<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Kekitiinwa (2017)
Title Virologic response to first-line efavirenz- or nevirapine-based anti-retroviral therapy in HIV-infected African children.
Citation Pediatr Infect Dis J
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 236
NumPts 236
Subtype A, C, D, B, CRF10_CD, CRF01_AE, G

 

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Page 1   listing Isolate 1 to Isolate 100 from Total 236 Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
28165_302 28165_302 NRTI NNRTI Y115F, M184V, T215F  V21I, V35T, T39E, K43R, D123S, K173A, Q174K, D177E, V179T, T200A, I202V, Q207A, R211K, F214L, V245Q, E248D, A272P, T286A, E291D, I293V, P294E L12I, E302ED 
28166_425 28166_425 NRTI NNRTI M41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219E L100I, K103N V35T, T39K, K49R, V60I, T107S, L109V, D121DY, K122E, D123DG, S162A, D177DE, T200I, I202IT, Q207E, R211K, D218DE, L228R, V245EK, D250E, A272P, Q278N, L282C, L283I, T286P, I293V V108L 
28168_294 28168_294 NRTI NNRTI L74V, Y115F, M184V, K219KN Y181C K20R, V21I, V35T, T39A, E40D, K49R, V60VI, A98S, K101KR, D123NS, I135T, K173S, Q174K, I178L, V179I, T200TA, Q207A, R211RS, V245Q, D250E, A272P, T286A, E291D, V292I, I293V, P294T P59PS, T131TI, E302ED 
28193_1139 28193_1139 NRTI NNRTI D67N, K70R, M184V, K219Q  V35T, K49R, V60I, I135IV, K166R, D177E, I178M, T200M, E203K, Q207E, R211K, V245M, E248D, D250E, I257L, K277R, L282C, T286A, I293V, E297K N57H 
28233_641 28233_641 NRTI NNRTI A62V, K65R, K70KT, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219KQ  V35T, S68G, T69TI, V118VI, K122E, D123S, I142V, K173S, Q174EK, D177E, V179I, T200A, I202V, Q207A, R211S, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, P294T  
28241_300 28241_300 NRTI NNRTI K65R, Y115F V106A, Y181C V35T, V60I, T69N, D121Y, K122E, I142V, D177E, I178M, G196E, T200I, E203Q, Q207D, R211K, V245K, D250E, A272P, L282C, L283I, T286A, I293V  
28255_282 28255_282 NRTI NNRTI K70N, L74I, Y115F, M184V K103N V35T, V60I, D121Y, K122E, D177E, I178M, E194D, T200I, Q207EG, R211K, H221Y, T240K, V245K, D250E, A272P, K275R, K277KR, Q278H, L282C, T286A, I293V P225R 
28257_219 28257_219 NRTI NNRTI L74V, Y115F, M184V Y181YC, G190A K20R, V21I, V35P, T39A, E40D, V60I, V90VI, K101KR, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, V189I, G196E, T200A, Q207A, R211S, F214L, H221HY, V245E, D250E, A272T, T286A, E291D, I293V, P294T K30E 
28259_1180 28259_1180 NRTI NNRTI D67DN, K70KR, M184V, T215TAIV, K219KE  V21I, V35T, K66KR, K122E, D123G, K173A, Q174K, D177E, V179I, G196GE, T200A, Q207D, V245Q, R284K, E291D, I293V G18C 
28261_257 28261_257 NRTI NNRTI M41ML, D67DN, M184V, T215Y, K219R  V21I, V35T, T39K, K43KE, S48E, K49R, V60I, P119PS, I135M, K173S, Q174K, D177E, V179I, T200A, I202V, Q207A, H221CY, V245Q, E248D, D250E, S251C, T286A, E291D, V292I, I293V, P294T D256DA 
