Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Pujari (2018)
Title Integrase Resistance-Associated Mutations on Raltegravir Failure in Western India: A Preliminary Analysis.
Citation JAIDS
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 22
NumPts 22
Subtype C, A

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
IIDIN1 IIDIN1 RAL  Y143R  K14R, V31I, L101I, T112A, T124A, T125A, K136Q, A169G, V201I, L213I, L234I, D278A, S283G R224G, L241I 
IIDIN10 IIDIN10 RAL  N155H  K14R, V32I, D41N, K42Q, L101I, T112V, T124A, T125A, K136Q, V201I, L234I  
IIDIN11 IIDIN11 RAL   V151I, G163R E11D, V31I, D41S, K42Q, L63I, L74I, V75I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, V165I, I200M, V201I, I203M, L234I  
IIDIN12 IIDIN12 RAL  F121FY G163GR S17N, R20K, S24D, N27D, Q44H, L74I, L101I, T112V, T124A, T125A, K136Q, D167E, I200L, V201I, I204L, I220V, Q221K, L234I  
IIDIN13 IIDIN13 RAL  Y143R T97A S24G, D25E, L74I, F100Y, L101I, T112V, S119T, T125A, K136Q, V201I, T206S, T218L, I220V, L234I, R269K, D278A, S283G  
IIDIN14 IIDIN14 RAL  N155H V151I E11D, D25E, V31I, K42Q, L45Q, L101I, T112V, S119P, T122I, T124A, K136Q, V201I, K211R, T218I, I220V, L234I, R269K, D278A, S283G  
IIDIN15 IIDIN15 RAL  N155H  K136Q, I141V, V165I, V201I, I203M, I208L, K211Q, T218I, I220V, L234I, N254K, R269K, D278A, S283G D229N 
IIDIN16 IIDIN16 RAL  Y143R  E11D, V31I, K42Q, I84M, L101I, T112V, T124A, T125A, K136Q, E198Q, V201I, K215N, L234I, D278A, S283G  
IIDIN17 IIDIN17 RAL    L28M, D41S, K42Q, L63I, I84M, L101I, T112V, T124A, T125A, K136R, K160E, V165I, V201I, I203M, T218I, I220V, L234I, S255D, D256E, D278A, S283G  
IIDIN18 IIDIN18 RAL  N155H T97A, V151I P30S, V31I, M50I, I60T, I72V, I84M, F100Y, L101I, S119R, T125A, K136T, H171Q, V201I, K211R, L234V, D278A, S283G, D288N E13K 
IIDIN19 IIDIN19 RAL  Y143C T97A K14R, V31I, K42Q, M50I, I84M, L101I, T112V, S119R, T124A, T125A, K136Q, Q164H, V201I, I203M, L234I, R269K, D278A, S283G  
IIDIN2 IIDIN2 RAL  E92Q, Y143R T97A D6N, K14R, N18H, V31I, K42Q, G59E, L63I, L74I, L101I, T112V, S119T, T124A, T125A, K136Q, V201I, T210I, I220V, L234I, D278A, S283G G4R 
IIDIN20 IIDIN20 RAL  Y143R T97A, G163R S17N, L28I, P30A, I84M, L101I, T112V, T125A, K136Q, Q177H, V201I, L234I, D278A, S283G M178S 
IIDIN21 IIDIN21 RAL  N155H  V31I, K42Q, L101I, T112V, T124A, T125A, K136Q, G163V, V201I, I203M, D232E, L234I, D278A  
IIDIN22 IIDIN22 RAL  N155H G163R K14R, L28I, K42Q, L45Q, I84M, L101I, T112V, T124A, T125A, I135V, K136Q, V201I, T218I, I220V, L234I, G277C, D278A, S283G  
IIDIN3 IIDIN3 RAL   F121C, A128T E11D, L28I, K42Q, L45Q, L101I, T112V, S123G, T124A, K127R, I162V, K173R, K188R, S195T, A196P, V201I, Q209P, Q221N, L234I, S283G, D286N G149R, E170V, M178I, H183R 
IIDIN4 IIDIN4 RAL  Y143R L74M, T97A K14R, V31I, K42Q, L101I, T112V, S119T, T124A, T125A, I135V, K136Q, E170A, S195H, V201I, N222H, L234I, D278A, S283G Y194F 
IIDIN5 IIDIN5 RAL  N155H V151I V31I, D41N, K42Q, L45Q, V77A, L101I, T112V, T124A, T125A, K136Q, G197R, V201I, I208M, Q221H, L234I, N254K, S255G, R269K, D278A, S283G  
IIDIN6 IIDIN6 RAL  E92Q, N155H  K14R, V31I, I72V, L101I, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, I208L, S283G  
IIDIN7 IIDIN7 RAL  Y143R L74M, T97A, G163R L101I, T112V, S119T, T124A, K136Q, V201I, T218I, L234I, D278A, S283G, R284G, E287A G47A 
IIDIN8 IIDIN8 RAL    E11D, L28I, K42Q, L45Q, L101I, T112V, T124A, T125A, I135V, K136Q, V201I, T218S, L234I, D256E, R269K  
IIDIN9 IIDIN9 RAL  N155H V151I V31I, K42Q, L101I, T112V, T124A, T125A, K136Q, K160R, V165I, I200L, V201I, I203M, D232N, L234I, D278A, S283G