Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Prevalence of NRTI DRMs and DRM Patterns in Patients Receiving a Tenofovir (TDF)-Containing First-Line Regimen

Last updated on 2015-2-9

Major NRTI DRMs

K65R, D67d, T69i, K70R, L74I/V, Y115F, Q151M, M184I/V, T215F/Y

Number of patients receiving a TDF-containing firstline regimen

772

Number of patients with ≥1 major NRTI DRMs

467

Table 10a. Prevalence of major NRTI DRMs: TDF-containing regimens
DRM% in Pts with DRMs
(n=467)
%Cumulative
M184V
72.6
72.6
K65R
48.0
93.4
M184I
13.7
98.7
Y115F
11.6
99.6
Q151M
0.9
99.8
T215Y
1.9
100.0
L74I
6.2
-
L74V
4.9
-
K70R
4.7
-
T215F
1.7
-

    Footnotes:
  1. Shown minimum DRM prevalence ≥0.5%
  2. DRMs are ordered according to their incremental contribution to the %cumulative column.
  3. A complete list of all NRTI DRMs including those with lower scores can be queried using the form at the following page: Prevalence of DRMs by ARV-class, ARV and HIVDB mutation score. This page will contain data for K65N and K70E/G/Q/N uncommon NRTI DRMs that may be associated with minimally reduced TDF susceptibility.

Table 10b. Prevalence of major NRTI DRM patterns: TDF-containing regimens

Pattern% in Pts with DRMs
(n=467)
%Cumulative
M184V
28.3
28.3
K65R, M184V
20.1
48.4
K65R
11.3
59.7
M184I
5.4
65.1
K65R, M184I
4.5
69.6
L74I, M184V
3.9
73.5
K65R, Y115F, M184V
3.6
77.1
K65R, Y115F
3.2
80.3
K70R, M184V
2.6
82.9
L74V, M184V
2.4
85.3
M184I, M184V
2.4
87.7
M184V, T215F
1.3
89.0
Y115F, M184V
1.3
90.3
K65R, L74V, Y115F
0.9
91.2
K65R, L74V, M184V
0.9
92.1
M184V, T215Y
0.9
93.0
K65R, K70R, M184V
0.9
93.9
K65R, M184I, M184V
0.6
94.5
Y115F
0.6
95.1
L74I, Y115F, M184V
0.6
95.7

    Footnotes:
  1. shown minimum pattern prevalence ≥0.5%
  2. A complete list of all NRTI DRMs patterns including those with lower scores can be queried using the form at the following page: Prevalence of DRMs by ARV-class, ARV and HIVDB mutation score.