| Subject | Isolate | NRTIs | NNRTIs | NRTI Mut | NNRTI Mut | Common | Unusual |
|---|
| CO0041V3 | CO0041V3 | None | None | | | V35T, E36A, T39E, S48T, V60I, K122E, I135T, K173A, D177E, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A, Q334H, G335D, R356K, G359T, T377Q, K390R, A400T, E404D, E432D, V435A, A437V, V458I, V466I, D471E, H483Q, L491S, S519N, K530R, A534S, V548I, A554S | |
| CO0053V5 | CO0053V5 | None | None | | | V35T, E36A, T39E, S48T, D121H, K122E, D123E, I135T, K173A, D177E, T200A, Q207A, R211K, V245Q, A272P, E291D, V292I, I293V, Q334N, R356K, G359T, T377M, K390R, A400R, T403A, E404D, K431T, V435A, L452M, V466I, V467I, S468T, T470N, D471E, H483Q, L491S, K527Q, A534S, A554S | |
| CO0077V1 | CO0077V1 | None | None | | | V35T, E36A, T39E, S48T, K122E, T139A, A158S, K173T, Q174K, D177E, T200A, Q207E, R211K, V245L, K249Q, D250E, A272P, K277R, E291D, V292I, I293V, P294V, Q334H, G335E, R356K, G359T, T377L, T386V, K390R, A400T, E404D, V435A, F440Y, L452I, V466I, D471E, H483Q, L491S, S519N, K527T, K530R, A534S, A554S | |
| CO0098V3 | CO0098V3 | None | None | | | V35T, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, G196E, T200A, Q207A, R211S, V245E, D250E, A272P, K275R, V276I, T286A, E291D, I293V, E297K, E312D, G335D, M357K, G359S, T369A, A371V, I375V, A376V, A400T, T403M, E404D, E432D, V435A, R461K, D471E, Q480H, H483Y, L491S, E514D, S519N, Q524K, K527E, E529D, A534S, A554S | |
| CO0260V5 | CO0260V5 | None | None | | | V35T, E40D, V60I, D121H, K122E, D123S, T165I, K173L, Q174K, D177E, V179I, T200A, Q207A, R211S, E248D, T286A, E291D, V292I, I293V, P294T, E312D, V317A, G335D, R356K, M357K, G359S, T369A, I375V, A376V, T377M, T386A, A400T, T403M, E404D, E432D, V435A, A446S, D471E, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527G, E529D, A534S, A554S, V559I | |
| CO0272V4 | CO0272V4 | None | None | | | P4Q, K11I, V35T, K122E, I135T, K173S, D177E, V179I, I202V, Q207A, R211S, F214L, V245K, L283I, E291D, I293V, P294T, L295M, E312D, I329V, G335D, R356K, M357R, G359S, A371V, I375V, A376V, T377M, K395R, A400T, E404D, E432D, V435E, A437V, F440Y, D471E, Q480H, H483L, L491S, Q507H, K512R, L517I, S519N, Q524K, K527E, E529D, A534S, A554S | |
| CO0329V1 | CO0329V1 | None | None | | | V35T, T39L, K122E, D123S, K173S, Q174K, D177E, V179I, T200I, Q207A, R211S, V245M, A272P, T286A, E291D, V292I, I293V, P294T, E312D, G335D, M357R, G359S, T369A, A371V, I375V, A376V, T377L, K390R, A400T, E404D, E432D, D471E, Q480H, L491S, L503I, S519N, Q524K, K527G, E529D, L533M, A534S, A554S | |
| CO0330V4 | CO0330V4 | None | None | | | V35T, V60I, K122E, D123S, I135T, S162Y, K173S, Q174K, D177E, I178M, V179I, T200A, Q207A, E248D, D250E, K281R, T286A, E291D, V292I, I293V, E312D, V317A, G335D, M357Q, G359S, A371V, K374R, I375V, A376S, T377I, K390R, A400T, T403M, E404D, E432D, V435A, N447S, V466VI, D471E, Q480H, L491S, S519N, Q524K, K527G, E529D | |
| CO0335V1 | CO0335V1 | None | None | | | V35T, E40D, V60I, D121H, K122E, I135T, I142T, D177E, I178M, R199RK, Q207G, R211K, V245E, D250E, A272P, K277R, L282C, I293V, Q334K, G335D, P345Q, F346Y, R356K, T369A, K374R, A376I, T377Q, S379C, K390R, A400T, S468T, L469I, H483N, L491S, A502V, A534S, A554N, V559I | |
| CO0377V4 | CO0377V4 | None | None | | | V35T, T39E, E40D, S48T, D86DG, K104R, V118I, K122E, D123N, E138A, K173I, Q174K, V179VA, T200A, Q207E, R211K, F214L, P243T, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, D320DN, Q334H, G335D, R356K, G359T, T377L, T386I, K390R, A400T, E404D, E432D, V435A, A446S, L452I, R461K, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531I, A534S, A554S | |
| CO0434V7 | CO0434V7 | None | None | | | V35I, V60I, K64R, D121Y, K122E, D123G, I135T, K173L, Q174K, D177E, V179I, Q207A, R211S, D250E, A272P, K275R, V276I, T286A, E291D, V292I, I293V, P294T, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E404D, V435I, R463K, D471E, Q480H, H483L, L491S, K512R, S519N, Q524K, K527G, E529D, A534S, A554S | L193L* |
