HIVdb version 8.4 (last updated 2017-06-16)

Drug Resistance Rules Editor: NRTI

(PI · NNRTI · INSTI)

This page makes it possible to evaluate the effect of new drug resistance rules (i.e., scores for individual mutations or combinations of mutations) on the complete set of 4750 distinct patterns of NRTI-resistance mutations in sequences in HIVDB ranked by their frequency. Click ‘edit’ to modify the scores for an individual mutation or mutation combination. Click ‘Add Rule’ to add a new mutation combination rule. After making a change, click ‘Preview’ to see the effect of the change on the 200 most frequent mutation patterns. Click ‘Save Changes’ to download a JSON file containing the complete set of NRTIrules with saved changes. Use the ‘Recover Changes’ button to retrieve a saved set of rules. At this time, it is not possible to evaluate the effect of a completely new mutation because the 4750 distinct patterns of NRTI-resistance mutations have been produced in advanced.

RuleABCAZTD4TDDIFTC3TCTDFoperations
M41L5151510005
A62V5555555
K65E10010100010
K65N30-103030151530
K65R45-156060303060
D67E510105005
D67G510105005
D67H510105005
D67N515155005
D67S510105005
D67T510105005
D67Deletion30303030151530
S68Deletion1503030151515
T69D001030000
T69G1051010005
T69Insertion60606060303060
T69Deletion1503030151515
K70E15-101515101015
K70G15-101515101015
K70N1501515101015
K70Q1501515101015
K70R5301510005
K70S1501515101015
K70T1501515101015
K70Deletion1503030151515
L74I300060005
L74V300060000
V75A003015000
V75I5555555
V75M0103015000
V75S003015000
V75T006030000
F77L5101010555
Y115F600000015
F116Y10101010555
Q151L30303030101010
Q151M60606060151515
M184I15-10-10106060-10
M184V15-10-10106060-10
L210W5151510005
T215A5202010005
T215C5202010005
T215D5202010005
T215E5202010005
T215F104040150010
T215I5202010005
T215L5202010005
T215N5202010005
T215S5202010005
T215V5202010005
T215Y104040150010
K219E510105005
K219N510105005
K219Q510105005
K219R510105005
K219W010105000
Combination RuleABCAZTD4TDDIFTC3TCTDFoperations
Q151M + M184IV0101000010
L210W + T215ACDEILNSV5555005
L210W + T215FY101010105510
E40F + M41L + L210W + T215FY5555005
M41L + L210W101010100010
M41L + L210W + T215FY5000555
M41L + T215ACDEILNSV5555005
M41L + T215FY151010105510
M41L + E44AD + L210W + T215FY5555005
M41L + D67EGN + T215FY5555555
K65R + Q151M010000010
D67EGN + T215FY + K219ENQR5555005
D67EGN + K70R + M184IV + K219ENQR20000000
D67EGN + K70R + K219ENQR10101010101010
K70EGNQST + M184IV001000010
K70R + T215FY5555005
L74IV + M184IV15000000
F77L + F116Y + Q151M10101010151515