<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Herring (2001)
Title Natural variation in HIV-1 integrase.
Citation Unpublished
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 16
NumPts 16
Subtype B

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
1052 PT1052
Consensus 
None    L101I, T125A, I135V, M154L, K211R, S230N  
  clone: 1 None    L101I, T125A, I135V, M154L, K211R, S230N  
  clone: 2 None    L101I, T125A, I135V, M154L, K211R, S230N H16P 
  clone: 3 None    L101I, T125A, I135V, M154L, K211R, S230N  
  clone: 4 None    L101I, T125A, I135V, M154L, K211R, S230N  
1101 PT1101
Consensus 
None    S17N, T124A, T125A, D232E, D256E  
  clone: 1 None    S17N, S39N, T124A, T125A, D232E, D256E D167N 
  clone: 2 None    S17N, T124A, T125A, D232E, D256E  
  clone: 3 None  E138K  S17N, T124A, T125A, D232E, D256E  
  clone: 4 None    S17N, T124A, T125A, D232E, D256E  
1117 PT1117
Consensus 
None    S17N, T124A, T125A, D232E, D256E  
  clone: 1 None    S17N, T124A, T125A, A175V, D232E, D256E  
  clone: 2 None    S17N, M50T, T124A, T125A, D232E, D256E  
  clone: 3 None    S17N, T124A, T125A, V180I, D232E, D256E  
  clone: 4 None    S17N, T124A, T125A, D232E, D256E  
1609 PT1609
Consensus 
None    E10D, M50I, I72V, T124N, K156N, D256E  
  clone: 1 None    E10D, M50I, I72V, T124N, K156N, D256E  
  clone: 2 None   E92K E10D, M50I, I72V, T124N, K156N, D256E  
  clone: 3 None    E10D, M50I, I72V, T124N, D256E  
  clone: 4 None    E10D, M50I, I72V, T124N, K156N, D256E  
1620 PT1620
Consensus 
None    S17N, I72V, P90S, L101I, T124A, V201I S283G 
  clone: 1 None   V151A S17N, A23V, I72V, P90S, L101I, T124A, V201I S283G 
  clone: 2 None    S17N, I72V, P90S, L101I, T124A, V201I S283G 
  clone: 3 None    S17N, I72V, P90S, L101I, T124A, V201I S283G 
  clone: 4 None    I72V, P90S, L101I, H183Y, V201I, K219E R263G, S283G 
  clone: 5 None    S17N, I72V, P90S, L101I, T124A, V201I S283G 
1658 PT1658
Consensus 
None    N27G, V32I, I72V, L101I, I135V, S230G  
  clone: 1 None    E11D, S24N, V31I, S119P, T122I, V201I, D207G, A265V D286E 
  clone: 2 None    E11D, S24N, V31I, S119P, T122I, V201I, A265V  
  clone: 3 None    N27G, V32I, I72V, L101I, I135V, S230G  
  clone: 4 None    E10G, N27G, V32I, I72V, L101I, I135V, S230G  
  clone: 5 None    N27G, V32I, D55G, S57G, I72V, L101I, I135V, S230G  
1660 PT1660
Consensus 
None    E11D, S24N, V31I, I72V, S119P, T122I, V201I, T218S, A265V  
  clone: 1 None    N27G, V32I, I72V, L101I, T122A, S230G, A265V  
  clone: 2 None    E11D, S24N, V31I, I72V, S119P, T122I, V201I, Q216*, T218S, A265V S283N 
  clone: 3 None    D6E, K7Q, Q9P, E11D, N27G, V32I, I72V, L101I, I135V, S230G I5M, E48V, G197R 
  clone: 4 None    D6E, K7Q, Q9P, E11D, N27G, V32I, I72V, L101I, I135V, S230G, S255G I5M 
  clone: 5 None    E11D, S24N, V31I, I72V, I89L, S119P, T122I, V201I, T218S, D256E, A265V Q44P, G70R 
  clone: 6 None    E11D, S24N, V31I, I72V, S119P, T122I, V201I, T218S, A265V  
  clone: 7 None    E11D, S24N, V31I, S119P, T122I, V201I, T218S, A265V K273E 
1661 PT1661
Consensus 
None    E10D, N27G, V31I, I72V, L101I, I135V, S230G  
  clone: 1 None    E10D, N27G, V31I, I72V, L101I, I135V, V201I, S230G M22T 
  clone: 2 None    E10D, N27G, V31I, H51Q, I72V, L101I, I135V, S230G  
  clone: 3 None  E92V  E10D, N27G, V31I, I72V, L101I, I135V, S230G  
  clone: 4 None    E10D, N27G, V31I, I72V, L101I, I135V, S230G  
  clone: 5 None    E10D, N27G, V31I, I72V, L101I, I135V, S230G G82R, T93I 
1663 PT1663
Consensus 
None    I72V, S119G, T122I, V201I, D256E  
  clone: 1 None    I72V, S119G, T122I, T124A, V201I, K211R, D256E  
  clone: 2 None    R20K, I72V, S119G, T122I, I182V, V201I, K211R, L234X, D256E M22T 
