Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Essential Data on INI DRMs

Last updated on 2016-6-20

Prevalence of INI DRMs in ARV-naive and -treated patients and their contributions to reduced INI susceptibility
DRM HIVDB
Score
SDRM Prevalence (%) Phenotypic Fold Resistance
ARV-Naive
(n=10059)
ARV-Treated
(n=1038)
RAL
(n=302)
EVG
(n=233)
N155H
60
 
0.02
31
15
17
Q148H
60
 
0.01
22
46
27
Q148R
60
 
0.02
8
33
37
Y143R
60
 
0
7
26
3
E92Q
60
 
0
6
7
15
Y143C
60
 
0
4
8
1.7
S147G
60
 
0.04
2
1.0
5
Y143H
60
 
0.06
1
3
1.1
T66I
60
 
0.03
1
1.3
8
Q148K
60
 
0.01
0.9
21
>50
Y143S
60
 
0.01
0.7
9
2
T66A
60
 
0.04
0.6
1.1
6
Y143G
60
 
0
0.4
12
3
F121Y
60
 
0.01
0.4
8
34
Y143K
60
 
0
0.2
NA
NA
T66K
60
 
0
0.2
13
47
Y143A
60
 
0
0.1
17
4
E92V
60
 
0
0.1
NA
NA
P145S
60
 
0.02
0
NA
NA
Q146P
60
 
0
0
NA
12
V151L
60
 
0.02
0
NA
NA
G140S
30
 
0.02
25
3
7
G140A
30
 
0
2
3
6
G140C
30
 
0
0.7
NA
NA
R263K
30
 
0.1
0.6
1.6
5
E92G
30
 
0.04
0.3
NA
NA
V151A
30
 
0.01
0.1
NA
NA
G118R
30
 
0
0
4
3
N155T
30
 
0
0
NA
NA
N155S
30
 
0
0
NA
NA
E138K
15
 
0.2
6
1.8
1.1
S230R
15
 
0.03
4
NA
NA
E138A
15
 
0.01
3
1.3
2
E138T
15
 
0
0.5
NA
NA
H51Y
15
 
0.02
0.4
1.2
3
Q148N
15
 
0
0.2
NA
NA
S153F
15
 
0.02
0.2
1.4
1.9
S153Y
15
 
0.01
0
1.5
5
T97A
10
 
1
13
4
4
E157Q
10
 
2
7
NA
NA
G163R
10
 
0.4
7
1.2
0.9
G163K
10
 
0.2
2
NA
NA
Q95K
10
 
0.09
2
NA
NA

    Footnotes:
  1. HIVDB Score: The highest score for RAL (raltegravir) and EVG (elvitegravir).
  2. SDRM (Surveillance Drug Resistance Mutation): Nonpolymorphic DRMs that have been used for TDR surveillance (Bennett DE et al. PLoSOne 2009).
  3. Without Major DRMs: Primary DRMs are more likely to occur without additional DRMs. However, many co-occurring DRMs have primary roles in conferring resistance to different ARVs.
  4. Phenotypic Fold Resistance: The contribution of each DRM to reduced INI susceptibility (fold increase in the INI concentration required to inhibit a fixed virus inoculum by 50%) determined using published regression analyses. All results are based on susceptibility tests performed using the PhenoSense assay (Monogram, South San Francisco) or HeLa-CD4 reporter gene assay. The complete dataset used for the regression analyses is downloadable (HIVDB Genotype-Phenotype Dataset, http://hivdb.stanford.edu/cgi-bin/GenoPhenoDS.cgi. Red: Large contribution to reduced in vitro susceptibility. Pink: Statistically significant modest contribution to reduced in vitro susceptibility. Negative values indicate contribution to increased in vitro susceptibility.