<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Cavaco-Silva (2014)
Title HIV-2 integrase polymorphisms and longitudinal genotypic analysis of HIV-2 infected patients failing a raltegravir-containing regimen.
Citation PLoS ONE
SelectedGene IN
SelectedSpecies HIV2
SelectedType Clinical
NumIsolates 79
NumPts 72
Host Human

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
BM16604 BM16604 None   S138ST T23S, S39T, A49P, V60T, P119A, I172M, Y227F, E246D, V259I, V260I I18N, I19M, L30K, I58L, Y65C, E69ED, A197S, R215A, N219K, Q224R, L277M, S280G, P281S, H282N, L283LV 
BM17043 BM17043 None    L2I, T23S, S39T, V60T, P119A, I172V, T206A, Y227F, D256E, V260I, R269K I18N, I19V, L30K, A41P, I58L, Y65C, V133I, E167D, R215A, N219K, Q224R, L277M, S280G 
BM17109 BM17109 None    T23S, S39T, V60T, P119A, F220L, N222K, Y227F, E246D, V260I I18N, I19V, K20R, L30N, I58V, Y65C, A197S, R215A, N219K, K221Q, Q224R, L277M, S280G, P281S, L283V 
BM18379 BM18379 None   S138ST T23S, L30T, S39T, I50IV, V60T, I72V, I84IV, L101LI, T111TR, P119A, I172V, R215T, S218L, Y227F, E246D, R269K K4KR, I18N, I28L, N55D, I58L, Y65C, S93ST, N219K, Q224R, L234LQ, E240D, S280G, P281PS 
BM18747 BM18747 None    T23S, S39T, V60T, I72V, P119A, I172V, Y227F, I250L, V259I, V260I I18N, I19V, L30N, R34K, E57D, I58L, Y65C, S93T, E167D, R215A, N219K, Q224R, L277M, S280G, P281S 
BM19240 BM19240 None    L30Q, S39T, V60T, I72IV, P119A, I172V, I175V, S218L, K221R, Y227F, D256E I18N, T23C, I58L, Y65C, R215AS, N219K, Q224R, L277M, S280G, P281S 
BM19552 BM19552 None    T23S, S39T, V60T, P119A, S163N, I172V, N219R, F220L, Y227F, E246D, V260I I18N, K20Q, I28L, L30K, E57D, I58L, Y65C, S93T, V133I, A197S, R215A, Q224R, L277V, S280G, A286T 
BM19562 BM19562 None    T23S, S39T, V60T, I72V, P119A, I172V, Y227F, I250L, V259I, V260I I18N, I19V, L30N, R34K, E57D, I58L, Y65C, S93T, E167D, R215A, N219K, Q224R, L277M, S280G, P281S 
BM19661 BM19661 None    T23S, S39T, V60T, P119A, I172V, T206A, F220L, Y227F, E246D, V249I, D256E, V259I, V260I I18N, I19V, I28L, L30K, I58L, Y65C, V133VI, R215A, N219K, Q224R, V251A, S280G, P281S 
BM20575 BM20575 None    T23S, S39T, V60T, P119A, S163D, I172V, Y227F, E246D K4R, I18N, I19V, I28L, L30N, I58L, Y65C, S93T, E167D, R215A, N219K, Q224R, Q275K, L277M 
BM20853 BM20853 None    T23S, S39T, V60T, I72V, P119A, S163D, I172V, Y227F, E246D I18N, I19IV, I28L, L30K, A41P, I58L, Y65C, S93T, R215A, N219K, Q224R, S280G, P281S 
BM21558 BM21558 None    T23S, S39T, I84V, P119A, I172V, I210IV, S218SL, F220L, Y227F, E246D, R269K I18N, I19V, L30K, A41T, I58L, Y65C, V133VI, E167D, Q214QH, R215AT, N219K, K221KQ, Q224R, T255TA, S280G, P281S 
BM21583 BM21583 None    T23S, S39T, S163D, F220L, Y227F, V260I K4KR, I18N, I19V, L30N, I58L, V60VAIT, Y65C, Q96QH, I110IV, P119AD, V133VI, R215A, N219K, E240Q, L277LM, H282N 
