<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Billings (2016)
Title HIV-1 genetic diversity among incident infections in Mbeya, Tanzania.
Citation ARHR
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 95
NumPts 95
Subtype C, A, D, CRF10_CD

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
CO0041V3 CO0041V3 None None   V35T, E36A, T39E, S48T, V60I, K122E, I135T, K173A, D177E, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317A, Q334H, G335D, R356K, G359T, T377Q, K390R, A400T, E404D, E432D, V435A, A437V, V458I, V466I, D471E, H483Q, L491S, S519N, K530R, A534S, V548I, A554S  
CO0053V5 CO0053V5 None None   V35T, E36A, T39E, S48T, D121H, K122E, D123E, I135T, K173A, D177E, T200A, Q207A, R211K, V245Q, A272P, E291D, V292I, I293V, Q334N, R356K, G359T, T377M, K390R, A400R, T403A, E404D, K431T, V435A, L452M, V466I, V467I, S468T, T470N, D471E, H483Q, L491S, K527Q, A534S, A554S  
CO0077V1 CO0077V1 None None   V35T, E36A, T39E, S48T, K122E, T139A, A158S, K173T, Q174K, D177E, T200A, Q207E, R211K, V245L, K249Q, D250E, A272P, K277R, E291D, V292I, I293V, P294V, Q334H, G335E, R356K, G359T, T377L, T386V, K390R, A400T, E404D, V435A, F440Y, L452I, V466I, D471E, H483Q, L491S, S519N, K527T, K530R, A534S, A554S  
CO0098V3 CO0098V3 None None   V35T, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, G196E, T200A, Q207A, R211S, V245E, D250E, A272P, K275R, V276I, T286A, E291D, I293V, E297K, E312D, G335D, M357K, G359S, T369A, A371V, I375V, A376V, A400T, T403M, E404D, E432D, V435A, R461K, D471E, Q480H, H483Y, L491S, E514D, S519N, Q524K, K527E, E529D, A534S, A554S  
CO0260V5 CO0260V5 None None   V35T, E40D, V60I, D121H, K122E, D123S, T165I, K173L, Q174K, D177E, V179I, T200A, Q207A, R211S, E248D, T286A, E291D, V292I, I293V, P294T, E312D, V317A, G335D, R356K, M357K, G359S, T369A, I375V, A376V, T377M, T386A, A400T, T403M, E404D, E432D, V435A, A446S, D471E, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527G, E529D, A534S, A554S, V559I  
CO0272V4 CO0272V4 None None   P4Q, K11I, V35T, K122E, I135T, K173S, D177E, V179I, I202V, Q207A, R211S, F214L, V245K, L283I, E291D, I293V, P294T, L295M, E312D, I329V, G335D, R356K, M357R, G359S, A371V, I375V, A376V, T377M, K395R, A400T, E404D, E432D, V435E, A437V, F440Y, D471E, Q480H, H483L, L491S, Q507H, K512R, L517I, S519N, Q524K, K527E, E529D, A534S, A554S  
CO0329V1 CO0329V1 None None   V35T, T39L, K122E, D123S, K173S, Q174K, D177E, V179I, T200I, Q207A, R211S, V245M, A272P, T286A, E291D, V292I, I293V, P294T, E312D, G335D, M357R, G359S, T369A, A371V, I375V, A376V, T377L, K390R, A400T, E404D, E432D, D471E, Q480H, L491S, L503I, S519N, Q524K, K527G, E529D, L533M, A534S, A554S  
CO0330V4 CO0330V4 None None   V35T, V60I, K122E, D123S, I135T, S162Y, K173S, Q174K, D177E, I178M, V179I, T200A, Q207A, E248D, D250E, K281R, T286A, E291D, V292I, I293V, E312D, V317A, G335D, M357Q, G359S, A371V, K374R, I375V, A376S, T377I, K390R, A400T, T403M, E404D, E432D, V435A, N447S, V466VI, D471E, Q480H, L491S, S519N, Q524K, K527G, E529D  
CO0335V1 CO0335V1 None None   V35T, E40D, V60I, D121H, K122E, I135T, I142T, D177E, I178M, R199RK, Q207G, R211K, V245E, D250E, A272P, K277R, L282C, I293V, Q334K, G335D, P345Q, F346Y, R356K, T369A, K374R, A376I, T377Q, S379C, K390R, A400T, S468T, L469I, H483N, L491S, A502V, A534S, A554N, V559I  
CO0377V4 CO0377V4 None None   V35T, T39E, E40D, S48T, D86DG, K104R, V118I, K122E, D123N, E138A, K173I, Q174K, V179VA, T200A, Q207E, R211K, F214L, P243T, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, D320DN, Q334H, G335D, R356K, G359T, T377L, T386I, K390R, A400T, E404D, E432D, V435A, A446S, L452I, R461K, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531I, A534S, A554S  
CO0434V7 CO0434V7 None None   V35I, V60I, K64R, D121Y, K122E, D123G, I135T, K173L, Q174K, D177E, V179I, Q207A, R211S, D250E, A272P, K275R, V276I, T286A, E291D, V292I, I293V, P294T, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E404D, V435I, R463K, D471E, Q480H, H483L, L491S, K512R, S519N, Q524K, K527G, E529D, A534S, A554S L193L* 