| CO0439V5 | CO0439V5 | None | None | | | V35T, V60I, K122E, D123E, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, D250E, K281R, T286A, V292T, I293V, P294T, I326V, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377M, T386S, A400T, T403M, E404D, E432D, V435I, V466I, T470I, D471E, Q480H, H483Y, L491S, K512R, Q524K, K527E, E529D, A534S, A554S | |
| CO0543V2 | CO0543V2 | None | None | | | V21I, V35T, V60I, D123S, I135T, S162H, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245I, E248D, D250E, T286A, E291D, V292I, I293V, E312D, G335D, M357K, G359S, K366R, A371V, I375V, A376T, T377L, K388R, A400T, T403M, E404D, E432D, V435I, V458I, D471E, Q480H, L491S, S519N, Q524K, K527G, E529D, A534S, A554S, K558R | |
| CO0694V7 | CO0694V7 | None | None | | | V35T, T39E, E40D, S48T, K104R, V118I, D123N, E138A, K173I, Q174K, P176S, T200A, Q207E, R211K, F214L, P243T, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377L, T386I, K390R, A400T, E404D, E432D, A446S, L452I, R461K, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531I, A534S, A554S | |
| CO0735V4 | CO0735V4 | None | None | | | V35T, E40D, K49R, V60I, K122E, D123S, S162H, K173T, T200A, E204K, Q207E, R211K, P243T, V245S, A272P, K277R, E291D, V292I, I293V, P294T, D324E, Q334N, G335D, R356K, G359T, K366R, T377Q, S379C, K390R, E399D, A400T, T403M, E404D, K431R, E432D, V435I, L452I, S468T, T470V, H483K, L491S, S519N, K527N, K530R, A534S, A554S | E42K |
| CO0778V2 | CO0778V2 | None | None | | | V35T, K49R, V60I, D121Y, K122E, I135R, S162N, K173A, D177E, T200A, E204K, Q207E, R211K, V245Q, D250E, K277R, L282C, L283I, T286A, I293V, D324E, Q334R, G335D, T338TA, P345Q, F346Y, R356K, M357T, A360V, T377Q, T386P, K390R, A400T, D471N, H483N, L491S, E492T, A534S, A554N, V559I | N137S |
| CO0783V0 | CO0783V0 | None | None | | | K11E, V35T, T39S, V60I, R83K, D121H, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, Q207A, R211S, V245E, D250E, K281R, T286A, E291D, V292I, I293V, P294T, E312D, G335D, M357K, G359S, K366R, T369A, I375V, A376V, T377M, A400T, T403M, E404D, E432D, V435A, S468P, D471E, Q480H, H483Y, L491S, Q509H, K512R, E516G, S519N, Q524K, K527E, E529D, A534S, A554S | |
| CO0815V3 | CO0815V3 | None | None | | | V35T, T39E, E40D, D121Y, K122E, D123G, I135R, S162C, D177E, T200A, Q207E, R211K, V245Q, A272P, I274V, Q278N, T286A, E291D, V292I, I293V, Q334H, G335D, F346Y, R356K, G359T, K366R, T377L, K390R, A400T, E404D, V417I, P421H, A446S, L452V, V466I, H483Q, L491S, S519N, K530R, A534S, A554S | Q340QP |
| CO0844V2 | CO0844V2 | None | None | | | E6K, V35T, E36A, T39E, S48T, K122E, I135M, K166R, K173A, D177E, T200A, Q207E, R211K, V245K, D250E, A272P, K275R, K277G, T286A, E291D, I293V, G333E, M357K, G359S, T369A, A371V, I375V, A376V, T377M, T386A, K390R, A400T, T403A, E404D, E432D, V435A, D471E, Q480H, L491S, K512R, L517I, S519N, Q524K, K527E, E529D, A534S, A554S, V559I | |
| CO0907V4 | CO0907V4 | None | None | | | V35T, E40D, K49R, I50V, V60I, D123E, I135T, K173S, Q174K, D177E, V179I, T200K, Q207A, R211K, V245I, D250E, K281R, L283I, T286A, E291D, I293V, P294T, L295M, K311R, E312D, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E404D, V435I, S468P, L469F, H483N, A554Q | |
| CO0921V2 | CO0921V2 | None | None | | | V35T, E36A, T39E, S48T, V60I, I135V, K173A, D177E, Q197E, T200A, Q207E, R211K, V245Q, E248D, D250E, K277R, K281R, E291D, I293V, Q334N, G335D, R356K, G359A, T369S, T377M, K390R, T397V, A400T, E404D, E432D, L452I, V466I, S468P, D471E, H483Q, L491P, S519N, K530R, A534S, V548I, A554S | |
| CO0984V2 | CO0984V2 | None | None | | | V35T, E36A, T39E, S48T, K122E, D123N, I135V, S162C, K173T, Q174K, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, I293V, Q334N, G335D, R356K, G359T, T377M, K390R, E396D, A400T, E404D, V435A, A437V, K451R, V466I, V467I, S468H, D471E, H483Q, L491S, S519N, I526V, K530R, A554N | |
| CO3016V6 | CO3016V6 | None | None | | | V35T, K49R, I50V, V60I, D121Y, K122E, I142T, Q207E, F214L, V245Q, D250E, A272S, K277R, T286A, I293V, Q334H, G359S, A371V, A376S, K390R, A400T, T403I, E404D, V435T, L452I, R461K, V466I, V467I, S468T, D471E, H483Q, L491S, K527N, K530R, A534S, A554S | |
