HIVdb version 8.7 (last updated on 2018-10-19)

Drug Resistance Rules Editor: INSTI

(PI · NRTI · NNRTI · INSTI)

This page makes it possible to evaluate the effect of new drug resistance rules (i.e., scores for individual mutations or combinations of mutations) on the complete set of 199 distinct patterns of INSTI-resistance mutations in sequences in HIVDB ranked by their frequency. Click ‘edit’ to modify the scores for an individual mutation or mutation combination. Click ‘Add Rule’ to add a new mutation combination rule. After making a change, click ‘Preview’ to see the effect of the change on the 200 most frequent mutation patterns. Click ‘Save Changes’ to download a JSON file containing the complete set of INSTIrules with saved changes. Use the ‘Recover Changes’ button to retrieve a saved set of rules. At this time, it is not possible to evaluate the effect of a completely new mutation because the 199 distinct patterns of INSTI-resistance mutations have been produced in advanced.

RuleBICDTGEVGRALoperations
H51Y10101515
T66A006015
T66I556015
T66K15156060
E92G003015
E92Q10106030
E92V006030
Q95K001010
T97A001010
G118R15153030
F121Y10106060
E138A10101515
E138K10101515
E138T10101515
G140A10103030
G140C10103030
G140S10103030
Y143A551060
Y143C551060
Y143G551060
Y143H551060
Y143K551060
Y143R551060
Y143S551060
P145S00600
Q146P00600
S147G00600
Q148H25256060
Q148K30306060
Q148N001510
Q148R25256060
V151A003015
V151L15156030
S153F1515150
S153Y1515150
N155H10106060
N155S003030
N155T003030
E157Q001010
G163K001515
G163R001515
S230R10202020
R263K25253025
Combination RuleBICDTGEVGRALoperations
E138AKT + G140ACS10101515
E138AKT + Q148HKR101000
G140ACS + Q148HKR101000
Y143ACGHRS + G163R5550
Y143ACGHRS + S230R5550
Q148HKR + N155H101000
Q148HKR + G163KR5500
E157Q + R263K101000
H51Y + R263K1010150
L74FM + Y143ACGHRS5550
L74FM + Q148HKR10101010
E92Q + N155H5500
T97A + Y143ACGHRS0050
T97A + Q148HKR151500