<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Bercoff (2010)
Title Polymorphisms of HIV-2 integrase and selection of resistance to raltegravir.
Citation Retrovirology
SelectedGene IN
SelectedSpecies HIV2
SelectedType Clinical
NumIsolates 52
NumPts 52
Host Human

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
19970068 19970068 None    Y15F, S39T, V60T, P119A, S163D, I172M, F220L, Y227F, V259I, R269RK K4KR, I18N, T23A, I28L, L30KN, R34RK, A41AT, I58L, Y65C, S93ST, R215A, N219K, Q224R, I250V, L277LM, S280SG, L283V 
19980385 19980385 None    S39T, V60T, I72V, P119A, S163D, I172V, I175V, I201L, F220L, Y227F, E229EG, E246D, V260I, R269K K4R, I18N, I19V, T23AS, L30K, I58L, Y65C, Q96H, A197S, R215A, N217D, N219K, Q224R, T255A, L277M, P281PS, H282N 
19990547 19990547 None    T23S, S39T, V60T, P119A, R164K, V259I, V260I, R269K K4R, I18N, I19V, L30K, I58L, Y65C, Q214QH, R215A, N219K, L234Q, T255A, S280G, P281PS 
19990656 19990656 None    T23S, S39T, V60T, I72V, P119A, S163D, I172V, I175V, I201L, F220L, Y227F, E246D, V260I, R269K K4R, I18N, I19V, L30K, I58L, Y65C, Q96H, A197S, R215A, N217D, N219K, Q224R, T255A, L277M, P281PS, H282N 
20010473 20010473 None    Y15F, T23S, S39T, P119A, I172M, T206A, N222K, Y227F, E246D, V249VI, V259VI, V260I, R269K I18N, I19V, L30K, I58L, V60I, Y65C, E167D, R215A, N219K, Q224R, V251VA, R274RT, L277M, S280G, P281PS, G285D, A286T 
20010866 20010866 None    T23S, S39T, V60T, P119A, S163D, I172V, R215T, F220L, Y227F, E246D, V259I, V260I I18N, L30K, I58L, Y65C, S93ST, E167D, A197S, N219K, Q224R, T255A, L277V, S280G, A286AT 
20040941 20040941 None    T23S, S39T, V60T, I72IV, P119A, S163N, I172V, F220L, Y227F, E246D, R269RK I18N, L30K, I58L, Y65C, A197S, R215A, N219K, K221Q, Q224R, S280G, P281S, A286T 
20050011 20050011 None    T23S, L30Q, S39T, V60T, I72V, P119A, I172V, F220L, Y227F, E246D, V259I, V260VI I18N, I19V, I58L, Y65C, S93T, V133VI, E167D, A197S, R215A, N219K, Q224R, L277M, S280G 
20050388 20050388 None    T23S, S39T, V60T, I72V, P119A, M154MI, I172V, F220L, Y227F, E246D, V259I, V260I I18N, I19V, I28L, L30K, I58L, Y65C, S93T, V133I, R215A, N219K, Q224R, T255A, L277M, S280G, P281T, H282N 
20050508 20050508 None    T23S, S39T, V60T, P119A, I172V, Y227F, E246D, V259I, V260I I18N, I19V, I28L, L30K, A41T, I58L, Y65C, A197S, R215A, N219K, Q224R, L277M, S280G, P281S, A286T 
20050775 20050775 None    T23S, S39T, V60T, P119A, R215T, N219T, E246D, V259I, V260I I18N, I19V, I28L, L30K, I58V, Y65C, Q224R, L277M, S280G 
20070313 20070313 None   S138T S39T, V60T, P119A, I172V, F220L, Y227F, E246D, V260I I18N, I19IV, T23A, L30K, A41P, I58L, Y65C, A153S, R215A, N219K, K221Q, Q224R, T255A, L277M, S280G, P281PS 
20080321 20080321 None    L2I, Y15F, S39T, V60T, P119AT, S163D, I172M, F220L, Y227F, V259I K4R, I18N, T23AV, I28IL, L30N, R34K, I58IL, Y65C, S93ST, R215A, N219K, Q224R, I250V, L283V 
20080511 20080511 None   S138T S39T, V60T, P119A, I172V, F220L, Y227F, E246D, V260I I18N, T23A, L30K, A41P, I58L, Y65C, A153S, R215A, N219K, K221Q, Q224R, T255A, L277M, S280G 
