Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Bercoff (2010)
Title Polymorphisms of HIV-2 integrase and selection of resistance to raltegravir.
Citation Retrovirology
SelectedGene IN
SelectedSpecies HIV2
SelectedType Clinical
NumIsolates 52
NumPts 52
Host Human

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
19970068 19970068 None    Y15F, S39T, S163D, I172M, R269RK, G278GS K4KR, V19I, S23A, I28L, N30NK, R34RK, A41AT, S93ST, I133V, I180V, S197A, D222N, L250V, I260V, M275ML, S279P, L281V 
19980385 19980385 None    S39T, I72V, S163D, I172V, I175V, I201L, E229EG, E246D, L250I, R269K, G278S K4R, S23SA, N30K, Q96H, I133V, I180V, N217D, D222N, T255A, I259V, S279SP, H280N 
19990547 19990547 None    S39T, R164K, Q214QH, L220F, L250I, R269K K4R, N30K, I133V, I180V, S197A, D222N, R224Q, F227Y, L234Q, T255A, M275L, S279SP 
19990656 19990656 None    S39T, I72V, S163D, I172V, I175V, I201L, E246D, L250I, R269K, G278S K4R, N30K, Q96H, I133V, I180V, N217D, D222N, T255A, I259V, S279SP, H280N 
20010473 20010473 None    Y15F, S39T, I172M, T206A, L220F, D222K, E246D, V249VI, L250I, R269K, G283D, D286DN N30K, T60I, I133V, E167D, I180V, S197A, V251VA, I259IV, S279SP 
20010866 20010866 None    S39T, S163D, I172V, A215T, E246D, L250I, M275V V19I, N30K, S93ST, I133V, E167D, I180V, D222N, T255A, S279P 
20040941 20040941 None    S39T, I72IV, S163N, I172V, E246D, L250I, R269RK V19I, N30K, I133V, I180V, K221Q, D222N, I259V, I260V, M275L 
20050011 20050011 None    N30Q, S39T, I72V, I172V, E246D, L250I S93T, I133IV, E167D, I180V, D222N, I260IV, S279P 
20050388 20050388 None    S39T, I72V, M154MI, I172V, E246D, L250I I28L, N30K, S93T, I180V, S197A, D222N, T255A, S279T, H280N 
20050508 20050508 None    S39T, I172V, L220F, E246D, L250I I28L, N30K, A41T, I133V, I180V, D222N 
20050775 20050775 None    S39T, A215T, K219T, L220F, E246D, L250I I28L, N30K, L58V, I133V, I180V, S197A, D222N, F227Y, S279P 
20070313 20070313 None   S138T S39T, I172V, E246D, L250I V19VI, S23A, N30K, A41P, I133V, A153S, I180V, S197A, K221Q, D222N, T255A, I259V, S279SP 
20080321 20080321 None    L2I, Y15F, S23X, S39T, A119AT, S163D, I172M, G278S K4R, V19I, I28IL, R34K, L58LI, S93ST, I133V, I180V, S197A, D222N, L250V, I260V, M275L, S279P, L281V 
20080511 20080511 None   S138T S39T, I172V, E246D, L250I V19I, S23A, N30K, A41P, I133V, A153S, I180V, S197A, K221Q, D222N, T255A, I259V, S279P 
20080618 20080618 None   S138T S39T, S163D, I172V, A215AT, E246D, L250I, M275V V19I, N30K, S93T, I133V, E167D, I180V, D222N, T255A, S279P 
20080869 20080869 None    N30Q, S39T, I72V, I172V, E246D, L250I S93T, I133V, E167D, I180V, D222N, I260V, S279P 
20081032 20081032 None    S39T, R164K, L220F, L250I, R269K K4R, N30K, I133V, E167D, I180V, S197A, D222N, R224Q, M275L, S279P 
20081171 20081171 None   S138T K14KR, S17G, S23V, N30Q, I50V, T111TA, S163D, I175V, I180A, S218L, L220F, L250I, D256E, D270H, S277C, L281M, G283D, D286A V19M, A41D, Q42K, S93T, E125D, I133V, E167D, N170V, T171S, I172L, S197A, I201V, L213LH, K221KQ, D222N, R224Q, F227Y, V251I, I259V, I260V, Q273K, M275L, S279T, H280D, E285Q, G287R 
20081313 20081313 None    L2I, K71R, I72V, G134GS, S163D, I172V, A215T, E246D, L250I K4R, I28L, N30K, E69EK, S93T, G118GS, I133V, I180V, S197A, D222N, I259V, M275L 