CO0439V5 CO0439V5 None None   V35T, V60I, K122E, D123E, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, D250E, K281R, T286A, V292T, I293V, P294T, I326V, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377M, T386S, A400T, T403M, E404D, E432D, V435I, V466I, T470I, D471E, Q480H, H483Y, L491S, K512R, Q524K, K527E, E529D, A534S, A554S  
CO0543V2 CO0543V2 None None   V21I, V35T, V60I, D123S, I135T, S162H, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245I, E248D, D250E, T286A, E291D, V292I, I293V, E312D, G335D, M357K, G359S, K366R, A371V, I375V, A376T, T377L, K388R, A400T, T403M, E404D, E432D, V435I, V458I, D471E, Q480H, L491S, S519N, Q524K, K527G, E529D, A534S, A554S, K558R  
CO0694V7 CO0694V7 None None   V35T, T39E, E40D, S48T, K104R, V118I, D123N, E138A, K173I, Q174K, P176S, T200A, Q207E, R211K, F214L, P243T, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377L, T386I, K390R, A400T, E404D, E432D, A446S, L452I, R461K, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531I, A534S, A554S  
CO0735V4 CO0735V4 None None   V35T, E40D, K49R, V60I, K122E, D123S, S162H, K173T, T200A, E204K, Q207E, R211K, P243T, V245S, A272P, K277R, E291D, V292I, I293V, P294T, D324E, Q334N, G335D, R356K, G359T, K366R, T377Q, S379C, K390R, E399D, A400T, T403M, E404D, K431R, E432D, V435I, L452I, S468T, T470V, H483K, L491S, S519N, K527N, K530R, A534S, A554S E42K 
CO0778V2 CO0778V2 None None   V35T, K49R, V60I, D121Y, K122E, I135R, S162N, K173A, D177E, T200A, E204K, Q207E, R211K, V245Q, D250E, K277R, L282C, L283I, T286A, I293V, D324E, Q334R, G335D, T338TA, P345Q, F346Y, R356K, M357T, A360V, T377Q, T386P, K390R, A400T, D471N, H483N, L491S, E492T, A534S, A554N, V559I N137S 
CO0783V0 CO0783V0 None None   K11E, V35T, T39S, V60I, R83K, D121H, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, Q207A, R211S, V245E, D250E, K281R, T286A, E291D, V292I, I293V, P294T, E312D, G335D, M357K, G359S, K366R, T369A, I375V, A376V, T377M, A400T, T403M, E404D, E432D, V435A, S468P, D471E, Q480H, H483Y, L491S, Q509H, K512R, E516G, S519N, Q524K, K527E, E529D, A534S, A554S  
CO0815V3 CO0815V3 None None   V35T, T39E, E40D, D121Y, K122E, D123G, I135R, S162C, D177E, T200A, Q207E, R211K, V245Q, A272P, I274V, Q278N, T286A, E291D, V292I, I293V, Q334H, G335D, F346Y, R356K, G359T, K366R, T377L, K390R, A400T, E404D, V417I, P421H, A446S, L452V, V466I, H483Q, L491S, S519N, K530R, A534S, A554S Q340QP 
CO0844V2 CO0844V2 None None   E6K, V35T, E36A, T39E, S48T, K122E, I135M, K166R, K173A, D177E, T200A, Q207E, R211K, V245K, D250E, A272P, K275R, K277G, T286A, E291D, I293V, G333E, M357K, G359S, T369A, A371V, I375V, A376V, T377M, T386A, K390R, A400T, T403A, E404D, E432D, V435A, D471E, Q480H, L491S, K512R, L517I, S519N, Q524K, K527E, E529D, A534S, A554S, V559I  
CO0907V4 CO0907V4 None None   V35T, E40D, K49R, I50V, V60I, D123E, I135T, K173S, Q174K, D177E, V179I, T200K, Q207A, R211K, V245I, D250E, K281R, L283I, T286A, E291D, I293V, P294T, L295M, K311R, E312D, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E404D, V435I, S468P, L469F, H483N, A554Q  
CO0921V2 CO0921V2 None None   V35T, E36A, T39E, S48T, V60I, I135V, K173A, D177E, Q197E, T200A, Q207E, R211K, V245Q, E248D, D250E, K277R, K281R, E291D, I293V, Q334N, G335D, R356K, G359A, T369S, T377M, K390R, T397V, A400T, E404D, E432D, L452I, V466I, S468P, D471E, H483Q, L491P, S519N, K530R, A534S, V548I, A554S  
CO0984V2 CO0984V2 None None   V35T, E36A, T39E, S48T, K122E, D123N, I135V, S162C, K173T, Q174K, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, I293V, Q334N, G335D, R356K, G359T, T377M, K390R, E396D, A400T, E404D, V435A, A437V, K451R, V466I, V467I, S468H, D471E, H483Q, L491S, S519N, I526V, K530R, A554N  
CO3016V6 CO3016V6 None None   V35T, K49R, I50V, V60I, D121Y, K122E, I142T, Q207E, F214L, V245Q, D250E, A272S, K277R, T286A, I293V, Q334H, G359S, A371V, A376S, K390R, A400T, T403I, E404D, V435T, L452I, R461K, V466I, V467I, S468T, D471E, H483Q, L491S, K527N, K530R, A534S, A554S  