20080618 20080618 None   S138T T23S, S39T, V60T, P119A, S163D, I172V, F220L, Y227F, E246D, V259I, V260I I18N, L30K, I58L, Y65C, S93T, E167D, A197S, R215AT, N219K, Q224R, T255A, L277V, S280G, A286AT 
20080869 20080869 None    T23S, L30Q, S39T, V60T, I72V, P119A, I172V, F220L, Y227F, E246D, V259I I18N, I19V, I58L, Y65C, S93T, E167D, A197S, R215A, N219K, Q224R, L277M, S280G 
20081032 20081032 None    T23S, S39T, V60T, P119A, R164K, Y227F, V259I, V260I, R269K K4R, I18N, I19V, L30K, I58L, Y65C, E167D, R215A, N219K, S280G 
20081171 20081171 None   S138T K14KR, S17G, T23V, L30Q, I50V, V60T, T111TA, P119A, S163D, I175V, V180A, S218L, D256E, D270H I18N, I19M, A41D, Q42K, I58L, Y65C, S93T, E125D, E167D, N170V, T171S, I172L, I201V, L213LH, R215A, N219K, K221KQ, V251I, R274G, Q275K, S279C, S280G, P281T, H282D, L283M, G285D, A286T, E288Q 
20081313 20081313 None    L2I, T23S, V60T, K71R, I72V, P119A, G134GS, S163D, I172V, R215T, F220L, Y227F, E246D, V260I K4R, I18N, I19V, I28L, L30K, I58L, Y65C, E69EK, S93T, G118GS, N219K, Q224R, S280G, P281S 
20090342 20090342 None    L2I, L31I, S39T, V60T, I72V, P119A, S163D, I172V, T206A, F220L, Y227F, E246D, D256E K4R, I18N, T23A, L30K, Y65C, R215A, N219K, Q224R, L277M, S280SG, P281S 
ITG12880 ITG12880 None    Y15F, S39T, P119A, I172V, T206A, L213F, F220L, Y227F, E246D, V259I, R269K I18N, I19V, T23A, L30K, A56T, I58L, V60I, Y65C, Q96QH, E167D, R215A, N219K, Q224R, L277M, S280G, P281PS 
ITG17659 ITG17659 None    L30Q, S39T, S163N, F220L, E246D, D270N I18N, A41T, Y65C, N219I, T255A, P281S 
ITG24071 ITG24071 None    T23S, S39T, V60T, I72V, P119A, I172M, R215T, Y227F, E246D P7PS, I18N, I28L, L30K, A41T, I58V, Y65C, E125D, N219K, Q224R, L277M, S280G, P281S, H282N, L283V 
ITG2545 ITG2545 None    T23S, S39T, V60T, P119A, I172V, R215T, Y227F, E246D I18N, I28L, L30K, A41T, I58V, Y65C, V133VI, N219K, Q224R, L277M, S280G, P281S, H282N 
ITG28175 ITG28175 None    Y15F, S39T, I72IV, P119A, I172V, F185FY, T206A, F212FY, L213F, F220L, Y227F, E246D, V259I, R269K I18N, I19V, T23A, L30K, A56T, I58L, V60I, Y65C, Q96CY, E167D, R215A, N219K, Q224R, L277M, S280G, P281PS 
V060880 V060880 None   S138T L2I, T23S, S39T, V60T, M63I, P119A, S163D, F220L, Y227F, E246D, D256E, V259I K4R, I18N, I19V, G27R, I28L, L30K, I58L, Y65C, S81N, V133I, A197S, R215A, N219K, Q224R, V251I, T255S, S280G 
V061132 V061132 None   S138T K4N, S17G, T23V, L30Q, A56S, V60T, I72V, P119A, N160S, S163D, I175V, R215T, S218L, D256E, D270H I18N, I19V, A41D, Q42K, I58L, Y65C, S93T, E125D, V129A, V133I, E167D, N170V, T171S, V180T, L200I, I201V, N219K, K221Q, Q224R, V251I, R274G, Q275K, S279C, S280G, P281A, H282D, L283V, G285D, A286T, E288Q 
V061139 V061139 None    L30Q, S39T, P119A, I172V, E246D I18N, Y65C, E167D, E276G 
V063475 V063475 None    L30Q, S39T, V60T, P119A, I172M, I175V, Y227F I18N, I19V, T23A, I28L, I58L, Y65C, R215A, N219K, Q224R, L277M, S280G, P281T, H282N 
V063553 V063553 None    L30H, S39T, I172V, N222K, E246D I18N, I19V, T23I, Y65C, V133VI 
V071200 V071200 None    L30Q, S39T, P90S, S163D, T206A, N222K, E246D I18N, I58V, Y65C, Q91QR, T255A 
V071737 V071737 Unknown  N155H  L30Q, S39T, M154T, S163N I18N, Y65C, S93T, H157R, L234Q, S280G, P281S 