BM21735 BM21735 None    L30T, S39T, V60T, P119A, S163D, I172V, R215S, F220L, Y227F, E246D, R269K K4KR, I18N, I19V, T23C, I28L, R34K, I58L, Y65C, V133I, N219K, Q224R, E276G, L277M, S280G, P281S, G285S 
BM21782 BM21782 None   S138T L2I, Y15F, T23S, S39T, V60T, I72V, P119A, I172V, I175V, T206A, R215T, N219E, F220L, Y227F, E246D, V260VI, R269K K4KR, I18N, I19V, L30K, A41AT, E57D, I58L, Y65C, S93T, Q224R, S280G, P281S 
BM21800 BM21800 None   S138T T23S, S39T, V60T, I72V, P119A, I172V, F220L, Y227F, E246D, R269K I18N, I19V, L30N, R34K, A41P, I58L, Y65C, S93T, V133I, A197S, R215A, N219K, K221Q, Q224R, E240K, L277M, S280G, P281S, H282N 
BM22178 BM22178 None    S39T, V60T, I72IV, P119A, I172V, V180A, T206A, Y227F, E246D, V260I K4R, I18N, I19V, K20Q, T23A, I28L, L30K, I58L, Y65C, R215A, N219K, Q224R, L277M, S280SG, P281S, A286T 
BM22709 BM22709 None    T23S, S39T, V60T, I72V, P119A, Q124H, I172V, F220L, Y227F, E246D I18N, I19V, I28L, L30N, A41T, I58L, Y65C, A153S, E167D, A197S, R215A, N219K, Q224R, L277V, S280G, A286T 
BM22796 BM22796 None    T23S, S39T, V60T, P119A, S163D, I172V, T206A, F220L, Y227F, V260I K4R, I18N, I19V, L30N, A41AT, E57A, I58V, Y65C, Q96Y, A197S, R215A, N217K, N219K, K221Q, Q224R, L277M, S280G, P281S, H282Q, E284G, G285GR, A286T 
BM23158 BM23158 None   S138T T23S, S39T, V60T, I72IV, T122IV, R164K, I172M, I175V, T206A, R215T, F220L, Y227F, E246D, V259I I18N, I19V, L30K, I58V, Y65C, S93ST, E125D, V180T, N219K, Q224R, T255A, S280G, P281PS 
BM23495 BM23495 None    T23S, I50T, V60T, I72V, P119A, S163D, T206A, F220L, Y227F, E246D, V259I K4R, I18N, I28L, L30K, I58L, Y65C, S93T, I175L, R215A, N219K, Q224R, T255A, L277M 
BM24243 BM24243 None    Y15F, T23S, I72V, P119A, I172V, V180I, T206A, F220L, Y227F, I250L, V259I, V260I, I268IV, R269K I18N, I19V, I28L, L30K, A41T, I58L, V60I, Y65C, S93T, V133I, H157P, E167D, E173K, R215A, N219K, Q224R, L277M, S280G, P281S 
BM25708 BM25708 None    Y15F, L31I, S39T, H51Q, V60T, P119A, S163D, I172M, L213F, S218L, S279SN I18N, I19V, K20Q, T23A, I28L, L30K, I58L, Y65C, V133A, R215A, N219K, K221Q, E240K, T255A, S280G, A286T 
BM26527 BM26527 None    T23S, S39T, V60M, P119A, V180I, F220L, Y227F, V259I, V260I, R269K I18N, L30K, A41P, I58L, Y65C, S93ST, M178R, C182Y, A197S, R215A, N219K, Q224R, T255A, L277M, S280G, P281PS, H282HN, A286AT 
BM26716 BM26716 None    T23S, L30Q, S39T, V60T, I72V, P119A, I172V, V180I, T206A, F220L, Y227F, E246D, V259I I18N, I19V, I28L, I58L, Y65C, E87EK, S93T, V129A, V133I, E167D, R215A, N219K, Q224R, L277M, A286T 
BM28874 BM28874 None    T23S, V32VI, S39T, V60T, P119A, T206A, F220L, Y227F, V260I K4KR, I18N, I19V, K20Q, I28L, L30K, I50M, I58L, Y65C, S93T, V133I, N170I, Q214H, R215A, N217ND, N219K, Q224R, L277M, S280G, P281S 
