Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Prevalence of NNRTI DRMs in ARV-Naive Patients

Last updated on 2015-2-9

Major NNRTI DRMs

L100I, K101P, K103N/S, V106A/M, Y181C/I/V, Y188C/H/L, G190A/E/Q/S, M230L

Table 6a. Prevalence of major NNRTI DRMs in ARV-naive patients by region

Sub-Saharan Africa
n=11628
361 with major DRMs
South/Southeast Asia
n=6830
146 with major DRMs
Latin America
n=5715
225 with major DRMs
Upper-income countries
n=24898
1089 with major DRMs
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
K103N
57.5
57.5
Y181C
41.4
41.4
K103N
63.0
63.0
K103N
67.0
67.0
Y181C
20.6
73.7
K103N
37.4
76.8
Y181C
17.3
77.2
Y181C
14.7
78.0
G190A
18.0
86.8
G190A
17.2
84.8
G190A
13.6
85.8
G190A
11.7
86.4
L100I
3.1
89.5
V106M
5.1
88.9
Y188L
6.2
91.4
Y188L
5.1
90.5
G190E
2.2
91.7
V106A
2.0
90.9
G190S
3.7
94.4
K103S
3.4
92.2
K103S
3.1
93.4
K103S
7.1
92.9
K103S
4.3
96.3
Y188H
1.6
93.6
Y188L
1.3
94.7
G190E
2.0
94.9
Y188C
1.2
97.5
Y188C
1.4
94.9
V106M
1.3
95.6
Y188L
2.0
97.0
M230L
4.9
98.8
V106A
1.6
96.0
V106A
0.9
96.5
M230L
1.0
98.0
V106M
1.2
99.4
V106M
1.1
97.0
Y188C
1.3
97.4
G190S
2.0
99.0
Y181V
0.6
100.0
G190S
1.3
97.8
Y181I
0.9
98.2
Y181I
1.0
100.0
L100I
1.2
-
G190E
0.8
98.7
Y188H
0.9
99.1
Y188C
1.0
-
K101P
1.2
-
M230L
0.8
99.2
M230L
0.4
99.6
L100I
0.0
-
V106A
0.6
-
Y181I
1.0
99.6
G190S
0.4
100.0
G190Q
0.0
-
Y188H
0.6
-
L100I
2.4
99.9
Y181V
0.9
-
K101P
0.0
-
G190Q
0.0
-
K101P
1.1
100.0
K101P
0.4
-
Y181V
0.0
-
G190E
0.0
-
Y181V
0.1
-
G190Q
0.0
-
Y188H
0.0
-
Y181I
0.0
-
G190Q
0.0
-

    Footnotes:
  1. The prevalence of all DRMs including those with lower scores can be queried using the form at the following page: Prevalence of DRMs in ARV-Naive Patients

Table 6b. Prevalence of major NNRTI DRMs in ARV-naive patients by subtype

A
n=3408
39 with major DRMs
B
n=26882
644 with major DRMs
C
n=7519
72 with major DRMs
D
n=1295
21 with major DRMs
G
n=1450
11 with major DRMs
01
n=5499
35 with major DRMs
02
n=2706
28 with major DRMs
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
DRMDRM%DRM%
Sum
K103N
53.4
53.4
K103N
67.8
67.8
K103N
53.3
53.3
K103N
45.7
45.7
K103N
52.4
52.4
Y181C
43.2
43.2
K103N
68.3
68.3
Y181C
28.8
100
Y181C
13.6
100
Y181C
23.7
100
G190A
28.3
100
Y181C
23.8
100
K103N
38.3
100
Y181C
22.0
100
G190A
9.6
100
G190A
11.4
100
G190A
17.8
100
Y181C
19.6
100
Y188L
19.0
100
G190A
17.3
100
G190A
14.6
100
Y181I
2.7
100
Y188L
5.4
100
V106M
5.9
100
L100I
6.5
100
G190A
9.5
100
G190E
3.7
100
G190E
4.9
100
Y181V
2.7
100
K103S
4.0
100
K103S
4.4
100
Y188H
4.3
100
Y188C
4.8
-
G190S
3.7
100
G190S
2.4
-
Y188C
2.7
100
L100I
2.3
100
Y181I
3.0
100
G190E
2.2
100
G190E
0
 
V106M
3.7
100
G190Q
0
 
G190E
1.4
100
G190S
1.8
100
L100I
1.5
100
K103S
2.2
-
G190Q
0
 
M230L
2.5
100
K101P
0
 
L100I
1.4
100
Y188H
1.7
100
Y188L
1.5
100
G190Q
0
 
G190S
0
 
Y188C
2.5
100
K103S
0
 
V106A
1.4
100
V106A
1.6
100
G190E
0.7
100
G190S
0
 
K101P
0
 
V106A
1.2
100
L100I
0
 
Y188L
1.4
100
M230L
1.2
100
G190S
0.7
100
K101P
0
 
K103S
0
 
Y181I
1.2
100
M230L
0
 
K101P
1.4
-
Y188C
1.2
100
Y188C
0.7
100
M230L
0
 
L100I
0
 
K103S
3.7
-
V106A
0
 
K103S
1.4
-
K101P
1.1
100
K101P
0.7
-
V106A
0
 
M230L
0
 
L100I
1.2
-
V106M
0
 
M230L
1.4
-
G190E
0.8
100
M230L
0.7
-
V106M
0
 
V106A
0
 
G190Q
0
 
Y181I
0
 
G190Q
0
 
V106M
0.7
100
G190Q
0
 
Y181I
0
 
V106M
0
 
K101P
0
 
Y181V
0
 
G190S
0
 
Y181I
0.5
100
V106A
0
 
Y181V
0
 
Y181I
0
 
Y181V
0
 
Y188C
0
 
V106M
0
 
Y181V
0.2
100
Y181V
0
 
Y188C
0
 
Y181V
0
 
Y188H
0
 
Y188H
0
 
Y188H
0
 
G190Q
0
 
Y188H
0
 
Y188L
0
 
Y188H
0
 
Y188L
0
 
Y188L
0
 

    Footnotes:
  1. The prevalence of all DRMs including those with lower scores can be queried using the form at the following page: Prevalence of DRMs in ARV-Naive Patients