28265_270 28265_270 NRTI NNRTI M41ML, M184V G190A K20R, V21I, V35T, T39A, K43R, F77S, K122E, D123G, K173S, Q174K, D177E, V179I, G196E, Q207A, R211S, F214L, V245Q, A272P, E291D, I293V  
28266_305 28266_305 NRTI NNRTI M41L, M184MV, T215F  P14A, K20R, V21I, V35T, V60I, V90I, K122E, D123S, I135T, S162H, K173AT, Q174K, D177E, V179I, Q207E, R211K, D250E, A272T, T286A, V292I, I293V D17M, P19R 
28687_222 28687_222 NRTI NNRTI  K103KN, P225PH K20R, V21I, V35T, T39KN, V60I, K122E, D123N, Q145C, K173S, Q174K, D177E, V179I, T200TA, I202V, Q207A, R211S, V245E, D250E, K281KR, T286TA, E291D, V292I, I293V P119H 
28692_273 28692_273 NRTI NNRTI M184V, T215Y  K20R, V35T, K122E, D123G, I135V, S162C, K173S, D177E, T200A, Q207A, R211S, V245Q, E248N, A272P, K277R, Q278H, T286A  
28693_295 28693_295 NRTI NNRTI L74V, Y115F, M184V, T215A, K219E Y181C, G190A V35T, E36A, T39D, K49R, V60I, L109LI, V118I, K122E, D123N, I135T, K173A, D177G, V179I, I202V, Q207A, L210I, D218E, P243H, V245K, D250E, A272P, K277R, E291D, V292I, I293V, P294T  
28700_452 28700_452 NRTI NNRTI M184V  V60I, K122E, D123N, I135T, K173S, Q174R, D177E, I178IL, V179I, T200A, Q207D, V241VI, E248ED, D250E, A272Q, T286A, V292I, I293V  
28702_263 28702_263 NRTI NNRTI L74V, Y115F, M184V V108I, Y181C V35T, E40D, K49R, D121Y, K122E, D177E, I178L, T200I, E204K, Q207E, R211K, F214L, V245K, D250E, I257L, A272P, K277R, L282C, T286A, I293V  
28713_885 28713_885 NRTI NNRTI Y115YF, M184V K103KN V35T, K49R, V60I, V90VI, K102KR, K122E, D123N, I135T, S162Y, F171Y, K173S, Q174K, D177E, I178M, V179I, T200A, Q207AT, R211S, F214FL, V245K, D250E, I257V, T286A, E291D, V292I, I293V, P294T  
35359_949 35359_949 NRTI NNRTI V75M Y188L V21I, V35T, T39S, V60I, K122E, D123NS, I135T, F171Y, K173S, Q174K, T200A, Q207A, R211S, E248Q, D250E, A272P, K275R, V276I, Q278H, T286A, E291D, V292I, I293V, P294T  
35364_646 35364_646 NRTI NNRTI D67DN, K70KR, M184V  K20R, V35T, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, T200K, Q207G, R211S, F214L, V245E, D250E, K281R, T286A, E291D, I293V, P294T  
35374_835 35374_835 NRTI NNRTI M184V K103N V35T, E36A, T39D, S105A, K122E, I142IV, D177E, I178V, T200I, Q207E, R211K, V245E, D250E, A272S, K281R, L282C, R284K, T286A, I293V  
42165_239 42165_239 NRTI NNRTI M184V K103N, V108I V60I, D121H, K122E, I135T, K173LS, Q174K, D177E, V179I, T200A, E203D, Q207A, R211S S191SF 
42192_875 42192_875 NRTI NNRTI   V60I, K122E, D123N, I135T, E138A, K173S, Q174K, D177EG, I178IV, V179I, T200E, I202V, Q207A, R211S  
42194_695 42194_695 NRTI NNRTI L74V, Y115F, M184V V106M, G190A, F227L K49R, V60I, K101Q, K122E, D123S, I135T, E138A, S162C, K173S, Q174R, V179IL, T200A, Q207E  
