Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

INI Mutation Pattern & Susceptibility

79 patterns of major drug resistance mutations (defined here) from 15881 clinical isolates obtained from 15252 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2017-4-17). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsNumber of
Sequences
RAL
foldn
EVG
foldn
DTG
foldn
None149701.05671.35621.044
155H257182545191.88
140S,148H1991391815093.07
143R6770196.2141.05
92Q354.51936171.44
143C3115172.8140.83
138K270.930.730.91
92Q,155H22105712532.03
138A,140S,148H21   
140S,148R201194 4.02
263K191.244.842.03
138K,140S,148H15   
148R15301010161.14
138K,147G,148R113421652 
138K,148R10753 3.52
143C,155H10   
66A90.927.620.32
66I91.051550.32
140A,148R91501  
143H85.5142.5140.92
147G81.168.071.02
138A61.111.310.91
140S51.635.030.81
92Q,140S,148K,155H5   
140S,143H,148H4   
143H,155H4   
138K,140C,148R4   
140S,148H,155H4   
121Y46.121320.61
143R,155H3   
145S30.712810.31
148R,155H3103216226.41
138K,140A,148K3   
66I,92Q,155H3   
138K,147G,155H315031503553
138K,140A,148R,155H2   
140C,148R22811981 
66A,155H2   
148H21985.140.44
138A,140A,148R2   
138K,140S,148R2   
138K,148R,155H2   
66I,92Q223212020.61
140S,148K,155H2   
92Q,140S,148R,155H2   
138A,140S,143H,148H2