CO3022V7 CO3022V7 None None   V35T, T39E, S48T, V60I, K122E, D123S, I135T, K173I, Q174K, D177N, T200A, Q207E, R211K, F214L, V245M, E248D, D250N, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, P345Q, M357K, G359S, K366R, A371V, I375V, A376V, T377M, T386A, A400T, E404D, E432D, D471E, Q480H, L491S, S519N, K527N, A534S, A554S  
CO3058V6 CO3058V6 None None   V35T, E40D, D121Y, K122E, I135T, S162C, K173S, Q174K, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, K311R, G335D, F346H, R356K, G359T, T377L, V381I, K390R, E404D, V435I, R461K, V466I, V467I, D471E, H483K, L491S, S519N, K530R, A534S, A554N  
CO3063V5 CO3063V5 None None   V35T, E36A, T39D, S48T, K122E, D123S, K166R, K173A, D177E, I195L, G196K, T200A, Q207D, R211K, T240A, V245Q, D250E, S251D, A272P, K277R, T286A, E291D, V292I, Q334G, G335D, R356K, M357I, G359T, T377M, I380V, K388R, K390R, A400T, E413D, I434M, V435I, A437V, E449D, L452M, D471E, Q480H, H483Q, L491S, S519N, K530R, A534S, A554S  
CO3083V4 CO3083V4 None None N348I  V35T, V60I, K122E, D123S, I135T, E138A, I142V, K173S, Q174K, V179I, I202V, Q207A, R211S, F214L, V245E, E248K, D250E, A272P, T286A, E291D, V292I, I293V, P294T, L295M, E312D, G335D, M357K, G359S, E370D, A371V, I375V, A376V, T377M, A400T, T403V, E404D, W410C, E432D, V435E, R461K, D471E, Q480H, L491S, K512R, E514D, S519N, Q524K, K527G, E529D, A554S P4R 
CO3103V3 CO3103V3 None None   V35T, E40D, K49R, V60I, D121Y, K122E, D123E, I135T, S162SN, E169D, K173A, Q174K, D177E, I178V, G196K, T200A, I202V, Q207QEGR, R211K, V245M, D250E, S251N, A272P, K277R, L282C, T286A, I293V, L310I, G335D, R356K, G359T, T386I, K390R, A400T, E404D, V435I, A446S, L452I, K454R, D471E, H483Q, L491S, S519N, K530R, A534S, A554S  
CO3168V4 CO3168V4 None None   V35T, T39E, S48T, K122E, D123S, K173A, D177E, T200A, Q207E, V245Q, E248N, A272P, K277R, E291D, V292I, I293V, S322A, Q334H, G335D, R356K, G359S, K366R, A376V, T377Q, T386A, K390R, A400T, E404D, I434L, V435A, A437I, L452I, V466I, S468T, D471E, H483Q, L491S, S519N, K527Q, K530R, A534S, A554S  
CO3256V2 CO3256V2 None None   K20R, V35T, K49R, V60I, K122E, D123G, I135M, K166R, K173A, D177E, T200A, Q207E, R211K, V245Q, D250E, Y271F, A272P, Q278H, T286A, E291D, V292I, I293V, G335D, R356K, M357K, G359S, K366R, T369A, A371V, I375V, A376I, T377M, T386A, K390R, A400T, T403A, E404D, E432D, V435A, A446S, D471E, Q480H, L491S, K512S, S519N, Q524K, K527G, E529D, A534S, A554S G273R 
CO3278V6 CO3278V6 None None   V35T, E36A, T39D, S48T, K122E, D123G, I135T, T165I, K173T, T200A, Q207E, R211K, F214L, V245K, A272P, K277R, T286A, E291D, V292I, I293V, K311R, Q334N, G335D, R356K, G359T, V365I, T377V, K390R, E396D, T397I, A400T, E404D, V435A, R461Q, L469I, D471E, T477A, H483Y, L491S, L517S, S519N, K527S, K530R, A534S, A554R  
CO3301V1 CO3301V1 None None   V35T, T39N, E40D, V60I, K122E, D123N, I135T, I142V, K173A, Q174K, D177E, I178M, V179I, G196S, Q197K, Q207A, R211S, V245I, D250E, T286A, E291D, V292I, I293V, E297K, L301F, E312D, V317A, I329V, G335D, M357Q, G359S, A371V, T377M, K390R, A400T, T403M, E404D, E432D, V435A, S468P, D471E, Q480H, L491P, I505V, K512R, S519N, Q524K, K527G, E529D, L533M, A534S, A554S  
CO3326V4 CO3326V4 None None   V35T, E36A, T39A, V60I, K122E, D123S, I135T, S162C, K173A, Q174K, D177E, V179T, T200A, Q207A, R211S, K281R, T286A, E291D, V292I, I293V, P294T, E312D, A327V, G335D, M357R, G359S, T369A, A371V, I375T, T377M, T386A, K395R, A400T, T403M, E404D, E432D, V435A, D471E, Q480H, H483Y, L491S, K512R, L517I, S519N, Q524K, K527G, E529D, A534S, A554S  
CO3337V2 CO3337V2 None None   V35T, E40D, K49R, V60I, K122E, D123N, D177E, I178M, T200I, Q207G, R211K, V245M, E248N, A272P, T286A, E291D, V292I, I293V, G335D, F346H, R356K, M357R, G359T, T377M, T386I, K390R, A400T, L469I, H483N, L491S, S519N, A534S, A554K, I556V I132IT 
