Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Prevalence of PI DRMs and DRM Patterns in Patients Receiving a First- or Second-Line Lopinavir (LPV/r)-Containing Regimen

Last updated on 2015-4-7

Major PI DRMs

I47A, I50V, L76V, V82A/F, I84A/C/V

Number of patients with virological failure on an initial LPV/r-containing regimen by subtype

RegimenNo. PtsNo. ReferencesABC0102DGFOthers
LPV
1214
47
7.2
16.6
60.3
6.6
4.1
1.1
2.8
0.5
0.7

Number of patients with ≥ intermediate resistance to LPV/r

203

Table 13a. Prevalence of major PI DRMs: LPV/r-containing regimens
DRM% in Pts with ≥ intermediate resistance
(n=203)
%Cumulative
V82A
59.6
59.6
L76V
32.5
74.9
I84V
15.3
82.8
I47A
8.4
88.2
V82F
2.5
90.1
I50V
4.9
91.6
Other*
8.4
100.0

    Footnotes:
  1. Shown minimum DRM prevalence ≥0.5%
  2. DRMs are ordered according to their incremental contribution to the %cumulative column.
  3. *Patterns of isolates containing other mutations shown in the table below.

Table 13b. Prevalence of major PI DRM patterns: LPV/r-containing regimens

Pattern% in Pts with ≥ intermediate resistance
(n=203)
%Cumulative
V82A
37.9
37.9
L76V, V82A
16.3
54.2
L76V
8.4
62.6
I84V
5.9
68.5
L76V, I84V
5.9
74.4
I47A
5.4
79.8
I50V, V82A
3.0
82.8
V82F
2.0
84.8
I47A, I84V
2.0
86.8
I50V
1.5
88.3
L76V, V82A, I84V
1.0
89.3
I47A, V82A
1.0
90.3
I50V, L76V
0.5
90.8
V82A, I84V
0.5
91.3
L76V, V82F
0.5
91.8
Other*
8.4
100

    Footnotes:
  1. *Patterns of isolates containing other mutations: M46I/I54V/V82S(4), I54V/V82M(3), I54V/L90M(1), V32I/M46I/I47V/I54M/L90M(1), I54V/V82T/L90M(1), M46I/I54V/V82T(1), I54V/V82T(1), I54V/V82S/V82T(1), L90M(1), M46I/L90M(1), M46I/I47V/I54V/V82S(1)