| CO3022V7 | CO3022V7 | None | None | | | V35T, T39E, S48T, V60I, K122E, D123S, I135T, K173I, Q174K, D177N, T200A, Q207E, R211K, F214L, V245M, E248D, D250N, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, P345Q, M357K, G359S, K366R, A371V, I375V, A376V, T377M, T386A, A400T, E404D, E432D, D471E, Q480H, L491S, S519N, K527N, A534S, A554S | |
| CO3058V6 | CO3058V6 | None | None | | | V35T, E40D, D121Y, K122E, I135T, S162C, K173S, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, K311R, G335D, F346H, R356K, G359T, T377L, V381I, K390R, E404D, V435I, R461K, V466I, V467I, D471E, H483K, L491S, S519N, K530R, A534S, A554N | |
| CO3063V5 | CO3063V5 | None | None | | | V35T, E36A, T39D, S48T, K122E, D123S, K166R, K173A, D177E, I195L, G196K, T200A, Q207D, R211K, T240A, V245Q, D250E, S251D, A272P, K277R, T286A, E291D, V292I, Q334G, G335D, R356K, M357I, G359T, T377M, I380V, K388R, K390R, A400T, E413D, I434M, V435I, A437V, E449D, L452M, D471E, Q480H, H483Q, L491S, S519N, K530R, A534S, A554S | |
| CO3083V4 | CO3083V4 | None | None | N348I | | V35T, V60I, K122E, D123S, I135T, E138A, I142V, K173S, Q174K, V179I, I202V, Q207A, R211S, F214L, V245E, E248K, D250E, A272P, T286A, E291D, V292I, I293V, P294T, L295M, E312D, G335D, M357K, G359S, E370D, A371V, I375V, A376V, T377M, A400T, T403V, E404D, W410C, E432D, V435E, R461K, D471E, Q480H, L491S, K512R, E514D, S519N, Q524K, K527G, E529D, A554S | P4R |
| CO3103V3 | CO3103V3 | None | None | | | V35T, E40D, K49R, V60I, D121Y, K122E, D123E, I135T, S162SN, E169D, K173A, Q174K, D177E, I178V, G196K, T200A, I202V, Q207QEGR, R211K, V245M, D250E, S251N, A272P, K277R, L282C, T286A, I293V, L310I, G335D, R356K, G359T, T386I, K390R, A400T, E404D, V435I, A446S, L452I, K454R, D471E, H483Q, L491S, S519N, K530R, A534S, A554S | |
| CO3168V4 | CO3168V4 | None | None | | | V35T, T39E, S48T, K122E, D123S, K173A, D177E, T200A, Q207E, V245Q, E248N, A272P, K277R, E291D, V292I, I293V, S322A, Q334H, G335D, R356K, G359S, K366R, A376V, T377Q, T386A, K390R, A400T, E404D, I434L, V435A, A437I, L452I, V466I, S468T, D471E, H483Q, L491S, S519N, K527Q, K530R, A534S, A554S | |
| CO3256V2 | CO3256V2 | None | None | | | K20R, V35T, K49R, V60I, K122E, D123G, I135M, K166R, K173A, D177E, T200A, Q207E, R211K, V245Q, D250E, Y271F, A272P, Q278H, T286A, E291D, V292I, I293V, G335D, R356K, M357K, G359S, K366R, T369A, A371V, I375V, A376I, T377M, T386A, K390R, A400T, T403A, E404D, E432D, V435A, A446S, D471E, Q480H, L491S, K512S, S519N, Q524K, K527G, E529D, A534S, A554S | G273R |
| CO3278V6 | CO3278V6 | None | None | | | V35T, E36A, T39D, S48T, K122E, D123G, I135T, T165I, K173T, T200A, Q207E, R211K, F214L, V245K, A272P, K277R, T286A, E291D, V292I, I293V, K311R, Q334N, G335D, R356K, G359T, V365I, T377V, K390R, E396D, T397I, A400T, E404D, V435A, R461Q, L469I, D471E, T477A, H483Y, L491S, L517S, S519N, K527S, K530R, A534S, A554R | |
| CO3301V1 | CO3301V1 | None | None | | | V35T, T39N, E40D, V60I, K122E, D123N, I135T, I142V, K173A, Q174K, D177E, I178M, V179I, G196S, Q197K, Q207A, R211S, V245I, D250E, T286A, E291D, V292I, I293V, E297K, L301F, E312D, V317A, I329V, G335D, M357Q, G359S, A371V, T377M, K390R, A400T, T403M, E404D, E432D, V435A, S468P, D471E, Q480H, L491P, I505V, K512R, S519N, Q524K, K527G, E529D, L533M, A534S, A554S | |
| CO3326V4 | CO3326V4 | None | None | | | V35T, E36A, T39A, V60I, K122E, D123S, I135T, S162C, K173A, Q174K, D177E, V179T, T200A, Q207A, R211S, K281R, T286A, E291D, V292I, I293V, P294T, E312D, A327V, G335D, M357R, G359S, T369A, A371V, I375T, T377M, T386A, K395R, A400T, T403M, E404D, E432D, V435A, D471E, Q480H, H483Y, L491S, K512R, L517I, S519N, Q524K, K527G, E529D, A534S, A554S | |
| CO3337V2 | CO3337V2 | None | None | | | V35T, E40D, K49R, V60I, K122E, D123N, D177E, I178M, T200I, Q207G, R211K, V245M, E248N, A272P, T286A, E291D, V292I, I293V, G335D, F346H, R356K, M357R, G359T, T377M, T386I, K390R, A400T, L469I, H483N, L491S, S519N, A534S, A554K, I556V | I132IT |
| CO3365V2 | CO3365V2 | None | None | | | V21I, V35T, T39A, E40D, V60I, D121H, I135T, K173L, Q174K, D177E, V179I, T200I, Q207E, R211K, V245E, E248D, D250E, K275Q, T286A, V292I, I293V, E297K, L325I, G335D, M357K, G359S, T369A, E370G, A371V, I375V, A376V, T377M, A400T, T403M, E404D, E432D, R463K, D471E, Q480H, L491S, K512R, E514D, S519N, Q524K, K527A, E529D, A534S, A554S | |
