Genotype-Treatment

Number of individuals according to subtype and drug-class experienced¹

Subtype ²	protease		RT		integrase
Subtype ²	PI-Naive	PI-Treated	RTI-Naive	RTI-Treated	INI-Naive	INI-Treated
B	24,126	9,315	22,174	24,524	3,270	183
A	3,960	189	3,215	867	295	1
C	8,169	464	7,465	3,607	1,079	2
D	1,554	234	1,180	549	138	6
F	1,081	1,527	684	555	222	4
G	1,321	256	1,316	1,103	151	1
CRF01_AE	4,023	112	3,654	2,336	751	1
CRF02_AG	3,528	135	2,607	933	552	2
Other	1,169	239	1,594	531	228
Total	48,931	12,471	43,889	35,005	6,686	200
¹ Well-characterized treatment history is available for 73,044 individuals from whom 66,609 protease, 69,454 RT and 7,406 integrase isolates have been sequenced and published; "Mutation Prevalence According to Subtype and Treatment" page analyzes sequences obtained from the individuals for each subtype and summarizes the frequency of each mutation from treated individuals in comparison to the frequency of that mutation from untreated individuals. ² "Other" subtypes include CRFs other than "CRF01_AE" and "CRF02_AG". Appendix II lists the CRFs available in HIVdb and how each CRF was mapped to a subtype for each gene for analysis.

Number of individuals according to regimen received

NRTI component	NNRTI component	PI component	NRTI + PI or NNRTI regimen
AZT (2,111) DDI (763) D4T (744) 3TC (275) ABC (222) DDC (220) TDF (35) FTC (3) AZT/3TC (4,498) D4T/3TC (4,175) DDI/D4T (1,667) AZT/DDI (1,574) AZT/DDC (807) DDI/3TC (235) 3TC/TDF (196) D4T/ABC (180) 3TC/ABC (163) DDI/ABC (130) AZT/D4T (86) DDC/D4T (75) DDI/TDF (72) FTC/TDF (63) AZT/ABC (60) DDC/3TC (60) D4T/TDF (30) ABC/TDF (16) DDI/DDC (12) AZT/TDF (11) DDC/ABC (9) DDC/TDF (4) AZT/3TC/ABC (538) AZT/DDI/3TC (226) D4T/3TC/ABC (124) DDI/D4T/3TC (102) DDI/D4T/ABC (89) 3TC/ABC/TDF (86) AZT/DDC/3TC (72) AZT/D4T/3TC (58) DDI/3TC/TDF (46) AZT/3TC/TDF (39) D4T/3TC/TDF (31) AZT/DDI/DDC (31) DDI/3TC/ABC (24) AZT/DDI/D4T (17) DDI/ABC/TDF (16) DDI/D4T/TDF (15) AZT/DDI/ABC (11) DDC/D4T/3TC (8) DDI/FTC/TDF (7) AZT/DDC/D4T (6) DDI/DDC/3TC (3) AZT/DDC/ABC (3) DDI/DDC/D4T (2) ABC/FTC/TDF (2) D4T/FTC/TDF (2) AZT/FTC/TDF (2) DDC/D4T/ABC (2) D4T/ABC/TDF (2) AZT/DDI/D4T/3TC (31) AZT/3TC/ABC/TDF (31) DDI/3TC/ABC/TDF (13) DDI/D4T/3TC/ABC (13) AZT/DDI/3TC/ABC (7) DDI/D4T/3TC/TDF (6) AZT/DDC/D4T/3TC (6) AZT/DDI/DDC/3TC (4) D4T/3TC/ABC/TDF (4) AZT/D4T/3TC/ABC (4) AZT/DDI/3TC/TDF (4) AZT/DDC/3TC/ABC (2) AZT/DDI/DDC/D4T/3TC (7) DDI/D4T/3TC/ABC/TDF (3) AZT/DDI/D4T/3TC/ABC (2)	NVP (4,294) EFV (2,924) DLV (193) ETR (11) RPV (1)	NFV (2,340) IDV (2,218) SQV (936) LPVr (785) SQVr (746) RTV (572) IDVr (371) APV (212) APVr (122) ATV (68) ATVr (55) DRVr (43) TPVr (18) FPVr (17) FPV (6) DRV (3) NFV/SQV (212) APV/LPVr (55) IDV/SQV (51) NFV/IDV (46) NFV/RTV (27) LPVr/SQV (20) NFV/APV (14) IDV/LPVr (13) APV/SQV (12) FPV/LPVr (8) APV/IDV (7) NFV/LPVr (4) LPVr/ATV (3) IDV/ATV (2) NFV/RTV/SQV (19) RTV/APV/SQV (16) RTV/IDV/SQV (12) NFV/RTV/IDV (11) RTV/APV/LPVr (5) NFV/IDV/SQV (5) RTV/FPV/ATV (4) RTV/APV/IDV (2) RTV/APV/ATV (2) RTV/IDV/LPVr (2) NFV/RTV/IDV/SQV (4)	D4T/3TC/NVP (1,504) AZT/3TC/IDV (953) AZT/3TC/EFV (790) D4T/3TC/EFV (745) AZT/3TC/NVP (707) D4T/3TC/IDV (695) AZT/3TC/NFV (621) D4T/3TC/NFV (620) AZT/3TC/SQV (347) DDI/D4T/NFV (343) DDI/D4T/EFV (290) AZT/3TC/LPVr (229) DDI/D4T/NVP (219) D4T/3TC/SQV (199) AZT/3TC/RTV (190) D4T/3TC/SQVr (169) D4T/3TC/RTV (149) DDI/D4T/IDV (138) AZT/3TC/SQVr (123) DDI/D4T/SQVr (120) AZT/DDC/SQV (113) D4T/NFV/NVP (104) AZT/3TC/ABC/EFV (101) AZT/3TC/IDVr (95) D4T/3TC/LPVr (78) D4T/3TC/IDVr (73) D4T/3TC/NFV/NVP (69) DDI/D4T/NFV/EFV (69) AZT/DDI/NVP (68) 3TC/TDF/EFV (59) AZT/DDI/NFV (59) AZT/DDI/IDV (56) 3TC/TDF/NVP (53) AZT/DDI/SQV (53) DDI/D4T/SQV (51) DDI/D4T/NFV/NVP (49) 3TC/TDF/LPVr (49) D4T/SQVr (48) AZT/3TC/NFV/EFV (47) AZT/DDC/IDV (46) DDI/D4T/RTV (45) DDI/3TC/IDV (45) DDI/D4T/IDVr (41) DDI/D4T/LPVr (40) AZT/DDI/EFV (39) D4T/IDV (39) AZT/DDI/RTV (39) DDI/TDF/EFV (38) DDI/NFV/NVP (36) 3TC/ABC/EFV (36) AZT/3TC/NFV/NVP (35) D4T/ABC/EFV (33) D4T/3TC/NFV/SQV (33) AZT/SQV (33) DDI/3TC/NFV (33) D4T/NFV (32) DDI/3TC/EFV (31)

