Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Anstett (2016)
Title Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity.
Citation J Antimicrob Chemother
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Lab
NumIsolates 3
Lab Parent Strain NL43


Lab IN Isolates : Susceptibility Data

IsolateINIMajorDRMsINIMinorDRMsMethodDrugFold Res.
E157Q  V151I TZM-McGill DTG 1.2 
     TZM-McGill RAL 0.5 
E157Q_R263K R263K V151I TZM-McGill DTG 0.7 
      TZM-McGill RAL 1.6 
R263K R263K V151I TZM-McGill DTG 2.7 
      TZM-McGill RAL 0.2