BM28876 BM28876 None    T23S, S39T, P119A, I172V, T206A, F220L, Y227F, E246D, V260I I18N, I19V, I28L, L30K, A41T, I58L, V60VI, Y65C, Q96QH, E167D, R215A, N219K, Q224R, L234Y, W235S, L241H, S280G 
BM28877 BM28877 None    Y15F, S17SG, T23S, I50V, V60T, I72V, I172V, I175V, V180A, S218L, N222K, Y227F, E246D, V259I, R269RK I18N, K20R, L30K, Y65C, S93T, H156HP, N170E, R188W, G189E, G190E, R215A, N219K, K221Q, T255A, S280G, P281S, H282R, A286T 
BM28955 BM28955 None    L2I, T23S, V60T, I72V, P119A, S163D, I172M, R215T, Y227F, V260I K4R, I18N, I19M, I28L, L30K, A41AT, Y65C, S93T, V133VA, N219K, Q224R, L277M, S280G 
BM29126 BM29126 None    T23S, S39ST, I50T, I172V, T206A, F220L, Y227F, E246D, V259I, V260I, R269K I18N, I19V, I28L, L30K, I58L, V60I, Y65C, S93T, E167D, R215A, N219K, Q224R, L277MV, S280SG, A286AT 
BM30143 BM30143 None    T23S, S39T, V60T, I72IV, P119A, S163D, I172V, F220L, Y227F, E246D, V259I I18N, L30K, I58L, Y65C, E167D, R215A, N219K, Q224R, T255A, V260VIM, L277M, S280G, P281S, L283LV 
BM30909 BM30909 None   S138ST L2I, Y15F, T23S, S39T, V60T, I72V, P119PAGR, I172V, I175V, V180A, T206S, F220L, N222K, Y227F, V259I, V260I I18N, I19IV, L30K, A41P, I50M, I58L, Y65C, S93T, E167D, R215A, N219K, K221Q, T255A, S280G, P281S 
BM31355 BM31355 None    T23S, L30Q, S39T, V60T, I72V, P119A, I172V, T206TA, F220L, Y227F, I250L, V259I, V260I I18N, I19V, A41P, I58L, Y65C, S93T, V133VI, E167D, A197S, R215A, N219K, Q224R, V251A, T255A, L277M, S280G, P281S 
BM31445 BM31445 None    L2I, T23S, S39T, A41AG, V60T, I72IV, P119A, S163D, I172V, T206A, F220L, Y227F, E246D, V259I, R274K K4R, I18N, I19V, I28L, L30K, I58L, Y65C, E167D, R215A, N219K, Q224R, L277V, S280G 
BM31845 BM31845 None    L2I, S39T, I50T, V60T, I72V, P119A, I172V, I175V, V180A, N222K, Y227F, V259I, V260I I18N, I19V, T23C, L30N, I58L, Y65C, S93T, E167D, A197S, R215A, N219K, K221Q, Q224R, I250IV, V251A, S279C, S280G, P281S 
BM31959 BM31959 None    T23S, L30Q, S39T, V60T, I72V, P119A, V133T, T206A, R215S, S218L, Y227F I18N, I19M, A41P, I58V, Y65C, S93T, E167D, Q214H, N219K, Q224R, H282N 
BM32450 BM32450 None   R95K L2I, T23S, S39T, V60T, I72V, P119A, S163D, I172V, T206A, F220L, Y227F, E246D, D256E K4R, I18N, I19V, I28L, L30K, I58L, Y65C, V133I, A197S, R215A, N219K, Q224R, E229EK, Q233H, S280G, P281S, H282N 
BM32511 BM32511 None    L2I, T23S, S39T, V60T, P119A, I172V, R215T, F220L, N222K, Y227F, E246D, R269K I18N, L30K, A41P, I58L, Y65C, V133I, A197S, N219K, K221Q, Q224R, L277M, S280G, P281S, L283V, G285D, A286T 
BM32677 BM32677 None    S39ST, V60T, I72IV, P119A, V133T, R164K, I172M, T206A, F220L, Y227F, E246D, V259I K4R, I18N, I19M, T23A, I28L, L30N, R34K, I58L, Y65C, S93T, R215A, N219K, Q224R, T255A, S280G, P281S 
