Clinical Trial Datasets
ACTG 333 clinical trial
Sevin AD, DeGruttola V, Nijhuis M, Schapiro JM, Foulkes AS, Para MF, Boucher CA. Methods for investigation of the relationship between drug-susceptibility phenotype and human immunodeficiency virus type 1 genotype with applications to AIDS clinical trials group 333. J Infect Dis. 2000 Jul;182(1):59-67.
Para MF, Glidden DV, Coombs RW, Collier AC, Condra JH, Craig C, Bassett R, Leavitt R, Snyder S, McAuliffe V, Boucher C, AIDS Clinical Trials Group Protocol 333 Team. Baseline Human Immunodeficiency Virus Type 1 Phenotype, Genotype, and RNA Response after Switching from Long-Term Hard-Capsule Saquinavir to Indinavir or Soft-GelndashCapsule Saquinavir in AIDS Clinical Trials Group Protocol 333. J Infect Dis. 2000 Sep;182(3):733-43.
PR Data in HIVDB
Nucleotide sequences in fasta format
ACTG333_PR_fasta.txt, Composite alignment (of sequences at baseline)
ACTG333_PR_composite.html, List of sequences with stop codon, ambiguity codon and unusual residues
ACTG333_PR_QA.txt, Method: Direct PCR, Dideoxy terminator sequencing
Timing: Multiple timepoints
Integrated view of ARV, genotypes, RNA and CD4 on 76 patients
The dataset includes data on 76 patients for whom sequences and ARV histories are available and contains data on mutations, RNA levels and CD4 counts.