CO3365V2 CO3365V2 None None   V21I, V35T, T39A, E40D, V60I, D121H, I135T, K173L, Q174K, D177E, V179I, T200I, Q207E, R211K, V245E, E248D, D250E, K275Q, T286A, V292I, I293V, E297K, L325I, G335D, M357K, G359S, T369A, E370G, A371V, I375V, A376V, T377M, A400T, T403M, E404D, E432D, R463K, D471E, Q480H, L491S, K512R, E514D, S519N, Q524K, K527A, E529D, A534S, A554S  
CO3415V1 CO3415V1 None None   T27S, V35T, E36A, T39E, S48T, K122E, D123S, E138A, S162C, K173A, D177G, T200A, E203D, Q207E, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, K311R, I329IL, Q334S, G335D, R356K, G359T, I375V, K390R, A400T, E404D, V435A, A437I, L452I, R461K, V467I, S468T, D471E, H483K, L491S, A508G, S519N, K527N, A534S, A554S  
CO3426V5 CO3426V5 None None   V35T, E36A, T39E, S48E, K104R, E138A, T139I, K173A, Q174K, I202V, R211K, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, L310I, Q334H, G335D, G359T, S379G, T386I, K390R, A400T, E404D, V417I, V435A, V466I, S468P, D471E, H483K, L491S, S519N, K530R, A534S, A554S  
CO3440V7 CO3440V7 None None   V35T, T39E, S48T, K104R, K122E, K173T, D177E, Q207E, R211K, V245Q, D250E, A272S, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377Q, S379C, K390R, A400T, E404D, V435A, L452I, V458I, D471E, Q480H, H483Q, L491S, S519N, K527G, K530R, A534S, V548I, A554S Q91R 
CO3468V1 CO3468V1 None None   P4S, V35T, E36D, K49R, V60I, D121H, I135T, I178M, I195T, T200I, Q207G, R211K, V245K, D250E, A272P, I274V, K281R, L282C, E297A, G335D, P345Q, F346Y, R356K, R358K, G359S, A360T, T377Q, S379C, K385R, K390R, A400T, R461RK, S468P, L469I, D471E, H483S, L491S, L517I, S519N, K530R, A534S, A554N, V559I  
CO3473V1 CO3473V1 None None   V35T, E36A, T39E, S48T, D121Y, K122E, I135T, I159V, K173S, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, I293V, Q334H, G335D, R356K, G359T, T377Q, K390R, A400T, E404D, E432D, V466I, S468T, D471E, Q480H, L484I, L491S, S519N, E529D, A534S, A554S, K558R  
CO3504V7 CO3504V7 None None   V35T, K49R, K122E, D123S, I135T, K173A, Q174K, D177E, I178M, V179I, Q207A, V245M, E248D, D250E, A272P, T286A, E291D, V292I, I293V, P294T, E312D, G335D, M357Q, G359T, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E404D, E432D, V442A, D471E, Q480H, H483Y, L491S, S519N, Q524K, K527G, E529D, A534S, A554S, K558R  
CO3589V1 CO3589V1 None None   V35T, E36A, T39E, E40D, S48T, D121Y, K122E, K173A, Q174K, D177E, T200A, Q207E, V245K, A272P, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, G359S, I375V, T377L, K390R, A400T, E413D, I434L, V435G, A437V, L452A, R461K, V466I, V467I, D471E, T477A, H483Q, L491S, S519N, K530R, A534S, V548I, A554S  
CO3637V5 CO3637V5 None None   V35T, T39E, S48T, K122E, D123G, I135T, I142V, S163T, K173A, D177G, T200A, Q207D, R211K, V245Q, E248D, A272S, K281R, E291D, V292I, I293V, E297Q, Q334N, G335D, R356K, G359S, K390R, A400S, E404D, F416Y, V435A, V466I, D471E, Q480H, H483Q, L491S, Q524E, K530R, V531I, A534S, A554N  
CO3651V7 CO3651V7 None None   V35T, E36A, T39E, E40D, S48T, K122E, D123G, S162C, K173A, Q174K, D177E, G196E, T200V, Q207E, V245Q, A272S, T286A, E291D, V292I, I293V, K311R, Q334H, G335D, R356K, R358K, G359H, K374Q, T377R, K390R, A400T, E404D, E432D, V435A, A437V, L452I, V466I, T470P, D471E, T477A, H483Q, L491V, S519N, K530R, A534S, A554K  
CO3672V4 CO3672V4 None None  A98G T27S, V35T, E36A, T39E, S48T, K49R, K122E, D123N, S162C, K173A, Q174K, D177E, I178L, T200A, E203D, Q207E, R211K, P243S, V245Q, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, A376S, T377Q, S379C, K390R, E399G, E404D, V435I, L452M, V458I, R461K, V467I, D471E, H483Q, L491S, S519N, K530R, A534T, V548I, A554N  
CO3718V3 CO3718V3 None None   P4H, K20R, V35T, T39A, V60I, K122E, D123S, I135T, I142V, K173A, Q174K, D177E, Q207A, R211S, F214L, V245M, D250E, T286A, E291D, I293V, P294T, E312D, V317A, G335D, Q336QR, M357K, G359S, K366R, T369A, A371V, I375V, A376V, T377M, T386A, A400T, T403M, E404D, V435A, D471E, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527S, E529D, V531I, A534S, A554S  
