Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Essential Data on PI DRMs

Last updated on 2016-6-20

Prevalence of PI DRMs in ARV-naive and -treated patients and their contributions to reduced PI susceptibility
DRM HIVDB
Score
SDRM Prevalence (%) Phenotypic Fold Resistance
ARV-Naive
(n=73775)
ARV-Treated
(n=21526)
ATV
(n=1100)
DRV
(n=590)
LPV
(n=1389)
L90M
60
0.3
28
3
1.2
1.9
I84V
60
0.03
11
4
3
3
D30N
60
0.02
6
3
0.9
1.1
N88D
60
0.04
5
NA
NA
NA
L76V
60
0.01
4
0.4
2
4
G48V
60
0
3
4
0.8
2
I54L
60
0.01
3
2
3
1.9
I50L
60
0.01
2
6
0.4
0.3
I54M
60
0
2
2
5
3
I50V
60
0.01
2
0.9
4
4
N88S
60
0.03
2
7
0.9
1.1
I47A
60
0
0.5
0.9
2
43
G48M
60
0
0.5
2
1.1
1.8
G48A
60
 
0
0.4
NA
NA
NA
G48Q
60
 
0
0.1
NA
NA
NA
I84A
60
0
0.1
47
NA
6
I84C
60
0
0.1
5
NA
1.9
G48S
60
 
0
0.1
NA
NA
NA
G48L
60
 
0
0.06
NA
NA
NA
G48T
60
 
0
0.03
NA
NA
NA
V82T
45
0
2
2
0.6
3
V82L
45
0.02
0.3
2
1.5
1.2
I47V
35
0.02
5
0.9
1.3
4
V82A
30
0.04
23
1.5
0.8
3
M46I
30
0.3
22
1.2
1.2
1.6
V32I
30
0.01
5
3
3
1.3
V82F
30
0
2
2.0
4
7
V82S
30
0
1
4
NA
6
V82C
30
0
0.6
1.3
1.3
3
V82M
30
0
0.5
1.0
1.2
0.9
N88G
30
 
0
0.2
NA
NA
NA
N88T
30
 
0.01
0.1
NA
NA
NA
T74P
25
 
0.03
2
2
1.5
1.4
N83D
25
0.02
1
3
0.9
1.3
I54V
20
0
24
3
1.4
4
M46L
20
0.3
9
1.5
1.3
1.6
I54A
20
0
1
12
NA
11
I54T
20
0.01
0.7
9
6
9
I54S
20
0
0.6
10
2
11
M46V
20
 
0.06
0.4
NA
NA
NA
L10F
15
 
0.2
9
1.4
1.5
2
G73S
15
0.04
8
2
1.2
1.5
Q58E
15
 
0.3
7
NA
NA
NA
F53L
15
0.03
6
1.7
1.1
1.3
K20T
15
 
0.09
6
2
1.1
1.9
L24I
15
0.01
6
2
1.0
1.8
G73T
15
0
2
2
1.6
1.5
L23I
15
0.02
1
NA
NA
NA
G73C
15
0
1
1.7
1.1
1.6
G73A
15
0
0.5
NA
NA
NA
L33F
10
 
0.4
13
1.2
2
1.8
K43T
10
 
0.1
6
NA
NA
NA
L89V
10
 
0.06
4
1.2
3
1.4
L24F
10
 
0.04
0.6
NA
NA
NA
L24M
10
 
0
0.1
NA
NA
NA
G73D
10
 
0.01
0.1
NA
NA
NA
G73V
10
 
0
0.1
NA
NA
NA

    Footnotes:
  1. HIVDB Score: The highest score for ATV (atazanavir), DRV (daurnavir), LPV (lopinavir).
  2. SDRM (Surveillance Drug Resistance Mutation): Nonpolymorphic DRMs that have been used for TDR surveillance (Bennett DE et al. PLoSOne 2009).
  3. Without Major DRMs: Primary DRMs are more likely to occur without additional DRMs. However, many co-occurring DRMs have primary roles in conferring resistance to different ARVs.
  4. Phenotypic Fold Resistance: The contribution of each DRM to reduced PI susceptibility (fold increase in the PI concentration required to inhibit a fixed virus inoculum by 50%) determined using published regression analyses. All results are based on susceptibility tests performed using the PhenoSense assay (Monogram, South San Francisco). The complete dataset used for the regression analyses is downloadable (HIVDB Genotype-Phenotype Dataset, http://hivdb.stanford.edu/cgi-bin/GenoPhenoDS.cgi. Red: Large contribution to reduced in vitro susceptibility. Pink: Statistically significant modest contribution to reduced in vitro susceptibility. Negative values indicate contribution to increased in vitro susceptibility.