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Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Hachiya (2015)
Title Natural polymorphism S119R of HIV-1 integrase enhances primary INSTI resistance.
Citation Antiviral Res
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
NumIsolates 599
NumPts 599
Subtype B, CRF01_AE, A


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Page 1   from Isolate 1 to Isolate 100 from Total 599 Clinical IN Isolates

SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
9238 9238 None    D6E, S17N, A23V, D25E, S39SN, L45V, T218S, I220L  
9241 9241 None    K14R, S39C, I84M, S119T, T124N, M154L, V201I, T206S, S230N, D232E  
9246 9246 None    E11D, R20RK, D25DE, V31I, G106GA, T112TI, S119T, E157Q, K160Q, S195T, I203M, T206S, Q216H, S230N, A265V S283G 
9254 9254 None    D6E, S17N, N27NH, L28I, L45I, T112K, I113V, T124N, T125A, K156N, I203M, K215N, I220V  
9259 9259 None    K7KR, S17N, R20RK, V31VI, S39SN, L45V, I72IATV, I113IV, T124A, K156N, K160KR, I203M, N222K, D270DE G47GE, S283G 
9260 9260 None    K14R, V31I, I60M, V88I, E96D, L101I, K111T, S119T, T124N, T125A, I135V, E157Q, V201I, T206S, I208L, I217S, S230N  
9264 9264 None    K14R, D25E, L28I, S39C, L45LI, L101I, I113V, T125TA, K156N, V176L, V201VI, T206S, K211R, K215N, D279G  
9280 9280 None    V31I, E96D, L101V, K111T, S119T, T124N, T125A, I135V, E157Q, F181L, E198Q, V201I, T206S, I217S, S230N  
9281 9281 None  T66TI  S17N, L28I, S39C, L101I, T112A, T124A, K160KR, D167E, V201I, L234I, R269K  
9287 9287 None    K156N  
9307 9307 None    K7R, V32I, S39C, S57N, G70GR, I84M, S119T, T124N, V201I, T206S, Q216R E287A 
9311 9311 None    V31I, L101IV, K111T, I113IV, S119T, T124N, T125A, I135V, F181FL, V201I, T206S, I208L, K211R, I217S, S230N  
9320 9320 None   V54VI K7R, S17N, R20K, I84IM, L101I, I113V, T124S, T125A, I135V, G163E, V201I, L234I  
9323 9323 None    D3DN, I72IV, T125TA, K156N, V201I, I203M, I220V A76AG 
9324 9324 None    K7KR, I72V, S119P, V201I, K211KQ, I220IL, R269RK  
9335 9335 None    D6DE, S39SCT, L101I, S119T, I135IV, I141IV, V201I, T206S, K215N, Q216QK, D253E H12HY, S283G 
9336 9336 None    S24G, D25E, L45V, T124N, K211R, T218S, I220L  
9338 9338 None    A23V, I72V, S119G, T122I, T125A, K156KR, K215N, Q221S, N222K, K240R, D256E, R269K  
9350 9350 None    E11D, S24N, D25DE, V31VI, V201I, T218TS R284RG 
9351 9351 None    E11D, L28I, V37I, K156N, V201I, K219KR  
9353 9353 None    E10EA, E11D, S17N, S24D, D25E, M50L, K111R, I113V, T125A  
9356 9356 None    S17N, L28I, L45IV, T124TA, G134GE, K156N, V201I, T218S, I220V  
9357 9357 None    E11D, K14R, S17T, M22I, A23V, S24SG, D25E, L28I, V31I, L45LV, L101I, K103KR, K111T, T125A, V126VA, V165I, L234I S283G, D288N 
9358 9358 None   V151I E11D, V31I, I72V, I84M, L101I, T124A, I135V, R187K, V201I, K215N, S230N, D256E  
9363 9363 None    S17N, L28I, L68LS, L101I, T124TA, K156N, V201VI I72ADNT 
9372 9372 None    S17N, L28I, S39C, L45LIM, I72IV, T124TA, K156N, V201I  
9379 9379 None   G163EK D6DN, E11D, V31I, V32VI, I72V, L101I, T112A, I135V, S195C, V201I, K215N, V249VI, R269RK, D279G W61W* 
9385 9385 None    E11D, V31I, L101I, K111A, I113IV, S119T, T124NS, T125A, I135V, V165VI, V201I, I204IV, T206S, I208IL, I217S, S230N  