CO3728V2 CO3728V2 None None   I2T, V35T, T39S, S48T, V60I, V118I, I135V, T139S, I142T, K173T, D177A, Q197E, T200A, Q207E, R211K, F214L, V245Q, E248D, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T369S, T377V, K390R, T397I, A400T, E404D, E432D, V435A, K451R, L452I, V466I, V467A, S468P, D471E, T477A, H483Q, L491P, S519N, K530R, A534S, V548I, A554R R78RG 
CO3800V5 CO3800V5 None None   V35T, T39E, S48T, V60I, A98S, K122E, D123S, A158S, K173T, Q174K, T200A, Q207A, L228Q, A272S, V276I, T286A, E291D, V292I, I293V, P294T, Q334H, G335D, R356K, G359T, K366R, T377M, K390R, E396D, A400T, E404D, A446S, E449D, L452I, V466I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S  
CO3812V6 CO3812V6 None None   V35T, E36A, T39E, S48T, K122E, E138A, T165I, K173T, T200A, Q207E, R211K, V245Q, A272P, I274V, K277R, T286A, E291D, I293V, P294A, Q334N, G335D, R356K, G359T, T369A, I375V, A376V, T377M, T386A, K390R, E396D, A400T, E404D, W410L, V435A, V466I, T470N, D471E, T477A, H483Q, D488E, L491S, V496I, K527N, K530R, A534S, A554S  
CO3817V2 CO3817V2 None None   V35T, T39E, S48T, E53D, A98S, K122E, D123N, E138S, T139A, I142V, K166R, K173A, T200A, Q207D, R211K, V245Q, E248D, A272P, K277R, L283I, E291D, V292I, I293V, D324E, Q334H, G335D, F346H, R356K, G359T, T377I, K390R, A400T, E404D, S468T, L469M, H483N, L491S, S519N, K527N, K530R, V531I, A534S, A554N  
CO3873V1 CO3873V1 None None   P4S, K20R, V35T, E36A, T39E, G45GE, S48T, V60I, D123S, S162H, M164MI, E169R, K173E, D177E, T200A, Q207E, R211K, V245K, A272P, K277R, E291D, V292I, I293V, Q334H, G335D, F346L, R356K, G359T, A376S, T377M, T386I, K390R, A400T, E404D, V435I, R461K, V466I, T470M, D471E, H483Q, L491P, S519N, K527N, K530R, A534S, A554S  
CO3878V2 CO3878V2 None None   V35T, V60I, K122E, D123N, I135T, I142V, K173L, Q174K, D177E, V179I, Q207A, R211S, D250E, T286A, I293V, P294T, G335D, M357K, G359S, K366R, A371V, I375V, A376V, T377M, A400T, T403M, E404D, E432D, V435E, F440Y, R463K, S468T, D471E, Q480H, H483Y, L491A, K512R, S519N, Q524K, K527G, E529D, A554S, V559I  
CO3892V6 CO3892V6 None None   V35T, E36A, T39E, S48T, K122E, D123S, K173T, D177E, T200A, Q207R, R211K, V245Q, E248N, A272P, E291D, V292I, I293V, V317A, Q334E, R356K, G359S, T377V, K390R, A400I, E404D, T409N, V435A, A437V, F440Y, E449D, D471E, H483Q, L491P, S519N, K530R, A534S, V548I, A554N I309T 
CO3969V6 CO3969V6 None None   E6A, V35T, E36A, T39E, S48T, K122E, D123S, K166R, K173T, D177E, T200A, Q207D, R211K, V245I, D250E, A272S, K277R, K281R, T286A, E291D, V292I, I293V, G333E, Q334Y, R356K, G359T, A360T, A376S, T377L, K385R, T386V, K390R, E399D, A400T, E404D, V435G, F440Y, V466I, D471E, T477A, H483Q, L491P, E492D, S519N, L525M, K527Q, K530R, A534S, A554S  
CO3979V3 CO3979V3 None None   T7TI, V35T, E36A, T39E, S48T, K122E, D123S, S162C, K166R, K173A, D177E, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359S, A376S, T377M, K390R, A400T, I434M, V435A, A437V, L452R, R461RK, V466I, D471E, T477A, I482V, H483Q, L491S, S519N, E529D, A534S, A554N S468SY 
CO6022V7 CO6022V7 None None   V35T, E36A, T39E, E40D, S48T, K122E, D123S, A158S, S162A, K173A, D177E, T200A, E204K, Q207E, V245Q, A272P, K275Q, Q278H, T286A, E291D, V292I, I293V, Q334H, G335D, P345T, F346H, R356K, M357R, G359T, T377Q, K390R, E404N, A437V, R461K, S468T, D471E, H483K, L491S, S519N, K530R, A534S, A554S  
CO6033V4 CO6033V4 None None   V35M, E36A, T39E, E44K, S48T, D86N, A98S, A158S, S162A, E169K, K173T, D177E, T200A, Q207E, R211K, V245Q, D250E, A272Q, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, T338S, R356K, G359T, K366R, Q373H, K390R, A400T, E404D, V435A, L452I, R463K, D471E, H483Q, L491S, D511N, L517I, S519N, E529D, A534S, D549N, A554S G544E 
CO6040V4 CO6040V4 None None   V35M, E36A, T39E, S48T, A98S, A158S, S162A, K173T, D177E, T200A, Q207E, R211K, V245Q, D250E, A272Q, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, T338S, R356K, G359T, K366R, Q373H, T377I, K390R, A400T, E404D, V435A, L452I, D471E, H483Q, L491S, I505V, L517I, S519N, E529D, A534S, A554S K73R, D192G, D488N 
