Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Prevalence of NRTI DRMs and DRM Patterns in Patients Receiving NRTI/NNRTI First-Line Regimens

Last updated on 2015-2-9

Major NRTI DRMs

K65R, D67d, T69i, K70R, L74I/V, Y115F, Q151M, M184I/V, T215F/Y

Number of patients with virological failure on a NRTI/NNRTI first-line regimen

4926

Number of patients with ≥1 major NRTI DRMs

3624

Table 8a. Prevalence of major NRTI DRMs
DRM% in Pts with DRMs
(n=3624)
%Cumulative
M184V
91.1
91.1
K65R
10.8
96.4
M184I
4.3
98.7
T215Y
10.3
99.2
K70R
13.9
99.6
Y115F
3.3
99.7
T215F
8.6
99.8
Q151M
3.2
99.9
L74I
2.5
100.0
L74V
4.2
100.0

    Footnotes:
  1. Shown minimum DRM prevalence ≥0.5%
  2. DRMs are ordered according to their incremental contribution to the %cumulative column.
  3. A complete list of all NRTI DRMs including those with lower scores can be queried using the form at the following page: Prevalence of DRMs by ARV-class, ARV and HIVDB mutation score

Table 8b. Prevalence of major NRTI DRM patterns

Pattern% in Pts with DRMs
(n=3624)
%Cumulative
M184V
54.1
54.1
K70R, M184V
7.5
61.6
M184V, T215Y
7.0
68.6
M184V, T215F
3.9
72.5
K65R, M184V
3.6
76.1
K65R
3.1
79.2
K70R, M184V, T215F
3.0
82.2
L74V, M184V
1.9
84.1
M184I
1.7
85.8
K70R, M184V, T215Y
1.3
87.1
Q151M, M184V
1.2
88.3
M184I, M184V
0.9
89.2
L74I, M184V
0.8
90.0
K65R, M184I
0.7
90.7
K65R, Y115F
0.6
91.3
K65R, Y115F, M184V
0.6
91.9
L74V, Y115F, M184V
0.6
92.5
L74V, M184V, T215Y
0.6
93.1

    Footnotes:
  1. shown minimum pattern prevalence ≥0.5%
  2. A complete list of all NRTI DRMs patterns including those with lower scores can be queried using the form at the following page: Prevalence of DRMs by ARV-class, ARV and HIVDB mutation score.