| CO3415V1 | CO3415V1 | None | None | | | T27S, V35T, E36A, T39E, S48T, K122E, D123S, E138A, S162C, K173A, D177G, T200A, E203D, Q207E, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, K311R, I329IL, Q334S, G335D, R356K, G359T, I375V, K390R, A400T, E404D, V435A, A437I, L452I, R461K, V467I, S468T, D471E, H483K, L491S, A508G, S519N, K527N, A534S, A554S | |
| CO3426V5 | CO3426V5 | None | None | | | V35T, E36A, T39E, S48E, K104R, E138A, T139I, K173A, Q174K, I202V, R211K, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, L310I, Q334H, G335D, G359T, S379G, T386I, K390R, A400T, E404D, V417I, V435A, V466I, S468P, D471E, H483K, L491S, S519N, K530R, A534S, A554S | |
| CO3440V7 | CO3440V7 | None | None | | | V35T, T39E, S48T, K104R, K122E, K173T, D177E, Q207E, R211K, V245Q, D250E, A272S, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377Q, S379C, K390R, A400T, E404D, V435A, L452I, V458I, D471E, Q480H, H483Q, L491S, S519N, K527G, K530R, A534S, V548I, A554S | Q91R |
| CO3468V1 | CO3468V1 | None | None | | | P4S, V35T, E36D, K49R, V60I, D121H, I135T, I178M, I195T, T200I, Q207G, R211K, V245K, D250E, A272P, I274V, K281R, L282C, E297A, G335D, P345Q, F346Y, R356K, R358K, G359S, A360T, T377Q, S379C, K385R, K390R, A400T, R461RK, S468P, L469I, D471E, H483S, L491S, L517I, S519N, K530R, A534S, A554N, V559I | |
| CO3473V1 | CO3473V1 | None | None | | | V35T, E36A, T39E, S48T, D121Y, K122E, I135T, I159V, K173S, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, I293V, Q334H, G335D, R356K, G359T, T377Q, K390R, A400T, E404D, E432D, V466I, S468T, D471E, Q480H, L484I, L491S, S519N, E529D, A534S, A554S, K558R | |
| CO3504V7 | CO3504V7 | None | None | | | V35T, K49R, K122E, D123S, I135T, K173A, Q174K, D177E, I178M, V179I, Q207A, V245M, E248D, D250E, A272P, T286A, E291D, V292I, I293V, P294T, E312D, G335D, M357Q, G359T, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E404D, E432D, V442A, D471E, Q480H, H483Y, L491S, S519N, Q524K, K527G, E529D, A534S, A554S, K558R | |
| CO3589V1 | CO3589V1 | None | None | | | V35T, E36A, T39E, E40D, S48T, D121Y, K122E, K173A, Q174K, D177E, T200A, Q207E, V245K, A272P, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, G359S, I375V, T377L, K390R, A400T, E413D, I434L, V435G, A437V, L452A, R461K, V466I, V467I, D471E, T477A, H483Q, L491S, S519N, K530R, A534S, V548I, A554S | |
| CO3637V5 | CO3637V5 | None | None | | | V35T, T39E, S48T, K122E, D123G, I135T, I142V, S163T, K173A, D177G, T200A, Q207D, R211K, V245Q, E248D, A272S, K281R, E291D, V292I, I293V, E297Q, Q334N, G335D, R356K, G359S, K390R, A400S, E404D, F416Y, V435A, V466I, D471E, Q480H, H483Q, L491S, Q524E, K530R, V531I, A534S, A554N | |
| CO3651V7 | CO3651V7 | None | None | | | V35T, E36A, T39E, E40D, S48T, K122E, D123G, S162C, K173A, Q174K, D177E, G196E, T200V, Q207E, V245Q, A272S, T286A, E291D, V292I, I293V, K311R, Q334H, G335D, R356K, R358K, G359H, K374Q, T377R, K390R, A400T, E404D, E432D, V435A, A437V, L452I, V466I, T470P, D471E, T477A, H483Q, L491V, S519N, K530R, A534S, A554K | |
| CO3672V4 | CO3672V4 | None | None | | A98G | T27S, V35T, E36A, T39E, S48T, K49R, K122E, D123N, S162C, K173A, Q174K, D177E, I178L, T200A, E203D, Q207E, R211K, P243S, V245Q, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, A376S, T377Q, S379C, K390R, E399G, E404D, V435I, L452M, V458I, R461K, V467I, D471E, H483Q, L491S, S519N, K530R, A534T, V548I, A554N | |
| CO3718V3 | CO3718V3 | None | None | | | P4H, K20R, V35T, T39A, V60I, K122E, D123S, I135T, I142V, K173A, Q174K, D177E, Q207A, R211S, F214L, V245M, D250E, T286A, E291D, I293V, P294T, E312D, V317A, G335D, Q336QR, M357K, G359S, K366R, T369A, A371V, I375V, A376V, T377M, T386A, A400T, T403M, E404D, V435A, D471E, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527S, E529D, V531I, A534S, A554S | |
| CO3728V2 | CO3728V2 | None | None | | | I2T, V35T, T39S, S48T, V60I, V118I, I135V, T139S, I142T, K173T, D177A, Q197E, T200A, Q207E, R211K, F214L, V245Q, E248D, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T369S, T377V, K390R, T397I, A400T, E404D, E432D, V435A, K451R, L452I, V466I, V467A, S468P, D471E, T477A, H483Q, L491P, S519N, K530R, A534S, V548I, A554R | R78RG |
