HIVdb version 8.7 (last updated on 2018-10-19)

Drug Resistance Rules Editor: NNRTI

(PI · NRTI · NNRTI · INSTI)

This page makes it possible to evaluate the effect of new drug resistance rules (i.e., scores for individual mutations or combinations of mutations) on the complete set of 2595 distinct patterns of NNRTI-resistance mutations in sequences in HIVDB ranked by their frequency. Click ‘edit’ to modify the scores for an individual mutation or mutation combination. Click ‘Add Rule’ to add a new mutation combination rule. After making a change, click ‘Preview’ to see the effect of the change on the 200 most frequent mutation patterns. Click ‘Save Changes’ to download a JSON file containing the complete set of NNRTIrules with saved changes. Use the ‘Recover Changes’ button to retrieve a saved set of rules. At this time, it is not possible to evaluate the effect of a completely new mutation because the 2595 distinct patterns of NNRTI-resistance mutations have been produced in advanced.

RuleDOREFVETRNVPRPVoperations
A98G1515103015
L100I1560306060
L100V1030103015
K101E1515153045
K101H010101510
K101P1060606060
K103H0600600
K103N0600600
K103S0450600
K103T0150600
V106A60450600
V106I150101010
V106M30600600
V108I10100150
E138A0010015
E138G010101015
E138K010101045
E138Q010101015
E138R010101015
V179D010101010
V179E010101010
V179F010151515
V179L010101015
Y181C1030306045
Y181F015156030
Y181G015156030
Y181I2030606060
Y181S015156030
Y181V2030606060
Y188C10600600
Y188F306006030
Y188H10300600
Y188L6060106060
G190A045106015
G190C1060106010
G190E6060456060
G190Q6060456045
G190S3060106015
G190T1060106010
G190V1060106010
H221Y1010101515
P225H30450450
F227C6045304545
F227I30100300
F227L30150300
F227V30100300
M230I1515153030
M230L6045306060
L234I300000
K238N0100100
K238T0300300
Y318F30100300
N348I000150
Combination RuleDOREFVETRNVPRPVoperations
L100I + K103N150000
K101E + Y181C05550
K101E + M184I000015
K101E + Y188L00500
K101E + G190A50500
K101E + G190S50500
K103N + Y181C100000
K103R + V179D02002015
V106A + F227L1515000
V108I + Y181C100000
V108I + L234I150000
E138K + M184I000015
V179F + Y181C0015015
V179T + Y181C0010010
Y181C + G190A200000
Y181C + G190ACSTV0010010
Y181C + G190CSTV100000
A98G + Y181C55555
A98G + F227C1515151515