42197_652 42197_652 NRTI NNRTI  K103N, Y188L K43E, K49R, K64R, K122E, D123N, E138A, K173S, V179I, I202V, Q207A G45GR 
42198_908 42198_908 NRTI NNRTI L74V, Y115F, M184V K101P, G190A T69N, K122KE, D123N, Q145C, K173S, P176Q, D177E, V179I, T200A, I202V, Q207A, L210LS, R211K  
42201_479 42201_479 NRTI NNRTI L74V, Y115F, M184V Y181I V60I, K122E, D123S, I135T, I142IT, S162A, K173L, Q174K, N175Y, V179I, T200A, I202V, Q207E, F214L, H221Y  
42202_957 42202_957 NRTI NNRTI L74V, V75I, Y115F, M184V Y181C, G190A K49R, V60I, T69N, D121Y, K122E, D123DE, K126Q, I132L, S162C, D177DE, I178M, V179I, T200A, Q207E, F214L, H221Y  
42204_736 42204_736 NRTI NNRTI  P225PH K43E, K122E, D123S, E138EG, K173S, I202IV, Q207A, R211RS  
42214_611 42214_611 NRTI NNRTI L74V, Y115F, M184V K103N, Y188C, M230L K43KE, V60I, T69N, K122E, D123N, S163I, K166R, K173S, D177E, V179I, G196E, T200A, I202V, Q207A, R211RS  
65487_1026 65487_1026 NRTI NNRTI   M41MV, K122E, D123N, I142IV, E169D, K173S, D177E, T200R, I202V, Q207A, R211RKNS G45GR 
65489_1137 65489_1137 NRTI NNRTI D67N, T69DN, K70R, L74V, Y115F, M184LV, K219H G190A K43KE, V60I, L109LV, D121Y, K122E, D177E, V179VI, T200I, E203K, Q207E, R211K, D237DE  
65491_533 65491_533 NRTI NNRTI D67N, K70R, M184V, T215IV, K219Q  V60I, D121H, K122E, D123G, I135T, I142V, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L P226PL 
65493_520 65493_520 NRTI NNRTI M41L, D67DN, K70KR, M184V, L210W, T215F, K219KE  V60VI, V90I, K101KQ, K122E, I142V, S162Y, K173L, Q174K, D177E, V179I, T200E, E203K, Q207D, R211NS  
65496_936 65496_936 NRTI NNRTI L74V, M184V K103N, Y181C K122E, I135T, I142V, K173S, Q174K, V179I, T200E, E203EK, Q207A, R211S  
65497_892 65497_892 NRTI NNRTI M184V  E44D, K49R, V60I, S68G, K103KE, D121Y, K122E, D177E, I178M, I195L, Q207G, R211K, F214FL, E224D S191SF, Y232YC 
65515_699 65515_699 NRTI NNRTI M41L, D67N, K70R, M184V, L210W, T215FY, K219E  V60I, K122E, D123GS, I135T, S162A, K173S, Q174K, D177E, I178M, T200A, Q207A, R211NS  
65516_496 65516_496 NRTI NNRTI T69D, L74I, Y115F, M184V Y181C K43KE, S48Q, K49R, V60I, D121H, K122E, D123E, D177E, V179VI, G196E, Q207E, R211K, L228R  
65528_1164 65528_1164 NRTI NNRTI K65R, K70T, V75I, Y115F, F116Y, M184V V108I V60I, S68G, T69I, K102R, K122E, D123N, K173S, D177G, I202V, Q207A, R211S, L228LH M41MI 
65529_622 65529_622 NRTI NNRTI  K103N, G190A V60I, D121Y, K122E, D177E, I178M, T200M, Q207E, R211K  
65530_907 65530_907 NRTI NNRTI L74V, Y115F, M184V Y181C, G190A K49R, V60I, E138T, S162C, V179I, T200L, E203K, Q207D, R211K, H221Y  
65535_343 65535_343 NRTI NNRTI M184V, L210W, T215F  K49R, T139K, E169D, D177E, I178L, Q207E, H208Y, R211K  
65537_389 65537_389 NRTI NNRTI L74V, Y115F, M184V L100I, K103N, V108I K49R, V60I, D121HY, K122E, I142V, S163T, T165I, D177E, I178M, T200TA, Q207E, R211K, H221Y, L228Q  
