Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Clinical Trial Datasets

ACTG 384 clinical trial (revised April 24, 2008)
References
Shafer RW, Smeaton LM, Robbins GK, De Gruttola V, Snyder SW, D'Aquila RT, Johnson VA, Morse GD, Nokta MA, Martinez AI, Gripshover BM, Kaul P, Haubrich R, Swingle M, McCarty SD, Vella S, Hirsch MS, Merigan TC; AIDS Clinical Trials Group 384 Team. Comparison of four-drug regimens and pairs of sequential three-drug regimens as initial therapy for HIV-1 infection. N Engl J Med. 2003 Dec 11;349(24):2304-15.
Robbins GK, De Gruttola V, Shafer RW, Smeaton LM, Snyder SW, Pettinelli C, Dube MP, Fischl MA, Pollard RB, Delapenha R, Gedeon L, van der Horst C, Murphy RL, Becker MI, D'Aquila RT, Vella S, Merigan TC, Hirsch MS; AIDS Clinical Trials Group 384 Team. Comparison of sequential three-drug regimens as initial therapy for HIV-1 infection. N Engl J Med. 2003 Dec 11;349(24):2293-303.
HIVDB
PR Data in HIVDB
RT Data in HIVDB
Sequence Quality
22 RT sequences from 18 patients have been excluded from the viewable/downloadable datasets because of quality issues. The excluded sequences are listed here: excluded.html   excluded.txt
Sequences
Nucleotide sequences in fasta format
ACTG384_PR_fasta.txt,    ACTG384_RT_fasta.txt
Composite alignment (of sequences at baseline)
ACTG384_PR_composite.html,    ACTG384_RT_composite.html
List of sequences with stop codon, ambiguity codon and unusual residues
ACTG384_PR_QA.txt,   ACTG384_RT_QA.txt

Method: Direct PCR, Dideoxy terminator sequencing
Sample: Plasma
Timing: Multiple timepoints
Revision Note
Previously, there was uncertain treatment data on 63 patients. Treatment data on these 63 patients are now available. In addition, more complete treatment history on many other patients were made available. Besides treatment history data, the study arm assignments were made for the 63 patients and have changed for 12 other patients. No other data has changed due to this revision.
Browse
Integrated view of ARV, genotypes, RNA and CD4 on 902 patients
Study Arms (based on first regimen)
Arm A (Group 1)   Arm B (Group 2)   Arm C (Group 3)   Arm D (Group 4)   Arm E (Group 5)   Arm F (Group 6)

Patient-Study Arms:
patient_arm_mapping.html   excel-friendly version patient_arm_mapping.txt
 
Dataset
The dataset includes data on the 839 patients for whom sequences and ARV histories are available and the 63 patients for whom sequences are available but the ARV history is uncertain. Both sets contain data on mutations, RNA levels and CD4 counts.