| CO3800V5 | CO3800V5 | None | None | | | V35T, T39E, S48T, V60I, A98S, K122E, D123S, A158S, K173T, Q174K, T200A, Q207A, L228Q, A272S, V276I, T286A, E291D, V292I, I293V, P294T, Q334H, G335D, R356K, G359T, K366R, T377M, K390R, E396D, A400T, E404D, A446S, E449D, L452I, V466I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S | |
| CO3812V6 | CO3812V6 | None | None | | | V35T, E36A, T39E, S48T, K122E, E138A, T165I, K173T, T200A, Q207E, R211K, V245Q, A272P, I274V, K277R, T286A, E291D, I293V, P294A, Q334N, G335D, R356K, G359T, T369A, I375V, A376V, T377M, T386A, K390R, E396D, A400T, E404D, W410L, V435A, V466I, T470N, D471E, T477A, H483Q, D488E, L491S, V496I, K527N, K530R, A534S, A554S | |
| CO3817V2 | CO3817V2 | None | None | | | V35T, T39E, S48T, E53D, A98S, K122E, D123N, E138S, T139A, I142V, K166R, K173A, T200A, Q207D, R211K, V245Q, E248D, A272P, K277R, L283I, E291D, V292I, I293V, D324E, Q334H, G335D, F346H, R356K, G359T, T377I, K390R, A400T, E404D, S468T, L469M, H483N, L491S, S519N, K527N, K530R, V531I, A534S, A554N | |
| CO3873V1 | CO3873V1 | None | None | | | P4S, K20R, V35T, E36A, T39E, G45GE, S48T, V60I, D123S, S162H, M164MI, E169R, K173E, D177E, T200A, Q207E, R211K, V245K, A272P, K277R, E291D, V292I, I293V, Q334H, G335D, F346L, R356K, G359T, A376S, T377M, T386I, K390R, A400T, E404D, V435I, R461K, V466I, T470M, D471E, H483Q, L491P, S519N, K527N, K530R, A534S, A554S | |
| CO3878V2 | CO3878V2 | None | None | | | V35T, V60I, K122E, D123N, I135T, I142V, K173L, Q174K, D177E, V179I, Q207A, R211S, D250E, T286A, I293V, P294T, G335D, M357K, G359S, K366R, A371V, I375V, A376V, T377M, A400T, T403M, E404D, E432D, V435E, F440Y, R463K, S468T, D471E, Q480H, H483Y, L491A, K512R, S519N, Q524K, K527G, E529D, A554S, V559I | |
| CO3892V6 | CO3892V6 | None | None | | | V35T, E36A, T39E, S48T, K122E, D123S, K173T, D177E, T200A, Q207R, R211K, V245Q, E248N, A272P, E291D, V292I, I293V, V317A, Q334E, R356K, G359S, T377V, K390R, A400I, E404D, T409N, V435A, A437V, F440Y, E449D, D471E, H483Q, L491P, S519N, K530R, A534S, V548I, A554N | I309T |
| CO3969V6 | CO3969V6 | None | None | | | E6A, V35T, E36A, T39E, S48T, K122E, D123S, K166R, K173T, D177E, T200A, Q207D, R211K, V245I, D250E, A272S, K277R, K281R, T286A, E291D, V292I, I293V, G333E, Q334Y, R356K, G359T, A360T, A376S, T377L, K385R, T386V, K390R, E399D, A400T, E404D, V435G, F440Y, V466I, D471E, T477A, H483Q, L491P, E492D, S519N, L525M, K527Q, K530R, A534S, A554S | |
| CO3979V3 | CO3979V3 | None | None | | | T7TI, V35T, E36A, T39E, S48T, K122E, D123S, S162C, K166R, K173A, D177E, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359S, A376S, T377M, K390R, A400T, I434M, V435A, A437V, L452R, R461RK, V466I, D471E, T477A, I482V, H483Q, L491S, S519N, E529D, A534S, A554N | S468SY |
| CO6022V7 | CO6022V7 | None | None | | | V35T, E36A, T39E, E40D, S48T, K122E, D123S, A158S, S162A, K173A, D177E, T200A, E204K, Q207E, V245Q, A272P, K275Q, Q278H, T286A, E291D, V292I, I293V, Q334H, G335D, P345T, F346H, R356K, M357R, G359T, T377Q, K390R, E404N, A437V, R461K, S468T, D471E, H483K, L491S, S519N, K530R, A534S, A554S | |
| CO6033V4 | CO6033V4 | None | None | | | V35M, E36A, T39E, E44K, S48T, D86N, A98S, A158S, S162A, E169K, K173T, D177E, T200A, Q207E, R211K, V245Q, D250E, A272Q, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, T338S, R356K, G359T, K366R, Q373H, K390R, A400T, E404D, V435A, L452I, R463K, D471E, H483Q, L491S, D511N, L517I, S519N, E529D, A534S, D549N, A554S | G544E |
| CO6040V4 | CO6040V4 | None | None | | | V35M, E36A, T39E, S48T, A98S, A158S, S162A, K173T, D177E, T200A, Q207E, R211K, V245Q, D250E, A272Q, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, T338S, R356K, G359T, K366R, Q373H, T377I, K390R, A400T, E404D, V435A, L452I, D471E, H483Q, L491S, I505V, L517I, S519N, E529D, A534S, A554S | K73R, D192G, D488N |