65562_722 65562_722 NRTI NNRTI L74V, Y115F, M184V Y181C V60I, K66KR, T69TN, K82R, K122KE, D123KN, K173A, D177E, V179I, T200TA, I202V, Q207A, R211N, H221Y  
65585_469 65585_469 NRTI NNRTI K65R, Q151QL, M184V  K122E, D123N, K173S, D177E, V179I, I202V, Q207AT, R211S, L228LF P52PL, P226PS, P236PS 
65590_675 65590_675 NRTI NNRTI L74V, Y115F, M184V Y181C S48T, T69NS, K101KR, K122E, D123DG, I135L, K173T, Q174K, D177A, V179VI, T200A, Q207E, R211RK, D218E  
65591_834 65591_834 NRTI NNRTI M184V G190A K122E, D123N, K173S, V179I, V189VI, T200A, I202V, Q207A, R211K  
65741_300 65741_300 NRTI NNRTI K65R, Y115F, M184V V106A, Y181C V60I, S68G, T69N, K122E, I142V, D177E, G196E, T200I, I202IV, E203Q, Q207D, R211K, F214L, H221HY, E224ED  
65751_1075 65751_1075 NRTI NNRTI M184V, K219KE P236PL K122E, D123N, K173S, V179I, D192DN, T200K, I202V, Q207A, R211RS, F214FL  
65754_788 65754_788 NRTI NNRTI M184V  V60I, K122E, D123N, K173S, D177E, V179I, I202V, Q207A, R211S A114AS, F116FL 
65761_461 65761_461 NRTI NNRTI L74V, Y115F, M184V K101E, G190S T69NS, K122E, E138G, K173S, D177E, V179T, T200K, Q207A, R211NS  
65770_1058 65770_1058 NRTI NNRTI D67G, K70R, L74I, Y115YF, M184V, T215F, K219Q  K49R, K64KR, T69N, V118I, K122E, D123S, I135IT, T165I, K173S, Q174K, D177E, V179I, I202V, Q207A, R211K, F214L, D218E  
65773_800 65773_800 NRTI NNRTI L74V, M184V, K219KN A98G, Y181C K173A, Q174K, D177E, V179I, I202V, Q207A, R211K, H221Y  
65774_500 65774_500 NRTI NNRTI M184MV  K49KR, V60I, K122E, D123DE, I135T, K173KN, Q174QK, D177E, I178M, T200TA, Q207E, R211K  
65776_306 65776_306 NRTI NNRTI   V60I, K122E, D177E, T200I, Q207E, R211K  
65777_280 65777_280 NRTI NNRTI L74V, Y115F, M184V K101E, Y181C, G190S S48T, K49R, T69N, K122E, D123N, K173S, Q174K, D177E, V179I, V189VI, T200A, Q207E, L210LS, R211RK, L228R  
65788_1131 65788_1131 NRTI NNRTI   V60I, I135T, D177E, I178M, T200M, Q207E, R211K  
65789_755 65789_755 NRTI NNRTI L74V, Y115F, M184V K101P, G190A K49R, V60I, K122E, I135T, T139TA, K173S, Q174K, D177E, V179I, V189I, Q207A, L210LS, R211S  
65790_802 65790_802 NRTI NNRTI  K103KN V60I, V118I, K122E, I135T, K173A, Q174K, D177DE, I178IL, V179VI, T200A, Q207E, R211K, F214L  
65792_442 65792_442 NRTI NNRTI L74V, Y115F, M184V K103N, P225H, K238T K122E, D123G, E138G, Q145C, K173L, Q174K, D177E, T200E, I202V, Q207A, R211S  
65797_1105 65797_1105 NRTI NNRTI L74V, Y115YF, M184V K103N, Y188C V60I, D121H, K122E, I135T, S162C, K173A, Q174K, D177E, V179T, G196E, Q207A, R211N  
65806_794 65806_794 NRTI NNRTI M41ML, L74V, Y115F Y181C V60I, K122E, D123S, I135T, T139TI, K166KR, E169ED, K173AV, Q174KR, D177EG, V179I, G196GE, T200A, I202V, Q207D, H221Y  
66026_837 66026_837 NRTI NNRTI M41L, D67N, M184V, L210W, T215Y A98G K49R, E53D, V60I, D121Y, K122E, I135V, D177E, I178M, T200I, E203EK, Q207N, R211K  
