<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Brenner (2016)
Title Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors.
Citation J Antimicrob Chemother
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Lab
NumIsolates 4
Lab Parent Strain NL43

Lab IN Isolates (including Susceptibility Data)

IsolateINIMajorDRMsINIMinorDRMsMethodDrugFold Res.
118R G118R  HeLa-CD4 reporter gene DTG 1.0 
     HeLa-CD4 reporter gene EVG 0.9 
     HeLa-CD4 reporter gene MK-2048 0.4 
     HeLa-CD4 reporter gene RAL 0.8 
118R138K G118R, E138K  HeLa-CD4 reporter gene DTG 1.7 
     HeLa-CD4 reporter gene EVG 4.1 
     HeLa-CD4 reporter gene MK-2048 139 
     HeLa-CD4 reporter gene RAL 4.4 
66A118R138K T66A, G118R, E138K  HeLa-CD4 reporter gene DTG 6.5 
     HeLa-CD4 reporter gene EVG 6.6 
     HeLa-CD4 reporter gene MK-2048 175 
     HeLa-CD4 reporter gene RAL 4.6 
66AL74M118R138K151I T66A, G118R, E138K L74M, V151I HeLa-CD4 reporter gene DTG 8.0 
      HeLa-CD4 reporter gene EVG 10 
      HeLa-CD4 reporter gene MK-2048 300 
      HeLa-CD4 reporter gene RAL 11