| CO6041V3 | CO6041V3 | None | None | | | E6K, V35T, E36V, T39E, S48T, V60I, K102Q, K122E, D123G, K173A, D177E, T200A, Q207E, V245K, A272P, K277R, T286A, E291D, V292I, I293V, G335D, P345Q, F346H, R356K, M357Q, G359T, T377Q, K390R, A400T, E404D, E413D, V467I, L469I, H483N, S519N, K527N, K530R, A534S, A554S | |
| CO6095V1 | CO6095V1 | None | None | | | V35T, E40D, V60I, D121H, K122E, D123E, I135T, K173S, Q174K, V179I, T200R, Q207A, R211S, F214L, V245K, D250E, T286A, I293V, E312N, G335D, M357K, G359A, T369A, A371V, I375V, A376V, T377L, A400T, T403M, E404D, E432D, D471E, Q480H, L491S, K512R, L517I, S519N, Q524K, K527G, E529D, A534S, A554S | |
| CO6106V5 | CO6106V5 | None | None | | | V35T, E36A, T39E, S48T, K122E, K173A, D177E, G196R, T200V, Q207E, R211K, V245K, A272K, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377M, I380V, K390R, A400T, E404D, V435A, L452K, K454R, V466I, S468T, T470N, D471E, H483Q, L491S, L503I, S519N, K527N, A534S, A554S | |
| CO6139V7 | CO6139V7 | None | None | | | V35T, T39E, S48T, K122E, D123G, K173T, D177E, I178M, T200A, E204K, Q207E, E224K, V245Q, E248N, D250E, A272P, K277R, T286A, E291D, V292I, I293V, H315S, Q334H, G335D, R356K, G359S, T369A, T377R, K390R, A400T, E404D, I411L, V417I, V435A, F440Y, A446S, L452I, V466I, D471E, T477A, H483Q, L491S, S519N, K530R, A534S, V548I, A554S | |
| CO6146V7 | CO6146V7 | None | None | | | E28EK, V35T, E36A, T39E, S48T, K122E, D123G, A158S, K173A, D177E, T200A, Q207E, V245E, A272K, K277R, E291D, V292I, I293V, E300K, Q334H, G335D, R356K, G359S, K366R, T377Q, K390R, E404D, V435A, G436E, A437V, N447S, L452I, V466I, S468T, D471E, H483Q, L491S, L517I, S519N, A534S, V548I, A554S | |
| CO6161V5 | CO6161V5 | None | None | | | V35T, K49R, I50V, V60I, K122E, D123S, I135T, T139A, I142V, K173A, Q174K, D177E, I178M, V179I, Q207A, R211K, V245I, K275R, V276I, K277R, Q278H, T286A, E291D, V292I, I293V, P294T, E312D, I326V, G335D, M357K, G359S, A371V, I375A, T377M, A400T, E404D, E432D, V435A, K465R, D471E, Q480H, H483Y, L491S, K512S, E514D, S519N, Q524K, K527G, E529D, A534S, A554S | |
| CO6172V5 | CO6172V5 | None | None | | | V35T, T39E, S48T, K122E, D123N, I135T, K173E, Q174K, D177E, G196E, T200A, Q207D, F214L, V245Q, D250E, A272S, K277R, T286A, E291D, V292I, I293V, P294L, S322T, Q334H, G335D, E344D, R356K, G359T, T377L, K390R, E399D, A400I, E404D, E432D, V435A, A437V, D471E, Q480H, L491S, S519N, K530R, A534S, A554S | S3SN |
| CO6273V3 | CO6273V3 | None | None | | | E28D, V35T, V60I, K104R, D121H, K122E, I135T, E138A, I142T, T165I, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, E248D, A272P, K277R, L283I, T286A, E291D, I293V, Q334H, G335D, R356K, G359T, I375V, T377Q, T386I, K390R, A400T, T403M, E404D, E432D, S468P, D471E, K476KE, T477A, H483K, S519N, K527Q, K530R, V531I, A534S, A554N, K558R | |
| CO6273V4 | CO6273V4 | None | None | | | V35T, V60I, K65KE, K122E, D123N, I135T, E138A, I142T, T165I, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, A272P, K277R, L283I, T286A, E291D, I293V, Q334H, G335D, R356K, G359T, I375V, T377Q, T386I, K390R, A400T, T403M, E404D, E432D, V435E, S468P, D471E, T477A, H483K, L491S, S519N, K527Q, K530R, V531I, A534S, A554N, K558R | |
| CO6322V4 | CO6322V4 | None | None | | | V35T, E36A, T39E, S48T, D123E, I135T, E138A, S162C, K173A, D177E, T200V, Q207E, F214L, V245K, A272K, K277R, E291D, V292I, I293V, I329L, Q334D, G335D, R356K, G359T, V381I, K390R, A400T, E404D, V417VI, V435L, L452A, V467I, D471E, H483Q, L491S, E492Q, S519N, A534S, A554S | |
| CO6405V4 | CO6405V4 | None | None | | | V35T, E40D, I50V, V60I, V118I, D121C, K122E, I142V, Q207E, R211K, F214L, V245Q, P247A, A272ST, V317A, S322L, I326V, Q334N, G359S, A371V, I375V, A376C, K390R, E399D, A400T, T403V, V435I, A446S, S468P, L469F, H483N, S519N, A554Q | |
| CO6471V1 | CO6471V1 | None | None | | | V35T, T39K, S48T, V60I, K122E, D123S, I135T, K173V, Q174K, D177E, T200A, Q207E, V245Q, A272P, K277R, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, T386V, K390R, A400T, E404D, V435A, L452I, R461K, D471E, H483Q, L491S, S519N, K527Q, E529D, K530R, A534S, V548I, A554S | |
