Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Zhang (2018)
Title Accumulation of multiple mutations in vivo confers cross-resistance to new and existing integrase inhibitors.
Citation J Infect Dis
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 12
NumPts 11
Subtype B, C

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
25296D 25296D.PH-INT-05 INI  G140S, Q148H T97A M50I, L101I, S119R, S123C, S283G  
31945A 31945A.PH-INT-04 INI  G140S, Q148H  S17N, V31I, L101I, T125A, K156N, V165I, K215N, S255R  
33973A 33973A.PH-INT-01 INI  G140S, Q148H  S24SN, M50I, L101I, S119R, S123C, F223FL, S283G  
39642A 39642A.PH-INT-02 INI  G140S, Q148H  L101I, S119P, T122I, K136N, I203M, Q216H  
41133A 41133A.PH-INT-25 INI  G140S, Q148H  S17N, L101I, V201X, I208L  
52246C 52246C.PH-INT-18 INI  G140S, Q148H L74M, T97A M50I, L101I, I113L, S119R, T124A, F139Y, S283G  
53528A 53528A.PH-INT-01 INI  G140S, Q148H L74M, T97A M50I, L101I, I113L, S119R, T124A, F139Y, S283G V201VG 
54080A 54080A.PH-INT-27 INI  G140S, Q148H  K7KR, R20RK, S39SC, M50X, L101I, K111KQ, G193E, V201I, D286N S255SC, P261PS 
  54080A.PH-INT-01 INI  G140S, Q148H  K7R, R20K, M50T, L101I, K111Q, G193E, V201I, D286N  
54271B 54271B.PH-INT-08 INI  G140S, Q148H  S24N, S39C, I113V, T124N, T125A, V201I A175S 
63867A 63867A.PH-INT-01 INI  G140S, Q148H T97A K14R, S24N, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, K211Q, L234I, D278A  
66786A 66786A.PH-INT-04 INI  G140S, Q148H L74M, T97A M50I, L101I, K103R, I113L, S119R, T124A, F139Y, S283G