Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

INI Mutation Pattern & Susceptibility

79 patterns of major drug resistance mutations (defined here) from 15881 clinical isolates obtained from 15252 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2017-4-17). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug.The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. The Q1 and Q3 indicate the first and third quartile.

Mutation PatternsNumber of
Sequences
RALEVGDTG
foldnQ1Q3foldnQ1Q3foldnQ1Q3
None149701.05670.81.11.35621.11.71.0440.91.1
155H25718251327451936591.881.42.0
140S,148H199139188715415091146003.072.05.0
143R677019221506.2143.0341.051.01.3
92Q354.5193.66.0361731441.441.31.8
143C3115175.5682.8141.64.90.830.81.2
138K270.930.80.90.730.61.20.91  
92Q,155H221057651501253941662.031.92.4
138A,140S,148H21         
140S,148R20119474175   4.02  
263K191.241.12.24.843.8232.031.77.0
138K,140S,148H15         
148R15301029341016921181.141.01.6
138K,147G,148R11342  1652     
138K,148R107536079   3.52  
143C,155H10         
66A90.92  7.62  0.32  
66I91.050.91.41559.7260.32  
140A,148R91501        
143H85.5142.7132.5141.84.40.92  
147G81.161.02.58.074.1191.02  
138A61.11  1.31  0.91  
140S51.631.42.05.034.05.00.81  
92Q,140S,148K,155H5         
140S,143H,148H4         
143H,155H4         
138K,140C,148R4         
140S,148H,155H4         
121Y46.12  132  0.61  
143R,155H3         
145S30.71  281  0.31  
148R,155H31032  1622  6.41  
138K,140A,148K3         
66I,92Q,155H3         
138K,147G,155H3150315015015031501505533764
138K,140A,148R,155H2         
140C,148R2281  1981     
66A,155H2         
148H219817205.144.95.80.440.40.5
138A,140A,148R2         
138K,140S,148R2         
138K,148R,155H2         
66I,92Q2232  1202  0.61  
140S,148K,155H2         
92Q,140S,148R,155H2         
138A,140S,143H,148H2