79260_1125 79260_1125 NRTI NNRTI M184V Y181C V60I, K122E, D123S, I135T, T139R, S162A, K173S, Q174K, D177E, I178L, V179I, T200A, Q207A, R211S, H221Y  
79266_473 79266_473 NRTI NNRTI D67G, K70R, Y115F, M184V, T215I, K219E  K49R, V60I, T69TN, K101R, D121H, K122E, D177E, G196E, T200A, Q207E E42V 
79268_702 79268_702 NRTI NNRTI M41L, M184V, T215FY A98G V118VI, K122E, D123N, I135V, T165I, K173S, D177E, V179I, T200A, I202IV, Q207A, R211K, F214FL, L228LR  
79272_265 79272_265 NRTI NNRTI M41ML, M184V, T215Y  S68SGR, V90VI, K122E, D123S, I135V, T139KR, S162AD, K173S, D177E, V179I, Q207A, R211S  
79275_288 79275_288 NRTI NNRTI   V60I, K122E, D123S, I135T, K173ST, Q174K, D177E, V179I, I202V, Q207D, R211S  
79293_830 79293_830 NRTI NNRTI M41L, D67N, M184V, T215Y  E44ED, I135V, S162A, K173E, Q174R, T200A, Q207E, R211K, D218E  
79295_657 79295_657 NRTI NNRTI L74V, Y115F, M184V K103N, G190A, F227L S48T, V60I, S68N, K122E, D123N, E138A, S162C, K173T, Q174K, T200A, Q207QE, R211K, F214L, H221Y  
79298_572 79298_572 NRTI NNRTI D67N, K70R, L74LI, M184V, K219Q  K64Y, K122KE, K173A, Q174K, D177E, I178M, E203K, Q207E, R211K, F214FL, L228LH D218DGNS 
79303_659 79303_659 NRTI NNRTI M41ML, D67N, K70R, M184V, T215F, K219Q A98AG, K101E S48E, V60I, T69N, I94IL, K122E, D123S, I135R, K173A, Q174K, D177E, I178L, T200A, Q207E, H208HY, R211K, D218DE  
79304_272 79304_272 NRTI NNRTI D67N, T69D, K70R, L74LI, M184V, K219H  K43E, I94L, K122E, D123N, S162C, D177E, T200A, E203K, Q207K, L210I, R211K, K223KR  
79336_1066 79336_1066 NRTI NNRTI L74V, Y115F, M184V V106M, V179D K46KQ, S48T, K103R, S117T, K122E, D123S, I135T, I142V, T165I, K173T, Q174R, T200A, I202V, Q207E, R211K, F214L, H221Y  
79338_1151 79338_1151 NRTI NNRTI L74V, Y115F, M184V, K219E K101KEGR, K103KN, Y181C S48T, V90VI, K122E, D123S, S162C, K166KR, K173A, Q174K, D177E, V179I, E194D, Q197K, T200A, I202V, Q207E, H221Y  
79339_468 79339_468 NRTI NNRTI D67N, K70R, M184V, T215TI, K219EQ  S48T, T69TA, K102KQ, K122E, D123G, I135IT, S162A, I167IV, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K  
79341_905 79341_905 NRTI NNRTI M184MV  S48T, K122E, D123G, K173A, D177E, T200A, Q207E, R211K  
79342_1021 79342_1021 NRTI NNRTI   S48T, V60I, K122E, D123DG, S162SN, T165TI, K173A, Q174K, D177E, T200A, Q207E  
79353_274 79353_274 NRTI NNRTI D67NS, K70R, Y115YF, M184V, T215F, K219E  K43KR, K122E, D123N, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S  
79359_417 79359_417 NRTI NNRTI L74V, Y115F, M184V K103N, P225H V60I, D121DY, K122E, I135L, E138G, D177E, T200L, Q207E, R211K  
79369_239 79369_239 NRTI NNRTI M184V K103N, V108I V60I, V90VI, D121H, K122E, I135T, K173S, Q174K, D177E, V179I, T200A, E203D, Q207A, R211S, L228R  
79379_259 79379_259 NRTI NNRTI M184V  K122E, D123N, A158S, K173S, T200A, Q207A, R211S  