| CO6480V4 | CO6480V4 | None | None | | | E6D, V35T, E36A, T39E, S48T, V90I, K104R, K122E, A158S, K173A, Q174K, T200A, Q207D, R211K, V245Q, D250E, A272P, E291D, V292I, I293V, Q334H, G335D, A355S, R356K, G359T, T377L, S379C, K390R, E404D, V417I, V435A, L452M, V466I, V467I, S468A, T470N, D471E, H483K, L491S, S519N, K527N, K530R, A534S, A554S | G273R |
| CO6540V3 | CO6540V3 | None | None | | | E6K, K11Q, V35T, T39E, S48T, K122E, D123G, I135V, K173A, D177E, G196E, Q197K, T200A, Q207E, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, K390R, A400T, E404D, I434M, V435A, A437V, L452I, S468T, T470I, D471E, H483Q, L491S, S519N, K530R, A534S, A554R | |
| CO6545V3 | CO6545V3 | None | None | | | E6K, K11Q, V35T, T39E, S48T, K122E, D123G, I135V, K173A, D177E, G196E, Q197K, T200A, Q207E, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, K390R, A400T, E404D, I434M, V435A, A437V, L452I, S468T, T470I, D471E, H483Q, L491S, S519N, K530R, A534S, A554R | |
| CO6577V5 | CO6577V5 | None | None | | | K11R, V35T, T39I, E40D, V60I, D121Y, K122E, D123E, Q174R, D177E, Q207E, R211K, V245K, D250E, S251T, A272P, K275R, K277R, Q278H, L282C, I293V, P294S, G335D, P345Q, F346H, R356K, A360T, T377Q, S379C, K390R, A400T, V435M, S468P, L469F, H483N, S519N, V548I, A554Q | |
| CO6592V5 | CO6592V5 | None | None | | | V35T, T39M, V60I, K122E, D123N, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, V245K, D250E, K275Q, T286A, E291D, V292I, I293V, P294T, Q334H, G335D, R356K, M357R, G359T, A360T, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E404D, W410Y, E432D, A446S, D471E, Q480H, H483C, L491S, Q509T, S519N, Q524K, K527E, E529D, A554F | |
| CO6631V3 | CO6631V3 | None | None | | | K20R, V35T, E36A, T39E, E40D, S48T, K122E, D123E, T165I, K173A, G196E, Q197K, T200A, Q207E, V245Q, E248D, A272P, K277R, E291D, V292I, I293V, E297R, S322A, Q334N, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435P, V466I, D471E, H483Q, G490E, L491S, S519N, V531I, A534T, A554S | P421A |
| CO6637V7 | CO6637V7 | None | None | | | V35T, K43R, V60I, T69I, K122E, D123N, I135T, K173L, Q174K, D177E, V179I, T200E, I202V, Q207A, R211S, F214L, V245K, D250E, A272P, K277R, T286A, E291D, V292I, I293V, K311R, E312N, D324E, G335D, R356K, M357K, G359S, T369A, A371V, I375V, A376V, T377M, T386S, E399D, A400T, T403M, E404D, E432D, V435A, R461K, D471E, Q480H, H483L, L491S, L503M, K512R, S519N, Q524K, K527G, E529D, A534S, A554N, K558R | |
| CO6644V2 | CO6644V2 | None | None | | | V35T, E36A, T39E, S48T, K102KR, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245K, A272K, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, K366R, Q367L, A371V, I375V, T377M, S379C, K390R, E404D, V435A, L452I, V466I, S468T, T470N, D471E, H483Q, L491S, L517I, S519N, A534S, V548I, A554S | |
| CO6647V5 | CO6647V5 | None | None | | | V35T, E36A, T39E, S48T, K122E, D123G, S162C, K166R, K173A, D177E, T200A, I202V, Q207E, V245Q, A272P, E291D, V292I, I293V, G335D, F346H, R356K, G359T, K366R, T377M, K390R, E404D, V435A, A437V, A446S, L452M, V466I, D471E, H483K, L491S, S519N, K530R, A534S, A554N | |
| CO6650V1 | CO6650V1 | None | None | | | K11R, V35T, E40D, V60I, D121Y, K122E, D123E, Q174R, D177E, Q207E, R211K, V245K, D250E, S251R, A272P, K275R, K277R, Q278H, L282C, I293V, P294S, G335D, P345Q, F346H, R356K, A360T, T377Q, S379C, K390R, A400T, V435M, A437V, S468P, L469F, H483N, S519N, V548I, A554Q | |
| CO6728V5 | CO6728V5 | None | None | | | V35T, E36A, T39E, S48T, K173R, V179I, T200A, Q207E, V245I, A272S, T286A, I293V, P294T, Q334H, G335D, R356K, G359T, A371V, T377M, K390R, E396D, A400T, E404D, Y405C, E432D, L452I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, V548I, A554N | |
| CO6763V2 | CO6763V2 | None | None | | | V35T, E36A, T39E, S48T, K102R, K122E, D123S, K173A, D177E, T200A, Q207E, P243H, V245Q, A272S, K281R, T286A, E291D, I293V, G335D, R356K, G359S, K366R, T369A, A376T, T377M, K390R, K395R, A400T, E404D, L452I, R461K, V466I, D471E, H483Q, L491S, S519N, K530R, A534S, A554Q | |
| CO6785V5 | CO6785V5 | None | None | | | V35T, E36A, T39E, S48T, K49R, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245K, A272K, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, R358K, G359T, K366R, Q367M, L368V, T377M, S379C, K390R, E404D, V435A, L452I, V466I, S468T, T470N, D471E, H483Q, L491S, L517I, S519N, A534S, V548I, A554K | |
