Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Seki (2015)
Title Effects of raltegravir or elvitegravir resistance signature mutations on the barrier to dolutegravir resistance in vitro.
Citation Antimicrob Agents Chemother
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Lab
NumIsolates 6
Lab Parent Strain NL43


Lab IN Isolates : Susceptibility Data

IsolateINIMajorDRMsINIMinorDRMsMethodDrugFold Res.
E138K_G140S_Q148H E138K, G140S, Q148H V151I HeLaCD4-ViiV DTG 4.5 
      HeLaCD4-ViiV EVG 1,600 
      HeLaCD4-ViiV RAL 500 
E138K_G140S_Q148R E138K, G140S, Q148R V151I HeLaCD4-ViiV DTG 8.3 
      HeLaCD4-ViiV EVG 190 
      HeLaCD4-ViiV RAL >660 
E138K_G140S_Q18H_M154I E138K, G140S V151I HeLaCD4-ViiV DTG 8.4 
      HeLaCD4-ViiV EVG 2,400 
      HeLaCD4-ViiV RAL >660 
G193E  V151I HeLaCD4-ViiV DTG 1.3 
     HeLaCD4-ViiV EVG 1.3 
     HeLaCD4-ViiV RAL 1.3 
T97A_G140S_Q148H G140S, Q148H T97A, V151I HeLaCD4-ViiV DTG 13 
      HeLaCD4-ViiV EVG 3,900 
      HeLaCD4-ViiV RAL >660 
V75I_E138K_G140S_Q148H_M154I E138K, G140S, Q148H V151I HeLaCD4-ViiV DTG 21 
      HeLaCD4-ViiV EVG 2,600 
      HeLaCD4-ViiV RAL >660