79381_287 79381_287 NRTI NNRTI  K103N V60I, V90VI, K122E, D123S, E138EQ, I142V, T165TI, K173AS, I178L, T200A, Q207A, R211N  
79382_297 79382_297 NRTI NNRTI M184MV K103N, P225H V60I, A98S, K122E, D123S, I135T, K173S, V189VI, T200A, Q207A, R211S, F214L  
79399_1056 79399_1056 NRTI NNRTI L74V, Y115F, M184V Y181I K122E, D123N, I135IT, K173S, D177G, V179I, T200A, I202V, Q207A, R211K, H221Y  
79402_1096 79402_1096 NRTI NNRTI L74V, Y115F, M184V Y181C S48T, K122E, D123GS, I135T, I142IT, T165TI, K173KT, Q174R, D177E, I178L, V179VI, T200A, E203EG, Q207E, R211RK, F214FL, H221HY, D237DN  
79403_933 79403_933 NRTI NNRTI L74V, Y115F, M184V K103KN, V179VDE, P225H V60I, K122E, D123S, S134SN, I135T, E138G, T139TM, S162A, K173S, Q174K, I178IL, T200A, Q207A, R211S, F214L L228C 
79432_368 79432_368 NRTI NNRTI D67N, K70R, M184V, K219Q  S48T, V60VI, T69TN, K102KR, K122E, D123G, K173A, D177E, T200A, E203K, Q207E  
79436_268 79436_268 NRTI NNRTI M41ML, D67DN, K70KR, M184V, T215F, K219KEQ  K49R, V60VI, K122KE, D123DN, I135IM, K173S, Q174K, D177E, V179I, T200A, Q207A  
79438_287 79438_287 NRTI NNRTI  K103N V60I, V90VI, K122E, D123S, I142V, K173S, I178L, T200A, Q207A, R211N  
82852_221 82852_221 NRTI NNRTI K65R, Y115F, M184V K103N, Y181C S48T, K122E, D123S, K173A, Q174K, D177E, I202V, Q207K, R211K, F214L  
82861_256 82861_256 NRTI NNRTI M41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219E  E44D, S48T, V60I, K102Q, K122E, D123S, I135IT, T139TI, S162C, D177E, I178L, G196GE, T200A, E203K, Q207D, R211K  
82862_229 82862_229 NRTI NNRTI D67N, K70R, M184V, T215F, K219E A98G S48T, V60I, K122E, D123S, I135T, I142V, K173A, Q174K, I178L, T200A, E203K, Q207E, R211K  
82863_276 82863_276 NRTI NNRTI M41L, D67N, K70R, L74LI, M184V, L210L*W, T215F, K219E A98G S48T, V60I, K122E, S162Y, K173T, Q174K, N175NY, D177E, T200A, E203EA, Q207E, R211K, F214L R72RT 
82878_290 82878_290 NRTI NNRTI  K103N S48T, V118I, K122E, D123N, I135T, E138A, K173T, Q174K, G196E, T200A, E204Q, Q207E, F214L  
83604_847 83604_847 NRTI NNRTI Y115F, M184V, T215F  K49R, V60I, D121Y, K122E, I135V, T139AV, D177E, I178M, T200I, Q207E, R211K  
83605_989 83605_989 NRTI NNRTI D67N, K70R, M184V, T215Y, K219E A98AG S68SG, K122E, D123S, S162SDGN, T165TI, K173S, D177E, V179I, I195L, G196K, T200A, I202V, Q207A  
83615_1014 83615_1014 NRTI NNRTI K65R, D67N, M184V, K219E V179D, Y181C K49R, V60I, K102Q, K103R, K122E, D123N, I135V, N175NH, D177E, T200I, E204Q, Q207E, R211K  
83622_185 83622_185 NRTI NNRTI D67DN, K70KR, M184V K103N V60I, D121Y, K122E, D177E, I178M, Q207DE, R211K, L228LR K173K*ST 
83645_290 83645_290 NRTI NNRTI M184MV K103N, P225PH S48T, S68SG, V118I, D121DH, K122E, D123DN, I135T, E138A, K173T, Q174K, I178L, G196E, T200A, E204Q, Q207E, F214L, L228LR