| CO6811V5 | CO6811V5 | None | None | | | V8I, T27A, V35T, E36A, T39E, S48T, K102Q, K122E, D123G, K173M, Q174K, T200A, Q207E, V245K, A272P, I274V, Q278H, T286A, E291D, V292I, I293V, G335D, F346H, R356K, G359T, T377Q, S379C, K390R, A400T, E404D, E413D, V435A, R461K, D471E, H483K, S519N, K527Q, K530R, A534S, A554N, V559I | |
| CO6812V3 | CO6812V3 | None | None | | | V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135T, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, M357V, G359T, T377M, K390R, A400T, E404D, V435A, A437V, L452I, V466I, D471E, T477A, H483Q, L491S, S519N, V531I, A534S, A554K | |
| CO6830V7 | CO6830V7 | None | None | | | V35T, T39M, K122E, D123S, I135T, T165I, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, V245K, D250E, A272T, K277R, T286A, E291D, V292I, I293V, P294T, G335D, R356K, M357R, G359S, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E404D, W410Y, E432D, A446S, D471E, Q480H, H483Y, L491S, Q509I, S519N, Q524K, K527G, E529D, A554S | |
| CO6838V1 | CO6838V1 | None | None | | | V35T, E36A, T39E, S48T, K122E, D123G, I135T, K166R, K173A, D177E, G196R, T200A, Q207E, R211K, V245Q, A272K, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377M, K390R, E404D, V435A, L452I, V466I, S468T, D471E, H483Q, L491S, S519N, A534S, A554S | T472I |
| CO6847V7 | CO6847V7 | None | None | | | V35T, E36A, T39E, S48T, K122E, D123G, A158S, K173A, D177E, T200A, Q207E, R211K, V245K, A272K, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, K366R, V381I, K390R, L422I, V435A, A437V, N447S, L452I, V466I, S468T, D471E, H483Q, L491S, L517I, S519N, A534S, V548I, A554S | |
| CO6854V1 | CO6854V1 | None | None | | | P4S, V21I, V35T, E36A, T39E, S48T, K122E, D123N, K173T, Q174K, T200A, Q207E, V245K, A272S, T286A, E291D, V292I, I293V, P294T, R307K, Q334H, G335D, R356K, G359T, A376T, T377M, T386A, K390R, E396D, A400T, E404D, L452A, R461K, V466I, S468T, D471E, T477A, H483Q, G490E, L491S, S519N, K527N, K530R, V531I, A534S, I542V, A554S | |
| CO6867V2 | CO6867V2 | None | None | | | V35T, T39K, S48T, K122E, A158S, K173T, D177E, T200A, Q207E, V245Q, D250E, A272P, K277R, L283I, T286A, E291D, I293V, Q334H, G335D, P345T, F346H, R356K, G359T, T377Q, K390R, E404D, E432D, V435A, A437I, L452M, D471E, H483K, L491S, S519N, K527N, E529K, K530R, A534S, A554N | |
| CO6917V7 | CO6917V7 | None | None | | | V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135T, K173A, D177E, T200A, Q207E, V245L, A272P, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, M357ML, G359S, K366R, Q373H, T377M, K390R, A400T, E404D, V435A, L452I, V466I, V467I, D471E, H483Q, L491S, Q509H, L517I, S519N, K527R, K530R, A534S, A554S | |
| CO6952V1 | CO6952V1 | None | None | | | K11R, V35T, E40D, V60I, D121Y, K122E, D123DE, Q174R, D177E, Q207E, R211K, V245K, D250E, A272P, K275R, K277R, Q278H, L282C, I293V, P294S, G335D, P345Q, F346H, R356K, A360T, T377Q, S379C, K390R, A400T, V435M, A437V, S468P, L469F, H483N, S519N, V548I, A554Q | T7M |
| CO6974V7 | CO6974V7 | None | None | M41L | | E6D, V35T, E40D, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, Q207D, R211S, V245E, D250E, T286A, E291D, V292I, I293V, E312N, S322A, G335D, A355T, M357K, G359S, T369A, A371V, I375V, A376I, T377M, A400T, T403M, E404D, E432D, V435T, A437V, L452Q, T470N, D471E, Q480H, H483Y, L491S, K512R, E514D, S519N, Q524K, K527E, E529D, A534S, A554S, V559I | |
| CO6975V2 | CO6975V2 | None | None | | | V8I, T27A, K32Q, V35T, E36A, T39E, S48T, K102Q, K122E, D123G, K173T, Q174K, T200A, Q207E, V245K, A272P, I274V, Q278H, T286A, E291D, V292I, I293V, G335D, F346H, R356K, G359T, T377Q, S379C, K390R, A400T, E404D, E413D, V435A, L452I, R461K, D471E, H483K, L491S, S519N, K527Q, K530R, A534S, A554S | |
| CO6980V0 | CO6980V0 | None | None | K70N | | V35T, E36A, T39E, K43R, S48T, K102Q, D121Y, K122E, K173T, Q174K, D177E, T200A, Q207E, V245Q, E248D, A272P, K275R, V276I, K277R, K281R, E291D, V292I, I293V, P294T, Q334H, G335D, R356K, R358K, G359T, Q367M, I375V, T377M, K390R, E404D, L452K, V458I, D471E, H483Q, L491S, S519N, A534S, V548I, A554S | |
