Clinical Trial Datasets
ACTG 302 clinical trial
Shulman, NS, Hughes MD, Winters MA, Shafer RW, Zolopa AR, Hellmann NS, Bates M, Whitcomb JM, Katzenstein DA. Subtle Decreases in Stavudine Phenotypic Susceptibility Predict Poor Virologic Response to Stavudine Monotherapy in Zidovudine-Experienced Patients. JAIDS. 2002 Oct 1;31(2):121-7.
Katzenstein, DA, Hughes MD, Albrecht M, Liou SH, Murphy R, Balfour H, Para M, Hammer S. AIDS Clinical Trials Group 302 Study Team. Virologic and CD4 Cell Response to Zidovudine or Zidovudine and Lamivudine Following Didanosine Treatment of Human Immunodeficiency Virus Infection. AIDS Res Hum Retroviruses. 2001 Feb 10;17(3):203-10.
Nucleotide sequences in fasta format
Composite alignment (of sequences at baseline)
List of sequences with stop codon, ambiguity codon and unusual residues
Method: Direct PCR, Dideoxy terminator sequencing
Integrated view of ARV, genotypes, RNA and CD4 on 47 patients
This dataset was created on 47 patients for whom sequences and ARV histories are available and contains files with treatment, mutations, RNA levels and CD4 counts.
Note on Dataset
These 47 patients belong to the subjects in the arm randomized to be treated with AZT, 3TC, ddI.
One patient without RNA level provided was excluded from the provided data: Ptid 29458.