Genotype-Phenotype

Number of isolates according to phenotype method and drug resistance mutation¹

Method²	NRTI			NNRTI			PI			INI
Method²	WT	MT	Total	WT	MT	Total	WT	MT	Total	WT	MT	Total
PhenoSense	352	1,285	1,637	836	916	1,752	538	1,187	1,725	68	106	174
Antivirogram	176	951	1,127	649	949	1,598	289	1,139	1,428	70	47	117
Others	42	208	250	103	107	210	65	247	312	53	132	185
¹ Phenotypic resistance test results are available for 10,515 isolates including 9,206 clinical isolates and 1,309 lab isolates; for each ARV drug class, the number of isolates are shown in WT (wildtype) and MT (mutants) isolates; WT genotypes are defined as lacking any of major drug resistance mutations (DRMs) listed here: PI-associated DRMs for PI, NRTI-associated for NRTI, NNRTI-associated for NNRTI and INI-associated DRMs for INI. ² PhenoSense - Monogram, South San Francisco; Antivirogram - Virco, Belgium;

Appendixes: HIV-1 Group M virus

Number of virus samples according to geographical region and subtype

Continent	Regions	Subtypes
Africa (n = 17,718)	South Africa (4,524), Cameroon (2,367), Uganda (2,289), Kenya (960), Nigeria (790), Zambia (660), Zimbabwe (621), Cote d'Ivoire (469), Botswana (418), Tanzania (390), Burkina Faso (385), Mali (377), Malawi (333), Ghana (294), Morocco (249), Angola (236), Mozambique (227), Senegal (222), DRC (217), Algeria (142), Ethiopia (134), Central African Republic (132), Benin (128), CAR (124), Burundi (123), Gabon (116), Niger (99), Guinea (91), Equatorial Guinea (86), Togo (81), Rwanda (81), Chad (79), Africa (49), Swaziland (47), Seychelles (42), Libya (36), Madagascar (31), Sudan (30), Zaire (12), Guinea-Bissau (7), Congo-Brazzaville (6), Dijibouti (4), Liberia (4), Somalia (3), Gambia (3)	C (7,398), CRF02_AG (3,469), A1 (2,458), D (1,526), G (929), B (383), CRF06_cpx (332), A (210), CRF11_cpx (179), U (110), CRF01_AE (101), K (90), F2 (84), F1 (72), H (61), J (52), CRF13_cpx (38), CRF09_cpx (38), CRF10_CD (37), F (33), A2 (22), F1 (F2) (16), CRF37_cpx (14), CRF45_cpx (10), CRF26_AU (10), CRF18_cpx (9), CRF22_01A1 (9), CRF05_DF (5), CRF25_cpx (4), CRF49_cpx (3), CRF21_A2D (3), CRF27_cpx (3), CRF36_cpx (2), CRF16_A2D (2), CRF14_BG (2), CRF30_0206 (1), F1 (F) (1), A3 (1), CRF43_02G (1)
Asia (n = 10,473)	Thailand (1,588), China (1,521), India (1,483), Taiwan (1,444), Vietnam (1,295), Japan (641), Korea (550), Cambodia (547), Singapore (366), Israel (317), Malaysia (221), Uzbekistan (154), Kazakhstan (93), Saudi Arabia (60), Iran (55), Republic Of Georgia (44), Lebanon (25), Yemen (19), Afghanistan (15), Indonesia (13), Myanmar (9), Turkey (7), Nepal (6)	CRF01_AE (4,400), B (3,121), C (1,798), CRF07_BC (419), A1 (362), CRF08_BC (137), CRF02_AG (52), A (48), D (31), G (28), CRF33_01B (15), U (12), CRF35_AD (10), CRF06_cpx (10), CRF34_01B (5), F1 (5), CRF43_02G (5), CRF25_cpx (4), CRF03_AB (2), CRF12_BF (2), CRF10_CD (2), F (1), K (1), A2 (1), CRF18_cpx (1), H (1)
Europe (n = 17,676)	Spain (2,837), France (2,463), Italy (1,911), Germany (1,373), Portugal (1,279), Ireland (868), U.K. (838), Sweden (754), Denmark (566), Romania (547), Russia (536), Belgium (473), Estonia (396), Greece (382), Europe (339), Switzerland (327), Luxembourg (311), Ukraine (190), Netherlands (131), Slovenia (126), Poland (121), Republic of Latvia (117), Cyprus (116), Austria (101), Norway (95), Bulgaria (81), Greenland (75), Serbia (68), Albania (66), Finland (60), Azerbaijan (41), Yugoslavia (33), Hungary (30), Slovakia (10), Belarus (9), Moldova (6)	B (10,947), A1 (1,446), G (1,392), C (1,011), CRF02_AG (755), F1 (719), CRF06_cpx (410), CRF01_AE (293), D (257), K (57), U (57), A (47), CRF12_BF (34), F (28), H (27), CRF11_cpx (23), CRF14_BG (23), CRF04_cpx (18), J (18), CRF42_BF (17), CRF05_DF (15), CRF03_AB (14), F2 (13), A2 (12), CRF13_cpx (12), F1 (F) (8), CRF47_BF (5), CRF23_BG (4), CRF18_cpx (4), A1 (A2) (3), CRF09_cpx (2), CRF10_CD (2), F1 (F2) (1), CRF27_cpx (1), CRF19_cpx (1)
North America (n = 39,144)	U.S. (35,440), Canada (2,517), Cuba (551), Honduras (336), Mexico (187), Trinidad (33), Barbados (27), Puerto Rico (25), Antigua (8), Saint Vincent (6), Saint Lucia (5), Grenada (4), Dominica (3), Montserrat (1), Panama (1)	B (38,165), C (305), CRF02_AG (106), A1 (87), CRF19_cpx (83), CRF01_AE (76), D (73), G (56), CRF18_cpx (39), CRF20_BG (24), F1 (24), CRF24_BG (22), U (21), H (13), F (10), CRF06_cpx (8), CRF23_BG (7), A (7), CRF12_BF (6), K (5), J (2), F1 (F2) (1), F2 (1), CRF08_BC (1), CRF09_cpx (1), CRF10_CD (1)
Oceania (n = 458)	Australia (458)	B (448), D (3), K (3), A1 (2), A (1), CRF06_cpx (1)
South America (n = 6,314)	Brazil (4,142), Argentina (1,286), Peru (376), Venezuela (281), Chile (162), Colombia (37), Uruguay (13), Guyana (6), Suriname (5), Ecuador (4), Bolivia (2)	B (4,425), C (731), F1 (485), CRF12_BF (411), U (112), F (82), D (17), F1 (F) (13), CRF31_BC (8), CRF02_AG (7), CRF29_BF (4), CRF38_BF1 (4), A (3), A1 (2), CRF28_BF (2), CRF16_A2D (2), K (1), CRF05_DF (1), CRF44_BF (1), CRF07_BC (1), CRF17_BF (1), CRF06_cpx (1)

