<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Mesplede (2014)
Title Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity.
Citation J Antimicrob Chemother
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Lab
NumIsolates 3
Lab Parent Strain NL43


Lab IN Isolates : Susceptibility Data

IsolateINIMajorDRMsINIMinorDRMsMethodDrugFold Res.
E138K E138K V151I TZM-McGill DTG 0.4 
      TZM-McGill EVG 0.8 
      TZM-McGill RAL 1.0 
E138K_R263K E138K, R263K V151I TZM-McGill DTG 4.3 
      TZM-McGill EVG 16 
      TZM-McGill RAL 1.0 
R263K R263K V151I TZM-McGill DTG 2.3 
      TZM-McGill EVG 22 
      TZM-McGill RAL 1.2