Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Prevalence of NNRTI DRMs and DRM Patterns in Patients Receiving NRTI/NNRTI First-Line Regimens

Last updated on 2015-2-9

Major NNRTI DRMs

L100I, K101P, K103N/S, V106A/M, Y181C/I/V, Y188C/H/L, G190A/E/Q/S, M230L

Number of patients with virological failure on a NRTI/NNRTI first-line regimen

4926

Number of patients with ≥1 major NNRTI DRMs

3899

Table 11a. Prevalence of major NNRTI DRMs
DRM% in Pts with DRMs
(n=3899)
%Cumulative
K103N
48.6
48.6
Y181C
25.9
68.7
G190A
20.0
80.2
V106M
16.6
88.7
Y188L
5.7
92.3
G190S
3.5
95.0
V106A
1.7
96.2
G190E
1.0
97.1
Y181V
1.1
97.9
Y181I
0.8
98.5
G190Q
0.6
99.1
Y188C
2.0
99.5
M230L
4.6
99.7
K103S
2.5
99.8
Y188H
1.2
99.9
L100I
2.9
100.0
K101P
1.1
-

    Footnotes:
  1. Shown minimum DRM prevalence ≥0.5%
  2. DRMs are ordered according to their incremental contribution to the %cumulative column.
  3. A complete list of all NNRTI DRMs including those with lower scores can be queried using the form at the following page: Prevalence of DRMs by ARV-class, ARV and HIVDB mutation score

Table 11b. Prevalence of major NNRTI DRM patterns

Pattern% in Pts with DRMs
(n=3899)
%Cumulative
K103N
28.7
28.7
Y181C
13.3
42.0
G190A
7.1
49.1
V106M
5.3
54.4
K103N, Y181C
4.5
58.9
Y181C, G190A
4.3
63.2
Y188L
3.6
66.8
K103N, V106M
2.8
69.6
V106M, G190A
2.7
72.3
G190S
2.5
74.8
K103N, M230L
2.4
77.2
L100I, K103N
2.3
79.5
K103N, G190A
2.1
81.6
V106M, Y188C
1.1
82.7
V106A
1.1
83.8
K103N, Y181C, G190A
1.0
84.8
G190E
0.9
85.7
K103S, G190A
0.9
86.6
K103N, Y188L
0.8
87.4
Y181V
0.8
88.2
K101P, K103N
0.7
88.9
V106M, M230L
0.7
89.6
V106M, Y181C
0.6
90.2
V106M, Y188L
0.6
90.8
Y181I
0.6
91.4
Y181C, G190S
0.6
92.0
G190Q
0.5
92.5
K103S, V106M
0.5
93.0

    Footnotes:
  1. shown minimum pattern prevalence ≥0.5%
  2. A complete list of all NNRTI DRMs patterns including those with lower scores can be queried using the form at the following page: Prevalence of DRMs by ARV-class, ARV and HIVDB mutation score.