BM33738 BM33738 None    L2I, S39T, V60T, P119A, I172V, I175V, T206A, L213F, F220L, Y227F, E246D, V259I, V260I, R269K I18N, L30K, I50M, I58L, Y65C, V141I, E167D, R215A, N219K, Q224R, T255A, S280G, G285S 
BM33853 BM33853 None    L2I, L30Q, S39T, V60T, I72IV, P119A, V180I, H181Y, T206TA, I210IV, F220L, Y227F, E246D, D256E I18N, I19V, Y65C, S93T, M178I, E207D, Q214QH, R215A, N219K, Q224R, T255TA, S280G, P281S 
BM34602 BM34602 None    T23S, S39T, V60T, P119A, L213F, F220L, Y227F, V260I, R269K I18N, L30K, N55D, I58L, Y65C, S93T, R215A, N219K, Q224R, L277M, S280SG 
BM35346 BM35346 None   S138T S17T, S39T, I72V, P119A, I172V, I175V, V180I, Y227F, I250L, V260I I18N, I19V, T23C, I28L, L30M, R34K, I58L, V60IT, Y65C, E167D, R215A, N219K, Q224R, S280G 
BM35855 BM35855 None    T23S, S39T, V60T, I72V, P119A, V180I, T206A, F220L, Y227F, E246D, S279N I18N, I28L, L30K, N55D, I58L, Y65C, Q96H, R215A, N219K, Q224R, P281S, H282HN 
BM35864 BM35864 None    T23S, S39T, A41N, I72V, P119A, R164K, I172V, T206A, F212FL, F220L, Y227F, E246D, V260I, R269K I18DN, I19V, I28L, L30K, I58L, V60I, Y65C, S93T, H156L, E167D, R215A, N219K, Q224R, S280G, A286T 
BM35953 BM35953 None    L2I, T23S, S39T, V60T, I72V, P119G, I172V, F220L, N222K, Y227F, E246D, V260I, R269K I18N, I19V, L30K, I58L, Y65C, V133I, A197S, R215A, N219K, K221Q, Q224R, T255A, L277M, S280G, P281S, L283V 
BM36649 BM36649 None    T23S, S39T, V60T, I72IV, P119A, S163SN, I172M, T206A, F220L, Y227F, E246D, V259I I18N, I19IV, L30K, A41AT, N55D, I58F, Y65C, S93T, S106G, R215A, N219K, Q224R, T255A, L277M, S280G, A286AT 
BM38011 BM38011 None    T23S, S39T, V60T, P119A, I172V, R215N, F220L, Y227F, E246D I18N, I19V, L30N, I58L, Y65C, S93T, V133I, E167D, A197S, Q214QH, N219K, Q224R, L277M, S280G, P281S, A286T 
BM38018 BM38018 None    S17T, T23S, L30Q, S39T, V60T, I72V, P119A, R164K, V180I, L200V, I210V, K216KR, S218L, Y227F I18N, I19V, I28L, A41P, Y65C, S93T, V133VI, S163SDGN, L177V, R215A, N219K, Q224R, S280G, P281S 
BM38019 BM38019 None   S138T Y15F, T23S, S39T, V60T, I72V, P119A, R164K, F220L, Y227F, E246D I18N, I19IV, L30K, R34K, N55D, I58L, Y65C, S93T, V180T, A197AS, R215AT, N219K, Q224R, T255A, S280G 
BM38341 BM38341 None    L30Q, S39T, V60T, I72V, P119A, S163N, I172V, F220L, Y227F, E246D, V259I I18N, I19V, T23C, I28IL, A41T, I58L, Y65C, S93T, V133I, E167D, A197S, L200F, R215A, N219K, Q224R, L277M, S280SG 
BM38589 BM38589 None    L2I, T23S, S39T, I50IT, V60T, I72V, P119A, I172V, I175V, Y227F, R228RK, E246D, V259I I18N, I19V, L30K, I58L, Y65C, S93T, A197S, E207D, R215A, Q224R, S280G, G285GS 
BM39196 BM39196 None   S138T T23S, S39T, V60T, P119A, I172V, F220L, Y227F, E246D, V259I, V260I I18N, I19V, I28L, L30K, A41T, I58L, Y65C, A197S, R215A, N219K, Q224R, L277M, S280G, A286T 
