Clinical Trial Datasets
ACTG 384 clinical trial (revised April 24, 2008)
Shafer RW, Smeaton LM, Robbins GK, De Gruttola V, Snyder SW, D'Aquila RT, Johnson VA, Morse GD, Nokta MA, Martinez AI, Gripshover BM, Kaul P, Haubrich R, Swingle M, McCarty SD, Vella S, Hirsch MS, Merigan TC; AIDS Clinical Trials Group 384 Team. Comparison of four-drug regimens and pairs of sequential three-drug regimens as initial therapy for HIV-1 infection. N Engl J Med. 2003 Dec 11;349(24):2304-15.
Robbins GK, De Gruttola V, Shafer RW, Smeaton LM, Snyder SW, Pettinelli C, Dube MP, Fischl MA, Pollard RB, Delapenha R, Gedeon L, van der Horst C, Murphy RL, Becker MI, D'Aquila RT, Vella S, Merigan TC, Hirsch MS; AIDS Clinical Trials Group 384 Team. Comparison of sequential three-drug regimens as initial therapy for HIV-1 infection. N Engl J Med. 2003 Dec 11;349(24):2293-303.
Nucleotide sequences in fasta format
Composite alignment (of sequences at baseline)
List of sequences with stop codon, ambiguity codon and unusual residues
Method: Direct PCR, Dideoxy terminator sequencing
Timing: Multiple timepoints
Previously, there was uncertain treatment data on 63 patients. Treatment data on these 63 patients are now available. In addition, more complete treatment history on many other patients were made available. Besides treatment history data, the study arm assignments were made for the 63 patients and have changed for 12 other patients. No other data has changed due to this revision.
The dataset includes data on the 839 patients for whom sequences and ARV histories are available and the 63 patients for whom sequences are available but the ARV history is uncertain. Both sets contain data on mutations, RNA levels and CD4 counts.