20090342 20090342 None    L2I, L31I, S39T, I72V, S163D, I172V, T206A, E246D, L250I, D256E, G278GS K4R, V19I, S23A, N30K, L58I, I133V, I180V, S197A, D222N, I259V, I260V 
ITG12880 ITG12880 None    Y15F, S39T, I172V, T206A, L213F, E246D, L250I, R269K S23A, N30K, A56T, T60I, Q96QH, I133V, E167D, I180V, S197A, D222N, I260V, S279SP 
ITG17659 ITG17659 None    S23T, N30Q, S39T, T60V, A119P, S163N, A215R, E246D, L250I, D270N, G278S V19I, A41T, L58I, I133V, I180V, S197A, K219I, D222N, R224Q, F227Y, T255A, I259V, I260V, M275L 
ITG24071 ITG24071 None    S39T, I72V, I172M, A215T, L220F, E246D, L250I P7PS, V19I, I28L, N30K, A41T, L58V, E125D, I133V, I180V, S197A, D222N, I259V, I260V, H280N, L281V 
ITG2545 ITG2545 None    S39T, I172V, A215T, L220F, E246D, L250I V19I, I28L, N30K, A41T, L58V, I133IV, I180V, S197A, D222N, I259V, I260V, H280N 
ITG28175 ITG28175 None    Y15F, S39T, I72IV, Q96X, I172V, F185FY, T206A, L213F, E246D, L250I, R269K S23A, N30K, A56T, T60I, I133V, E167D, I180V, S197A, F212FY, D222N, I260V, S279SP 
V060880 V060880 None   S138T L2I, S39T, M63I, S163D, E246D, L250I, D256E K4R, G27R, I28L, N30K, S81N, I180V, D222N, V251I, T255S, I260V, M275L, S279P 
V061132 V061132 None   S138T K4N, S17G, S23V, N30Q, A56S, I72V, N160S, S163D, I175V, A215T, S218L, L220F, L250I, D256E, D270H, S277C, S279A, G283D, D286A A41D, Q42K, S93T, E125D, V129A, E167D, N170V, T171S, I180T, S197A, L200I, I201V, K221Q, D222N, F227Y, V251I, I259V, I260V, Q273K, M275L, H280D, L281V, E285Q, G287R 
V061139 V061139 None    S23T, N30Q, S39T, T60V, I172V, A215R, K219N, L220F, E246D, L250I, G278S V19I, L58I, I133V, E167D, I180V, S197A, D222N, R224Q, F227Y, I259V, I260V, E274G, M275L, S279P 
V063475 V063475 None    N30Q, S39T, I172M, I175V, L220F, L250I S23A, I28L, I133V, I180V, S197A, D222N, I259V, I260V, S279T, H280N 
V063553 V063553 None    N30H, S39T, T60V, A119P, I172V, A215R, K219N, L220F, D222K, E246D, L250I, G278S S23I, L58I, I133IV, I180V, S197A, R224Q, F227Y, I259V, I260V, M275L, S279P 
V071200 V071200 None    S23T, N30Q, S39T, T60V, P90S, A119P, S163D, T206A, A215R, K219N, L220F, D222K, E246D, L250I, G278S V19I, L58V, Q91QR, I133V, I180V, S197A, R224Q, F227Y, T255A, I259V, I260V, M275L, S279P 
V071737 V071737 None  N155H  S23T, N30Q, S39T, T60V, A119P, M154T, S163N, A215R, K219N, L220F, L250I V19I, L58I, S93T, I133V, H157R, I180V, S197A, D222N, R224Q, F227Y, L234Q, I259V, I260V, M275L 
V074155 V074155 None   S138T N30Q, S39T, I84V, I172M, I175V, L220F, E246D, L250I S23A, I28L, I133V, I180V, S197A, D222N, I259V, I260V, S279T, H280N 
V080553 V080553 None    S39T, I72V, I172V, E246D, L250I I28L, N30K, A41T, I180V, D222N, T255A, I260V, S279P 
V082661 V082661 None   S138T S17G, S23V, N30Q, S163D, I175V, L213F, A215T, S218L, L220F, L250I, D256E, D270H, S277C, G278S, S279A, G283D R34K, A41D, Q42K, S93T, E125D, I133V, E167D, N170V, T171S, I180T, S197A, I201V, D222N, R224Q, V251I, I259V, I260V, Q273K, M275L, H280D, L281V 
V086011 V086011 None    N30H, S39T, H51HQ, T60X, I72IV, I172V, A215R, K219N, L220F, D222K, E246D, L250I, G278S S23I, A56AT, L58I, G59GV, I133A, L158LP, E167D, I180V, S197A, R224Q, F227Y, I259V, I260V, M275L, S277SN 
V086050 V086050 None    S23T, N30Q, S39T, S163N, I172V, I175T, F185Y, A215R, K219N, L220F, D222K, E246D, L250I, G278S A41T, A56T, L58V, T60I, I133V, I180V, S197A, R224Q, F227Y, I259V, I260V, M275L, S279P 