Mapping CRF subtypes from viruses to each genes

CRFs	No. viruses	Mapped subtype
CRFs	No. viruses	protease	RT	integrase
CRF01_AE	4,889	CRF01_AE (3,583)	CRF01_AE (4,400)	CRF01_AE (326)
CRF02_AG	4,392	CRF02_AG (3,805)	CRF02_AG (3,373)	CRF02_AG (537)
CRF03_AB	16	A (15)	B (15)	B (3)
CRF04_cpx	18	CRF04_cpx (14)	CRF04_cpx (15)	CRF04_cpx (4)
CRF05_DF	21	CRF05_DF (21)	CRF05_DF (21)	CRF05_DF (3)
CRF06_cpx	762	CRF06_cpx (604)	CRF06_cpx (533)	CRF06_cpx (111)
CRF07_BC	420	B (420)	CRF07_BC (420)	C (5)
CRF08_BC	138	C (137)	CRF08_BC (138)	C (4)
CRF09_cpx	41	CRF09_cpx (38)	CRF09_cpx (39)	CRF09_cpx (6)
CRF10_CD	42	D (41)	CRF10_CD (41)	CRF10_CD (4)
CRF11_cpx	202	CRF11_cpx (183)	CRF11_cpx (160)	CRF11_cpx (22)
CRF12_BF	453	F (440)	CRF12_BF (438)	F (29)
CRF13_cpx	50	CRF13_cpx (45)	CRF13_cpx (39)	CRF13_cpx (10)
CRF14_BG	25	G (22)	G (24)	G (5)
CRF16_A2D	4	A (4)	A (4)	A (1)
CRF17_BF	1	CRF17_BF (1)	CRF17_BF (1)	F (1)
CRF18_cpx	53	CRF18_cpx (51)	CRF18_cpx (50)	CRF18_cpx (6)
CRF19_cpx	84	D (83)	D (83)	CRF19_cpx (4)
CRF20_BG	24	CRF20_BG (24)	CRF20_BG (24)	G (3)
CRF21_A2D	3	D (3)	CRF21_A2D (3)	A (3)
CRF22_01A1	9	A (2)	A (1)	A (7)
CRF23_BG	11	CRF23_BG (11)	CRF23_BG (11)	G (2)
CRF24_BG	22	CRF24_BG (22)	CRF24_BG (22)	G (3)
CRF25_cpx	8	F (6)	B (6)	B (7)
CRF26_AU	10	F (10)	CRF29_BF (10)	F (4)
CRF27_cpx	4	CRF27_cpx (4)	CRF27_cpx (4)	CRF27_cpx (3)
CRF28_BF	2	F (2)	B (2)	B (2)
CRF29_BF	4	F (4)	CRF29_BF (4)	F (4)
CRF30_0206	1	CRF30_0206 (1)	CRF30_0206 (0)	CRF30_0206 (0)
CRF31_BC	8	C (8)	CRF31_BC (8)	C (0)
CRF33_01B	15	CRF33_01B (14)	CRF33_01B (14)	CRF01_AE (3)
CRF34_01B	5	B (5)	CRF01_AE (5)	CRF01_AE (3)
CRF35_AD	10	CRF35_AD (9)	CRF35_AD (10)	A (4)
CRF36_cpx	2	CRF36_cpx (2)	CRF36_cpx (2)	CRF36_cpx (2)
CRF37_cpx	14	G (12)	CRF37_cpx (3)	CRF37_cpx (4)
CRF38_BF1	4	CRF38_BF1 (4)	CRF38_BF1 (4)	CRF38_BF1 (4)
CRF42_BF	17	CRF42_BF (17)	CRF42_BF (17)	CRF42_BF (17)
CRF43_02G	6	CRF43_02G (5)	CRF43_02G (4)	CRF43_02G (5)
CRF44_BF	1	CRF44_BF (1)	CRF44_BF (1)	CRF44_BF (1)
CRF45_cpx	10	CRF45_cpx (10)	CRF45_cpx (10)	CRF45_cpx (4)
CRF47_BF	5	CRF47_BF (5)	CRF47_BF (5)	CRF47_BF (2)
CRF49_cpx	3	CRF49_cpx (3)	CRF49_cpx (3)	CRF49_cpx (3)