Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Prevalence of NRTI DRMs in ARV-Naive Patients

Last updated on 2015-2-9

Major NRTI DRMs

K65R, D67d, T69i, K70R, L74I/V, Y115F, Q151M, M184I/V, T215F/Y

Table 5a. Prevalence of major NRTI DRMs in ARV-naive patients by region

Sub-Saharan Africa
n=11628
87 with major DRMs
South/Southeast Asia
n=6830
67 with major DRMs
Latin America
n=5715
131 with major DRMs
Upper-income countries
n=24898
782 with major DRMs
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
M184V
64.3
64.3
M184V
54.1
54.1
M184V
68.8
68.8
M184V
52.1
52.1
K70R
20.2
72.6
L74I
13.1
65.6
K70R
24.0
81.2
T215Y
31.4
72.1
Y115F
7.1
79.8
M184I
13.1
77.0
T215Y
24.0
91.7
K70R
24.4
87.5
K65R
7.1
86.9
K70R
13.1
86.9
M184I
5.2
94.8
K65R
5.3
91.2
M184I
6.0
92.9
K65R
13.1
95.1
T215F
12.5
97.9
T215F
10.8
94.1
L74I
4.8
95.2
Y115F
1.6
96.7
L74I
2.1
99.0
L74V
6.8
95.8
T215Y
19.0
97.6
L74V
4.9
98.4
K65R
2.1
100.0
M184I
3.5
97.4
L74V
6.0
98.8
T215F
6.6
100.0
L74V
3.1
-
Q151M
3.3
98.7
T215F
11.9
100.0
T215Y
13.1
-
Q151M
1.0
-
L74I
4.8
99.8
Q151M
0.0
-
Q151M
4.9
-
D67d
0.0
-
Y115F
2.9
100.0
D67d
0.0
-
D67d
0.0
-
T69i
0.0
-
D67d
0.0
-
T69i
0.0
-
T69i
0.0
-
Y115F
0.0
-
T69i
0.0
-

    Footnotes:
  1. The prevalence of all DRMs including those with lower scores can be queried using the form at the following page: Prevalence of DRMs in ARV-Naive Patients

Table 5b. Prevalence of major NRTI DRMs in ARV-naive patients by subtype

A
n=3408
27 with major DRMs
B
n=26882
275 with major DRMs
C
n=7519
29 with major DRMs
D
n=1295
19 with major DRMs
G
n=1450
9 with major DRMs
01
n=5499
33 with major DRMs
02
n=2706
7 with major DRMs
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
M184V
67.5
67.5
M184V
53.7
53.7
M184V
60.4
60.4
M184V
79.2
79.2
M184V
60.0
60.0
M184V
61.1
61.1
M184V
50.0
50.0
T215F
15.0
100
T215Y
29.7
100
T215Y
18.8
100
T215Y
41.7
100
T215Y
20.0
100
K65R
13.0
100
K70R
28.6
100
T215Y
15.0
100
K70R
26.0
100
T215F
14.6
100
K70R
29.2
100
K65R
13.3
100
K70R
13.0
100
Y115F
28.6
100
K70R
12.5
100
T215F
10.5
100
K70R
10.4
100
Y115F
4.2
100
L74I
6.7
100
L74I
11.1
100
T215Y
14.3
100
K65R
7.5
100
L74V
6.4
100
M184I
10.4
100
T215F
8.3
-
M184I
6.7
100
T215Y
11.1
100
M184I
7.1
100
L74I
7.5
100
M184I
4.5
100
K65R
8.3
100
L74I
4.2
-
Y115F
6.7
100
M184I
5.6
100
L74I
14.3
-
M184I
7.5
100
K65R
4.3
100
L74V
6.2
100
D67d
0
 
K70R
13.3
-
T215F
5.6
100
L74V
7.1
-
L74V
2.5
100
L74I
4.3
100
L74I
4.2
100
K65R
0
 
T215F
13.3
-
L74V
3.7
100
T215F
7.1
-
Y115F
2.5
100
Q151M
3.3
100
Y115F
2.1
100
L74V
0
 
L74V
6.7
-
Q151M
3.7
-
D67d
0
 
D67d
0
 
Y115F
2.3
100
D67d
0
 
M184I
0
 
Q151M
6.7
-
D67d
0
 
K65R
0
 
Q151M
0
 
D67d
0
 
Q151M
0
 
Q151M
0
 
D67d
0
 
T69i
0
 
Q151M
0
 
T69i
0
 
T69i
0
 
T69i
0
 
T69i
0
 
T69i
0
 
Y115F
0
 
T69i
0
 

    Footnotes:
  1. The prevalence of all DRMs including those with lower scores can be queried using the form at the following page: Prevalence of DRMs in ARV-Naive Patients