  clone: 3 None    K14R, I72V, S119G, T122I, V201I, D256E  
  clone: 4 None    V37I, S119G, T122I, T125A, V201I, D256E G82E 
  clone: 5 None    I72V, S119G, T122I, T124A, V201I  
  clone: 6 None    A21T, M50L, I72V, E87X, S119G, T122I, T125A, V201I D202G, K211I 
1664 PT1664
Consensus 
None    E10D, N27G, V31I, I72V, L101I, S230G  
  clone: 1 None    E10D, N27G, V31I, I72V, L101I, R224W, S230G Y226H 
  clone: 2 None    E10D, N27G, V31I, I72V, L101I, I135V, S230G  
  clone: 3 None    E10D, N27G, V31I, I72V, L101I, I135V, S230G A8V 
  clone: 4 None    E10D, N27G, L28M, V31I, I72V, L101I, K160E, K211R, S230G F26L, S283G 
  clone: 5 None    L2W, E10D, N27G, V31I, I72V, L101I, S230G  
  clone: 6 None    E10D, N27G, V32I, I72V, L101I, Q164K, S230G  
  clone: 7 None    E10D, N27G, I72V, L101I, S230G  
1665 PT1665
Consensus 
None    N27G, V31I, I72V, L101I, S230G  
  clone: 1 None    S17N, N27G, V31I, I72V, L101I, S230G  
  clone: 2 None    N27G, V31I, I72V, L101I, S230G  
  clone: 3 None    N27G, V32I, I72V, L101I, M154I, V201I, S230G  
  clone: 4 None    N27G, V31I, I72V, L101I, I113L, S230G I204T 
  clone: 5 None    N27G, V31I, V54A, I72V, L101I, M154I, S230G, I251V K14E, I113T 
1672 PT1672
Consensus 
None    D6E, E10D, M50I, L101I, S119G, T124N, T125A, K156N  
  clone: 1 None    D6E, E10D, D25E, M50I, L101I, S119G, T124N, T125A, K156N  
  clone: 2 None    D6E, E10D, M50I, L101I, S119G, T124N, T125A, K156N  
  clone: 3 None    D6E, E10D, V31M, M50I, L101I, S119G, T124N, T125A, K156N  
  clone: 4 None    D6E, E10D, M50I, L101I, S119G, T124N, T125A, K156N, I208L D25N, E69K, E152K 
  clone: 5 None    D6E, E10D, S17N, M50I, L101I, T122I, T124N, K156N S81N 
1687 PT1687
Consensus 
None    E10D, M50I, L101I, T112I, T125A, K156N, V201I, I203M, I208L, N222K, S230N  
  clone: 1 None    E10D, M50I, L101I, T112I, T125A, K156N, V201I, I203M, I208L, N222K, S230N L234P 
  clone: 2 None    E10D, S17N, M50I, L101I, T112I, T125A, K156N, V201I, I203M, I208L, N222K, S230N  
  clone: 3 None    E10D, M50I, L101I, T112I, T125A, K156N, V201I, I203M, I208L, N222K, S230N  
  clone: 4 None    E10D, M50I, L101I, T112I, T125A, K156N, E157K, V201I, I203M, I208L, N222K, S230N L74P 
1688 PT1688
Consensus 
None    M50I, V201I, D232E, A265V  
  clone: 1 None    M50I, V201I, I217V, D232E, A265V  
  clone: 2 None    V31I, M50I, V201I, D232E, A265V  
  clone: 3 None    L45T, M50I, D232E, A265V D6G, D202G 
  clone: 4 None    M50I, G189R, V201I, D232E, A265V  
1702 PT1702
Consensus 
None    I72V, K111T, T124N, T125A, V126L, G193R, T206S, S230N  
  clone: 1 None    I72V, K111T, T124N, T125A, V126L, G193R, T206S, S230N, Q274R E69E*, R284G 
  clone: 2 None    I72V, K111T, T124N, T125A, V126L, G193R, T206S, S230N  
  clone: 3 None    I72V, K111T, T124N, T125A, V126L, G193R, T206S, K211R, S230N F223S, R262S, R284G 
  clone: 4 None    I72V, K111T, T124N, T125A, V126L, M154V, G193R, T206S, S230N  
  clone: 5 None    M50T, I72V, K111T, T124N, T125A, V126L, G193R, T206S, S230N  
  clone: 6 None    I72V, K111T, T125A, V126L, M154I, G193R, T206S, I208M, S230N R20G, F26L, E48K, D64G, N120D, I135T, G237R 
1708 PT1708
Consensus 
None    E11D, L101I, F181L, S195T, I220L S283G 
  clone: 1 None    E11D, L101I, T122I, K160R, F181L, S195T, I220L S283G 
  clone: 2 None    E11D, L101I, T122I, F181L, S195T, I220L, I268V W19R, E152K, S283G 
  clone: 3 None    E11D, L101I, F181L, S195T, I220L S283G 
  clone: 4 None    E11D, L101I, S119G, F181L, S195T, I220L G94R, S283G 
  clone: 5 None    G4E, D6N, R20K, D41N, L101I, F181L, S195T, I220L D3N, A8T, E11N, E13K, D25N, G47E, E48K, S283G 
  clone: 6 None    E11D, L101I, T112A, T122P, F181L, S195T, I220L S283G