CO6041V3 CO6041V3 None None   E6K, V35T, E36V, T39E, S48T, V60I, K102Q, K122E, D123G, K173A, D177E, T200A, Q207E, V245K, A272P, K277R, T286A, E291D, V292I, I293V, G335D, P345Q, F346H, R356K, M357Q, G359T, T377Q, K390R, A400T, E404D, E413D, V467I, L469I, H483N, S519N, K527N, K530R, A534S, A554S  
CO6095V1 CO6095V1 None None   V35T, E40D, V60I, D121H, K122E, D123E, I135T, K173S, Q174K, V179I, T200R, Q207A, R211S, F214L, V245K, D250E, T286A, I293V, E312N, G335D, M357K, G359A, T369A, A371V, I375V, A376V, T377L, A400T, T403M, E404D, E432D, D471E, Q480H, L491S, K512R, L517I, S519N, Q524K, K527G, E529D, A534S, A554S  
CO6106V5 CO6106V5 None None   V35T, E36A, T39E, S48T, K122E, K173A, D177E, G196R, T200V, Q207E, R211K, V245K, A272K, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377M, I380V, K390R, A400T, E404D, V435A, L452K, K454R, V466I, S468T, T470N, D471E, H483Q, L491S, L503I, S519N, K527N, A534S, A554S  
CO6139V7 CO6139V7 None None   V35T, T39E, S48T, K122E, D123G, K173T, D177E, I178M, T200A, E204K, Q207E, E224K, V245Q, E248N, D250E, A272P, K277R, T286A, E291D, V292I, I293V, H315S, Q334H, G335D, R356K, G359S, T369A, T377R, K390R, A400T, E404D, I411L, V417I, V435A, F440Y, A446S, L452I, V466I, D471E, T477A, H483Q, L491S, S519N, K530R, A534S, V548I, A554S  
CO6146V7 CO6146V7 None None   E28EK, V35T, E36A, T39E, S48T, K122E, D123G, A158S, K173A, D177E, T200A, Q207E, V245E, A272K, K277R, E291D, V292I, I293V, E300K, Q334H, G335D, R356K, G359S, K366R, T377Q, K390R, E404D, V435A, G436E, A437V, N447S, L452I, V466I, S468T, D471E, H483Q, L491S, L517I, S519N, A534S, V548I, A554S  
CO6161V5 CO6161V5 None None   V35T, K49R, I50V, V60I, K122E, D123S, I135T, T139A, I142V, K173A, Q174K, D177E, I178M, V179I, Q207A, R211K, V245I, K275R, V276I, K277R, Q278H, T286A, E291D, V292I, I293V, P294T, E312D, I326V, G335D, M357K, G359S, A371V, I375A, T377M, A400T, E404D, E432D, V435A, K465R, D471E, Q480H, H483Y, L491S, K512S, E514D, S519N, Q524K, K527G, E529D, A534S, A554S  
CO6172V5 CO6172V5 None None   V35T, T39E, S48T, K122E, D123N, I135T, K173E, Q174K, D177E, G196E, T200A, Q207D, F214L, V245Q, D250E, A272S, K277R, T286A, E291D, V292I, I293V, P294L, S322T, Q334H, G335D, E344D, R356K, G359T, T377L, K390R, E399D, A400I, E404D, E432D, V435A, A437V, D471E, Q480H, L491S, S519N, K530R, A534S, A554S S3SN 
CO6273V3 CO6273V3 None None   E28D, V35T, V60I, K104R, D121H, K122E, I135T, E138A, I142T, T165I, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, E248D, A272P, K277R, L283I, T286A, E291D, I293V, Q334H, G335D, R356K, G359T, I375V, T377Q, T386I, K390R, A400T, T403M, E404D, E432D, S468P, D471E, K476KE, T477A, H483K, S519N, K527Q, K530R, V531I, A534S, A554N, K558R  
CO6273V4 CO6273V4 None None   V35T, V60I, K65KE, K122E, D123N, I135T, E138A, I142T, T165I, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, A272P, K277R, L283I, T286A, E291D, I293V, Q334H, G335D, R356K, G359T, I375V, T377Q, T386I, K390R, A400T, T403M, E404D, E432D, V435E, S468P, D471E, T477A, H483K, L491S, S519N, K527Q, K530R, V531I, A534S, A554N, K558R  
CO6322V4 CO6322V4 None None   V35T, E36A, T39E, S48T, D123E, I135T, E138A, S162C, K173A, D177E, T200V, Q207E, F214L, V245K, A272K, K277R, E291D, V292I, I293V, I329L, Q334D, G335D, R356K, G359T, V381I, K390R, A400T, E404D, V417VI, V435L, L452A, V467I, D471E, H483Q, L491S, E492Q, S519N, A534S, A554S  
CO6405V4 CO6405V4 None None   V35T, E40D, I50V, V60I, V118I, D121C, K122E, I142V, Q207E, R211K, F214L, V245Q, P247A, A272ST, V317A, S322L, I326V, Q334N, G359S, A371V, I375V, A376C, K390R, E399D, A400T, T403V, V435I, A446S, S468P, L469F, H483N, S519N, A554Q  
CO6471V1 CO6471V1 None None   V35T, T39K, S48T, V60I, K122E, D123S, I135T, K173V, Q174K, D177E, T200A, Q207E, V245Q, A272P, K277R, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, G359T, T377M, T386V, K390R, A400T, E404D, V435A, L452I, R461K, D471E, H483Q, L491S, S519N, K527Q, E529D, K530R, A534S, V548I, A554S  
