Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Home Genotype-RX Genotype-Pheno Genotype-Clinical HIVdb Program

NNRTI-Resistance Mutations and Response to New NNRTI-Containing Regimens

Three fundamental types of correlations form the basis of drug resistance knowledge: (i) Correlations between genotypic data with the treatments of persons from whom sequenced HIV-1 isolates have been obtained (genotype-treatment); (ii) Correlations between genotype and in vitro drug susceptibility (genotype-phenotype); and (iii) Correlations between genotype and the clinical response to a new treatment regimen (genotype-outcome). The following table summarizes the results of published studies linking RT genotype and the clinical response to a new NNRTI-containing regimen.

Nearly all publications on genotype and clinical outcome have described only the results of their analyses. None have published their underlying data, in part, because until now there had been no resource for making such data publicly available. As this database has now been modified to represent such data we have written to the authors of those studies that are most relevant today to request such data.
Etravirine (ETR)
ReferencePrevious NNRTIFollow-up NNRTIOther RxNo.PtsWkEffect of Baseline Mutations on Response
Madruga_(2007), Katlama_(2007), Lazzarin_(2007)93% had received >= 1 NNRTI. All had >=1 NNRTI resistance mutation at screening or from a historical genotypeETR vs placeboDRV/RTV + OB4062413 baseline mutations were associated with a decreased response to ETR: V90I, A98G, L100I, K101EP, V106I, V179DF, Y181CIV, G190AS. When 3 or more of these mutations were present, the response to ETR was no different from placebo.

Abbreviations

  • Pts: patients
  • W: week
  • M: month
  • NA: not available
  • DRM: drug-resistance mutation
  • OB: optimized background
  • PI: protease inhibitor
  • NRTI: nucleoside RT inhibitor
  • NNRTI: non-nucleoside RT inhibitor
  • Rx: regimen
  • DRV: darunavir
  • ETR: etravirine
  • RTV: ritonavir
References

The Team

The Data