Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

INI Mutation Pattern & Susceptibility

47 patterns of major drug resistance mutations (defined here) from 8345 clinical isolates obtained from 7995 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2014-5-10). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug.The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. The Q1 and Q3 indicate the first and third quartile.

Mutation PatternsNumber of
Sequences
RALEVGDTG
foldnQ1Q3foldnQ1Q3foldnQ1Q3
None808715521.6405.0473.09.81.0111.02.0
140S,148H5287118720010002  3.062.04.1
155H502110172437433451.941.62.0
143R267918241508.0133.5341.031.01.3
138K110.92  0.62     
143C1015167.0682.9131.9150.81  
148R9318303511441011291.02  
140S,148R7119474175   4.01  
92Q76.085.56.837633431.62  
143H66.8133.0132.6131.84.80.91  
66A60.91  7.61  0.31  
138A,140S,148H6         
138A5         
140A,148R51501        
92Q,140S,148K,155H5         
143C,155H4         
138K,147G,148R4342  1652     
92Q,155H31057651501253941662.12  
66I31.051.01.415512660.31  
147G31.031.01.18.046.08.71.01  
140S,148H,155H2         
138K,140S,148H2         
145S2         
140S21.82  4.52     
121Y26.91  111     
143R,155H2         
92Q,140S,148R,155H2         
138A,140S,143H,148H2         
143H,155H2