Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

INI Mutation Pattern & Susceptibility

47 patterns of major drug resistance mutations (defined here) from 8345 clinical isolates obtained from 7995 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2014-5-10). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsNumber of
Sequences
RAL
foldn
EVG
foldn
DTG
foldn
None808715525.0471.011
140S,148H528711100023.06
155H5021103741.94
143R2679188.0131.03
138K110.920.62 
143C1015162.9130.81
148R931811441.02
140S,148R71194 4.01
92Q76.083761.62
143H66.8132.6130.91
66A60.917.610.31
138A,140S,148H6   
138A5   
140A,148R51501  
92Q,140S,148K,155H5   
143C,155H4   
138K,147G,148R43421652 
92Q,155H3105712532.12
66I31.051550.31
147G31.038.041.01
140S,148H,155H2   
138K,140S,148H2   
145S2   
140S21.824.52 
121Y26.91111 
143R,155H2   
92Q,140S,148R,155H2   
138A,140S,143H,148H2   
143H,155H2