HIVdb version 8.4 (last updated 2017-06-16)

Drug Resistance Rules Editor: PI

(NRTI · NNRTI · INSTI)

This page makes it possible to evaluate the effect of new drug resistance rules (i.e., scores for individual mutations or combinations of mutations) on the complete set of 5635 distinct patterns of PI-resistance mutations in sequences in HIVDB ranked by their frequency. Click ‘edit’ to modify the scores for an individual mutation or mutation combination. Click ‘Add Rule’ to add a new mutation combination rule. After making a change, click ‘Preview’ to see the effect of the change on the 200 most frequent mutation patterns. Click ‘Save Changes’ to download a JSON file containing the complete set of PIrules with saved changes. Use the ‘Recover Changes’ button to retrieve a saved set of rules. At this time, it is not possible to evaluate the effect of a completely new mutation because the 5635 distinct patterns of PI-resistance mutations have been produced in advanced.

RuleATV/rDRV/rFPV/rIDV/rLPV/rNFVSQV/rTPV/roperations
L10F05151051500
K20T505501550
L23I000001500
L24F505551050
L24I1001015101010-5
L24M505551050
D30N000006000
V32I15153015151505
L33F55105510510
K43T0000010010
M46I10010101030105
M46L100101010201010
M46V100101052055
I47A01060156030030
I47V101035151520030
G48A1000101030600
G48L1000101030600
G48M3000101030600
G48Q1000101030600
G48S1000101030600
G48T1000101030600
G48V3000101030600
I50L60-10-5-5-100-5-5
I50V020600301515-5
F53L10000010150
I54A150101515201520
I54L15206010202015-10
I54M1520601520201520
I54S150101515201520
I54T150101515201520
I54V150101515201520
Q58E0000010015
G73A1001015515150
G73C1001015515150
G73D5055510100
G73S1001015515150
G73T1001015515150
G73V5055510100
T74P10510105201025
L76V020603030100-5
V82A15015303030150
V82C150151515301510
V82F151530303030100
V82L100151010101045
V82M100153025301510
V82S300153030301530
V82T300153030301545
N83D1000100151025
I84A6030606060606060
I84C6015606030606030
I84V6015606030606030
N88D10000060100
N88G1500003000
N88S60-5-1015060150
N88T1500003000
L89V0510501000
L90M25020301560450
Combination RuleATV/rDRV/rFPV/rIDV/rLPV/rNFVSQV/rTPV/roperations
V11IL + V32I05555500
V11IL + I54LM05555500
V32I + I47AV55555500
V32I + I54LM55555500
V32I + L76V05555500
V32I + I84V05555500
V32I + L89V05555500
M46IL + I84V + L90M50555555
M46ILV + L76V001010101000
M46ILV + V82ACFLMST10010101010100
M46ILV + L90M100101001050
I47AV + I54LM55555500
I47AV + I84V05555500
F53L + L90M1001010010100
I54ALMSTV + V82ACFLMST10010101010100
I54ALMSTV + L90M1001010510100
I54LM + I84V05555500
I54LM + L89V05555500
G73ACSTV + L90M1001010010100
V82ACFLMST + L90M1001010510100