INI Mutation Pattern & Susceptibility| 41 patterns of major drug resistance mutations (defined here) from 5016 clinical isolates obtained from 4740 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2013-1-18). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004. The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class.
 Subscripts indicate the number of sequences assayed for resistance to the designated drug.The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. The Q1 and Q3 indicate the first and third quartile.
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| Mutation Patterns | Number of
Sequences | RAL | EVG | DTG |
|---|
| foldn | Q1 | Q3 | foldn | Q1 | Q3 | foldn | Q1 | Q3 |
|---|
| None | 4826 | 1.264 | 0.9 | 1.6 | 1.764 | 1.0 | 2.7 | 1.03 | 0.5 | 2.5 | | 155H | 35 | 1912 | 15 | 23 | 458 | 37 | 76 | 1.62 | | | | 140S,148H | 35 | 1619 | 119 | 1000 | 10005 | 100 | 4440 | 4.11 | | | | 143R | 19 | 436 | 20 | 60 | 3.93 | 2.1 | 7.7 | 1.31 | | | | 143C | 9 | 324 | 3.5 | 130 | 1.11 | | | 0.81 | | | | 143H | 7 | 2.11 | | | 1.21 | | | 0.91 | | | | 92Q | 7 | 6.09 | 5.5 | 7.3 | 407 | 33 | 67 | 1.62 | | | | 121Y | 7 | 7.02 | | | 112 | | | | | | | 148R | 6 | 329 | 30 | 36 | 1095 | 101 | 129 | 1.02 | | | | 138A,140S,148H | 6 | | | | | | | | | | | 66A | 5 | 1.03 | 0.9 | 3.8 | 333 | 7.6 | 54 | 0.31 | | | | 92Q,140S,148K,155H | 5 | | | | | | | | | | | 138K | 4 | 0.93 | 0.9 | 1.0 | 0.63 | 0.2 | 0.7 | | | | | 140A,148R | 4 | 1253 | 96 | 150 | 1002 | | | | | | | 138K,147G,148R | 4 | 342 | | | 1652 | | | | | | | 140S,148R | 3 | 1194 | 74 | 175 | | | | 4.01 | | | | 140S,148H,155H | 2 | | | | | | | | | | | 138K,140C,148R | 2 | | | | | | | | | | | 138A | 2 | | | | | | | | | | | 138K,140S,148H | 2 | | | | | | | | | | | 140S | 2 | 2.03 | 1.6 | 3.0 | 4.03 | 0.2 | 5.0 | | | | | 92Q,155H | 2 | 1057 | 65 | 150 | 1253 | 94 | 166 | 2.12 | | | | 147G | 2 | 1.15 | 1.0 | 1.6 | 8.76 | 8.0 | 9.5 | 1.01 | | | | 92Q,140S,148R,155H | 2 | | | | | | | | | | | 143H,155H | 2 | | | | | | | | | |
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