CO6480V4 CO6480V4 None None   E6D, V35T, E36A, T39E, S48T, V90I, K104R, K122E, A158S, K173A, Q174K, T200A, Q207D, R211K, V245Q, D250E, A272P, E291D, V292I, I293V, Q334H, G335D, A355S, R356K, G359T, T377L, S379C, K390R, E404D, V417I, V435A, L452M, V466I, V467I, S468A, T470N, D471E, H483K, L491S, S519N, K527N, K530R, A534S, A554S G273R 
CO6540V3 CO6540V3 None None   E6K, K11Q, V35T, T39E, S48T, K122E, D123G, I135V, K173A, D177E, G196E, Q197K, T200A, Q207E, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, K390R, A400T, E404D, I434M, V435A, A437V, L452I, S468T, T470I, D471E, H483Q, L491S, S519N, K530R, A534S, A554R  
CO6545V3 CO6545V3 None None   E6K, K11Q, V35T, T39E, S48T, K122E, D123G, I135V, K173A, D177E, G196E, Q197K, T200A, Q207E, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, K390R, A400T, E404D, I434M, V435A, A437V, L452I, S468T, T470I, D471E, H483Q, L491S, S519N, K530R, A534S, A554R  
CO6577V5 CO6577V5 None None   K11R, V35T, T39I, E40D, V60I, D121Y, K122E, D123E, Q174R, D177E, Q207E, R211K, V245K, D250E, S251T, A272P, K275R, K277R, Q278H, L282C, I293V, P294S, G335D, P345Q, F346H, R356K, A360T, T377Q, S379C, K390R, A400T, V435M, S468P, L469F, H483N, S519N, V548I, A554Q  
CO6592V5 CO6592V5 None None   V35T, T39M, V60I, K122E, D123N, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, V245K, D250E, K275Q, T286A, E291D, V292I, I293V, P294T, Q334H, G335D, R356K, M357R, G359T, A360T, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E404D, W410Y, E432D, A446S, D471E, Q480H, H483C, L491S, Q509T, S519N, Q524K, K527E, E529D, A554F  
CO6631V3 CO6631V3 None None   K20R, V35T, E36A, T39E, E40D, S48T, K122E, D123E, T165I, K173A, G196E, Q197K, T200A, Q207E, V245Q, E248D, A272P, K277R, E291D, V292I, I293V, E297R, S322A, Q334N, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435P, V466I, D471E, H483Q, G490E, L491S, S519N, V531I, A534T, A554S P421A 
CO6637V7 CO6637V7 None None   V35T, K43R, V60I, T69I, K122E, D123N, I135T, K173L, Q174K, D177E, V179I, T200E, I202V, Q207A, R211S, F214L, V245K, D250E, A272P, K277R, T286A, E291D, V292I, I293V, K311R, E312N, D324E, G335D, R356K, M357K, G359S, T369A, A371V, I375V, A376V, T377M, T386S, E399D, A400T, T403M, E404D, E432D, V435A, R461K, D471E, Q480H, H483L, L491S, L503M, K512R, S519N, Q524K, K527G, E529D, A534S, A554N, K558R  
CO6644V2 CO6644V2 None None   V35T, E36A, T39E, S48T, K102KR, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245K, A272K, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, K366R, Q367L, A371V, I375V, T377M, S379C, K390R, E404D, V435A, L452I, V466I, S468T, T470N, D471E, H483Q, L491S, L517I, S519N, A534S, V548I, A554S  
CO6647V5 CO6647V5 None None   V35T, E36A, T39E, S48T, K122E, D123G, S162C, K166R, K173A, D177E, T200A, I202V, Q207E, V245Q, A272P, E291D, V292I, I293V, G335D, F346H, R356K, G359T, K366R, T377M, K390R, E404D, V435A, A437V, A446S, L452M, V466I, D471E, H483K, L491S, S519N, K530R, A534S, A554N  
CO6650V1 CO6650V1 None None   K11R, V35T, E40D, V60I, D121Y, K122E, D123E, Q174R, D177E, Q207E, R211K, V245K, D250E, S251R, A272P, K275R, K277R, Q278H, L282C, I293V, P294S, G335D, P345Q, F346H, R356K, A360T, T377Q, S379C, K390R, A400T, V435M, A437V, S468P, L469F, H483N, S519N, V548I, A554Q  
CO6728V5 CO6728V5 None None   V35T, E36A, T39E, S48T, K173R, V179I, T200A, Q207E, V245I, A272S, T286A, I293V, P294T, Q334H, G335D, R356K, G359T, A371V, T377M, K390R, E396D, A400T, E404D, Y405C, E432D, L452I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, V548I, A554N  
CO6763V2 CO6763V2 None None   V35T, E36A, T39E, S48T, K102R, K122E, D123S, K173A, D177E, T200A, Q207E, P243H, V245Q, A272S, K281R, T286A, E291D, I293V, G335D, R356K, G359S, K366R, T369A, A376T, T377M, K390R, K395R, A400T, E404D, L452I, R461K, V466I, D471E, H483Q, L491S, S519N, K530R, A534S, A554Q  
CO6785V5 CO6785V5 None None   V35T, E36A, T39E, S48T, K49R, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245K, A272K, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, R358K, G359T, K366R, Q367M, L368V, T377M, S379C, K390R, E404D, V435A, L452I, V466I, S468T, T470N, D471E, H483Q, L491S, L517I, S519N, A534S, V548I, A554K  