9393 9393 None    S17N, A23AV, L28I, V31VI, D41DE, L45LI, T124TA, K156N, I203IM, Q216H, D256E, D278DN, D279DAG D286DN 
9403 9403 None    I72IT, S119G, T122I, T125A, K156N, R187K, I203IM, K215N, Q221S, N222K  
9407 9407 None    L28I, L45I, K111KR, K156N, I203M, T218S  
9415 9415 None    A23V, V31VI, I72IV, Q95H, S119G, T122I, T125A, K215N, Q221S, N222K, D256E  
9416 9416 None    D6E, E10D, A23AV, V31VI, V32I, L45I, D55DG, I60M, L101I, K156N, V201I, K215N, Q216K S283SG, D286N 
9422 9422 None    V31I, L45V, M50MI, L74I, G163E, V201I, T218S  
9427 9427 None    S17N, A23AV, L28LI, G70GR, K156S, V201I, I220V  
9430 9430 None    S39SN, K111R, K156N, V201I, I203M P233PL 
9444 9444 None    K7Q, E10A, E11D, K14R, S24SN, N27S, L28I, K34KR, T125A, K156N, E157Q  
9461 9461 None    E11D, K14R, V31I, I60M, L101I, K111T, S119T, T125A, I135V, V201I, T206S, I208L, I217S, Y227YF, S230N  
9476 9476 None    E10D, D41DN, I72IT, I84M, T124A, T125TA, K156N, E157Q, V201I, I203M, T218S S283SG 
9484 9484 None    S17N, L28I, L45IV, T124A, T125TA, K156N, V201I, T218S, I220V  
9485 9485 None    I72V, T125A, K156N, V176L, A205S  
9488 9488 None   V54VI D3E, S17N, A23AS, V32VI, I72V, I84IM, P90PS, T112TA, T124TN, T125A, V201I, I203IM, A205AS, A265AV A33AS, S39IMR, L45LHQ, R284RG, Q285Q* 
9494 9494 None    K14KR, S17N, S24D, L28I, S39C, V88VIL, Y99YH, V201I, E212EA  
9501 9501 None    V31I, I72IV, I84IM, L101V, K111T, S119T, T124N, T125A, I135V, S153SF, V201I, I203IMV, A205S, T206S, I208L, I217S F100FL, S123SR, C130CR, D286DN 
9512 9512 None    E11D, K14KR, S17ST, M22MI, A23V, S24SG, D25DE, L28I, V37I, A91T, L101I, S119G, T122I, T125A, K156N, E157Q, K211R, K215N, Q221S, N222K, D256E V281VL 
9521 9521 None    E11D, L28LIM, V31VI, V32VI, I84M, L101LI, K103KR, T112V, T124N, M154L, V165VI, S195C, V201I, I203M, K215N, S230N  
9522 9522 None    E11D, L28LIM, V31VI, V32VI, I84M, L101LI, K103KR, T112V, T124N, M154L, V176VI, S195C, V201I, I203M, K215KN, S230N  
9525 9525 None    S17N, R20RK, L45I, E48EK, T124A, K156N, K160KR, V201I, I204IV, I208L, T218S D286N 
9526 9526 None    E11D, A23V, L28I, V37I, I72V, L74LV, L101I, T112IV, S119T, H171HL, V201I, T206S  
9531 9531 None    E11D, A23V, S24N, L28I, V37I, I72V, L101I, S119G, T122I, T125A, E157Q, K160Q, I203M, K215N, Q221S, N222K  
9567 9567 None    I72IT, I84L, K156N, I203M  
9582 9582 None    V31I, T124N, I203L, K215N, I220L, Q221S, N222K, D256E, R269K V201IT 
9592 9592 None    D6S, E10D, E13D, V32I, S39SC, I72IV, G163T, H171HY, K211R, A265AV H12HY 
9610 9610 None    S17N, L28I, L45V, T124A, K156N, V201I, T218S, I220V  
9622 9622 None    E11D, S24N, T112I, T125TA, V201I, I203IM, S230SN V79VL, S283SG 
9634 9634 None    E11ED, S24N, K111KR, K156KN, T206TS, I208L, E212A, K215N, I220L  
9646 9646 None    A23AT, L28I, L101I, K156N, K215N, D279G  
9653 9653 None    E10D, V31I, L45I, I72IV, L101I, K156N, V201VI, D256E  
9663 9663 None    E11D, K14R, S24N, L28I, L45I, K111R, T112I, K156N, E157Q, K173R, K211R, T218S  
9667 9667 None   L74LIM, V151VI D25DE, V31I, S57N, I72IT, I84M, L101I, S119P, T125TA, H171Q, Q177L, V201I, T206S, K215N  
9672 9672 None    L28I, V31I, L74I, L101I, I113V, K156N, H171Y, D256E P109PL 
9679 9679 None    D6E, E10D, K14KR, S17N, I72T, I73IV, I84IM, P90PA, L101I, I113IV, T124A, T125TA, K156N, E157Q, A205S, I220L  