BM39754 BM39754 None    S39T, V60T, I72V, P119A, I172V, Y227F, E246D, R269K K4R, I18N, T23A, I28L, L30K, I58L, Y65C, S93T, E167D, A197S, I201IV, R215A, N219K, K221Q, Q224R, L277M, S280G, A286AT 
BM41864 BM41864 None   S138T T23S, L30Q, L31I, S39T, V60T, P119A, I172V, T206A, F220L, Y227F, E246D, R269K I18N, I19M, Q42Q*, E57D, I58L, Y65C, S93ST, H114HQ, A197S, R215A, N219KR, Q224R, S280G, P281S, A286T 
BM44207 BM44207 None    T23S, L31I, S39T, V60T, I72V, P119A, I172V, T206A, S218L, F220L, Y227F, E246D, I268IV, R269K I18N, I19V, K20Q, I28ILM, L30K, N55D, I58L, Y65C, V133I, A197AS, Q214H, R215AS, N219K, Q224R, L277M, S280G, P281S 
BM44558 BM44558 None   S138T T23S, S39T, V60T, I72V, P119A, I172V, I175V, F220L, N222K, Y227F, E246D, V260I, R269K, D278DG K4KNRS, I18N, L30KN, R34RK, A41T, I58L, Y65C, V133VI, R215A, N219K, K221Q, Q224R, T255A, A286T 
BM44683 BM44683 None   S138T S17T, L30T, S39T, V60T, P119A, F220L, Y227F, I250L, V259I, V260I, S279N I18N, I19V, T23C, I28L, I58V, Y65C, A197S, R215A, N219K, Q224R, L277M, S280G, P281S, A286T 
BM45160 BM45160 None    S39T, I50V, V60T, I72V, I84V, P119A, R215S, Y227F, E246D, V259I I18N, I19V, T23A, I28L, R34K, I58L, Y65C, S93T, A153S, A197S, N219K, Q224R, S280G, A286T 
BM46095 BM46095 None    T23S, S39ST, I50T, I172V, T206A, F220L, Y227F, E246D, V259I, V260I, R269K I18N, I19V, I28L, L30K, I58L, V60I, Y65C, S93T, E167D, R215A, N219K, Q224R, L277M, S280SG, A286AT 
BM46206 BM46206 None    T23S, S39T, V60T, I84IV, P119A, H156R, S163D, I175V, I210IV, Y227F, I250L, D256E, V260I I18N, I19IV, K20Q, I28L, L30K, I58L, Y65C, S93T, E167D, A197S, R215A, N219K, Q224R, V251A, L277M, S280G, P281S 
BM46587 BM46587 None    T23S, L30T, V60T, I72V, L113V, P119A, S163N, T206A, F220L, Y227F, V249VI, I250L, V259I, V260I I18N, I19V, Y65C, Q96H, E167D, V180T, I201T, R215A, N219K, Q224R, V251A, T255A, L277M, S280G, P281S 
BM47037 BM47037 None    T23S, S39T, V60T, P119PA, S163D, N219R, Y227F, E246D, V249VI, D256E, I267IV, R269K K4R, I18N, I19V, I28L, L30K, I58L, Y65C, T122TIM, V133VI, E167D, A197S, R215A, Q224R, S280G, P281S 
HIV2_001 BM32050 RAL  Q148R  I72V, P119A, I172V, T206A, F220L, Y227F, E246D, V259I, R269K I18N, T23A, I28L, L30K, A41T, I58L, V60I, Y65C, S93T, E167D, R215A, N219K, Q224R, S280SG, A286S 
HIV2_002 BM19690 RAL  N155H E92A, S138T S39T, Q44QH, V60T, I72V, I84V, P119A, I172V, F220L, Y227F, E246D, V259I I18N, I19V, T23C, I28L, L30K, A41T, I58L, Y65C, S93T, A153G, G190E, A197S, R215A, N219K, Q224R, S280G 
HIV2_003 BM22175 RAL  N155H  T23S, S39T, V60T, I84V, P119A, I172V, I175V, T206A, R215N, F220L, Y227F, E246D, V259I, V260I I18N, I19V, I28L, L30K, I50M, I58L, Y65C, S93T, A153G, N219K, Q224R, T255A, S280G, P281PS 