CO6811V5 CO6811V5 None None   V8I, T27A, V35T, E36A, T39E, S48T, K102Q, K122E, D123G, K173M, Q174K, T200A, Q207E, V245K, A272P, I274V, Q278H, T286A, E291D, V292I, I293V, G335D, F346H, R356K, G359T, T377Q, S379C, K390R, A400T, E404D, E413D, V435A, R461K, D471E, H483K, S519N, K527Q, K530R, A534S, A554N, V559I  
CO6812V3 CO6812V3 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135T, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, M357V, G359T, T377M, K390R, A400T, E404D, V435A, A437V, L452I, V466I, D471E, T477A, H483Q, L491S, S519N, V531I, A534S, A554K  
CO6830V7 CO6830V7 None None   V35T, T39M, K122E, D123S, I135T, T165I, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, V245K, D250E, A272T, K277R, T286A, E291D, V292I, I293V, P294T, G335D, R356K, M357R, G359S, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E404D, W410Y, E432D, A446S, D471E, Q480H, H483Y, L491S, Q509I, S519N, Q524K, K527G, E529D, A554S  
CO6838V1 CO6838V1 None None   V35T, E36A, T39E, S48T, K122E, D123G, I135T, K166R, K173A, D177E, G196R, T200A, Q207E, R211K, V245Q, A272K, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377M, K390R, E404D, V435A, L452I, V466I, S468T, D471E, H483Q, L491S, S519N, A534S, A554S T472I 
CO6847V7 CO6847V7 None None   V35T, E36A, T39E, S48T, K122E, D123G, A158S, K173A, D177E, T200A, Q207E, R211K, V245K, A272K, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, K366R, V381I, K390R, L422I, V435A, A437V, N447S, L452I, V466I, S468T, D471E, H483Q, L491S, L517I, S519N, A534S, V548I, A554S  
CO6854V1 CO6854V1 None None   P4S, V21I, V35T, E36A, T39E, S48T, K122E, D123N, K173T, Q174K, T200A, Q207E, V245K, A272S, T286A, E291D, V292I, I293V, P294T, R307K, Q334H, G335D, R356K, G359T, A376T, T377M, T386A, K390R, E396D, A400T, E404D, L452A, R461K, V466I, S468T, D471E, T477A, H483Q, G490E, L491S, S519N, K527N, K530R, V531I, A534S, I542V, A554S  
CO6867V2 CO6867V2 None None   V35T, T39K, S48T, K122E, A158S, K173T, D177E, T200A, Q207E, V245Q, D250E, A272P, K277R, L283I, T286A, E291D, I293V, Q334H, G335D, P345T, F346H, R356K, G359T, T377Q, K390R, E404D, E432D, V435A, A437I, L452M, D471E, H483K, L491S, S519N, K527N, E529K, K530R, A534S, A554N  
CO6917V7 CO6917V7 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135T, K173A, D177E, T200A, Q207E, V245L, A272P, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, M357ML, G359S, K366R, Q373H, T377M, K390R, A400T, E404D, V435A, L452I, V466I, V467I, D471E, H483Q, L491S, Q509H, L517I, S519N, K527R, K530R, A534S, A554S  
CO6952V1 CO6952V1 None None   K11R, V35T, E40D, V60I, D121Y, K122E, D123DE, Q174R, D177E, Q207E, R211K, V245K, D250E, A272P, K275R, K277R, Q278H, L282C, I293V, P294S, G335D, P345Q, F346H, R356K, A360T, T377Q, S379C, K390R, A400T, V435M, A437V, S468P, L469F, H483N, S519N, V548I, A554Q T7M 
CO6974V7 CO6974V7 None None M41L  E6D, V35T, E40D, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, Q207D, R211S, V245E, D250E, T286A, E291D, V292I, I293V, E312N, S322A, G335D, A355T, M357K, G359S, T369A, A371V, I375V, A376I, T377M, A400T, T403M, E404D, E432D, V435T, A437V, L452Q, T470N, D471E, Q480H, H483Y, L491S, K512R, E514D, S519N, Q524K, K527E, E529D, A534S, A554S, V559I  
CO6975V2 CO6975V2 None None   V8I, T27A, K32Q, V35T, E36A, T39E, S48T, K102Q, K122E, D123G, K173T, Q174K, T200A, Q207E, V245K, A272P, I274V, Q278H, T286A, E291D, V292I, I293V, G335D, F346H, R356K, G359T, T377Q, S379C, K390R, A400T, E404D, E413D, V435A, L452I, R461K, D471E, H483K, L491S, S519N, K527Q, K530R, A534S, A554S  
CO6980V0 CO6980V0 None None K70N  V35T, E36A, T39E, K43R, S48T, K102Q, D121Y, K122E, K173T, Q174K, D177E, T200A, Q207E, V245Q, E248D, A272P, K275R, V276I, K277R, K281R, E291D, V292I, I293V, P294T, Q334H, G335D, R356K, R358K, G359T, Q367M, I375V, T377M, K390R, E404D, L452K, V458I, D471E, H483Q, L491S, S519N, A534S, V548I, A554S