V086051 V086051 None   S138T S17G, S23V, N30Q, S163D, I172V, I175V, I180A, L213F, A215N, S218L, L220F, L250I, D256E, D270H, S277C, G278S, S279A, G283D R34K, A41D, Q42K, S93T, A98P, E125D, I133V, E167D, N170V, T171S, S197A, I201V, N217K, K221Q, D222N, R224Q, F227Y, V251I, I259V, I260V, Q273K, M275L, H280D, L281MV 
V086052 V086052 None    S23T, N30Q, S39T, T60V, I133T, S163N, A215R, K219N, L220F, L250I, G278S E6Q, H16L, V19L, L58V, A119S, I180V, S197A, D222N, R224Q, F227Y, T255A, I259V, I260V, M275L 
V086119 V086119 None    S23T, N30Q, S39T, A119P, S163D, I172IV, A215R, K219N, L220F, D232DE, L250I, G278S K4KR, V19I, L58I, S93ST, I133V, N170NS, I180V, S197A, D222N, R224Q, Y226YF, F227Y, L234LQ, I259V, I260IV, M275L, S279P 
V086120 V086120 None    S23T, N30Q, S39T, T60V, S163N, A215R, K219X, L220F, K236R, E246D, L250I, G278S V19I, L58V, I133A, I180V, S197A, D222N, R224Q, F227Y, L234Q, I259V, I260V, M275L, S277N 
V086121 V086121 None   S138T I72V, I175V, I180A, S218L, L220F, L250I, D270H, S277C, S279A, L281M, G283D, R284G, D286A E3L, A41D, Q42K, S93ST, E125D, I133V, L158P, E167D, N170V, T171S, S197A, I201V, K221Q, D222N, R224Q, F227Y, V251I, T255A, I259V, I260V, Q273K, E274D, M275L, H280D, E285Q, G287R 
V086122 V086122 None    N30Q, S39T, T60V, A119P, I175V, A215R, K219N, L220F, E246D, L250I, G278S, D286N V19M, S23I, L58I, S93T, I133V, I180T, S197A, D222N, R224Q, F227Y, T255A, I259V, I260V, M275L, S279P 
V086123 V086123 None   S138T E13G, S17G, S23V, N30Q, I50V, H51Q, I72V, A119P, T122I, S163D, I175V, I204V, L213F, S218L, L220F, L250I, D256E, S277C, L281M, G283D, D286A E6V, R34K, A41D, Q42K, S93T, E125D, I133V, E167D, N170V, T171S, I180V, S197A, I201V, K221Q, D222N, R224Q, F227Y, V251I, I259V, D270Q, Q273K, E274G, M275L, S279T, H280D, E285Q, G287R 
V086124 V086124 None    S23T, N30Q, S39T, A119P, S163D, A215R, K219N, L220F, D232E, L250I, G278S V19I, L58I, S93ST, I133V, I180V, S197A, D222N, R224Q, Y226F, F227Y, L234Q, I259V, I260V, M275L, S279P 
V086127 V086127 None    S23T, N30Q, S39T, T60V, A119P, S163N, A215R, K219N, L220F, E246D, L250I, I267V, G278S V19I, A41T, L58I, I133V, I180V, S197A, D222N, R224Q, F227Y, L234Q, I259V, I260V, M275L, S279P 
V086130 V086130 None   S138T S23V, N30Q, A119P, S163N, A169S, I172V, A215R, K219N, L220F, E246D, L250I, G278S K4KR, V19I, S39K, L58I, I180V, S197A, D222N, R224Q, F227Y, I259V, I260V, M275L, S279P, G283S 
V086131 V086131 None    V19X, S39T, Q214H, K221X, E246D, L250I I28L, N30K, R34K, N55D, I133V, I180V, S197A, D222N, T255A, I259V, M275L, S277N 
V086136 V086136 None    S23T, N30Q, S39T, L58X, T60V, I72V, I84IV, P90PS, A119P, M154MI, S163SN, I172V, A215R, K219N, L220F, E246D, L250I, G278GS, E288EG F1FL, V19I, N55ND, S93T, V141I, A153AS, I180V, S197A, D222N, R224Q, F227Y, I259V, I260V, M275L 
V086139 V086139 None    S23V, N30Q, S39T, T60V, A119P, I172V, A215R, K219N, L220X, D222K, E246D, L250I, G278S V19M, A41P, L58I, I133IV, I180V, S197A, R224Q, F227Y, T255A, I259V, I260V, M275L, S279SP 
V086140 V086140 None    S23T, N30Q, S39T, T60V, A119P, A215R, K219N, L220F, E246D, L250I, G278S V19I, L58V, I133V, E136G, I180V, S197A, D222N, R224Q, F227Y, I259V, I260V, M275L, S279P 
V086141 V086141 None    S23T, N30Q, S39T, T60V, T111S, A119P, A215R, K219N, L220F, E246D, L250I, G278S, R284K V19I, L58I, I133V, I180V, S197A, D222N, R224Q, F227Y, I259V, I260V, M275L, G283S