A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

There are two methods for indicating which algorithms you would like to have run on your input sequences. You can use any of them in combination. Choose one or more of the default algorithms and/or upload a user-created algorithm in ASI format.

Algorithms

Selection Input Select one or more previously published algorithms using the checkboxes below. ANRSV2009.07     HIVDB     RegaV8.0.2     The ASI grammar definition has been updated slightly and it is not backwards compatible so please bear with us and follow this link to the old website to submit your own rules defined in the previous ASI grammar. The new ASI grammar will be documented and available shortly.

Sequence information can be entered in FASTA, plain text, or GRF (Bayer Diagnostics) format. Sequences in FASTA format or plain text can be pasted in the text box (option A) or uploaded (option B). GRF files can only be uploaded (option C). Using options A or B, it is possible to analyze up to 100 sequences at a time (character limit:600,000)

The output can be customized to display the results using the original interpretation of each algorithm or a normalized interpretation in which the 3 levels of the ANRS and Rega are assigned Susceptible (S), Intermediate (I), Resistant (R) and the HIVDB levels are mapped to SIR: Susceptible, Potential Low-Level => S; Low-level, Intermediate => I; Resistant => R and an optional identifier and date. For further explanations and sample datasets please see the Release Notes.

Sequences
Text Input Paste sequence text in the text box below. Text File Upload Choose a file to upload from your computer using the file selection box below. GRF File Upload Choose a GRF (Bayer Diagnostics) file to upload from your computer using the file selection box below.

Identifier (Optional)		Output Analysis:
Date (Optional)		Original	SIR SpreadSheet