Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

INI Mutation Pattern & Susceptibility

94 patterns of major drug resistance mutations (defined here) from 20458 clinical isolates obtained from 19740 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2018-9-28). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsNumber of
Sequences
RAL
foldn
EVG
foldn
DTG
foldn
None1931216201.46160.9110
155H303183245271.715
140S,148H24114330150224.129
143R8979226.2181.28
92Q434.52240211.47
143C3915203.51817
138K380.860.860.84
263K291.194.6928
92Q,155H271398150534
140S,148R25143515026.23
138A,140S,148H2414311501101
148R22301092714
138K,140S,148H21143315039.24
66I180.971570.44
138K,148R13654132223
138K,147G,148R133421652 
66A120.927.620.32
140A,148R12116415032.83
143C,155H10   
147G91.178813
143H85.5142.5140.92
138A71.111.310.91
140S,148H,155H6   
121Y69.462761.15
138K,140C,148R5143115018.61
140S51.454.250.63
92Q,140S,148K,155H5   
118R413767106
140S,143H,148H4   
148H41985.350.44
143H,155H4   
145S40.712810.31
138K,140A,148K414311501631
138A,140A,148R4   
140C,148R386217429.11
143R,155H3   
138K,140S,148R3   
148R,155H3102311434.32
66I,92Q,155H3   
138K,148R,263K3   
138K,147G,155H315031503553
92Q,143R2   
138K,140A,148R,155H2   
146P20.816.510.51
92Q,143H2   
66A,155H2   
138K,148R,155H2   
66I,92Q223212020.61
140S,148K,155H2   
92Q,140S,148R,155H2   
138A,140S,143H,148H2   
155S2   
147G,263K22.224.826.32
140S,147G,148K2   
66A,92Q2