9680 9680 None    E11D, K14KR, V31VI, V32VI, I72V, V77A, L101I, M154L, V165I, S195C, E198D, V201I, K215N, D279DG  
9690 9690 None    E11D, K14R, R20RK, S24A, L28I, V31VIM, L45V, A80S, L101I, G163AT, T206TS, D256E  
9692 9692 None   V151I K7KR, I72IV, K111R, T124N, T125A, V126L, I161IT  
9698 9698 None    S17N, G70GE, L101I, T112TI, I113V, T124A, K156N, V201VI G149GR 
9700 9700 None    V31VI, K156N, E157EQ, V201VI R284RG 
N0636 N0636 None    E11D, S24A, L45LV, A80S, L101I, G163A  
N0649 N0649 None    E13ED, V31VI, L74I, L101I, S119P, G163GE, H171Q, V201I, I203L, K215N, Q221S, N222K, D256E  
N0676 N0676 None    S17SN, K111KR, I113V, T125A, K156N K7MT, Q95Q* 
N0685 N0685 None    M22L, L45V, M50MI, L101LI, T125TA, G163GE, V165VI, D167DE, H171HQ, F181L, V201VI, L234LI, I268IL, D270DN L63LF 
N0691 N0691 None    S17N, S57N, V77I, I84M, S119T, T124A, V201I, T206S, I220L  
N0693 N0693 None    V31I, L101I, T124N, G163E, E198Q, V201I  
N0695 N0695 None    E11D, K14R, S24A, L28I, L45V, A80S, L101I, I135IV, G163A  
N0697 N0697 None    L101I, I113IV, K156N, K211KQ, I217IV, T218TS S283G 
N0700 N0700 None    R20RK, M50I, L101I, K111R, T124TA, A196P, V201I S283G 
N0704 N0704 None    E10D, V31VI, K156N, V201VI, T218TS S283G 
N0707 N0707 None    Q95QR, L101I, T124A, T125A, I135V, F181L, V201I, I203M R284G 
N0712 N0712 None    T124TA, T125A, V126L, I135V, G163T, A196P, I200L, V201I, T218TS Q214Q*, Q252Q* 
N0716 N0716 None    K14KR, V31VI, V32I, L101I, S119P, T125TA, H171HQ, V201I, I203L, K215N, Q221S, N222K, D256E  
N0734 N0734 None    K14R, S17C, I84L, L101I, T124A, T125A, M154I, V165I, E198D, V201I G106GE 
N0740 N0740 None    E11ED, L45V, M50I, I113V, G163E Q216Q* 
N0752 N0752 None    E11D, R20RK, N27G, V37I, I72V, L101I, G106A, K111R, I113V, G193E, V201I, K211R, S230N, K240R  
N0769 N0769 None    E11D, V31VI, V32I, V37I, T124N, V165I, L172LF, V201I, D256DE  
N0791 N0791 None    E10Q, I72V, T125A, K156N, V201I, C280S  
N0793 N0793 None    E11D, L74LV, A91T, L101I, T124A, T125A, I135V, V201I, I203M, K215KN, S230SN  
N0797 N0797 None    V31VI, A91E, L101I, S119R, K136KQ, K215N, S230N, D232E  
N0801 N0801 None    K14R, R20RK, V31I, V88I, L101I, S119P, T124N, T125AV, V126VA, G163E, G193D, S195T, V201I, T206S, M275V, D278N D286N 
N0805 N0805 None    K7R, S17N, L28I, T125TA, K156N  
N0810 N0810 None    E10ED, E11ED, E13ED, S17N, L28I, S119SGR, T122TI, T125TA, K156N, I203L, K211R, N222NK D6DA 
N0811 N0811 None    K7R, E11ED, S17N, A23AV, L28I, K46KR, K156N F1FC 
N0837 N0837 None    V31I, I84IV, L101LI, I113IV, T125TA, K156N, V201I, K215KN, Q216QH  
N0842 N0842 None    S17N, L28I, K111KR, K156N, K211R  
N0856 N0856 None    E11D, V31I, V32I, V37I, S39C, I72V, I73V, I84L, P90PS, L101IV, K111T, T124TN, T125A, I162V, V165I, V176I, V201I, I203M, K211R, L234I, D253DE  
N0869 N0869 None    K14KR, V31I, S57N, L101I, I113IV, S119P, T122TAIV, G163E, V201I, T206S, S230SN, D256E  
N0875 N0875 None    E10D, L28I, K156N  
N0877 N0877 None    K7R, S17N, L28I, K156N, V165VI, H171HY  
N0897 N0897 None    K7R, K14R, S17N, L28I, M50I, L101I, K156N, V201I, K215R P233PL, D286DN 
N0901 N0901 None    D6DE, E11D, E13D, V31I, L101I, K111T, S119P, T122I, I135V, I208L, T218S  
N0907 N0907 None    E11D, S39C, L45V, L101I, V110I, G193E, V201I, D279G