HIV2_004 BM31028 RAL  E92Q, N155H T97A Y15F, T23S, L30T, S39T, Q44H, V60T, K71R, I72IV, P119A, K127R, S163D, T206A, F220L, Y227F, V260I K4R, I18N, A41P, Q45QH, I58L, Y65C, S93T, R215A, N219K, Q224R, S280G 
HIV2_005 BM36920 RAL  N155H E92A, S138ST L30Q, S39T, V60T, I72V, I84V, P119A, I172V, S218Q, F220L, N222K, Y227F, D232N, E246D, R269K, D278G K4R, I18N, I19M, T23A, I28L, R34K, I58L, Y65C, S93T, A153G, R215A, N219K, K221Q, Q224R, K236T, E240DN, T255A, E276D, S280G, P281S 
HIV2_006 BM19302 RAL  E92EQ, N155H  T23S, V60T, I72V, I84V, P119A, I172V, F220L, Y227F, E246D, V259I I18N, I19V, I28L, L30QR, I58L, Y65C, S93T, E167ED, A197S, R215A, N219K, Q224R 
  BM29665 RAL  E92Q, N155H  T23S, L30Q, V60T, I72V, I84V, P119A, H156R, I172V, F220FL, Y227F, E246D, V259I I18N, I19V, I28L, V32VM, A33S, R34RK, C43W, I58L, Y65C, S93T, A197S, R215A, N219K, Q224R, I250IV 
  BM46590 RAL  N155H E92G, V151VI T23S, S39T, K46KR, I72V, P119A, I172V, T206A, S218SL, F220L, Y227F, E246D, I268IV, R269K I18N, L30K, A41P, I58L, V60I, Y65C, N160NK, E167D, Q214QH, R215A, N219K, Q224R 
  BM36989 RAL, Unknown  E92Q, N155H  T23S, L30Q, K46R, V60T, I72V, I84IV, P119A, H156R, I172V, F220FL, Y227F, E246D, V259I I18N, I19V, I28L, I58L, Y65C, S93T, A153AS, H157HNRS, N160ND, E167ED, A197S, Q214QH, R215A, N219K, Q224R 
HIV2_007 BM20055 RAL  N155H  Y15F, T23S, V32I, I72V, P119PA, I172IV, T206A, L213F, F220L, Y227F, V259I, V260I, R269K I18N, L30K, A41T, I58L, Y65C, S93T, E167D, R215A, N219K, Q224R, L242LP, T255A 
  BM23864 RAL  N155H  Y15F, T23S, V32I, K46KR, I72V, T122TI, I172IV, T206A, L213F, F220L, Y227F, D232DN, V259I, V260I, R269K I18N, L30K, A41T, I58L, Y65C, Q91QR, S93T, E167D, R215A, N219K, Q224R, T255A 
  BM32818 RAL  E92EQ, N155NH  Y15F, T23S, V32I, K46KR, I72IV, P119PA, I172V, T206A, L213F, F220L, Y227F, V259I, V260I, R269K I18N, L30K, A41T, I58L, Y65C, S93T, H156HDGR, E167D, R215A, N219K, Q224R, T255A 
  BM47172 RAL  E92Q T97A Y15F, T23S, V32VI, K46R, I72V, P119A, I172V, T206A, L213F, F220L, Y227F, V259I, V260VI, R269K I18N, L30K, A41T, I58L, Y65C, S93T, H156G, N160K, E167D, N170D, R215A, N219K, Q224R, T255TA, L277M, S280SG, P281PS, L283LV 
HIV2_009 BM25541 RAL  E92Q T97A, S138T T23S, S39T, V60T, P119A, R164K, I172IM, Y227F, E246D, V259I, K264KR, R269K K4R, I18N, I19V, L30K, I58V, Y65C, E85EK, S93ST, H156GR, V180T, R215A, N219K, Q224R, S280G 
HIV2_010 BM32451 RAL   S138T S39T, I50T, V60T, P119A, T122TI, I172M, I175V, F220L, Y227F, E246D, V259I, V260I I18N, K20KR, T23C, L30N, I58L, Y65C, S93T, V133VI, R215A, N219K, Q224R 
  BM45481 RAL  E92EQ T97A, S138T S39T, I50T, V60T, P119A, H156HR, I172M, I175V, F220L, Y227F, E246D, V259I, V260I I18N, T23C, L30N, I58L, Y65C, S93T, R215A, N219K, Q224R, S280SG