K,155H||5|| || || |
|143C,155H||4|| || || |
|140S,148H,155H||2|| || || |
|138K,140S,148H||2|| || || |
|145S||2|| || || |
|143R,155H||2|| || || |
|92Q,140S,148R,155H||2|| || || |
|138A,140S,143H,148H||2|| || || |
|143H,155H||2|| || || |