V074155 V074155 None   S138T L30Q, S39T, V60T, I84V, P119A, I172M, I175V, Y227F, E246D I18N, I19V, T23A, I28L, I58L, Y65C, R215A, N219K, Q224R, L277M, S280G, P281T, H282N 
V080553 V080553 None    T23S, S39T, V60T, I72V, P119A, I172V, F220L, Y227F, E246D, V259I I18N, I19V, I28L, L30K, A41T, I58L, Y65C, V133I, A197S, R215A, N219K, Q224R, T255A, L277M, S280G 
V082661 V082661 None   S138T S17G, T23V, L30Q, V60T, P119A, S163D, I175V, L213F, R215T, S218L, Y227F, D256E, D270H I18N, I19V, R34K, A41D, Q42K, I58L, Y65C, S93T, E125D, E167D, N170V, T171S, V180T, I201V, N219K, V251I, R274G, Q275K, S279C, P281A, H282D, L283V, G285D, A286T 
V086011 V086011 None    L30H, S39T, H51HQ, I72IV, P119A, I172V, N222K, E246D, S279SN I18N, I19V, T23I, A56AT, G59GV, V60VF, Y65C, V133A, L158LP, E167D, P281S 
V086050 V086050 None    L30Q, S39T, P119A, S163N, I172V, I175T, F185Y, N222K, E246D I18N, I19V, A41T, A56T, I58V, V60I, Y65C 
V086051 V086051 None   S138T S17G, T23V, L30Q, V60T, P119A, S163D, I172V, I175V, V180A, L213F, R215N, S218L, D256E, D270H I18N, I19V, R34K, A41D, Q42K, I58L, Y65C, S93T, A98P, E125D, E167D, N170V, T171S, I201V, N217K, N219K, K221Q, V251I, R274G, Q275K, S279C, P281A, H282D, L283MV, G285D, A286T 
V086052 V086052 None    L30Q, S39T, V133T, S163N E6Q, H16L, I18N, I19L, I58V, Y65C, P119S, T255A, P281S, A286T 
V086119 V086119 None    L30Q, S39T, V60T, S163D, I172IV, D232DE, V260VI K4KR, I18N, Y65C, S93ST, N170NS, Y226YF, L234LQ 
V086120 V086120 None    L30Q, S39T, P119A, S163N, N219NT, K236R, E246D, S279N I18N, I58V, Y65C, V133A, L234Q, P281S 
V086121 V086121 None   S138T T23S, V60T, I72V, P119A, I175V, V180A, S218L, D270H E3L, I18N, I19V, L30N, A41D, Q42K, I58L, Y65C, S93ST, E125D, L158P, E167D, N170V, T171S, I201V, R215A, N219K, K221Q, V251I, T255A, Q275K, E276D, S279C, S280G, P281A, H282D, L283M, G285D 
V086122 V086122 None    L30Q, S39T, I175V, E246D I18N, I19M, T23I, Y65C, S93T, V180T, T255A 
V086123 V086123 None   S138T E13G, S17G, T23V, L30Q, I50V, H51Q, V60T, I72V, T122I, S163D, I175V, I204V, L213F, S218L, D256E, V260I E6V, I18N, I19V, R34K, A41D, Q42K, I58L, Y65C, S93T, E125D, E167D, N170V, T171S, I201V, R215A, N219K, K221Q, V251I, D270Q, R274G, Q275K, E276G, S279C, S280G, P281T, H282D, L283M, G285D, A286T, E288Q 
V086124 V086124 None    L30Q, S39T, V60T, S163D, D232E I18N, Y65C, S93ST, Y226F, L234Q 
V086127 V086127 None    L30Q, S39T, S163N, E246D, I267V I18N, A41T, Y65C, L234Q 
V086130 V086130 None   S138T T23V, L30Q, V60T, S163N, A169S, I172V, E246D K4KR, I18N, S39K, Y65C, V133I, G285S 
V086131 V086131 None    T23S, S39T, V60T, P119A, F220L, Y227F, E246D, V260I, S279N I18N, I19IM, I28L, L30K, R34K, N55D, I58L, Y65C, Q214H, R215A, N219K, K221QR, Q224R, T255A, S280G, P281S 
V086136 V086136 None    L30Q, S39T, I72V, I84IV, P90PS, M154MI, S163SN, I172V, E246D F1FL, I18N, N55ND, I58IV, Y65C, S93T, V133I, V141I, A153AS, S280SG, P281S, A286AS 
V086139 V086139 None    T23V, L30Q, S39T, I172V, N222K, E246D I18N, I19M, A41P, Y65C, V133VI, F220FS, T255A, P281PS 
V086140 V086140 None    L30Q, S39T, E246D I18N, I58V, Y65C, E136G 
V086141 V086141 None    L30Q, S39T, T111S, E246D I18N, Y65C, P281S, G285S, R287K